LncRNA CRNDE and HOTAIR: Molecules behind the scenes in the progression of gastrointestinal cancers through regulating microRNAs.

Gastrointestinal (GI) cancers, such as gastric cancer, hepatocellular carcinoma, colorectal cancer, and esophageal cancer, pose a significant medical and economic burden globally, accounting for the majority of new cancer cases and deaths each year. A lack of knowledge about the molecular mechanisms of GI cancers is reflected in the low efficacy of treatment for individuals with late stage and recurring illness. Understanding the molecular pathways that promote the growth of GI cancers may open doors for their therapy.

HF-free low temperature synthesis of MXene for electrochemical hydrogen production.

MXenes (two-dimensional (2D) transition-metal carbides, nitrides, and carbonitrides) are gaining significant interest as alternative electrocatalysts for the hydrogen evolution reaction due to their excellent properties, such as high electrical conductivity, large surface area, and chemical stability. MXenes are traditionally synthesized using hydrofluoric acid (HF), which raises safety and environmental concerns due to its highly corrosive and toxic nature. HF introduces fluoride functional groups on the surface of MXenes, which have been reported to have a detrimental effect on electrocatalysis.

Genomic insights into drug resistance and virulence determinants in rare pyomelanin-producing clinical isolates of Acinetobacter baumannii.

Purpose: Clinical isolates of multi-drug resistant Acinetobacter baumannii are a major cause of nosocomial infections, often attributed to the highly adaptable genome that helps it to thrive under environmental selection pressure. Here, we aim to provide genotypic-based surveys and comparative whole genome sequencing (WGS) analysis to explore the genomics of the rare pyomelanin-forming clinical isolates of A. baumannii from India.

Polymeric Nanodiscs Comprising 5-Fluorouracil for Inhibition of Protein Aggregation and Their Anti-Alzheimer's Activity in the Model.

Nanoconjugates are promising for therapeutic drug delivery and targeted applications due to the numerous opportunities to functionalize their surface. The present study reports the synthesis of 5-fluorouracil (5-FU)-entrapped polyvinylpyrrolidone (PVP) nanoconjugates, precisely 5-FU-PVP and 5-FU-PVP-Au, and the evaluation of protein aggregation inhibition efficiency. The 5-FU-loaded polymer nanoconjugates were functionalized with gold nanoparticles and analyzed using characterization techniques like dynamic light scattering, UV-visible spectroscopy, Fourier-transform infrared spectroscopy, and zeta potential analysis.

Effect of soluble fiber supplementation on lipid parameters in subjects with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials.

Background: There is no consensus in the existing literature regarding the effect of soluble fiber on the lipid profile of patients with type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis of randomized controlled trials aimed to assess the effect of soluble fiber on triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in T2DM patients.

Methods: PubMed/MEDLINE, Scopus, and ISI Web of sciences were searched for RCTs up to 4 May 2024.

Gold nanoparticle encapsulated hybrid MOF: synthesis, characterization, and co-drug delivery of 5-fluorouracil and curcumin.

The unique features of Metal-Organic Frameworks (MOFs), including structural flexibility, high surface area, and variable pore size, have drawn attention in cancer therapy. However, despite advances in surface functionalization, engineering structural features, and porosity, achieving controlled release, stability, scalability, and toxicity remains a challenge. The current study reports gold nanoparticle (AuNP) encapsulated dual metal-organic frameworks (MOFs) comprising zeolitic imidazolate (ZIF8) and cobalt-imidazole (ZIF67) by a simple precipitation method for dual drug delivery applications.

Advances in polysaccharide-based materials for biomedical and pharmaceutical applications: A comprehensive review.

Polysaccharides, the most abundant biopolymers in nature, have attracted the attention of researchers and clinicians due to its practicality in biomedical and pharmaceutical sciences. These biomaterials have high bioavailability and play structural and functional roles in living organisms. Polysaccharides are classified into several groups based on their origin, including plant polysaccharides and marine polysaccharides (like chitosan, hyaluronic acid, dextran, alginates, etc.

Extraction of diosgenin using different techniques from fenugreek seeds- A review.

Diosgenin, falls under the category of steroidal saponin present in fenugreek seeds (Trigonella foenum-graecum) in the amount of 0.2-09%. This compound possesses certain pharmacological characteristics like anti-inflammatory, anti-cancer, anti-oxidant etc.

Bile's Hidden Weapon: Modulating the Microbiome and Tumor Microenvironment.

The human gut microbiome is a dynamic and intricate ecosystem, composed of trillions of microorganisms that play a pivotal role in maintaining overall health and well-being. However, the gut microbiome is constantly exposed to various environmental factors, including the bile produced by the liver, which can significantly impact its composition and function. Bile acids, secreted by the liver and stored in the gallbladder, modulate the gut microbiome, influencing its composition and function.

Bio-inspired designs: leveraging biological brilliance in mechanical engineering-an overview.

Nature's evolutionary mastery has perfected design over the years, yielding organisms superbly adapted to their surroundings. This research delves into the promising domain of bio-inspired designs, poised to revolutionize mechanical engineering. Leveraging insights drawn from prior conversations, we categorize innovations influenced by life on land, in water, and through the air, emphasizing their pivotal contributions to mechanical properties.

Advancements in Exosome Proteins for Breast Cancer Diagnosis and Detection: With a Focus on Nanotechnology.

Breast cancer, a leading cause of mortality among women, has been recognized as requiring improved diagnostic methods. Exosome proteins, found in small extracellular vesicles, have emerged as a promising solution, reflecting the state of their cell of origin and playing key roles in cancer progression. This review examines their potential in breast cancer diagnosis, discussing advanced isolation and characterization techniques such as ultracentrifugation and microfluidic-based approaches.

Lump, lump-periodic, lump-soliton and multi soliton solutions for the potential Kadomtsev-Petviashvili type coupled system with variable coefficients.

In this article, the potential Kadomtsev-Petviashvili (pKP) type coupled system with variable coefficients is studied, which have many applications in wave phenomena and soliton interactions in a two-dimensional space with time. In this framework, Hirota bilinear form is applied to acquire diverse types of interaction lump solutions from the foresaid equation. Abundant lump, lump-periodic, lump-soliton and multi soliton solutions to the pKP system are presented by the Hirota bilinear form and a mixture of exponentials and trigonometric functions.

Factors influencing the chiral imprinting in perovskite nanoparticles.

Chiral perovskites have emerged as a new class of nanomaterials for manipulation and control of spin polarized current and circularly polarized light for applications in spintronics, chiro-optoelectronics, and chiral photonics. While significant effort has been made in discovering and optimizing strategies to synthesize different forms of chiral perovskites, the mechanism through which chirality is imbued onto the perovskites by chiral surface ligands remains unclear. In this minireview, we provide a detailed discussion of one of the proposed mechanisms, electronic imprinting from a chiral ligand.

Ruthenium(II) N-heterocyclic carbene polymer based sensors for detection of predatory drugs like ketamine and scopolamine.

The current demand in the field of abusive drug research is to have a highly sensitive and rapid method for detecting ketamine and scopolamine, which are frequently used in drug-facilitated sexual assaults administered beverages and food. We report here the first electrochemical sensors of N-heterocyclic carbene (NHC) coordinated ruthenium organometallic 1-dimensional polymers and their multi-walled carbon nano tube (MWCNT)-based composite for detecting ketamine and scopolamine. The preparation of ruthenium NHC organometallics and the MWCNT composite as sensors offers significant advantages for electrochemical applications, with enhanced sensitivities of 121.

Crystalline engineering of FAPbI pyrrolidinium ionic liquid for stable perovskite solar cells with 21.72% efficiency.

Improving the crystallinity of formamidinium triiodide (FAPbI) perovskite layer is one of the most effective approaches to increase the photovoltaic performance and stability of FAPbI-based solar cells (FSCs). In the current study, FAPbI layers were fabricated through a sequential deposition method. The morphology and crystalline properties of the FAPbI layers were modified by controlling the lead iodide (PbI) precursor by adding pyrrolidinium (Pyr) material into the PbI layer and modulating the FAPbI crystallization.

Assorted optical solitons of the (1+1)- and (2+1)-dimensional Chiral nonlinear Schrödinger equations using modified extended tanh-function technique.

In this research article, the (1+1)- and (2+1)-dimensional Chiral nonlinear Schrödinger equations (CNLSEs) are studied, which play an important role in the development of quantum mechanics, particularly in the field of quantum Hall effect. Our primary goal is to obtain the analytical solutions utilizing novel methodology, particularly the modified extended tanh-function technique. We concentrate on the search to solitary wave solutions inside the (1+1)- and (2+1)-dimensional CNLSEs, which are relevant in domains such as optics, electro-magnetic wave propagation, plasma physics, optics and quantum mechanics.

Infrared thermochromic antenna composite for self-adaptive thermoregulation.

Self-adaptive thermoregulation, the mechanism living organisms use to balance their temperature, holds great promise for decarbonizing cooling and heating processes. This functionality can be effectively emulated by engineering the thermal emissivity of materials to adapt to background temperature variations. Yet, solutions that marry large emissivity switching ( ) with scalability, cost-effectiveness, and design freedom are still lacking.

The p53/miRNA Axis in Breast Cancer.

One of the main health issues in the modern world is cancer, with breast cancer (BC) as one of the most common types of malignancies. Different environmental and genetic risk factors are involved in the development of BC. One of the primary genes implicated in cancer development is the p53 gene, which is also known as the "gatekeeper" gene.

Green Approach for the Synthesis of 2-Phenyl-2-indazoles and Quinazoline Derivatives Using Sustainable Heterogeneous Copper Oxide Nanoparticles Supported on Activated Carbon and OER Study.

This research work reports the synthesis of copper oxide (CuO) nanoparticles supported on activated carbon by a simple impregnation method using 2-propanol as a green solvent, followed by calcination. The synthesized CuO@C is used as an efficient heterogeneous nanocatalyst for the synthesis of 2-indazoles and quinazolines utilizing commercially available 2-bromobenzaldehydes, primary amines, and sodium azide under ligand-free and base-free conditions. The present methodology demonstrates the formation of new N-N, C-N, and C═N bonds under one-pot reaction conditions using PEG-400 as a green solvent.

Synergistic impact of Fe-Zr in novel hybrid aminoclay catalytic TFC membrane for ultrafast emerging pollutant remediation.

Finding new class of materials to overcome limitation in conventional membranes is a challenging task. Use of naturally stable and sustainable alternative materials stock is an emerging task. In this direction, a novel iron-zirconium hybrid aminoclay (FZ-AC) has emerged as a promising catalyst effectively employed to alleviate fouling concerns within the framework of a biopolymer-based thin film composite (TFC), constructed on a cellulose acetate (CA) support.

Molecular Mechanism of lncRNAs in Regulation of Breast Cancer Metastasis; a Comprehensive Review.

Although the number of breast cancer deaths has decreased, and there have been developments in targeted therapies and combination treatments for the management of metastatic illness, metastatic breast cancer is still the second most common cause of cancer-related deaths in U.S. women.