DIAGNOSTICS OF LYMPHOGENIC METASTASIS IN PATIENTS WITH RECTAL CANCER BY COMBINING MRI WITH BLOOD CEA ASSESSMENT.

Aim: To improve the diagnostics of lymphogenic metastasis in patients with rectal cancer (RCa) by combining magnetic resonance imaging (MRI) with the blood carcinoembryonic antigen (CEA) level assessment.

Materials And Methods: We have systematized and analyzed the results of the examination and treatment of 77 patients with stage II-III rectal adenocarcinoma (T2-3N0-2M0). Before the start of neoadjuvant treatment as well as 8 weeks after its completion, computed tomography (CT) and MRI were performed.

CLINICOROENTGENOLOGICAL PECULIARITIES OF THE CONGENITAL AND ACQUIRED CRANIOFACIAL ANOMALIES.

The aim of the research was to study the relationship between the X-ray changes in the bones of the skull, the structure of the upper respiratory tract and concomitant general somatic diseases in patients with congenital and acquired craniomaxillofacial anomalies. The study included 52 patients aged 1 to 3 and 3 to 7 years, with congenital and acquired lower micrognathia in 19 (36.53±5.

Long-term safety of COVID vaccination in individuals with idiopathic inflammatory myopathies: results from the COVAD study.

Limited evidence on long-term COVID-19 vaccine safety in patients with idiopathic inflammatory myopathies (IIMs) continues to contribute to vaccine hesitancy. We studied delayed-onset vaccine adverse events (AEs) in patients with IIMs, other systemic autoimmune and inflammatory disorders (SAIDs), and healthy controls (HCs), using data from the second COVID-19 Vaccination in Autoimmune Diseases (COVAD) study. A validated self-reporting e-survey was circulated by the COVAD study group (157 collaborators, 106 countries) from Feb-June 2022.

Related Diastrophic Dysplasia in 42-Years Ukrainian Women.

Diastrophic dysplasia (DTD) is an uncommon pathology which falls under the group of skeletal dysplasias with its first symptoms observed from birth. The pathology is often featured by short stature and abnormally short extremities (also known as short-limbed dwarfism); the osseous structures of the body (bones and joints) are characterized through defective development in many body regions. More than 300 genes were reported to be involved in DTD etiology with autosomal recessive, autosomal dominant and X-linked manner.

TRAUMATIC EVENTS AND MENTAL DISEASES: THE ROLE OF CERTAIN NEUROTRANSMITTERS, METALLOENZYMES AND HORMONES.

Objective: Aim: To study the role of certain neurotransmitters (brain-derived neurotrophic factor (BDNF), 5-hydroxytryptamine (5-HT)), metalloenzymes (matrix met-alloproteinase-9) (MMP-9) and hormones (ghrelin) in the pathogenesis of mental disorders associated with stress under the impact of traumatic events.

Patients And Methods: Materials and methods: We conducted a systematic search of major electronic medical databases published before October 1, 2022. Such keywords as (post-traumatic stress disorder OR PTSD), (Brain-derived neurotrophic factor OR BDNF), (matrix metalloproteinase-9 OR MMP-9), (serotonin OR 5-HT), ghrelin, melatonin identified relevant studies.

TISSUE EXPRESSION OF NEURONAL PROTEINS DURING SCIATIC NERVE REGENERATION AND INFLUENCE OF DIFFERENT SPECTRUM LASER RADIATION.

Objective: Aim: To determine the effect of laser irradiation of different spectrum on the expression of neuronal proteins (GFAP, S100, NSE and NF-L) in the sciatic nerve during its regeneration after crossing and surgical suturing.

Patients And Methods: Materials and methods: The experiment was performed on 60 laboratory rats of the Wistar line (200-250 g) with crossing of the left sciatic nerve and sutur¬ing with an epineural suture end to end 30 minutes after neurotomy. 90 days later, an immunohistochemical study was performed using specific antibodies (Thermo Fisher Scientific; USA).

TbNdZnNi (x = 0.5, y = 4.83): a new intermetallic with a maximum disordered structure and its hydrogen storage properties.

The ternary TbNdZnNi (x = 0.5, y = 4.83) disordered phase belongs to the structural family based on the rhombohedral ThZn structure type.

Dynamics of changes in cadmium levels in environmental objects and its impact on the bio-elemental composition of living organisms.

As a result of intensive anthropogenic impact in the biosphere there is a rapid process of accumulation of heavy metal salts. They have led to the aggravation of problems associated with the pollution of ecosystems and basic food products of plant and animal origin. Environmental pollution by these compounds is caused by their persistence in environmental objects, migration ability, accumulation by plants.

MICROSTRUCTURE OF BIOPOLYMER MICRO-FIBROUS SCAFFOLD AND ITS INFLUENCE ON THE ABILITY TO RETAIN MEDICINES AND TISSUE REGENERATION.

The aim of the research is to study the microstructure, antibiotic-absorbing and framework capacity of the fibrous non-woven PCL matrices designed by us for the regeneration of tissues and capillaries. Samples of microfibrous non-woven matrices made by our technology out of polycaprolactone PCL (invention patent of Ukraine № 119958) were used in the work. Antibiotic retention in samples of matrix materials was evaluated during the 1st, 3rd, 5th, 7th, 14th, 18th and 21st days of the experiment.

Morphological prediction of lethal outcomes in the evaluation of lung tissue structural changes in patients on respiratory support with СOVID-19: Ukrainian experience.

The impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on lung tissue in patients on respiratory support is of significant scientific interest in predicting mortality. This study aimed to analyze post-mortem histological changes in the lung tissue of COVID-19 patients on respiratory support using vital radiology semiotics. A total of 41 autopsies were performed on patients who died of SARS-CoV-2 and had confirmed COVID-19 by polymerase chain reaction (PCR) and radiological evidence of lung tissue consolidation and ground glass opacity.

Structural and functional characteristics of the pulmonary hemomicrocirculatory bed in induced systemic sclerosis: an experimental study.

The objective of this study was to investigate the effects of prolonged exposure to the oxidative agent NaClO on histopathological changes in the lung tissues of laboratory animals. Specifically, the study aimed to examine morphological changes in the pulmonary microcirculation and the level of vascular cell adhesion molecule-1 (VCAM-1) as a functional activity indicator of endothelial cells in animals with induced systemic sclerosis (SSc). A laboratory animal model was used to assess the impact of long-term exposure to NaClO on lung tissues.

STUDY OF BONE RESORPTION AS A RISK FACTOR IN DENTAL IMPLANTATION IN PATIENTS WITH GENERALIZED PERIODONTITIS.

The method of dental implantation in patients with generalized periodontitis is one of the priority areas requiring in-depth study. The aim of the study was to increase the efficiency of dental implantation by developing methods for eliminating bone resorption in patients with generalized periodontitis. There were examined 240 patients with generalized periodontitis of I, II, III degree of development with partial adentia of the upper and lower jaws, who later underwent comprehensive periodontal treatment using dental implantation methods.

Delusion of Pregnancy: A Case Report and Literature Review.

Delusion of pregnancy is defined as a persistent belief that one is pregnant despite concrete evidence to the contrary. Despite being reported as an isolated event, delusion of pregnancy has been reported in many patients with underlying psychiatric conditions such as schizophrenia, bipolar disorder, psychotic depression, and other physiological disorders of mental function. This case study reports a case of a 44-year-old, drug-naïve female with delusion of pregnancy affected by paranoid schizophrenia.

IMPACT OF STATINS ON THE CLINICAL COURSE OF COVID-19-ASSOCIATED PNEUMONIA IN UNVACCINATED PATIENTS WITH ARTERIAL HYPERTENSION.

Objective: The aim: To assess the impact of statins on the severity and lethality rate in hypertensive patients with COVID-19-associated pneumonia.

Patients And Methods: Materials and methods: 106 unvaccinated hypertensive patients were enrolled in the study. 29 (27.

Long COVID in autoimmune rheumatic diseases.

Consequences of Corona Virus Disease-19 (COVID-19) in patients with rheumatic diseases (RDs) are clinically diverse. SARS-CoV-2 infection has been associated with various autoimmune and rheumatic manifestations over the past three years. Emerging evidence points to the possibility of Long COVID predisposition in rheumatic patients due to the changes in immune regulatory response.

Comorbidities in the COVID-19 Pandemic: Scopus-Based Bibliometric Analysis.

Background: Comorbidities attract enormous attention amid the coronavirus disease 2019 (COVID-19) pandemic. Mapping knowledge based on these clinical conditions is increasingly important since the pandemic is still raging and primarily affecting subjects with chronic diseases and comorbidities. Clinical presentation and complications of COVID-19 are still hot topics which are explored in numerous evidence-based publications.

THE EXISTENCE OF A FUNCTIONAL MATRIX IN THE DEVELOPMENT OF THE FACIAL SKELETON IN CHILDREN.

Aim - identifying the relationship between the presence of oral habits and the violation of the formation of the facial skeleton in children. Improving the effectiveness of comprehensive treatment of patients with pathological occlusion and existing oral habits through orthodontic treatment and elimination of oral habits. We conducted clinical, radiological methods of examination of 60 patients 12-15 years old with acquired maxillomandibular anomalies and oral habits, 15 persons aged 12-15 years without maxillomandibular anomalies and acquired deformities (norm group).

Public Attitudes Towards COVID-19, Antibiotic Resistance, Preventive Measures: A Multi Center Cross-Sectional Study in the Arab Countries.

Background And Aim: COVID-19 has shown how crucial awareness of the need to protect public health is to global security. Antibiotic resistance due to antibiotic misuse is seen as a worldwide health issue. Antibiotic use was significant during the COVID-19 epidemic, according to several nations.

EFFECTIVENESS OF ALPHA-LIPOIC ACID AND IPIDACRINE HYDROCHLORIDE IN PREVENTION OF PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY ASSESSED BY ELECTRONEUROMYOGRAPHY OF SUPERFICIAL PERONEAL AND SURAL NERVES.

Aim: To investigate the neurofunctional parameters in breast cancer (BC) patients with paclitaxel-induced peripheral neuropathy (PIPN) and to clarify the feasibility of using alpha-lipoic acid (ALA) in combination with the acetylcholinesterase inhibitor ipidacrine hydrochloride (IPD) for its prevention.

Materials And Methods: 100 BC patients (T1-4N0-3M0-1) prescribed for polychemotherapy (PCT) by the AT (paclitaxel, doxorubicin) or ET (paclitaxel, epirubicin) regimens in the neoadjuvant, adjuvant or palliative modes, were enrolled. The patients were randomized into two groups (n = 50 per group): group I treated by PCT only; group II treated with PCT plus the studied PIPN prevention scheme (ALA in combination with IPD).

Corrigendum: Attitude of Syrian students toward GAD patients: An online cross-sectional study.

[This corrects the article DOI: 10.3389/fpubh.2022.

Meta-analysis of the relation between irritable bowel syndrome and antibodies against endogenous gonadotropin-releasing hormone and its receptor.

This meta-analysis assessed the association between gonadotropin hormone-releasing hormone (GnRH) antibodies and irritable bowel syndrome (IBS). We defined a search strategy and implemented it with PubMed, Ovid, Scopus, and Web of Science databases for English language publications. The data were evaluated for acceptability, and randomized controlled studies as well as case-control, cross-sectional, and cohort studies reporting the prevalence of GnRH antibodies in IBS patients were included.

REPERFUSION INJURY IN ACUTE PERIOD OF MYOCARDIAL INFARCTION - WAYS OF PREVENTION AND CORRECTION.

Objective: The aim: To identify pathophysiological peculiarities of myocardial reperfusion injury and ways of its reduction based on the literature data analysis.

Patients And Methods: Materials and methots: This literature review was made by searching the PubMed database using key words . Additional data were sought in the Google search engine by entering key words: " risk factors, ischemic heart disease, arrhythmia, sudden cardiac death, heart rhythm, heart failure.

IMPROVEMENT OF THE HEALTH SERVICES FOR THE PREVENTION OF HIV TRANSMISSION FROM MOTHER TO CHILD AT THE LEVEL OF PRIMARY HEALTH CARE.

Objective: The aim: To analyze the problems of PMTCT of HIV and to clarify the ways for their solving through the increasing their obstetrical and gynecological services at the primary health care level.

Patients And Methods: Materials and methods: Bibliosemantic, statistical and method of structural and logical analysis. The research materials are the data of the statistical reports for the period 2016-2020.