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GABA alterations in pediatric sport concussion.

Neurology

November 2017

From the Seattle Children's Hospital and Research Institute (S.D.F., A.V.P., C.B., D.W.W.S., D.B., T.J., B.K., D.C, T.M.L., S.B., J.G.O.) and University of Washington (D.W.W.S., D.B., T.J., B.K., D.C., S.B., J.G.O.), Seattle.

Objective: To evaluate whether frontal-lobe magnetic resonance spectroscopy measures of γ-aminobutyric acid (GABA) would be altered in a sample of adolescents scanned after sport concussion because mild traumatic brain injury is often associated with working memory problems.

Methods: Eleven adolescents (age 14-17 years) who had sustained a first-time sport concussion were studied with MRI/magnetic resonance spectroscopy within 23 to 44 days after injury (mean 30.4 ± 6.

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