3,040 results match your criteria: "Izmir Katip Celebi University[Affiliation]"

Article Synopsis
  • Cerebral small vessel disease (SVD) can lead to various cerebrovascular issues, but research on sex differences in SVD is limited.
  • This study analyzed data from over 20,000 patients with acute ischemic stroke to examine whether the presence and severity of cerebral microbleeds (CMB) and other SVD markers differ between males and females.
  • Results showed that males had more frequent CMB while females had fewer lacunes but higher severe white matter hyperintensities, indicating distinct SVD characteristics based on sex.
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Objective: To compare psychological factors and the number of painful sites between wheelchair basketball athletes (WBA) with and without shoulder pain and examine their associations with shoulder pain.

Design: A cross-sectional, case-control study.

Methods: Forty-three WBA participated.

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Lighting up with membrane-targeting peptides.

Org Biomol Chem

November 2024

Precision Healthcare University Research Institute, Queen Mary University of London, Empire House, Whitechapel, London, E1 1HH, UK.

Article Synopsis
  • - The study focuses on fluorescent probes designed from membrane-disrupting peptides from mycobacteria, which can contain either L- or D-amino acids.
  • - These probes feature "always on" and environmentally sensitive fluorescent markers, allowing them to effectively label specific targets.
  • - The effectiveness of two specific probes in labeling was demonstrated, showcasing their potential application in research.
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Article Synopsis
  • The study aimed to investigate how in-hospital declines in hemoglobin levels affect long-term mortality and major adverse cardiovascular and cerebrovascular events (MACCE) in patients with ST-segment elevation myocardial infarction (STEMI) who received primary percutaneous coronary intervention (PCI).
  • Researchers categorized patients based on hemoglobin decline into low (<3 g/dl or no decline) and high (≥3 g/dl) groups, analyzing their mortality and MACCE rates.
  • Findings revealed that patients with high hemoglobin decline experienced significantly higher mortality (65%) and MACCE rates (71%) compared to those with low decline, suggesting a concerning link between hemoglobin decline and adverse outcomes in STEMI patients after PCI.
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  • The study focuses on translating the Measure of Activity Performance of the Hand (MAP-Hand) into Turkish and assessing its effectiveness for those with rheumatoid arthritis (RA).
  • The translated MAP-Hand was pilot tested on 30 participants and later administered to 185 adults, collecting various physical and health-related data.
  • Results indicated that the Turkish MAP-Hand is reliable and valid, showing high internal consistency and strong correlations with disease activity, pain levels, and hand strength, proving its usefulness in evaluating hand function.
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Article Synopsis
  • The study aimed to evaluate the reliability and validity of three questionnaires designed to assess dual-tasking difficulties in people with multiple sclerosis (PwMS).
  • A total of 356 participants across six countries were analyzed, showing that the questionnaires had strong test-retest reliability and internal consistency, with the DIDA-Q performing the best.
  • The findings indicate that these self-reported questionnaires are effective tools for measuring the impact of dual-task challenges on the daily lives of ambulatory PwMS in both research and clinical settings.
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Article Synopsis
  • Appendicitis is a common surgical emergency, but there's ongoing concern about the rate of unnecessary surgeries and uncertainty in diagnosis, prompting this study to evaluate existing risk prediction models for appendicitis.
  • The research involved 3,358 adult patients with right iliac fossa pain from 84 centers, focusing on data like clinical findings, diagnostic tests, and rates of unnecessary surgeries, using various risk scoring systems to analyze effectiveness.
  • Results showed that while the Adult Appendicitis Score performed best overall, the RIPASA score was more effective in men; both scoring systems demonstrated strong diagnostic capabilities, but female patients had higher rates of negative appendicectomy and lower surgery rates compared to males.
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Article Synopsis
  • The study evaluated five different scoring systems (FGSI, UFGSI, ACCI, qSOFA, LRINEC) to predict outcomes in patients with Fournier gangrene, analyzing data from 311 patients between 2010 and 2024.
  • Univariate and multivariate analyses showed that UFGSI and FGSI were the most effective scoring systems in predicting mortality, with higher values seen in non-survivor patients.
  • ROC analysis determined optimal cut-off values for each scoring system, with UFGSI proving to be the most accurate for predicting mortality, achieving 84% sensitivity and 97% specificity at a score ≥12.
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Article Synopsis
  • * Three cases of WS were examined, with diagnoses confirmed through genetic testing, revealing both known and novel mutations in the WFS1 gene.
  • * Early diagnosis of WS is crucial as it helps identify associated health issues, potentially reducing complications and improving patient outcomes.
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This study pioneered an eco-friendly approach for reutilizing Ground-granulated blast furnace slag (GGBFS) in paper production. This investigation is the first study focusing on the usage of paper production that presents both a new usage area of GGBFS and also a new sight. So, it can contribute to save the trees.

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Background: Distance walking fatigability (DWF) in people with multiple sclerosis (pwMS) is defined as a decrease in the distance walking over time. However, declines in gait quality (i.e.

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Objective: The objective of this study was to evaluate the fear, anxiety, and knowledge level in women who underwent gynecological surgical procedures during the COVID-19 pandemic.

Methods: This cross-sectional study was conducted on 188 women who underwent a gynecologic surgical operation in Muğla, Turkey. Data were collected by using demographics and obstetric detail form, questionnaire on knowledge, attitudes, and practice toward COVID-19, and State-Trait Anxiety Inventory-I (STAI-I).

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Purpose: Tamoxifen, a widely used drug for breast cancer treatment, is associated with adverse effects on the liver, including the development of fatty liver. This study aimed to investigate the potential protective effect of caffeine against tamoxifen-induced fatty liver in Wistar rats.

Methods: Rats were divided into normal control, tamoxifen + saline, and tamoxifen + caffeine.

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Background: Nanostructured materials used have unique properties and many uses in nanotechnology. The most striking of these is using herbal compounds for the green synthesis of nanoparticles. Among the nanoparticle types used for green synthesis, gold nanoparticles (AuNPs) are used for cancer therapy due to their stable structure and non-cytotoxic.

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Familial Mediterranean Fever (FMF) is an autosomal recessive genetic disorder, primarily observed in populations around the Mediterranean Sea, linked to MEFV gene mutations. These mutations disrupt inflammatory responses, increasing pyrin-protein production. Traditional diagnosis relies on clinical symptoms, family history, acute phase reactants, and excluding similar syndromes with MEFV testing, which is expensive and often inconclusive due to heterozygous mutations.

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Our primary aim with this study was to build a patient-level classifier for stroke territory in DWI using AI to facilitate fast triage of stroke to a dedicated stroke center. A retrospective collection of DWI images of 271 and 122 consecutive acute ischemic stroke patients from two centers was carried out. Pretrained MobileNetV2 and EfficientNetB0 architectures were used to classify territorial subtypes as middle cerebral artery, posterior circulation, or watershed infarcts along with normal slices.

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Phenotypic variations in knee osteoarthritis: insights from MRI and radiographic comparisons.

Skeletal Radiol

September 2024

Faculty of Medicine, Department of Radiology, Izmir Democracy University, Uckuyular, Gürsel Aksel Boulevard No: 14, Karabaglar, Izmir, 35140, Türkiye.

Objective: To investigate the correlation between MRI-based phenotypes (cartilage-meniscus, subchondral bone, and inflammatory) and radiography-based atrophic and hypertrophic phenotypes, aiming to demonstrate MRI's diagnostic capability in identifying complex osteoarthritis phenotypes that radiography cannot fully capture.

Materials And Methods: This single-center retrospective study examined knee radiographs and MRIs of patients from November 2021 to April 2023 to identify osteoarthritis phenotypes. Radiographs were staged by the Kellgren-Lawrence system, and both modalities were classified into atrophic or hypertrophic phenotypes.

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Background The need for blood arising from illness, surgery, and accidents is met through donations. With global population growth, both non-governmental organizations and public institutions are vital for blood supply and distribution. The Turkish Red Crescent, a leading non-governmental organization in blood donation and humanitarian aid, excels in both national and international contexts, ensuring a safe blood supply and reinforcing social solidarity during crises.

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Background/purpose: The objective of this study was to assess the root apical closure ages of first permanent molars retrospectively among a group of western Turkish children aged between 5 and 15 years using cone-beam computed tomography (CBCT).

Materials And Methods: CBCT images of 202 patients were examined. The patients were divided into 7 groups according to age: ≤8 years, 8-8.

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Article Synopsis
  • This study evaluated the effectiveness of first-line antiseizure medications in 1003 newly diagnosed children with epilepsy, focusing on their drug efficacy rates and resistance levels over an average follow-up period of 22 months.
  • The first-drug efficacy rate was approximately 67% for children with focal-onset seizures and 66% for those with generalized-onset seizures, while the overall first-drug failure rate was reported at 33%.
  • Notably, children with structural etiology exhibited a significantly lower first-drug efficacy rate of 53% and a 30% rate of drug-resistant epilepsy, compared to higher success rates in those with defined epilepsy syndromes (79%).
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Article Synopsis
  • Acute cardiorespiratory failure disrupts energy balance, with elevated lactate levels and decreased pH indicating severe conditions like Acute Cardiogenic Pulmonary Edema (ACPO), which has high mortality risk.
  • A study conducted in a metropolitan emergency department from May 2021 to August 2023 involving 106 patients with ACPO found that a lactate clearance below 14.29% was significantly linked to increased mortality.
  • The study suggests lactate clearance could be an important early indicator for treatment decisions in ACPO, but calls for further multicenter research to better understand its predictive value.
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HbA1c is the most widely used test as an indicator of glucoregulation in patients with type 2 diabetes mellitus (T2DM). Asprosin and oxidative stress levels can be reduced with good glycemic control (GC) and thus prevented or delayed micro/macro complications in patients with T2DM. The relationship between asprosin, which is thought to affect GC, and oxidative stress parameters such as lipid hydroperoxides (LOOHs), glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (Cu,Zn-SOD), and total antioxidant capacity (TAC) was evaluated in T2DM patients.

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High temperature photoluminescence dependence and energy migration of Tb-Incorporated KY(BO) phosphors.

Appl Radiat Isot

December 2024

Jazan University, College of Science, Department of Physical Sciences, Physics Division, P.O. Box 114, 45142, Jazan, Kingdom of Saudi Arabia; Nanotechnology Research Unit, College of Science, Jazan University, P.O. Box. 114, Jazan, 45142, Kingdom of Saudi Arabia. Electronic address:

This study investigates the structural and photoluminescence (PL) characteristics of Tb-incorporated KY(BO) (KYBO) phosphors synthesized via a microwave-assisted sol-gel technique. X-ray diffraction (XRD) and Rietveld refinement confirmed the formation of a pure hexagonal phase, with lattice expansion due to Tb³⁺ doping. PL studies revealed strong green emissions centered at 541 nm, attributed to the ⁵D₄ → ⁷F₅ transitions of Tb³⁺ ions, with the highest intensity observed at 5 wt% Tb³⁺.

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Background: Radiation-induced lung injury (RILI), a serious side effect of thoracic radiotherapy, can lead to acute radiation pneumonitis (RP) and chronic pulmonary fibrosis (PF). Despite various interventions, no effective protocol exists to prevent pneumonitis. Oxytocin (OT), known for its anti-inflammatory, antiapoptotic, and antioxidant properties, has not been explored for its potential in mitigating RILI.

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In rat models, it is well-documented that chronic administration of propionic acid (PPA) leads to autism-like behaviors. Although the intranasal (IN) insulin approach is predominantly recognized for its effects on food restriction, it has also been shown to enhance cognitive memory by influencing various proteins, modulating anti-inflammatory pathways in the brain, and reducing signaling molecules such as interleukins. This study seeks to explore the potential therapeutic benefits of IN insulin in a rat model of autism induced by PPA.

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