Ultrastructural assessment of human periodontal ligament fibroblast interaction with bovine pericardium membranes: An study.

Research towards regenerative dentistry focused on developing scaffold materials whose high performance induces cell adhesion support and guides tissue growth. An early study investigated the proliferation abilities and attachment of human periodontal ligament fibroblasts (HPLFs) on two bovine pericardium membranes with different thicknesses, 0.2 mm and 0.

Endovascular Treatment of Malfunctioning Dialysis Fistulas: A Multicenter Retrospective Analysis Comparing Transradial and Conventional Transvenous Access.

Background: Venous outflow is the favored access for endovascular management of dialysis fistulas. However, transradial access (TRA) offers advantages in specific clinical scenarios. The study aims to compare the efficacy, feasibility, and safety of TRA and transvenous access (TVA) in the endovascular management of malfunctioning dialysis fistulas, addressing the existing gap in comprehensive literature.

Conformational Space of 3-Chloropropionic Acid in Gas Phase Explored by Rotational Spectroscopy.

The conformational space of 3-chloropropionic acid has been studied under the isolated conditions of a supersonic expansion using Stark-modulated free-jet absorption millimeter-wave and centimeter-wave chirped-pulse Fourier transform microwave spectroscopy techniques. The rotational spectra originating from the three most stable conformers including Cl and Cl isotopologues were observed in both experiments using helium expansion while a partial conformational relaxation involving skeletal rearrangements takes place in an argon expansion. The rotational parameters, geometries, and energy order were determined from the experiment, allowing a comparison with quantum chemical predictions.

Development and Comparative Evaluation of a Reinstructed GPT-4o Model Specialized in Periodontology.

Background: Artificial intelligence (AI) has the potential to enhance healthcare practices, including periodontology, by improving diagnostics, treatment planning and patient care. This study introduces 'PerioGPT', a specialized AI model designed to provide up-to-date periodontal knowledge using GPT-4o and a novel retrieval-augmented generation (RAG) system.

Methods: PerioGPT was evaluated in two phases.

Ingestion of Multiple Magnets by Children: Diagnosis and Management When Ingestion is not Witnessed.

Aim: Foreign body ingestion, particularly that of magnets, is a significant issue for children aged 6 months to 3 years due to their prevalence in toys and household items. Most ingested foreign bodies pass naturally, but 10%-20% of such cases require endoscopic removal, and <1% require surgery.

Case Presentation: A 2-year-old girl presented with abdominal pain, nausea, and vomiting.

A Case Report Describing the Surgical Removal of Venous and Intracardiac Cement Leakage after Percutaneous Vertebroplasty in a Hybrid Operating Room.

Aim: Percutaneous vertebroplasty is generally considered a safe procedure, however, cases of cardioembolism and cardiac perforation have been reported.

Case Presentation: A 69-year-old woman was referred to our emergency department after an outpatient echocardiogram revealed a "thrombus-like" formation involving the right heart. Two weeks before she had undergone percutaneous vertebroplasty of the third to fifth lumbar vertebrae due to osteoporotic fractures.

Unveiling the Masquerade: Early Gastric Cancer Mimicking Advanced Disease with Ectopic Pancreas Intrusion.

Gastric cancer is a significant health concern worldwide, and its diagnosis and management are of paramount importance. Ectopic pancreas (EP) refers to an embryological abnormality where healthy pancreatic tissue develops without anatomical, vascular, or neural communication with the normal pancreas. We report the case of a patient whose initial endoscopic evaluation suggested early gastric cancer, but computed tomography scan (CT scan) and endoscopic ultrasound (EUS) indicated a locally advanced tumor.

Spinal Dumbbell Meningiomas: A Systematic Review.

Aim: This systematic review aims to synthesize the epidemiology, clinical presentation, diagnostic approaches, treatment strategies, and outcomes of spinal dumbbell meningiomas to enhance understanding and improve patient management.

Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, four major databases (PubMed, Scopus, Web of Science, and Cochrane Library) were searched until June 2024. Studies included patients diagnosed with spinal dumbbell intradural-extradural meningiomas, focusing on patient demographics, tumor characteristics, diagnostic methods, treatment modalities, and clinical outcomes.

Our Experience about Shared Venous Hemodynamics Map (SVHM): A Least Common Denominator for Computerized Comparison of the Results of Chronic Venous Disease (CVD) Treatment.

Aim: Varicose veins, while frequently perceived as a cosmetic concern, should be evaluated within the broader context of chronic venous insufficiency (CVI) affecting the lower extremities. The Mappa Emodinamica Venosa Condivisa, Italian for Shared Venous Hemodynamics Map (MEVeC) project aims to provide an objective method for assessing the hemodynamic disorders underlying CVI and standardizing the evaluation of therapeutic interventions for lower extremity CVI. To achieve objective treatment assessment, it is essential to ensure uniform expertise among phlebologists and the ability to replicate comparable clinical outcomes.

The generalized Hausman test for detecting non-normality in the latent variable distribution of the two-parameter IRT model.

This paper introduces the generalized Hausman test as a novel method for detecting the non-normality of the latent variable distribution of the unidimensional latent trait model for binary data. The test utilizes the pairwise maximum likelihood estimator for the parameters of the latent trait model, which assumes normality of the latent variable, and the maximum likelihood estimator obtained under a semi-non-parametric framework, allowing for a more flexible distribution of the latent variable. The performance of the generalized Hausman test is evaluated through a simulation study and compared with other test statistics available in the literature for testing latent variable distribution fit and an overall goodness-of-fit test statistic.

Clinical validity and reproducibility of a visual rating scale for cingulate island sign in a real-world memory clinic: An FDG-PET/MRI study.

Purpose: Brain [18F]FDG-PET is a supportive biomarker for cognitive impairment in Lewy bodies disease (LBD) showing reduced occipital metabolism and presence of the cingulate island sign (CIS), a relative preservation of posterior cingulate cortex (PCC) metabolism compared with precuneus and cuneus. We assess validation, clinical utility, and reproducibility of a qualitative visual CIS scale in the differential diagnosis with Alzheimer's disease (AD) in a memory clinic setting.

Methods: Sixty-seven patients were studied: 36 LBD, of whom 30 with dementia (DLB) and 6 with mild cognitive impairment (MCI-LB), and 31 AD (20 typical and 11 atypical presentations).

The role of vorasidenib in the treatment of isocitrate dehydrogenase-mutant glioma.

Isocitrate dehydrogenase (IDH)-mutant gliomas are the most common malignant primary brain tumors in young adults. This condition imposes a substantial burden on patients and their caregivers, marked by neurocognitive deficits and high mortality rates due to tumor progression, coupled with significant morbidity from current treatment modalities. Although surgery, radiation therapy, and chemotherapy improve survival, these treatments can adversely affect cognitive function, quality of life, finances, employment status, and overall independence.

Trehalose Cryopreservation of Human Mesenchymal Stem Cells from Cord Tissue.

Adequate hypothermic storage of human mesenchymal stem cells (hMSCs) is of fundamental importance since they have been explored in several regenerative medicine initiatives. However, the actual clinical application of hMSCs necessitates hypothermic storage for long periods, a process that requires the use of non-toxic and efficient cryo-reagents capable of maintaining high viability and differentiating properties after thawing. Current cryopreservation methods are based on cryoprotectant agents (CPAs) containing dimethylsulphoxide (DMSO), which have been shown to be toxic for clinical applications.

What is new in the pathogenesis and treatment of IgA glomerulonephritis.

Recently, new findings have been clarified concerning both pathogenesis and treatment of IgA nephritis. The four hits theory has been confirmed but several genetic wide association studies have allowed finding several genes connected with the pathogenesis of the disease. All these new genes apply to each of the four hits.

NGF-mediated crosstalk: unraveling the influence of metabolic deregulation on the interplay between neural and pancreatic cancer cells and its impact on patient outcomes.

Neural invasion is one of the most common routes of invasion in pancreatic cancer and it is responsible for the high rate of tumor recurrence after surgery and the pain generation associated with pancreatic cancer. Several molecules implicated in neural invasion are also responsible for pain onset including NGF belonging to the family of neutrophins. NGF released by cancer cells can sensitize sensory nerves which in turn results in severe pain.

Boosting Psychotherapy With Noninvasive Brain Stimulation: The Whys and Wherefores of Modulating Neural Plasticity to Promote Therapeutic Change.

The phenomenon of neural plasticity pertains to the intrinsic capacity of neurons to undergo structural and functional reconfiguration through learning and experiential interaction with the environment. These changes could manifest themselves not only as a consequence of various life experiences but also following therapeutic interventions, including the application of noninvasive brain stimulation (NIBS) and psychotherapy. As standalone therapies, both NIBS and psychotherapy have demonstrated their efficacy in the amelioration of psychiatric disorders' symptoms, with a certain variability in terms of effect sizes and duration.

Re-taking the field: resuming in-person fieldwork amid the COVID-19 pandemic.

Italy was among the first countries in Europe to be heavily impacted by the outbreak of COVID-19. Northern Italy and Lombardy, in particular, were the most affected areas. In September 2021, the team of "AIS, the digital turn" (AISdt), a project whose objectives include collecting data in 50 locations in Italy, across Lombardy and Piedmont, resumed in-person data collection.

Phage-resistance alters Lipid A reactogenicity: a new strategy for LPS-based conjugate vaccines against Rissen.

serovar Rissen ( Rissen) is an emerging causative agent of foodborne diseases. The current emergence of antibiotic resistance makes necessary alternative therapeutic strategies. In this study, we investigated the potential of a phage-resistant strain of Rissen (R) as a tool for developing an effective lipopolysaccharide (LPS)-based vaccine.

An overview of the literature on assistance dogs using text mining and topic analysis.

It is said that dogs are human's best friend. On occasion, dogs can be raised and trained to provide additional specific benefits to humans suffering from a range of physical or mental conditions, working as assistance dogs. In this article, we employed innovative techniques to review the vast and constantly expanding literature on the subject, which covers a multitude of aspects.

Taxonomic novelty in Pleomonodictydaceae and new reports for (Phaeosphaeriaceae), and (Pleurotremataceae).

This study introduces a novel genus , with its type . The specimen was collected on dead aerial branches of in Italy. Based on the examination of morphology and the results of phylogenetic analyses involving nuclear 18S rDNA (SSU), nuclear 28S rDNA (LSU), nuclear rDNA ITS1-5.

Clinical characterization of a novel p.Gly615Glu mutation in nine family members with familial hemiplegic migraine.

Familial hemiplegic migraine type 2 results from pathogenic variants in the gene, which encodes for a catalytic subunit of sodium/potassium ATPase. This extremely rare autosomal dominant disorder manifests with a spectrum of symptoms, most commonly pure hemiplegic phenotype, epilepsy, and/or intellectual disability. In this study, we detail the clinical features and genetic analysis of nine patients from a large family spanning four generations, with all carrying a previously unreported likely pathogenic variant, p.