1,149,977 results match your criteria: "Italy; Universita Internazionale Telematica Uninettuno[Affiliation]"

Atezolizumab plus bevacizumab as first-line treatment of unresectable hepatocellular carcinoma: interim analysis results from the phase IIIb AMETHISTA trial.

ESMO Open

January 2025

Medical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano (Milan), Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, (Milan), Italy. Electronic address:

Background: The treatment of advanced hepatocellular carcinoma (HCC) with atezolizumab and bevacizumab led to significant improvements in overall survival (OS), progression-free survival (PFS), and response rate compared with sorafenib in the phase III IMbrave150 trial. The etiology of background liver disease can differ between Eastern and Western populations, leading to a potentially different impact of systemic therapies; therefore the unequal representation must be considered in the IMbrave150 trial. To provide further data on the safety and effectiveness of atezolizumab and bevacizumab, the phase IIIb AMETHISTA (Atezolizumab plus bevacizumab in METastatic HCC Italian Safety TriAl) ran in a Western (Italian) population of patients with advanced HCC.

View Article and Find Full Text PDF

Health networking on cancer in the European Union: a 'green paper' by the EU Joint Action on Networks of Expertise (JANE).

ESMO Open

January 2025

Evaluative Epidemiology Unit, Department of Epidemiology and Data Science, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Health networking is in principle a formidable instrument to address many challenges posed by cancer, one of the two most common and most lethal non-communicable chronic diseases. The European Union (EU)'s Beating Cancer Plan foresaw the addition of new health networks to the four already existing European Reference Networks on rare cancers: the Network of Comprehensive Cancer Centres and several networks of expertise (NoEs), which will be shortly deployed on items as complex and poor-prognosis cancers, palliative care, survivorship, personalised primary and secondary prevention, omic technologies, hi-tech medical resources, and cancers in adolescents and young adults. The community of experts of the EU Joint Action, due to build such NoEs, has drafted this 'green paper', incorporating 13 open questions, in an effort to foster discussion on some open questions about health networking on cancer in the EU.

View Article and Find Full Text PDF

Quercetin derivatives in roasted Coffea arabica and its popular beverages.

Food Chem

January 2025

School of Pharmacy, Chemistry Interdisciplinary Project (ChIP), University of Camerino, Via Madonna delle Carceri s.n.c. 62032, Camerino, Italy.

This study is focused on quantification of six quercetin derivatives in roasted Coffea arabica L. from different geographical origins and post-harvest processing methods for the first time. Popular beverages (espresso and moka) were also studied.

View Article and Find Full Text PDF

Post-COVID-19 sequelae are associated with sustained SARS-CoV-2-specific CD4 immune responses.

Int Immunopharmacol

January 2025

Department of Health Sciences, Interdisciplinary Research Center of Autoimmune Diseases-IRCAD, University of Eastern Piedmont 28100 Novara, Italy; Center for Translational Research on Autoimmune and Allergic Diseases, University of Eastern Piedmont 28100 Novara, Italy. Electronic address:

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to widespread post-acute sequelae of COVID-19 (PASC), affecting multiple body systems. Despite its prevalence, PASC's pathogenesis remains unclear, with hypotheses suggesting viral persistence, immune activation, and autoimmune responses among the pathogenetic mechanism. This study aimed to evaluate T cell memory response in PASC patients, one year post-hospital discharge and correlate it with clinical parameters to identify a potential PASC-associated fingerprint.

View Article and Find Full Text PDF

On latent dynamics learning in nonlinear reduced order modeling.

Neural Netw

January 2025

MOX, Department of Mathematics, Politecnico di Milano, Piazza Leonardo da Vinci 32, Milan, 20133, Italy. Electronic address:

In this work, we present the novel mathematical framework of latent dynamics models (LDMs) for reduced order modeling of parameterized nonlinear time-dependent PDEs. Our framework casts this latter task as a nonlinear dimensionality reduction problem, while constraining the latent state to evolve accordingly to an unknown dynamical system. A time-continuous setting is employed to derive error and stability estimates for the LDM approximation of the full order model (FOM) solution.

View Article and Find Full Text PDF

Microplastic and microfiber contamination in the Tiber River, Italy: Insights into their presence and chemical differentiation.

Mar Pollut Bull

January 2025

Institute of Aquatic Ecology, HUN-REN Centre for Ecological Research, Karolina út 29-31, H-1113 Budapest, Hungary; National Laboratory for Water Sciences and Water Security, Institute of Aquatic Ecology, HUN-REN Centre for Ecological Research, Karolina út 29-31, H-1113 Budapest, Hungary; Institute of Chemistry, Eötvös Loránd University, Pázmány Péter sétány 1/A, H1113 Budapest, Hungary. Electronic address:

Microplastics (MPs) are an emerging environmental concern, but studies on these contaminants, particularly in river ecosystems, remain scarce. Research has indicated that MPs in the environment are predominantly microfibers (MFs); however, a few studies suggest that the MFs encountered are chiefly of natural origin. In this study, we aimed to improve the understanding of MP/MFs (both plastic and natural), among microparticle (solid particles >10 μm to <5000 μm; mainly of plastic as well as natural origin) loads in the Tiber River, Italy, by analyzing the physicochemical properties of surface water and assessing the abundance and characteristics of MPs-MFs at three sites: Ponte Grillo, Aniene, and Magliana, along a 60 km stretch.

View Article and Find Full Text PDF

Introduction And Importance: Debulking surgery is the main approach for recurrent adult granulosa cell tumors (AGCTs), but the effectiveness of laparoscopic extensive cytoreduction in advanced cases and its impact on quality of life (QoL) remains unclear.

Case Presentation: A 34-year-old woman, who had a right adnexectomy for AGCT in 2020, was referred with an 8-month history of a large left ovarian cyst and amenorrhea. Preoperative evaluations indicated a recurrence 18 months post-diagnosis.

View Article and Find Full Text PDF

Functional nanocrystal as effective contrast agents for dual-mode imaging: Live-cell sonoluminescence and contrast-enhanced echography.

Ultrason Sonochem

January 2025

Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy; Polito(BIO)Med Lab, Politecnico di Torino, 10129 Turin, Italy. Electronic address:

In the context of molecular imaging, the present work explores an innovative platform made of lipid-coated nanocrystals as contrast-enhanced agent for both ultrasound imaging and sonoluminescence. At first, the dynamics of gas bubbles generation and cavitation under insonation with either pristine or lipid-coated nanocrystals (ZnO-Lip) are described, and the differences between the two colloidal systems are highlighted. These ZnO-Lip show an unprecedented ability to assist cavitation, which is reflected in enhanced sonoluminescent light emission with respect to the pristine nanocrystals or the pure water.

View Article and Find Full Text PDF

Rational choices elicit stronger sense of agency in brain and behavior.

Cognition

January 2025

Chair of Philosophy of Mind, Faculty of Philosophy, Philosophy of Science and Religious Studies Ludwig-Maximilians-Universität München, Munich, Germany; Munich Center for Neuroscience, Ludwig-Maximilians-Universität München, Munich, Germany; Institute of Philosophy, School of Advanced Study, University of London, London, UK; Cognition, Values, Behaviour Lab, Ludwig-Maximilians-Universität München, Munich, Germany. Electronic address:

The sense of agency is the subjective feeling of control over one's own actions and the associated outcomes. Here, we asked whether and to what extent the reasons behind our choices (operationalized by value differences, expected utility, and counterfactual option sets) drive our sense of agency. We simultaneously tested these three dimensions during a novel value-based decision-making task while recording explicit (self-reported) and implicit (brain signals) measures of agency.

View Article and Find Full Text PDF

In sheep, gastrointestinal nematodes (GINs) can cause disease, reduced feed intake, and nutritional deficiencies. To counteract GINs, anthelmintics are widely used although it is well known they may enter the environment impacting ecosystems. In addition, anthelmintics resistance has rapidly developed and consequently, alternative approaches are crucial for profitable and sustainable sheep production.

View Article and Find Full Text PDF

New insights into persistent corneal subepithelial infiltrates following epidemic keratoconjunctivitis: The first case report with ultrastructural and immunohistochemical investigations.

Acta Histochem

January 2025

Section of Anatomy and Histology, Imaging Platform, Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, Florence 50134, Italy. Electronic address:

Epidemic keratoconjunctivitis (EKC) is one of the most severe clinical manifestations of human adenovirus ocular surface infection, which may lead to the formation of subepithelial infiltrates (SEIs) in the anterior corneal stroma in 20-50 % of cases. SEIs may be asymptomatic or give rise to corneal aberrations and visual impairment for months or years after acute infection, despite treatments. Here, we describe the ultrastructural and immunophenotypic features of the anterior corneal stroma of a patient who underwent superficial anterior lamellar keratoplasty (SALK) surgery to remove corneal opacities related to clinically significant and steroid-unresponsive, long-lasting SEIs after adenoviral EKC.

View Article and Find Full Text PDF

PhysioEx, a new Python library for explainable sleep staging through deep learning.

Physiol Meas

January 2025

Department of Electrical Engineering, KU Leuven, Kasteelpark Arenberg 10 postbus 2440 3001 LEUVEN Belgium, Leuven, Flanders, 3000, BELGIUM.

Sleep staging is a crucial task in clinical and research contexts for diagnosing and understanding sleep disorders. This work introduces PhysioEx, a Python library designed to support the analysis of sleep stages using deep learning and Explainable AI (XAI). Approach: PhysioEx provides an extensible and modular API for standardizing and automating the sleep staging pipeline, covering data preprocessing, model training, testing, fine-tuning, and explainability.

View Article and Find Full Text PDF

Riboli, A, Nardi, F, Osti, M, Cefis, M, Tesoro, G, and Mazzoni, S. Training load, official match locomotor demand, and their association in top-class soccer players during a full competitive season. J Strength Cond Res 39(2): 249-259, 2025-To examine training load and official match locomotor demands of top-class soccer players during a full competitive season and to evaluate their association.

View Article and Find Full Text PDF

Objectives: This fourth report aimed to provide insights into patient characteristics, outcomes, and standardized outcome ratios of patients implanted with durable Mechanical Circulatory Support across participating centers in the European Registry for Patients with Mechanical Circulatory Support (EUROMACS) registry.

Methods: All registered patients receiving durable mechanical circulatory support up to August 2024 were included. Expected number of events were predicted using penalized logistic regression.

View Article and Find Full Text PDF

Conservative Reconstruction of the Lower Limb with a Bilayer Porous Collagen Matrix after a Spider Bite.

Adv Skin Wound Care

January 2025

Marco Palmesano, MD, is Plastic Reconstructive and Aesthetic Surgeon, PhD Program in Applied Medical Surgical Sciences, University of Rome Tor Vergata, Rome, Italy. Davide Johan Bottini, MD, PhD, is Consultant in Maxillofacial Surgery, Policlinico Casilino Hospital, Rome. Also at University of Rome Tor Vergata, Gabriele Storti, MD, is Researcher and Consultant in Plastic Surgery; Lorenzo Secondi, MD, is Plastic Reconstructive and Aesthetic Surgeon, PhD Program in Applied Medical Surgical Sciences; and Carlo Cossi, MD; Alessio Calicchia, MD; Martina Giacalone, MD; and Irene Nunziata, MD, are Plastic Surgery Residents. Emanuela Basile, MD, is Consultant in Maxillofacial Surgery, Policlinico Casilino Hospital. Valerio Cervelli, MD, is Full Professor and Chief, Department of Plastic Surgery, University of Rome Tor Vergata.

Brown recluse spider bites may cause symptoms ranging from local cutaneous reactions to systemic visceral loxoscelism. Most bites are self-limiting, but some can lead to necrotic ulcerations with severe complications and soft tissue defects. Necrotizing ulcers are uncommon and have various clinical presentations, so no standard treatment exists.

View Article and Find Full Text PDF

Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain.

Proc Natl Acad Sci U S A

February 2025

Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.

Mutations in Leucine-rich repeat kinase 2 (LRRK2) and PTEN-induced kinase 1 (PINK1) are associated with familial Parkinson's disease (PD). LRRK2 phosphorylates Rab guanosine triphosphatase (GTPases) within the Switch II domain while PINK1 directly phosphorylates Parkin and ubiquitin (Ub) and indirectly induces phosphorylation of a subset of Rab GTPases. Herein we have crossed LRRK2 [R1441C] mutant knock-in mice with PINK1 knock-out (KO) mice and report that loss of PINK1 does not impact endogenous LRRK2-mediated Rab phosphorylation nor do we see significant effect of mutant LRRK2 on PINK1-mediated Rab and Ub phosphorylation.

View Article and Find Full Text PDF

Aims: How the underlying etiology and pathophysiology of left ventricular (LV) hypertrophy affects LA remodeling and function remains unexplored. The present study aims to investigate the influence of various hypertrophic phenotypes on LA remodeling and function.

Methods And Results: Patients with LV hypertrophy who underwent cardiac magnetic resonance (CMR) were compared to a control group.

View Article and Find Full Text PDF

A Novel Staging System of Cardiac Damage in Aortic Stenosis based on Multi-Chamber Myocardial Deformation.

Eur Heart J Cardiovasc Imaging

January 2025

Department of Cardiology, Istituto Auxologico Italiano, IRCCS, Milan, Italy.

Aims: This study evaluates whether multi-chamber myocardial deformation analysis using speckle tracking echocardiography (STE) can enhance validated current staging systems and improve risk stratification for patients with moderate-to-severe aortic stenosis (AS).

Methods And Results: We reanalyzed 2D, Doppler, and STE data obtained from two cohorts: derivation (654 patients, median age: 82 years; 51% men) and validation (237 patients, median age: 77 years; 55% men) with at least moderate AS (aortic valve area<1.5 cm2).

View Article and Find Full Text PDF

Results from the international collaborative systematic literature review informing the 2023 EULAR recommendations for the treatment of systemic sclerosis.

Ann Rheum Dis

January 2025

School of Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK; LTHT, NIHR Leeds Biomedical Research Centre, Leeds, UK. Electronic address:

Background: The EULAR recommendations for the treatment of systemic sclerosis (SSc) were updated in 2017, informed by a systematic literature review (SLR) completed in 2014.

Objectives: The aim of this new SLR was to provide the most up-to-date literature to underpin contemporary EULAR recommendations for the management of SSc.

Methods: 30 searches for 30 interventions (including several outcomes/clinical questions), and 1 dedicated search (with several interventions) for calcinosis were prioritised by the task force.

View Article and Find Full Text PDF

Objectives: To update the 2017 European Alliance of Associations for Rheumatology (EULAR) recommendations for treatment of systemic sclerosis (SSc), incorporating new evidence and therapies.

Methods: An international task force was convened in line with EULAR standard operating procedures. A nominal group technique exercise was performed in two rounds to define questions underpinning a subsequent systematic literature review.

View Article and Find Full Text PDF

CD19-CAR T-cell therapy induces deep tissue depletion of B cells.

Ann Rheum Dis

January 2025

Department of Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany; Deutsches Zentrum Immuntherapie (DZI), Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany, Erlangen, Germany. Electronic address:

Objectives: CD19-targeting chimeric antigen receptor (CAR) T-cell therapy can induce long-term drug-free remission in patients with autoimmune diseases (AIDs). The efficacy of CD19-CAR T-cell therapy is presumably based on deep tissue depletion of B cells; however, such effect has not been proven in humans in vivo.

Methods: Sequential ultrasound-guided inguinal lymph node biopsies were performed at baseline and after CD19-CAR T-cell therapy in patients with AIDs.

View Article and Find Full Text PDF

Shaping Future Medicinal Chemists: Perspectives from European Schools of Pharmacy within the GPA Network.

J Med Chem

January 2025

Centro Singular de Investigación en Química Biolóxica y Materiais Moleculares (CiQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.

View Article and Find Full Text PDF

First report of privet leaf blotch-associated virus (PLBaV) infecting lilac ( L.) in France.

Plant Dis

January 2025

INRA Bordeaux, UMR 1332 Biologie du Fruit et Pathologie, INRA - Université de Bordeaux, CS20032, Villenave d'Ornon , France, 33882 cedex;

Privet leaf blotch-associated virus (PLBaV) is an Idaeovirus discovered by high-throughput sequencing (HTS) in privet (Ligustrum japonicum L) in southern Italy in 2017 (Navarro et al., 2017). In privet, it causes a leaf blotch disease with yellowish or whitish chlorotic blotches or ringspots.

View Article and Find Full Text PDF