47,937 results match your criteria: "J.R.; and University of Barcelona[Affiliation]"

Wong and Bartlett explain the Fermi paradox by arguing that neither human nor extra-terrestrial civilizations can escape the time window singularity which, they claim, results from the way in which social characteristics of civilizations follow super-linear growth curves of cities. We question if data at the city level necessarily can lead to conclusions at the civilization level. More specifically, we suggest ways in which learnings from research, foresight, diversity and effective future government might act outside of their model to regulate super-linear growth curves of civilizations, and thus substantively increase the likelihood of civilizations progressing towards higher levels of the Kardashev scale.

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'No one has ever told us it will be fun'. Achieving fulfilment in medical practice.

J R Coll Physicians Edinb

December 2024

Department of Medicine, Glangwili General Hospital, Carmarthen, Wales, UK.

Facilitating a tutorial with medical students who appeared unusually tentative and apathetic prompted me to reflect upon the intergenerational character of Medicine and consider how we might counter the pervasive pessimism that leads to demoralisation and disillusionment. Engaging in local Communities of Practice may allow clinicians, old and new, to maintain enjoyment and fulfilment in Medicine.

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  • * A newly described species of tiny penguin helps fill a morphological gap between older Oligocene penguins from New Zealand and early Miocene forms from South America.
  • * Phylogenetic analysis suggests that penguin wings evolved quickly during this period, contributing to their swimming efficiency and ecological diversity, with evidence pointing to the role of Zealandia in this evolutionary process.
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Studies involving anatomical description and taxonomy of fossil odontocetes offer insights into their evolutionary history and diversity. This study analyses tusk-like teeth in odontocetes including the description of a new species, , from the Waitaki valley, North Otago, New Zealand. Dental features of , a gracile, longirostrine odontocete with procumbent tusk-like anterior teeth and slightly denticulate cheek teeth, are described in detail.

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We report on an articulated fossil boxfish (Tetraodontiformes, Ostraciidae) recently recovered from the Pliocene of the North Island of New Zealand. The specimen was collected from the Tangahoe Formation, a mid-Pliocene (c. 3.

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Article Synopsis
  • * The most significant discoveries of these fossils come from New Zealand's Kokoamu Greensand and Otekaike Limestone, revealing some of the largest and oldest eomysticetid specimens.
  • * Research indicates that Eomysticetidae may have engaged in skim-feeding, had rudimentary teeth and baleen, experienced significant growth in snout length, and possibly used Zealandia as a calving area, with extinction occurring around the Oligo-Miocene boundary.
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  • - The genus Lamnidae, known for species like the modern white shark, has a fossil record dating back to the late Oligocene and is found globally, with many extinct species recognized from the Cenozoic era.
  • - This text reports the first occurrences of two extinct species of Lamnidae in New Zealand, specifically on the South Island.
  • - Notably, fossil teeth from these species indicate some of the earliest known instances of these taxa, with one originating from late Miocene deposits and representing the southernmost findings of the group.
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The earliest Miocene (Aquitanian, 23-20 Ma) remains a critically under-sampled 'dark age' in cetacean evolution. This is especially true of baleen whales (mysticetes), Aquitanian specimens of which remain almost entirely unknown. Across the globe, the nature of the cetacean fossil record radically shifts at the Oligocene-Miocene boundary, with mysticetes and some archaic odontocete lineages suddenly disappearing despite the availability of cetacean-bearing rock units.

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The 47 vertebrate type specimens held in the University of Otago Geology Department are catalogued in detail. A short history of the collection is followed by lists of the type specimens under the Classes Actinopterygii, Reptilia, Aves and Mammalia. A fish trace-fossil is included at the end of the Actinopterygii.

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  • The Kekenodontidae are a group of late-surviving prehistoric whales known as archaeocetes from the Late Oligocene period found in the Southwest Pacific, including a newly identified species from New Zealand.
  • Phylogenetic studies show that this new genus fits into the Kekenodontidae family and is closely related to another unnamed kekenodontid, suggesting they represent the last of the archaeocetes before future evolutionary developments occurred.
  • The study highlights the unique dental characteristics of the juvenile holotype, which indicates the potential persistence of diphyodonty (having two sets of teeth) in these whales, a trait not observed in later cetaceans.
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  • Albatrosses have been extensively researched, but their fossil record is limited, mainly with fossils found in the Northern Hemisphere despite modern species being more common in the Southern Hemisphere.
  • A new species, identified from the earliest Miocene, is the earliest known albatross in New Zealand and provides the oldest confirmed record of related bird families from that region.
  • Phylogenetic studies show that this fossil is outside the main group of existing albatrosses, indicating that their early ancestors were already widespread by the beginning of the Neogene period and might have had some features of modern albatrosses.
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The moa footprints from the Pliocene - early Pleistocene of Kyeburn, Otago, New Zealand.

J R Soc N Z

November 2023

Australian Nuclear Science and Technology Organisation, Sydney, New Zealand.

In March, 2019, a trackway of seven footprints was found at a riverbank outcrop of Maniototo Conglomerate Formation in the Kyeburn River, Central Otago, South Island, New Zealand. In this study, we describe this first known occurrence of moa (Dinornithiformes) footprints to be found and recovered in Te Waipounamu/South Island. Footprints of the trackway were ∼46 mm deep, 272-300 mm wide and 260-294 mm in length.

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Pre-Miocene, stem odontocetes are known for their procumbent incisors and their function has been the subject of much speculation. Notable among these were and several related taxa from New Zealand. Though some studies hypothesise the function of these teeth was for thrusting, the here described has unique teeth which might have formed a cage around small fish.

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Many of the implications of climate change for Aotearoa (New Zealand) remain unclear. To identify so-far unseen or understudied threats and opportunities related to climate change we applied a horizon-scanning process. First, we collated 171 threats and opportunities across our diverse fields of research.

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Scientific evidence unequivocally shows that human activities cause climate change, but some people still deny it. Using New Zealand Attitudes and Values Study data from 2018 and 2019 ( = 34,733), we examined segmentation profiles regarding beliefs and concern about climate change ('Climate change is real', 'Climate change is caused by humans', 'I am deeply concerned about climate change'), the probabilities of transitioning to and from profiles over time, and the characteristics of individuals in each profile. Five profiles were identified with varying levels of climate change beliefs and concern.

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Evolutionary biogeography of Aotearoa.

J R Soc N Z

October 2023

Manaaki Whenua - Landcare Research, Auckland, New Zealand.

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Being thin-skinned can still reduce damage from dynamic puncture.

J R Soc Interface

October 2024

Department of Evolution, Ecology, and Behavior, School of Integrative Biology, University of Illinois Urbana-Champaign, 505 S. Goodwin Avenue, Urbana, IL 61801, USA.

The integumentary system in animals serves as an important line of defence against physiological and mechanical external forces. Over time, integuments have evolved layered structures (scales, cuticle and skin) with high toughness and strength to resist damage and prevent wound expansion. While previous studies have examined their defensive performance under low-rate conditions, the failure response and damage resistance of these thin layers under dynamic biological puncture remain underexplored.

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Endovascular procedures rely on navigating guidewires, catheters and other devices through tortuous vasculature to treat disease. A critical challenge in these procedures is catheter herniation, in which the device deviates from its intended path, often irrecoverably. To elucidate the mechanics of herniation, we developed a physical flow model of the aortic arch that enables direct measurement of device curvature during experimentally simulated neuroendovascular procedures conducted from an upper arterial access.

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A brain-wide solute transport model of the glymphatic system.

J R Soc Interface

October 2024

Department of Mechanical Engineering, University of Rochester, Rochester, NY 14627, USA.

Brain waste is largely cleared via diffusion and advection in cerebrospinal fluid (CSF). CSF flows through a pathway referred to as the glymphatic system, which is also being targeted for delivering drugs to the brain. Despite the importance of solute transport, no brain-wide models for predicting clearance and delivery through perivascular pathways and adjacent parenchyma existed.

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Subtle frequency matching reveals resonant phenomenon in the flight of Odonata.

J R Soc Interface

October 2024

Laboratoire de Physique et Mécanique des Milieux Hétérogènes (PMMH), CNRS UMR 7636, ESPCI Paris - PSL University, Sorbonne Université, Université Paris Cité, Paris 75005, France.

In this work, we investigate the connection between the flight flapping frequency and the intrinsic wing properties in Odonata (dragonflies and damselflies). For such large flying insect species, it has been noted that the wingbeat frequency is significantly lower than the structural resonance of the wing itself. However, the structural resonance mechanism is often evoked in the literature for flying and swimming animals as a means to increase locomotion performance.

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Uncertainties in exposure predictions arising from point measurements of carbon dioxide in classroom environments.

J R Soc Interface

October 2024

Department of Civil and Environmental Engineering, Skempton Building, South Kensington Campus, Imperial College London, London SW7 2BX, UK.

Article Synopsis
  • Predictions of airborne infection risk can be made using carbon dioxide measurements to estimate rebreathed air in environments like classrooms.
  • Environmental factors, especially how spaces are ventilated, lead to variability in these predictions, particularly in naturally ventilated areas common in UK classrooms.
  • Computational models reveal that the distribution of infectious breath in a classroom is influenced by both the distance from the source and ventilation patterns, but point CO measurements typically provide reasonably accurate exposure estimates, with uncertainties being less significant compared to other factors in airborne infection risk modeling.
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Relaxivity and In Vivo Human Performance of Brand Name Versus Generic Ferumoxytol.

Invest Radiol

October 2024

From the Department of Radiology, University of Wisconsin-Madison, Madison, WI (R.A.V., D.T., J.R., S.B.R.); Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands (R.A.V.); Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI (L.M.); Department of Mechanical Engineering, University of Wisconsin-Madison, Madison, WI (J.R.); Department of Medical Physics, University of Wisconsin-Madison, Madison, WI (S.B.R.); Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI (S.B.R.); Department of Medicine, University of Wisconsin-Madison, Madison, WI (S.B.R.); and Department of Emergency Medicine, University of Wisconsin-Madison, Madison, WI (S.B.R.).

Objectives: Ferumoxytol is a superparamagnetic iron-oxide product that is increasingly used off-label for contrast-enhanced magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA). With the recent regulatory approval of generic ferumoxytol, there may be an opportunity to reduce cost, so long as generic ferumoxytol has similar imaging performance to brand name ferumoxytol. This study aims to compare the relaxation-concentration dependence and MRI performance of brand name ferumoxytol with generic ferumoxytol through phantom and in vivo experiments.

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Evaluating the Performance and Bias of Natural Language Processing Tools in Labeling Chest Radiograph Reports.

Radiology

October 2024

From Drexel University College of Medicine, Philadelphia, Pa (S.M.S.); Department of Radiology, Columbia University Irving Medical Center, New York, NY (J.R.Z.); Department of Radiology, Wake Forest University Health Sciences Center, Winston-Salem, NC (K.H.); Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (J.J., V.P.); and Department of Diagnostic Imaging, St. Jude Children's Research Hospital, 262 Danny Thomas Plc, Memphis, TN 38105-3678 (P.H.Y.).

Background Natural language processing (NLP) is commonly used to annotate radiology datasets for training deep learning (DL) models. However, the accuracy and potential biases of these NLP methods have not been thoroughly investigated, particularly across different demographic groups. Purpose To evaluate the accuracy and demographic bias of four NLP radiology report labeling tools on two chest radiograph datasets.

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QSOX1 facilitates dormant esophageal cancer stem cells to evade immune elimination via PD-L1 upregulation and CD8 T cell exclusion.

Proc Natl Acad Sci U S A

October 2024

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, People's Republic of China.

Article Synopsis
  • - Dormant cancer stem cells (DCSCs) play a crucial role in tumor recurrence and metastasis due to their resistance to chemotherapy and ability to evade the immune system, mainly through enhanced PD-L1 signaling and the influence of quiescin sulfhydryl oxidase 1 (QSOX1).
  • - QSOX1, produced by quiescent fibroblasts, boosts PD-L1 expression in DCSCs and creates an environment that excludes CD8 T cells, thus supporting immune evasion.
  • - Targeting QSOX1 with Ebselen, in combination with anti-PD-1 and chemotherapy, shows promise for successfully eradicating dormant DCSCs and improving patient responses to treatment. *
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  • A new strain of Archaeon, called sp. strain NMX12-1, was discovered in ancient salt crystals from a 250 million-year-old formation in New Mexico.
  • The genome of this strain is 3.2 million base pairs long, consisting of a main chromosome of 2.6 million base pairs and five smaller plasmids.
  • The genome has a high GC content and encodes an acidic proteome, which is a typical feature of Haloarchaea, a group of salt-loving microorganisms.
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