Corrigendum: Cytokinins: a genetic target for increasing yield potential in the CRISPR era.

[This corrects the article DOI: 10.3389/fgene.2022.

Exploration of oxadiazole clubbed benzhydrylpiperazine pharmacophoric features as structural feature for antidepressant activity: In vitro, in vivo and in silico analysis.

Arylpiperazine clubbed various heterocyclic molecules present potential pharmacophoric structural features for the development of psychoactive drugs. There are various CNS active molecules possessing arylpiperazine moiety in their pharmacophore approved by USFDA. In the current study, we have explored the benzhydrylpiperazine moiety clubbed with various substituted oxadiazole moieties (AP1-12) for their monoamine oxidase (MAO) inhibition and antidepressant potential.

Corrigendum: Cytokinin and abiotic stress tolerance -What has been accomplished and the way forward?

[This corrects the article DOI: 10.3389/fgene.2022.

NHCs silver complexes as potential antimicrobial agents.

NHCs (-heterocyclic carbenes) are generally used as organic ligands that can coordinate with metal ions like silver to form stable complexes. These complexes have shown enhanced antimicrobial properties compared to silver alone. This document provides an overview of the reported NHC-based silver derivatives (acetates, chlorides, bromides, and iodides) who possess antimicrobial activity.

Individual and Simultaneous Electrochemical Detection of Allura Red and Acid Blue 9 in Food Samples Using a Novel LaYCrO Double Perovskite Decorated on HLNTs as an Electrocatalyst.

The present study involved the synthesis of LaYCrO double perovskites using a sol-gel approach. Additionally, a sonication method was implemented to prepare LaYCrO double perovskites decorated on halloysites (LaYCrO/HLNTs). The LaYCrO/HLNTs exhibited remarkable conductivity, electrocatalytic activity, and rapid electron transfer.

Production of green hydrogen from sewage sludge / algae in agriculture diesel engine: Performance Evaluation.

Alternative fuel opportunities can satisfy energy security and reduce carbon emissions. In this regard, the hydrogen fuel is derived from the source of environmental pollutants like sewage and algae wastewater through hydrothermal gasification technique using a KOH catalyst with varied gasification process parameters of duration and temperature of 6-30 min and 500-800 °C. The novelty of the work is to identify the optimum gasification process parameter for obtaining the maximum hydrogen yield using a KOH catalyst as an alternative fuel for agricultural engine applications.

Salicylic Acid Conjugate of Telmisartan Inhibits Chikungunya Virus Infection and Inflammation.

There is no approved antiviral for the management of the Chikungunya virus (CHIKV). To develop an antiviral drug that can manage both CHIKV and arthritis induced by it, an ester conjugate of telmisartan (TM) and salicylic acid (SA) was synthesized (DDABT1). It showed higher potency (IC of 14.

In vitro α-amylase and α-glucosidase inhibition study of dihydropyrimidinones synthesized via one-pot Biginelli reaction in the presence of a green catalyst.

A green catalyst WELPSA-catalyzed three-component condensation (Biginelli) process involving an aldehyde, barbituric/thiobarbituric/1,3-dimethylbarbituric acid, and urea/thiourea/guanidine hydrochloride in a single pot in presence of a green solvent for the production of DHPM have been presented. The catalyst is reusable and this methodology is scalable. By using the in vitro experiments, the antidiabetic potentiality of synthesized compounds that inhibit α-amylase along with α-glucosidase efficiencies was assessed.

Exploring antibiofilm potential of some new imidazole analogs against synthesis, antifungal activity, molecular docking and molecular dynamics studies.

A series of 1, 2, 4, 5-tetrasubstituted imidazole derivatives were synthesized and their antibiofilm potential against was evaluated . Two of the synthesized derivatives IC= 25 µg/mL) and (IC= 6 µg/mL),displayed better antifungal and antibiofilm potential than the standard drug Fluconazole (IC = 40 µg/mL) against . Based on the results, we escalated the real time polymerase chain reaction (RT-PCR) analysis to gain knowledge of the enzymes expressed in the generation and maintenance of biofilms and the mechanism of biofilm inhibition by the synthesized analogues.

CoFeO modified bentonite-based mixed matrix loose nanofiltration membranes for effective wastewater treatment.

Mixed-matrix membranes (MMMs) with an ideal polymer/hydrophilic flux enhancer interface considerably recuperates the separation and purification performance of membrane. In this direction, a novel CoFeO functionalized natural clay-bentonite (CoFeO@BT) material as a compatible flux enhancer was synthesized for preparation of mixed matrix based in polyethersulfone (PES) matrix. Here, the influences of CoFeO@BT on the morphology and performance of the MMMs membranes were systematically investigated using various analytical techniques.

Suitability of Adenosine Derivatives in Improving the Activity and Stability of Cytochrome c under Stress: Insights into the Effect of Phosphate Groups.

It is well known that adenosine and its phosphate derivatives play a crucial role in biological phenomena such as apoptosis and cell signaling and act as the energy currency of the cell. Although their interactions with various proteins and enzymes have been described, the focus of this work is to demonstrate the effect of the phosphate group on the activity and stability of the native heme metalloprotein cytochrome c (Cyt c), which is important from both biological and industrial aspects. In situ and in silico characterizations are used to correlate the relationship between the binding affinity of adenosine and its phosphate groups with unfolding behavior, corresponding peroxidase activities, and stability factors.

Anomaly detection using deep convolutional generative adversarial networks in the internet of things.

Advanced 5 G and 6 G technologies have accelerated the adoption of the Internet of Things (IoT) and are a priority in providing support for high-speed communication and fast data analysis. One of IoT networks benefits is automated networking, which unfortunately increases the risk of security, integrity, and privacy breaches. Therefore, in this paper, we propose a weighted stacked ensemble model combining deep convolutional generative adversarial and bidirectional long short-term memory networks.

Identification of hub genes and their expression profiling for predicting buffalo (Bubalus bubalis) semen quality and fertility.

Sperm transcriptomics provide insights into subtle differences in sperm fertilization competence. For predicting the success of complex traits like male fertility, identification of hub genes involved in various sperm functions are essential. The bulls from the transcriptome profiled samples (n = 21), were grouped into good and poor progressive motility (PM), acrosome integrity (AI), functional membrane integrity (FMI) and fertility rate (FR) groups.

All-Solid-State Supercapacitors Based on Cobalt Magnesium Telluride Microtubes Decorated with Tellurium Nanotubes.

Magnesium (Mg) has received very little exploration on its importance in the realm of battery-type energy storage technologies. They are abundantly present in seawater, and if successfully extracted and utilized in energy storage systems, it could lead to the long-term advancement of human civilization. Here, we fabricated an all-solid-state supercapacitor (ASSSC) using tellurium nanotubes decorated cobalt magnesium telluride microtubes (Te NTs@CoMgTe MTs) clad on nickel foam (NF).

Friedelin: Structure, Biosynthesis, Extraction, and Its Potential Health Impact.

Pharmaceutical companies are investigating more source matrices for natural bioactive chemicals. Friedelin (friedelan-3-one) is a pentacyclic triterpene isolated from various plant species from different families as well as mosses and lichen. The fundamental compounds of these friedelane triterpenoids are abundantly found in cork tissues and leaf materials of diverse plant genera such as Celastraceae, Asteraceae, Fabaceae, and Myrtaceae.

Synthesis of novel 5-[3-(4-chlorophenyl)-substituted-1,3-dimethylpyrimidine-2,4,6(1,3,5)-trione derivatives as potential anti-diabetic and anticancer agents.

In this work, we developed a series of novel 5-[3-(4-chlorophenyl)-substituted-1,3-dimethylpyrimidine-2,4,6(1,3,5)-trione derivatives a one-pot multicomponent reaction. The structures of the compounds were confirmed using analytical and spectroscopic techniques. Also, the synthesized compounds were screened for their anti-diabetic activity, cytotoxicity and studies.

Characterization of withanolides and bacoside A-loaded proniosomes: effect on oxidative stress and survival under hypergravity in rodent model.

Objective: This work provides characterization of withanolides and bacoside A proniosomes, and evaluating their potency in rat model for combating oxidative stress-induced blood-brain barrier (BBB) damage and their survival under hypergravity.

Significance: The delivery system was aimed for sustained drug release in plasma and brain, which could improve their efficiency and provide a therapeutic approach to combat oxidative damage and restore BBB integrity.

Methods: Proniosomes were prepared using withanolides extracted from the roots of and bacoside A derived from the leaf extract of by thin film hydration technique.

Biomimetic Helical Hydrogen Bonded Organic Framework Membranes for Efficient Uranium Recovery from Seawater.

Inspired by the uranyl-imidazole interactions via nitrogen's (N's) of histidine residues in single helical protein assemblies with open framework geometry that allows through migration/coordination of metal ions. Here, preliminary components of a stable hydrogen-bonded organic framework (HOF) are designed to mimic the stable single helical open framework with imidazole residues available for Uranium (U) binding. The imidazolate-HOF (HOF2-S) is synthesized with solvent-directed H-bonding in 1D array and tuned hydrophobic CH-π interactions leading to single helix pattern having enhanced hydrolytic stability.

Copper Nanoclusters as Novel Podium for Cancer Detection, Imaging, and Therapy Applications.

Nanoclusters (NCs) are meticulously small, kinetically stable, crystalline materials which hold immense potential as multifaceted catalysts for a broad range of biomedical applications. Metal NCs are atomically precise and exist within the range of Fermi wavelength of electrons. They are highly advantageous as functional materials as their physicochemical properties can be customized to meet specific requirements.

Facile one pot synthesis of 2-substituted benzimidazole derivatives under mild conditions by using engineered MgO@DFNS as heterogeneous catalyst.

Benzimidazole derivatives are considered as important heterocyclic motifs that show a wide range of pharmaceutical applications. In view of their wide-ranging bioactivities, it is imperative to direct research on the sustainable catalytic synthesis of benzimidazole. Therefore, herein, we report a novel approach for the synthesis of benzimidazole and its derivatives with engineered MgO supported on dendritic fibrous nano silica (MgO@DFNS) as a sustainable heterogeneous catalyst.

Advances in solar energy harvesting integrated by van der Waals graphene heterojunctions.

Graphene has garnered increasing attention for solar energy harvesting owing to its unique features. However, limitations hinder its widespread adoption in solar energy harvesting, comprising the band gapless in the molecular orbital of graphene lattice, its vulnerability to oxidation in oxidative environments, and specific toxic properties that require careful consideration during development. Beyond current challenges, researchers have explored doping graphene with ionic liquids to raise the lifespan of solar cells (SCs).

anti-prostate adenocarcinoma and lung cancer studies of phenoxyaniline--poly(methyl methacrylate) based nanocomposites controlled radical polymerization.

A phenoxyaniline-based macroinitiator is utilized for the first time in order to produce phenoxyaniline--poly(methyl methacrylate) composites through single electron transfer-living radical polymerization (SET-LRP) under mild conditions. A different weight percentage of Cloisite 93A is added into the polymer mixtures in order to increase their biochemical properties. The prepared block copolymer nanocomposites are characterized using ATR-IR, UV-vis-spectroscopy, XRD, Raman, TGA, DSC, a particle size analyzer, contact angle measurements and SEM in order to characterize their structural, thermal, surface and morphological properties.

Octahedral PdCu Catalysts on Diverse Support Materials for Efficient Hydrogen Evolution: Theoretical Investigation and Mechanistic Perspective.

This work showcases a novel strategy for the synthesis of shape-dependent alloy nanostructures with the incorporation of solid substrates, leading to remarkable enhancements in the electrocatalytic performance. Herein, an aqueous medium approach has been used to synthesize an octahedral PdCu alloy of different Pd:Cu ratios to better comprehend their electrocatalytic potential. With the aim to outperform high activity and efficient stability, zirconium oxide (ZrO), graphene oxide nanosheets (GONs), and hexagonal boron nitride nanosheets (hBNNs) solid substrates are occupied to decorate the optimized PdCu catalyst with a minimum 5 wt % metal loading.