Design, synthesis, molecular docking and pharmacological evaluation of novel triazine-based triazole derivatives as potential anticonvulsant agents.

Triazine-linked triazole compounds (4a-j) were designed, synthesized, and then examined for their anticonvulsant abilities. Compounds 4e, 4f, 4g, 4i, and 4j displayed significant anticonvulsant activity in both maximum electroshock seizure (MES) and pentylenetetrazole (PTZ) induced seizure during the preliminary screening. The phase II anticonvulsant activity statistics revealed that compounds 4e, 4f, 4g, 4i, and 4j demonstrated excellent activity as compared to the conventional drugs methaqualone and valproate, supporting the potential of these triazine-linked triazole analogues as novel anticonvulsant agents.

Structural Basis of Targeted Imaging and Therapy in Cancer Explorations with the Epigenetic Drugs.

Origin of cancer is strongly related to the unusual epigenetic regulation of gene function as indicated by recent reports. The covalent modifications to DNA or histones without affecting genomes that finally lead to phenotypical changes in cells or organisms are referred as "Epigenetics." The possibility to reprogram the epigenetics in the cancer epigenome is the most important target for cancer treatment and drug resistance.

New luminescent ordered liquid crystalline molecules with a 3-cyano-2-pyridone core unit.

The self-organized states of liquid crystals (LCs) have recently received a lot of attention because of their various applications, especially in the fields of electron transport materials and optoelectronic devices. In most of these applications, molecules containing a donor-acceptor skeleton have been widely employed and generally these molecular frameworks have been designed mainly on the basis of the donor-acceptor concept. Inspired from this concept, we synthesized a series of new donor-acceptor based luminescent molecules, 4,6-bis(4-alkyloxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile (Pn-series), carrying variable alkoxy chains [ = 8, 10, 12, 14, 16].

Ultrasensitive colorimetric detection of fluoride and arsenate in water and mammalian cells using recyclable metal oxacalixarene probe: a lateral flow assay.

Globally 3 billion people are consuming water with moderately high concentrations of fluoride and arsenic. The development of a simple point of care (PoC) device or home device for the detection of fluoride/arsenic ensures safety before consuming water. Till date, lateral flow assay (LFA) based PoC devices can detect nucleic acids, viruses and diseases.

Protonation induced redshift in the fluorescence of a pyridine derivative as a potential anti-counterfeiting agent.

A simple pyridine-based compound, (2,4,6-(4-(hexyloxy)phenyl)pyridine), was synthesized and exhibited excellent solubility in various organic solvents owing to the presence of three 4--hexyloxy chains in its molecular structure. Further, we studied the effect of various solvents on its absorption and emission properties. We observed a greater extent of redshift in the chloroform solvent compared to the rest of the solvents.

Investigation on Pathological Aspects, Mode of Transmission, and Tissue Tropism of Antheraea proylei Nucleopolyhedrovirus Infecting Oak Tasar Silkworm.

The temperate oak tasar silkworm, Antheraea proylei, is frequently infested with Antheraea proylei nucleopolyhedrovirus (AnprNPV) causing tiger band disease. This disease is one of the key factors that obstructs production and productivity of oak tasar sericulture. The current study aimed to investigate the pathogenicity of AnprNPV, its mode of transmission, and detection of AnprNPV in different tissues.

Electrocatalytic oxidation and amperometric determination of sulfasalazine using bimetal oxide nanoparticles-decorated graphene oxide composite modified glassy carbon electrode at neutral pH.

Cube-shaped samarium orthovanadate (SmVO) nanoparticles were interconnected with a graphene oxide sheet (GOS) using a simple and eco-friendly method to generate a SmVO@GOS nanocomposite. SmVO was characterized using various spectroscopic and microscopic techniques, which confirmed the wrapping of GOS around the SmVO nanoparticles. SmVO@GOS was then used to modify a glassy carbon electrode (GCE), which was evaluated for its electrochemical performance toward the assay of sulfasalazine (SSZ), an antibiotic drug.

Merging Rh-Catalyzed C-H Functionalization and Cascade Cyclization to Enable Propargylic Alcohols as Three-Carbon Synthons.

Reported herein is a reactivity of propargyl alcohols as "Three-Carbon Synthons" in a Rh(III)-catalyzed C-H functionalization of acetanilides, leading to the synthesis of core structures of isocryptolepine, γ-carbolines, dihydrochromeno[2,3-b]indoles, and diindolylmethanes (DIM) derivatives. The transformation involves a rhodium(III)-catalyzed C-H functionalization and heteroannulation to yield indoles followed by a cascade cyclization with both external and internal nucleophiles to afford diverse products. The role of the hydroxy group, the key function of the silver additive, the origin of the reverse regioselectivity and the rate-determining step, are rationalized in conformity with the combination of experimental, noncovalent interaction analysis and DFT studies.

Single nucleotide polymorphisms cumulating to genetic variation for fertility in crossbred ( × ) bull spermatozoa.

Spermatozoa from high-fertile (HF) and low-fertile (LF) breeding bulls were subjected to high-throughput next-generation sequencing to identify important Single nucleotide polymorphisms (SNPs) and novel variants associated with fertility. A total of 77,038 genome-wide SNPs were identified, among which, 10,788 were novel variants. A total of 42,290 and 34,748 variants were recorded with 6115 and 4673 novel variants in in HF and LF bulls, respectively.

Photocatalytic Activity Induced by Metal Nanoparticles Synthesized by Sustainable Approaches: A Comprehensive Review.

Nanotechnology is a fast-expanding area with a wide range of applications in science, engineering, health, pharmacy, and other fields. Among many techniques that are employed toward the production of nanoparticles, synthesis using green technologies is the simplest and environment friendly. Nanoparticles produced from plant extracts have become a very popular subject of study in recent decades due to their diverse advantages such as low-cost synthesis, product stability, and ecofriendly protocols.

Detection of Malicious Cloud Bandwidth Consumption in Cloud Computing Using Machine Learning Techniques.

The Internet of Things, sometimes known as IoT, is a relatively new kind of Internet connectivity that connects physical objects to the Internet in a way that was not possible in the past. The Internet of Things is another name for this concept (IoT). The Internet of Things has a larger attack surface as a result of its hyperconnectivity and heterogeneity, both of which are characteristics of the IoT.

Anti-amyloidogenic property of gold nanoparticle decorated quercetin polymer nanorods in pH and temperature induced aggregation of lysozyme.

Quercetin is an abundant plant polyphenol effective against several diseases due to its antioxidant and anti-inflammatory activity. Herein, we report novel polymeric quercetin nanorods and the former decorated with gold nanoparticles for the first time. The prepared conjugates quercetin-polyvinylpyrrolidone (Q-PVP) and quercetin-polyvinylpyrrolidone-gold nanoparticles (Q-PVP-Au) were characterized by UV-visible spectroscopy, Fourier transform infrared, dynamic light scattering, and zeta potential measurements.

Sodium docusate as a cleaning agent for forward osmosis membranes fouled by landfill leachate wastewater.

Membrane cleaning is critical for economic and scientific reasons in wastewater treatment systems. Sodium docusate is a laxative agent and removes cerumen (ear wax). Docusate penetrates the hard ear wax, making it softer and easier to remove.

ON donor tethered copper (II) and vanadium (V) complexes as efficacious anti-TB and anti-fungal agents with spectroscopic approached HSA interactions.

Antimicrobial drug resistance poses a significant threat worldwide, hence triggering an urgent situation for developing feasible drugs. 3D-transition metal coordination complexes being multifaceted, offer tremendous potency as drug candidates. However, there are fewer reports on non-toxic and safe transition metal complexes; therefore, we hereby attempted to develop novel copper and vanadium-based therapeutic agents.

The effect of geometry dependent Chamber Spatial Response Function in small field profile measurements.

The effect of Chamber-Spatial Response Function (CSRF) on beam profile measurements has been studied for Standard Ionization Chamber-Radiation Field Analyzer setup. The Chamber-Spatial Response Function is assumed to be Gaussian and parameterized through the projected geometry of the chamber along the measurement axis. CSRF widths was measured by constructing chamber diameter-FWHM correlation for a set of ionization chambers.

Cytokinin and abiotic stress tolerance -What has been accomplished and the way forward?

More than a half-century has passed since it was discovered that phytohormone cytokinin (CK) is essential to drive cytokinesis and proliferation in plant tissue culture. Thereafter, cytokinin has emerged as the primary regulator of the plant cell cycle and numerous developmental processes. Lately, a growing body of evidence suggests that cytokinin has a role in mitigating both abiotic and biotic stress.

Comprehensive Review on Medicinal Applications of Coumarin-Derived Imine-Metal Complexes.

Coumarins are fused six-membered oxygen-containing benzoheterocycles that join two synthetically useful rings: α-pyrone and benzene. A survey of the literature shows that coumarins and their metal complexes have received great interest from synthetic chemists, medicinal scientists, and pharmacists due to their wide spectrum of biological applications. For instance, coumarin and its derivatives have been used as precursors to prepare a large variety of medicinal agents.

Aqueous, Non-Polymer-Based Perovskite Quantum Dots for Bioimaging: Conserving Fluorescence and Long-Term Stability Simple and Robust Synthesis.

Perovskite quantum dots (PQDs) offer high photoluminescence quantum yields; however, due to their limited stability in aqueous media, to date their utilization in biomedical applications has been limited. The present work demonstrates highly fluorescent and stable aqueous PQDs that were synthesized using a facile engineered phase transfer method. Ligands were engineered to have a dual functionality, i.

Fundamentals and comprehensive insights on pulsed laser synthesis of advanced materials for diverse photo- and electrocatalytic applications.

The global energy crisis is increasing the demand for innovative materials with high purity and functionality for the development of clean energy production and storage. The development of novel photo- and electrocatalysts significantly depends on synthetic techniques that facilitate the production of tailored advanced nanomaterials. The emerging use of pulsed laser in liquid synthesis has attracted immense interest as an effective synthetic technology with several advantages over conventional chemical and physical synthetic routes, including the fine-tuning of size, composition, surface, and crystalline structures, and defect densities and is associated with the catalytic, electronic, thermal, optical, and mechanical properties of the produced nanomaterials.

Three-dimensional manganese cobaltate: a highly conductive electrocatalyst for paraoxon-ethyl detection.

The synthesis of manganese cobaltate (MnCoO) with the hybrid three-dimensional architecture has been developed as an electrocatalyst for the electrochemical sensing of paraoxon-ethyl (PEL). The detailed physicochemical and structural characterization of MnCoO is meticulously examined. The MnCoO-modified screen-printed carbon electrode (SPCE) exhibits good electrocatalytic activity for the reduction of PEL compared with the bare SPCE due to numerous unique properties.

Recent Developments and Future Perspective on Electrochemical Glucose Sensors Based on 2D Materials.

Diabetes is a health disorder that necessitates constant blood glucose monitoring. The industry is always interested in creating novel glucose sensor devices because of the great demand for low-cost, quick, and precise means of monitoring blood glucose levels. Electrochemical glucose sensors, among others, have been developed and are now frequently used in clinical research.

Drug re-engineering and repurposing: A significant and rapid approach to tuberculosis drug discovery.

The prevalence of tuberculosis (TB) remains the leading cause of death from a single infectious agent, ranking it above all other contagious diseases. The problem to tackle this disease seems to become even worse due to the outbreak of SARS-CoV-2. Further, the complications related to drug-resistant TB, prolonged treatment regimens, and synergy between TB and HIV are significant drawbacks.

X chromosome-linked genes in the mature sperm influence semen quality and fertility of breeding bulls.

The role of sperm expressed X-linked genes on bull fertility has not been studied in detail. The objective of the present study was to assess the influence of X-linked genes on the sperm functional parameters and field fertility rate in the Holstein Friesian cattle (n = 12) and Murrah buffalo (n = 7) bulls. The enrichment analysis (cattle = 8; buffalo = 8) of the X-linked genes was carried out using retrospective RNA-seq data and mRNA expression levels of functionally relevant genes were validated using the RT-qPCR.

Rational design of selenium inserted 1T/2H mixed-phase molybdenum disulfide for energy storage and pollutant degradation applications.

MoSbased materials are recognized as the promising candidate for multifunctional applications due to its unique physicochemical properties. But presence of lower number of active sites, poor electrical conductivity, and less stability of 2H and 1T MoSinherits its practical applications. Herein, we synthesized the Se inserted mixed-phase 2H/1T MoSnanosheets with abundant defects sites to achieve improved overall electrochemical activity.

Antifungal potential of Azotobacter species and its metabolites against Fusarium verticillioides and biodegradation of fumonisin.

Aims: In the study, seven Plant Growth Promoting Rhizobacteria (PGPR) Azotobacter species were screened against three strains of Fusarium verticillioides to test its antifungal activity. Azotobacter strains were tested for the degradation of fumonisin produced by F. verticillioides.