EFFECTIVENESS OF THE APPLICATION OF THE DEVELOPED BIOPOLYMER FIBROUS MATRIX WITH CENOBONE® BIOGEL FOR THE RECONSTRUCTION OF BONE TISSUE DEFECTS OF THE JAWS.

The aim of the research was to study the framework ability of the fibrous non-woven PCL matrices we've created during the restoration of bone tissue.There were performed some spectroscopic, histological and immunohistochemical, radiological and clinical analyses of the effectiveness of microfibrous non-woven PCL polycaprolactone matrices developed by us, in the work. The obtained results of morphological studies of bone tissue in the experiment of the implantation of a fibrous matrix indicated an increase in reparative osteogenesis in the form of an increase in osteoid areas up to 34.

FEATURES OF COL1A1 EXPRESSION IN BREAST CANCER TISSUE OF YOUNG PATIENTS.

Background: In the last decades, the incidence of breast cancer (BCa) in young women has been increasing steadily. The quantitative indicators of expression of collagen, which play important role in stromal microenvironment, and their association with the age and survival rates of BCa patients have not been yet definitively clarified.

Aim: To investigate the relationship between the COL1A1 gene expression at the mRNA and protein levels in BCa tissue and the clinicopatological features and survival rates of BCa patients of different age groups.

Choledochal cyst mimicking as choledocholithiasis: A case report and review of literature.

Choledochal cysts are rare congenital anomalies of the biliary system, mostly diagnosed during childhood. In adults, a lower incidence and symptom overlap with more common biliary conditions may hinder the diagnosis. This case study presents a 50-year-old female patient who presented with abdominal pain and multiple gallstones on ultrasonography which also showed a dilation of the common bile duct, presumably left by a stone that had already passed.

Treatment outcomes and risk factors for an unsuccessful outcome among patients with highly drug-resistant tuberculosis in Ukraine.

Objectives: To describe demographics, clinical features, and treatment outcomes of patients with highly drug-resistant tuberculosis (TB) in Ukraine, and to evaluate risk factors for an unsuccessful outcome.

Methods: Data from patients with multi-, pre-extensively, or extensively drug-resistant TB were collected prospectively from TB dispensaries in 15 out of 24 Ukrainian oblasts (regions) from 2020 to 2021. Treatment outcomes were evaluated using WHO definitions.

Pregnancy and umbilical cord pathology: structural and functional parameters of the umbilical cord.

Scientific research in the field of physiology and pathology of the umbilical cord is quite limited and imperfect. The purpose of the study was to evaluate the histological architecture of the pathological umbilical cord and investigate the relationship between the main parameters and placental postnatal macromorphometric characteristics, which serve as a reflection of placental dysfunction. Four groups of patients were included, each undergoing a postnatal histological and topographic examination of the umbilical cord: Wharton's jelly edema (10 samples), velamentous cord insertion (10 samples), single umbilical artery (10 samples), and physiological pregnancy (10 samples).

THE ROLE OF NEUROHORMONAL FACTORS IN THE FORMATION OF A PATIENT'S CLINICAL PROFILE AND THE IMPACT ON STRUCTURAL CARDIAC AND VASCULAR REMODELING IN PATIENTS WITH MYOCARDIAL INFARCTION AFTER REPERFUSION THERAPY.

Objective: The aim: To determine the dynamics of galectin-3 in the formation of the patient's clinical profile and the impact on structural cardiac and vascular remodeling in patients with myocardial infarction after reperfusion therapy.

Patients And Methods: Materials and methods: 140 patients with class II A CHF syndrome according to Vasilenko-Strazhesko FC II-III (NYHA), which occurred in patients with MI, and 22 patients with MI without signs of CHF were examined.

Results: Results: The average serum galectin-3 level of the studied patients was analyzed.

ACTIVITY OF PHOSPHATASES IN THE ORAL LIQUID OF PATIENTS FROM POLLUTED AREAS WHO ARE DIAGNOSED WITH GENERALIZED PERIODONTITIS AND RHEUMATOID ARTHRITIS.

Objective: The aim: To study the activity of acid and alkaline phosphatases as markers of bone metabolism in patients from bad environmental areas who are diagnosed with rheumatoid arthritis and are affected by generalized periodontitis.

Patients And Methods: Materials and methods: A total of 137 residents from Kalush district of the Ivano-Frankivsk region, Ukraine were enrolled in this investigation. There were 105 patients aged between 18 and 60 years with generalized periodontitis of the I-II degree severity selected for further research.

Comparison of SP263 and 22C3 immunohistochemistry PD-L1 assays for clinical efficacy of adjuvant atezolizumab in non-small cell lung cancer: results from the randomized phase III IMpower010 trial.

Background: Tumor samples from the phase III IMpower010 study were used to compare two programmed death-ligand 1 (PD-L1) immunohistochemistry assays (VENTANA SP263 and Dako 22C3) for identification of PD-L1 patient subgroups (negative, positive, low, and high expression) and their predictive value for adjuvant atezolizumab compared with best supportive care (BSC) in resectable early-stage non-small cell lung cancer (NSCLC).

Methods: PD-L1 expression was assessed by the SP263 assay, which measured the percentage of tumor cells with any membranous PD-L1 staining, and the 22C3 assay, which scored the percentage of viable tumor cells showing partial or complete membranous PD-L1 staining.

Results: When examining the concordance at the PD-L1-positive threshold (SP263: tumor cell (TC)≥1%; 22C3: tumor proportion score (TPS)≥1%), the results were concordant between assays for 83% of the samples.

RISK FACTORS FOR GC-RESISTANT PULMONARY SARCOIDOSIS.

Objective: The aim: The study aimed to conduct a retrospective analysis of unfavorable outcome rate and to search for clinical and anamnestic criteria for predicting glucocorticoid-resistant pulmonary sarcoidosis.

Patients And Methods: Materials and methods: There were examined 37 women and 31 men with stage II to III pulmonary sarcoidosis from 2018-2022. The mean patients' age was (35.

COMPARISON OF THE RESULTS OF STUDYING BY THE STUDENTS OF THE "CLINICAL ANATOMY AND OPERATIVE SURGERY" MODULE WITH DIFFERENT FORMS OF THE EDUCATIONAL FORMS OF THE EDUCATIONAL PROCESS IN CONDTIONS OF SOCIAL SHOCKS IN UKRAINE.

To evaluate the peculiarities of training and the influence of external factors on the training process in higher medical institutions, we have analyzed and compared the results of training in the conditions of social shocks that have occurred in Ukraine. We compared the results of the study of the discipline "Clinical Anatomy and Operative Surgery" in the traditional form of education and in the distance form of education in the conditions of the COVID-19 pandemic and during military operations. The analysis was carried out on the example of the results of the study of the module "Clinical Anatomy and Operative Surgery" by students of the II year of the Faculty of Medicine, specialty "Medicine", Ivano-Frankivsk National Medical University.

PREVENTIVE PLASTIC OF BUCCAL FRENUM IN СOMPLEX TREATMENT OF PATIENTS WITH ACQUIRED MAXILLOMANDIBULAR ANOMALIES.

Aim - improving the effectiveness of complex treatment of patients with maxillomandibular anomalies and disorders of the architectonics of the vestibule of the mouth. We conducted clinical, X-ray methods and cytomorphometric, rheographic examination of the oral mucosa of 30 patients 15-17-years old with acquired maxillomandibular anomalies and disorders of the architectonics of the vestibule of the mouth (buccal frenum) and 15 relatively healthy children - norm group. The patients of I group had surgical correction of buccal frenum, where the surgical wound was healing by secondary tension.

Diabetes mellitus in rheumatic diseases: clinical characteristics and treatment considerations.

New pathophysiological insights are now available on comorbidities in rheumatic diseases (RDs). Several nationwide studies point to the fact that comorbid diabetes mellitus (DM) increases the risk of adverse outcomes in patients with various RDs. Genetic factors, intensity of systemic inflammation, anti-inflammatory potential of therapeutic agents, and duration of RDs have been insufficiently explored in the context of comorbidities.

Delayed adverse events following COVID-19 vaccination in patients with systemic sclerosis and other autoimmune diseases: a substudy of the COVAD-2 cohort.

Data on short-term safety of COVID-19 vaccination in patients with systemic sclerosis (SSc) were explored previously in the first COVID-19 vaccination in autoimmune diseases (COVAD) survey conducted in 2021. However, delayed adverse events (ADEs) (occurring > 7 days post-vaccination) are poorly characterized in these patients with SSc. In this study, we analysed delayed COVID-19 vaccine-related ADEs among patients with SSc, other systemic autoimmune and inflammatory disorders (SAIDs) and healthy controls (HCs) using data from the second COVAD study conducted in 2022.

American Cranberry ( (Ait.) Pursh) Leaves Extract and Its Amino-Acids Preparation: The Phytochemical and Pharmacological Study.

The liver is an organ with several important biofunctions, for which there are very few effective and safe preparations that promote the functioning, protection, and regeneration of cells. Sufficiently safe preparations with hepatoprotective activity can be found in plants. The aim of our study was to investigate the chemical composition of an extract made from American cranberry ( (Ait.

ACCUMULATION OF HEAVY METALS IN THE COLON AND BLOOD OF PATIENTS WITH COLORECTAL CANCER.

Objective: The aim: To determine the accumulation of heavy metals, namely Cr, Cd, Cu, Pb, Zn by a tumour in correlation with unaffected colon tissue and blood of patients with colorectal cancer.

Patients And Methods: Materials and methods: The study is based on the results of observation of 180 patients with CRC. The following samples were taken from: the tumor, the colon and blood unaffected by the tumor - during the operative treatment of patients in the surgical department of the communal non-profit enterprise "Precarpathian Clinical Oncology Center of the Ivano-Frankivsk regional council" for 2018-2020.

INFLUENCE OF BAD HABITS ON THE DEVELOPMENT OF ACQUIRED DEFORMATIONS IN THE MAXILLOFACIAL AREA.

Objective: The aim: Identifying the relationship between the presence of oral habit and acquired maxillomandibular anomalies, influence of oral habits on the skeleton and muscular system formation in children.

Patients And Methods: Materials and methods: We conducted clinical, radiological methods of examination of 60 patients aged 9-12 with acquired maxillomandibular anomalies, 15 persons aged 9-12 years without maxillomandibular anomalies and acquired deformities (norm group) and 15 persons aged 9-12 years with hereditary syndromes, which are combined with bone deformities in the maxillofacial area (comparison group).

Results: Results: Clinical examination showed that oral habits were manifested in 98.

THE EFFECT OF RUTA GRAVEOLENS L. ETHANOLIC EXTRACTS ON SKIN ISOLATES OF STAPHYLOCOCCI AND PROPIONIBACTERIUM ACNES.

Objective: The aim: To define antimicrobial properties of 50%, 70% and 90% ethanolic extracts of Ruta graveolens L. against macrolide resistant (MLS-resistant) skin isolates of staphylococci and Propionibacterium acnes, and to determine MIC and MBC of investigated extracts.

Patients And Methods: Materials and methods: Extracts were prepared by the method of maceration.

SCREENING OF MEDICINAL AND AROMATIC PLANTS EXTRACTS FOR THE SYNERGISM WITH FLUCONAZOLE AGAINST CANDIDA ALBICANS AND CANDIDA TROPICALIS FUNGI ASSOCIATED WITH DENTURE STOMATITIS.

Objective: The aim: To conduct a primary screening of the ability of aqueous-ethanol extracts of medicinal plants to enhance the effect of fluconazole against resistant strains of Candida sp. associated with denture stomatitis, to justify the potential use of combined antifungal therapy.

Patients And Methods: Materials and methods: 40 biochemical tests using the VITEK 2 system with the use of VITEK 2 YST ID card (Biomerieux, France).

A large-scale analysis of refractive errors in students attending public primary schools in Mexico.

A cross-sectional, retrospective study was conducted from September 2013 through July 2014 to determine the prevalence of refractive errors among students attending public primary schools in Mexico. Among 3,861,156 students at 14,566 public primary schools in all 32 states of Mexico, teachers identified reduced visual acuity in 1,253,589 (32.5%) using visual acuity measurement.

CLINICAL EFFICACY OF TREATMENT OF WOMEN WITH CHRONIC RECURRENT UROGENITAL CHLAMYDIA INFECTION.

Objective: Aim: To to increase the efficacy of the treatment of women diagnosed with complicated urogenital chlamydia infection based on the study of the immune status, clinical and pathogenetic features of the course, development and implementation of pathogenetically substantiated therapy methods.

Patients And Methods: Materials and methods: Laboratory diagnostics of chlamydia infection was conducted with the use of direct immunofluorescence, enzyme immunoassay and cytological method. The dynamics of clinical symptoms was studied in the patients of Group I (64 women) who received Wobenzym in combination with Doxycycline and Group II (64 women) who were treated with conventional therapy (CT).

EVALUATION OF THE COMPLEX USE OF PLANT TEST-SYSTEMS TO DETERMINE THE NATURE AND INTENSITY OF THE MUTAGENIC BACKGROUND OF THE ENVIRONMENT.

Objective: Aim: A comprehensive evaluation of the effectiveness of the use of plant test-systems as biological objects for the identification of the specifitown of the effect of mutagens on the hereditary apparatus.

Patients And Methods: Materials and methods: With the use of test-systems (determination of the gonadotoxitown of plant pollen grains, the Allium cepa-test and the use of celandine greater Chelidonium majus as an accumulative phytoindicator) was analyzed the ecological situation of the areas in Ivano-Frankivsk region. The samples of soil, water, generative and vegetative organs of plants were taken in the territories of the Carpathian region and tested in the following areas: ecologically safe, conditionally ecologically safe and ecologically dangerous areas.

MORPHOLOGICAL CHARACTERISTICS OF THE ENDOCRINE FUNCTION OF THE HEART IN COMORBID PATHOLOGY.

Objective: Aim: To study the ultrastructural remodeling of atrial myoendocrine cells (AMC) of the atrial myocardium in streptozotocin-induced diabetes (SID) under chronic immobilization stress (CIS).

Patients And Methods: Materials and methods: 40 sexually mature white male rats (body weight 150-180 g) were included in the study. Four groups were formed: group 1 - animals with comorbid pathology (SID and CIS), group 2 - animals with SID, group 3 - animals with CIS, group 4 - intact animals.

Clinical and laboratory characteristics of COVID-19 in pregnant women.

This article discusses the distinct characteristics of COVID-19 in pregnant women and investigates potential early predictors of disease severity in this specific patient population. The study included 116 pregnant women with a confirmed diagnosis of COVID-19 in different trimesters of pregnancy. In addition to clinical features, we evaluated general clinical research methods, biochemical parameters (procalcitonin, C-reactive protein, D-dimer), and the leukocyte index of endogenous intoxication and lymphocytic index to identify potential early predictors of disease severity.

BRONCHIECTASIS IN ADULT PATIENTS: CLINICAL PECULIARITIES AND APPROACHES TO THE TREATMENT.

Objective: The aim: To perform a clinical analysis of bronchiectasis in adults, to analyze the effectiveness of nebulizer therapy with hypertonic NaCl solution with hyaluronic acid.

Patients And Methods: Materials and methods: All patients were performed clinical-functional examination (MRC dyspnea index, Sp O2, 6-minute walking test, external respiration function); calculated the index BODE, analyzed the SGRQ, studied the results of sputum. Statistical data analysis was performed using the Microsoft Excel for Microsoft 365 MSO 16.