"Thoracic anesthesia in patients with airborne disease".

Health care workers are at risk of infection from aerosolization of respiratory secretions, droplet and contact spread. This has gained great importance after the COVID19 pandemic. Intra-operative aerosol-generating procedures are arguably unavoidable in the routine provision of thoracic anesthesia.

Use of platelet-rich plasma in rheumatic diseases.

Platelet-rich plasma (PRP) has gained increasing recognition as a promising therapeutic agent in managing rheumatic diseases. Conventional treatments, including nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and disease-modifying antirheumatic drugs (DMARDs), primarily act on reducing inflammation but fail to address the underlying mechanisms of connective tissue degradation. PRP, an autologous preparation enriched with growth factors and bioactive molecules, is pivotal in modulating inflammation and fostering tissue regeneration.

The Implementation and Outcomes of Personalized Antihypertensive Therapy Based on Pharmacogenetic Testing: A Retrospective Study Examining Blood Pressure Control and Medication Tolerability.

Background: Hypertension management typically relies on standardized treatment regimens, which may not account for individual genetic variations that affect drug metabolism and response.

Objective: The objective of this study was to evaluate the effectiveness of personalized antihypertensive therapy, guided by pharmacogenetic testing, in terms of blood pressure (BP) control and medication tolerability.

Materials And Methods: A retrospective cohort study was conducted at Jinnah Postgraduate Medical Centre, Karachi, from January 2023 to December 2023.

Periodontitis upon hypothyroidism of young people.

Objective: Aim: To study the periodontal tissues and to establish the Magnesium content in oral liquid and capillary blood of young people with hypothyroidism from areas with Iodine deficiency.

Patients And Methods: Materials and Methods: In order to study the prevalence of periodontal disorders there were 330 people aged from 25 to 44 years from areas with natural Iodine deficiency enrolled in this examination. Primary hypothyroidism was diagnosed in 195 people (they made up the group I), and 135 people did not have any accompanying endocrine pathology (group II).

Cardiorenal outcomes associated with sodium-glucose co-transporter-2 inhibitors in chronic kidney disease stage 5 (CKD V): A propensity score-matched analysis.

Background: There remains a paucity of data regarding the cardio-renal benefits of sodium-glucose co-transporter-2 inhibitors (SGLT2i) in patients with chronic kidney disease stage 5 (CKD V) based on major clinical trials.

Objective: This retrospective study aimed to identify potential cardiovascular and renal outcomes associated with SGLT2i use in CKD V patients.

Methods: We queried the TriNetX Global collaborative network from Jan 2014 - Aug 2023 for patients ≥18 years diagnosed with CKD V but not on dialysis.

Effectiveness of the quercetin use in patients with COVID-19 with concomitant type 2 diabetes mellitus.

Objective: Aim: To conduct a comparative analysis of the effectiveness of basic therapy and basic therapy with the inclusion of quercetin in patients with COVID-19 with concomitant type 2 diabetes.

Patients And Methods: Materials and Methods: There were examined 60 patients with COVID-19 with concomitant T2DM. Upon admission into the hospital and again after 10 days, serum levels of interleukin-6, C-reactive protein, procalcitonin, ferritin, endothelin-1 were determined, and capillaroscopy of the nail plate was performed.

Lyme borreliosis in Ivano-Frankivsk district, Ukraine: a epidemiological and clinical characteristics (2000-2022).

Objective: Aim: To give epidemiological and clinical characteristics of the morbidity of Lyme borreliosis in Ivano-Frankivsk region for the period of 2000-2022 years.

Patients And Methods: Materials and Methods: There were used annual reports (form №1) from the State Institution "Ivano-Frankivsk Regional Center for Disease Control and Prevention of the Ministry of Health of Ukraine" and 200 of "Medical records of inpatients" (form 003/о) of the Ivano-Frankivsk Regional Clinical Infectious Diseases Hospital for 2000-2022 years.

Results: Results: The morbidity of Lyme borreliosis in the Ivano-Frankivsk region has been permanently increasing since 2000.

Polyphenolic Compounds in the Stems of Raspberry () Growing Wild and Cultivated.

The stems of L., a byproduct of the fruit-food industry, are known sources of bioactive compounds. The main objective of this study was to investigate the composition of polyphenolic compounds in stems.

Enhancing chronic disease management through physical activity and pedometry-based health monitoring.

Physical activity (PA) is a vital component in the management of chronic diseases, including cardiovascular, metabolic, and musculoskeletal conditions. In rheumatic diseases (RDs) such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and osteoarthritis (OA), PA has been shown to alleviate symptoms, enhance functional capacity, and improve quality of life. Given these advantages, wearable trackers and smartphone apps have revolutionized PA monitoring, offering quantitative reports of step counts, sedentary behavior, intensity, and energy expenditure.

ANALYSIS OF THE CLINICAL EFFECTIVENESS OF USING THE CREATED COMBINED FIBRIN-BONE SCAFFOLD FOR THE RECONSTRUCTION OF BONE TISSUE DEFECTS OF THE JAWS.

Unlabelled: The aim of the study was the clinical study of the framework ability of the PRF scaffold obtained by simultaneous centrifugation of the patient's blood and bone-plastic material.

Materials And Methods: A total of 60 patients, aged between 20 and 50 years, with radicular cysts of the jaws, were selected for inclusion into the clinical studies. All patients were divided into groups I and II, who underwent cystectomy and bone plastic surgery according to the standard technique using mineralized CenoBone®.

Impact of Age on Predictive Capabilities of Ferritin, Ferritin-Hemoglobin Ratio, IL-6, and sIL-2R for COVID-19 Severity and Mortality.

The study aimed to establish the impact of age on the predictive capability of ferritin, ferritin-hemoglobin ratio (FHR), IL-6, and sIL-2R in COVID-19 patients. Compared to patients with moderate condition, patients with severe condition had higher ferritin level (441.0 [188.

Mitral valve repair and replacement in infectious endocarditis: a systematic review and meta-analysis of clinical outcome.

Background: Infective endocarditis (IE) poses significant clinical challenges, often necessitating surgical intervention for improved patient outcomes. The choice between mitral valve repair (MVP) and mitral valve replacement (MVR) is crucial in managing IE. This systematic review and meta-analysis aims to compare the effectiveness of MVP and MVR in treating IE, focusing on outcomes such as postoperative bleeding, mortality, recurrent endocarditis, and stroke.

Morphometrical analysis of myelinated nerve fibers: is there a room for improvement?

Despite advancements in automatic approaches for histomorphometry analysis of peripheral nerves, manual and semi-automated methods are widely utilized. Standard software functions are often unsuitable for analysis due to their irregular shapes, especially in pathological conditions. This study aims to assess the reproducibility of nerves morphometric analysis and compare results obtained using both default and new alternative algorithms.

Ultrasonographic changes of carotid vessels in patients in the early recovery period of atherothrombotic stroke.

Objective: Aim: To study the state of extracranial carotid vessels in patients with atherothrombotic stroke in the early recovery period (ASERP) according to duplex scanning data.

Patients And Methods: Materials and Methods: 130 patients in ASERP, were studied. 69 men and 61 women.

NaOH-assisted hydrothermal reduction of graphene oxide.

The influence of the pH of the reaction medium on the structural characteristics of hydrothermally reduced graphene oxide, synthesized by the tour method, has been investigated. Varying the pH of the reaction medium within the range of 8.0, 10.

Impact of war on stroke incidence in Ivano-Frankivsk, Ukraine.

Stroke is an extensive health problem in Ukraine, the prominence and effects of which are aggravated by the burden of the ongoing Russo-Ukrainian War. In this study, we aimed to holistically examine the overall stroke epidemiology in Ivano-Frankivsk using data from a secondary healthcare center in the city. We determine an increasing trend in stroke admissions since 2020, with a notable 22.

Exploring the bidirectional relationship between sleep disorders and atrial fibrillation: implications for risk stratification and management.

Background: Atrial fibrillation (AF) is characterized by the absence of p-waves on ECG and irregular rhythm. It often presents with palpitations either palpitations may occur acutely over a short period or intermittently over several years. Other cardinal symptoms of atrial fibrillation include fatigue, dyspnea, and lightheadedness; it is important however to note that most affected individuals are asymptomatic.

Novel Combinations of Immunotherapies or DNA Damage Repair Inhibitors in Platinum-Refractory Extensive-Stage Small Cell Lung Cancer: The Phase II BALTIC Study.

Purpose: The phase II, multiarm, signal-searching BALTIC study (NCT02937818) assessed novel treatment combinations for platinum-refractory/resistant extensive-stage small cell lung cancer (ES-SCLC).

Patients And Methods: Patients with ES-SCLC with progressive disease during or within 90 days of completing first-line platinum-based chemotherapy received one of three regimens: durvalumab plus tremelimumab followed by durvalumab monotherapy (arm A), adavosertib plus carboplatin (arm B), or ceralasertib plus olaparib (arm C). The primary endpoint was the objective response rate.

Neuroinflammation: A Critical Factor in Neurodegenerative Disorders.

This review offers a comprehensive review of the signals and the paramount role neuroinflammation plays in neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis. The study explores the sophisticated interactions between microglial, astrocytic, and dendritic cells and how neuroinflammation affects long-term neuronal damage and dysfunction. There are specific pathways related to the mentioned inflammatory processes, including Janus kinases/signal transducer and activator of transcriptions, nuclear factor-κB, and mitogen-activated protein kinases pathways.

Tafamidis therapy in transthyretin amyloid cardiomyopathy: a narrative review from clinical trials and real-world evidence.

Background: Amyloidosis is a heterogeneous group of disorders caused by the extracellular deposition of insoluble misfolded proteins, leading to end-organ damage. Transthyretin amyloid cardiomyopathy (ATTR-CM) is a subtype in which a protein known as transthyretin accumulates within the heart tissue, progressively resulting in restrictive cardiomyopathy and heart failure. Due to the progressive nature of ATTR-CM, clinical management requires efficacious regimens to manage the debilitating condition and Tafamidis shows promising results in this regard.