94 results match your criteria: "Iwate Prefectural Isawa Hospital[Affiliation]"
Efficacy of valganciclovir prophylaxis in kidney transplant recipients following low-dose rituximab induction therapy: a multicenter retrospective study.
Clin Exp Nephrol
October 2024
Department of Urology, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata, 990-9585, Japan.
Article Synopsis
- Rituximab (RIT) is commonly used to help kidney transplant recipients (KTRs) who are ABO-incompatible, but the effectiveness of valganciclovir (VGCV) in preventing cytomegalovirus (CMV) infection after RIT is uncertain.
- A study of 213 KTRs showed that those receiving VGCV had a significantly higher rate of CMV disease (23.5%) compared to those not receiving it (5.5%), though both groups experienced similar rates of CMV infection.
- The results suggest that insufficient VGCV dosage does not effectively lower CMV disease incidence post-RIT, but following a standard VGCV protocol may be beneficial
Prognostic model for second progression-free survival and overall survival in patients with high-risk metastatic hormone-sensitive prostate cancer treated with abiraterone acetate and androgen deprivation therapy.
Prostate
January 2025
Department of Urology, Akita University Graduate School of Medicine, Akita, Japan.
Article Synopsis
- Researchers created and validated a risk model for high-risk metastatic hormone-sensitive prostate cancer (mHSPC) patients treated with abiraterone acetate (ABI) to better predict patient outcomes.
- The study involved 233 patients from three academic centers and validated the model on a separate group of 282 patients, analyzing factors that influence progression-free survival (PFS2) and overall survival (OS).
- Key findings showed that the model effectively categorized patients into risk groups, with poor-risk patients having significantly lower median PFS2 and OS compared to favorable and intermediate groups, aiding in treatment planning.
A prospective 10-year follow-up study after sublobar resection for ground-glass opacity-dominant lung cancer.
Sci Rep
September 2024
Japan North-East Thoracic Surgical Study Group (JNETS), Sendai, Japan.
This single-arm multi-institutional prospective study aimed to evaluate the 10-year outcomes of sublobar resection for small-sized ground-glass opacity-dominant lung cancer. Among 73 patients prospectively enrolled from 13 institutions between November 2006 and April 2012, 53 ground-glass opacity-dominant lung cancer patients underwent sublobar resection with wedge resection as the first choice. The inclusion criteria were maximum tumor size of 8-20 mm; ≥ 80% ground-glass opacity ratio on high-resolution computed tomography; lower F-fluorodeoxyglucose accumulation than the mediastinum; intraoperative pathological diagnosis of adenocarcinoma in situ; and no cancer cells on intraoperative cut margins.
View Article and Find Full Text PDFArticle Synopsis
- Radial incision and cutting (RIC) is explored as a new method for treating lower intestinal tract stenosis, aiming for high success rates and symptom relief, but patients often experience re-stenosis after the procedure.
- In a pilot study involving 20 patients, RIC was performed with the addition of triamcinolone acetonide (TA), and the safety and efficacy were assessed after two months, focusing on adverse events and symptom improvement.
- Results showed a delayed bleeding rate of 23.8%, but no perforations occurred; while symptoms improved, TA didn’t seem to significantly prevent re-stenosis, suggesting the need for further research.
Feasibility of initiating robotic surgery during the early stages of gastrointestinal surgery education.
Langenbecks Arch Surg
August 2024
Division of Surgery, Iwate Prefectural Isawa Hospital, 61 Ryugababa, Mizusawa-ku, Oshu-shi, Iwate, 023-0864, Japan.
Purpose: Minimally invasive surgery for gastrointestinal cancers is rapidly advancing; therefore, surgical education must be changed. This study aimed to examine the feasibility of early initiation of robotic surgery education for surgical residents.
Methods: The ability of staff physicians and residents to handle robotic surgical instruments was assessed using the da Vinci skills simulator (DVSS).
Real-world retrospective analysis of immune checkpoint inhibitor therapy for relapsed or refractory Hodgkin's lymphoma.
J Clin Exp Hematop
September 2024
Division of Hematology and Oncology, Department of Internal Medicine, Iwate Medical University School of Medicine, Yahaba, Japan.
Immune checkpoint inhibitors (ICI) are promising therapeutic agents for relapsed or refractory classical Hodgkin's lymphoma (RRcHL). This retrospective study evaluated patients with RRcHL registered in the clinical research program Tohoku-Hematology-Forum-26, between 2016 and 2020, and treated with ICI in 14 centers in Northeast Japan. We analyzed the usage, efficacy, and safety of ICI therapy (ICIT).
View Article and Find Full Text PDFComparing the Effectiveness of Afatinib and Osimertinib for Patients With PD-L1-positive -mutant Non-small Cell Carcinoma.
Cancer Diagn Progn
July 2024
Department of Respiratory Medicine, Tohoku University Hospital, Sendai, Japan.
Article Synopsis
- EGFR-TKIs like afatinib and osimertinib are effective for treating non-small cell lung cancer with EGFR mutations, but high PD-L1 levels may lead to poorer responses.
- A study analyzed 177 patients with PD-L1-positive EGFR-mutant NSCLC to compare the effectiveness of afatinib versus osimertinib.
- The findings indicated no significant difference in progression risk or overall survival between the two treatments, suggesting similar effectiveness for patients with this specific cancer profile.
Distal Bypass Improves Skin Perfusion Pressure at the Whole Foot Regardless of Angiosomes in Patients with Chronic Limb-Threatening Ischemia.
Ann Vasc Dis
June 2024
Division of Vascular Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Article Synopsis
- The study investigates how distal bypass surgery affects tissue blood pressure in direct (DRA) and indirect (IRA) revascularized angiosomes in patients with chronic limb-threatening ischemia (CLTI).
- A total of 29 limbs from 27 CLTI patients underwent repeated skin perfusion pressure (SPP) measurements before and after surgery, showing improvements in tissue blood flow for both DRA and IRA.
- The findings suggest that distal bypass surgery enhances tissue blood flow throughout the foot, not just in the connected angiosomes.
Background: The association between symptom interpretation and prognosis has not been investigated well among patients with acute coronary syndrome (ACS). As such, the present study evaluated the effect of heart disease awareness among patients with ACS on in-hospital mortality.
Methods and results: We performed a post hoc analysis of 1,979 consecutive patients with ASC with confirmed symptom interpretation on admission between 2014 and 2018, focusing on patient characteristics, recanalization time, and clinical outcomes.
Risk factors and pattern of metastatic recurrence after endoscopic resection with additional treatment for esophageal cancer.
Dis Esophagus
October 2024
Department of Gastroenterology, Sendai Kousei Hospital, Sendai, Miyagi, Japan.
Article Synopsis
- Esophageal cancers that penetrate the muscularis mucosa or submucosa can have a risk of lymph node metastasis after endoscopic resection, but the patterns of metastatic recurrence post-treatment are not well-studied.
- Researchers analyzed data from 220 patients in Japan who received additional treatments (esophagectomy, chemoradiotherapy, or radiation) after endoscopic resection between 2006 and 2017 to identify risk factors for metastatic recurrence.
- They found that lymphatic invasion is a key risk factor for recurrence, and while both esophagectomy and chemoradiotherapy show similar risks for metastasis, esophagectomy tends to have higher locoregional recurrence but better survival rates for patients who do experience
Endoscopic and histological risk stratification for gastric cancer using gastric intestinal metaplasia.
J Gastroenterol Hepatol
September 2024
Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
Article Synopsis
- The study investigates the relationship between intestinal metaplasia (IM) in the gastric mucosa and the risk of developing gastric cancer (GC), focusing on risk stratification using endoscopic and histological methods.
- A multicenter analysis involving 380 patients found that specific patterns, like light blue crest (LBC) and white opaque substance (WOS), along with histological IM, significantly correlated with increased GC risk.
- The results indicated that EGGIM and OLGIM scoring systems were effective tools for assessing GC risk, suggesting their potential use in clinical practice for better patient management.*
Risk stratification of synchronous gastric cancers including alcohol-related genetic polymorphisms.
J Gastroenterol Hepatol
August 2024
Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Background And Aim: We previously identified that ever-smoking and severe gastric atrophy in pepsinogen are risk factors for synchronous gastric cancers (SGCs). This study aimed to determine the association of alcohol drinking status or alcohol-related genetic polymorphism with SGCs and also stratify their risk.
Methods: This multi-center prospective cohort study included patients who underwent endoscopic submucosal dissection for the initial early gastric cancers at 22 institutions in Japan.
Real-world NUDT15 genotyping and thiopurine treatment optimization in inflammatory bowel disease: a multicenter study.
J Gastroenterol
June 2024
Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, Sendai, 980-8574, Japan.
Article Synopsis
- This study assessed the effectiveness of NUDT15 codon 139 genotyping to improve thiopurine treatment for inflammatory bowel disease (IBD) among 4628 patients in Japan.
- Retrospective analysis showed that while genotyping did not significantly change thiopurine induction rates, it led to customized dosing that reduced adverse events (AEs) and improved treatment retention.
- Findings indicated that starting doses and genotype-based adjustments can minimize risks, with specific genotypes correlating to different reactions to thiopurine treatments—providing a basis for more tailored treatment strategies.
Spontaneous complete regression of pancreaticoduodenal artery aneurysms with celiac artery occlusion after aorto-splenic bypass without additional treatment: a case report.
Surg Case Rep
April 2024
Department of Surgery, Iwate Prefectural Chubu Hospital, 17-10 Murasakino, Kitakami, Iwate, 024-8507, Japan.
Article Synopsis
- *A 68-year-old woman with multiple PDAAs underwent a two-stage hybrid therapy involving aorto-splenic bypass and resection of one aneurysm, resulting in spontaneous regression of the others.
- *The case suggests that improved blood flow dynamics can lead to PDAA regression, raising questions about the necessity of additional endovascular therapy, though more research is needed to predict rupture risks.
Article Synopsis
- - The study focuses on a new treatment method called radial incision and cutting (RIC) for lower gastrointestinal tract stenosis, which has advantages over traditional treatments like surgery and endoscopic balloon dilation (EBD), but still faces issues with restenosis.
- - Researchers are conducting a phase II trial involving 20 participants aged 20-80, comparing the safety of administering triamcinolone acetonide (TA) post-RIC, assessing both the safety and effectiveness of this approach.
- - Key outcomes include monitoring adverse events, the technical success of the RIC procedure, improvements in symptoms, and length of hospital stay, with the goal of providing data that could inform future studies on this treatment.
Pulmonary hypertension in an adult patient with congenital central hypoventilation syndrome: a case report.
Eur Heart J Case Rep
March 2024
Department of Cardiovascular Medicine, Iwate Prefectural Isawa Hospital, 61 Ryugababa, Oshu, Iwate 023-0864, Japan.
Background: Congenital central hypoventilation syndrome (CCHS) is a life-threatening disorder of autonomic respiratory control. Mutations in the paired-like homeobox 2B (PHOX2B) gene impair respiratory drive, causing hypercarbia and hypoxaemia. Most patients with CCHS are diagnosed in the neonatal period; however, a few are diagnosed in adulthood.
View Article and Find Full Text PDFIncidence of postoperative cytomegalovirus and BK-polyoma virus infections and graft loss in ABO-incompatible renal transplant recipients: a multicenter retrospective study.
Int Urol Nephrol
July 2024
Department of Urology, Hirosaki University School of Medicine, 5 Zaifu-Cho, Hirosaki, Aomori, 036-8562, Japan.
Objectives: The current study aimed to examine the incidence of perioperative infections and graft viability in ABO-compatible and ABO-incompatible renal transplant recipients.
Methods: We included 643 living donor renal transplant recipients registered in the Michinoku Renal Transplant Network from 1998 to 2021. Patients were divided into the ABO-compatible and ABO-incompatible kidney transplantation groups.
Is Short-term Antimicrobial Administration Sufficient? The Need for Considering Information on Infection-Related Variables and the Target Population.
Clin Infect Dis
October 2024
Department of General Internal Medicine, Japan.
ASO Author Reflections: Significance of Colorectal Cancer Screening Through Preoperative Total Colonoscopy for Gastric Cancer.
Ann Surg Oncol
February 2024
Division of Gastric Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
Impact of timing of rejection episode on cardiovascular events in living donor kidney transplantation: a multicenter retrospective study.
J Nephrol
December 2023
Department of Urology, Hirosaki University School of Medicine, 5 Zaifu-Cho, Hirosaki, Aomori, 036-8562, Japan.
Background: Cardiovascular diseases are still highly prevalent after kidney transplantation. However, little is known about the impact of the timing of rejection episodes on cardiovascular disease. The study aimed to analyze the influence of the timing of rejection episodes on cardiovascular events in recipients of living donor kidney transplantation.
View Article and Find Full Text PDFThe Effectiveness of Screening Total Colonoscopy for Preoperative Patients with Gastric Cancer.
Ann Surg Oncol
February 2024
Division of Gastric Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
Background: Colorectal cancer (CRC) is the most common cancer that coincides with gastric cancer (GC). Although the usefulness of total colonoscopy (TCS) as a CRC screening tool has been reported in preoperative patients with GC, the long-term outcome of patients with synchronous CRC (SCRC) remains unclear. This study aims to clarify the significance of preoperative screening TCS for GC in terms of survival outcomes.
View Article and Find Full Text PDFBackground: It has been reported that patients with acute myocardial infarction (AMI) transferred to low-volume primary percutaneous coronary intervention (PCI) hospitals (<115/year) in low population density areas experience higher in-hospital mortality rates. This study compared in-hospital outcomes of patients admitted to high-volume primary PCI hospitals (≥115/year) with those for other regional general hospitals.
Methods and results: Retrospective analysis was conducted on data obtained from 2,453 patients with AMI admitted to hospitals in Iwate Prefecture (2014-2018).
Real clinical outcomes of nivolumab plus ipilimumab for renal cell carcinoma in patients over 75 years old.
Int J Clin Oncol
November 2023
Department of Urology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan.
Background: Although nivolumab plus ipilimumab is the standard treatment for metastatic renal cell carcinoma (RCC), its efficacy and safety in older patients remain unclear. Therefore, this study aimed to assess the clinical outcomes of nivolumab plus ipilimumab for metastatic RCC in patients aged ≥ 75 years.
Methods: We enrolled 120 patients with metastatic RCC treated with nivolumab plus ipilimumab from August 2015 to January 2023.
A retrospective study of the efficacy of combined EGFR‑TKI plus VEGF inhibitor/cytotoxic therapy vs. EGFR‑TKI monotherapy for PD‑L1‑positive EGFR‑mutant non‑small cell lung cancer: North Japan Lung Cancer Study Group 2202.
Oncol Lett
August 2023
Department of Respiratory Medicine, Tohoku University Hospital, Sendai, Miyagi 980-8574, Japan.
Article Synopsis
- * Data from 263 patients were analyzed, showing combined therapy resulted in a lower risk of cancer progression (hazard ratio of 0.47) compared to first- and second-generation EGFR-TKIs.
- * The results suggest that combined therapy may offer a promising treatment option for NSCLC patients, as it shows improved progression-free survival compared to EGFR-TKI alone.
Presence of Helicobacter cinaedi in Atherosclerotic Abdominal Aortic Aneurysmal Wall.
Tohoku J Exp Med
September 2023
Department of Surgery, Tohoku University Graduate School of Medicine.
Article Synopsis
- * Researchers analyzed DNA samples from 39 AAA patients during surgery, specifically looking for the H. cinaedi-specific gene using nested PCR techniques.
- * Results showed that 23.1% of the patients tested positive for H. cinaedi in their aneurysm walls, marking the first time this bacterium has been identified in non-infectious AAA cases.