Melanoma extracellular vesicles membrane coated nanoparticles as targeted delivery carriers for tumor and lungs.

Targeting is the most challenging problem to solve for drug delivery systems. Despite the use of targeting units such as antibodies, peptides and proteins to increase their penetration in tumors the amount of therapeutics that reach the target is very small, even with the use of nanoparticles (NPs). Nature has solved the selectivity problem using a combination of proteins and lipids that are exposed on the cell membranes and are able to recognize specific tissues as demonstrated by cancer metastasis.

Integrative analysis of miRNA expression data reveals a minimal signature for tumour cells classification.

MicroRNAs (miRNAs) are pivotal biomarkers for cancer screening. Identifying distinctive expression patterns of miRNAs in specific cancer types can serve as an effective strategy for classification and characterization. However, the development of a minimal signature of miRNAs for accurate cancer classification remains challenging, hindered by the lack of integrated approaches that systematically analyse miRNA expression levels of miRNAs alongside their associated biological pathways.

Morphometric analysis revealed two different Mediterranean horse mackerel () stocks in the Adriatic Sea.

Phenotypical differentiation among individuals of Mediterranean horse mackerel in the Adriatic Sea was investigated through the analysis of several morphometric characters. Overall, 426 individuals of Mediterranean horse mackerels were sampled from the northern, central and southern Adriatic Sea during the summers of 2012 and 2013. Forty-six morphometric characters were measured for each individual and then compared using multivariate techniques (linear discriminant analysis).

A luminous and young galaxy at = 12.33 revealed by a JWST/MIRI detection of Hα and [O iii].

The James Webb Space Telescope has discovered a surprising population of bright galaxies in the very early Universe (≲500 Myr after the Big Bang) that is hard to explain with conventional galaxy-formation models and whose physical properties are not fully understood. Insight into their internal physics is best captured through nebular lines, but at these early epochs, the brightest of these spectral features are redshifted into the mid-infrared and remain elusive. Using the mid-infrared instrument onboard the James Webb Space Telescope, here we present a detection of Hα and doubly ionized oxygen ([O iii] 4959,5007 Å) from the bright, ultra-high-redshift galaxy candidate GHZ2/GLASS-z12.

Prediction of induction motor faults using machine learning.

Unplanned downtime in industrial sectors presents significant challenges, impacting both production efficiency and profitability. To tackle this issue, companies are actively working towards optimizing their operations and reducing disruptions that hinder their ability to meet customer demands and financial goals. Predictive maintenance, utilizing advanced technologies like data analytics, machine learning, and IoT devices, offers real-time equipment data monitoring and analysis.

Evaluation of longan () peel powder as fruit by-product additive in Nile tilapia () feed: Effects on growth, immunity, and immune-antioxidant gene expressions.

The study, herein, investigated the effects of the inclusion of longan peel (LP) powder in the diet of Nile Tilapia (), focusing on comparative evaluations of growth performance, immunity, and immune-antioxidant related gene expressions. For this purpose, a total of 300 healthy fish (average initial weight: 13.70 ± 0.

Recycled glass powder and calcium carbide residue geopolymer to stabilise silty sand soil: Mechanical performances and statistical analysis.

Geopolymerization is a soil improvement technique widely used for waste management in recent years. This study explores the potential of geopolymerization for roadbed improvement using waste materials. Recycled glass powder (RGP) and calcium carbide residue (CCR) were investigated as precursors and alkaline activators, respectively, to enhance the properties of silty sand soil.

The landscape of rare mitochondrial DNA variants in sudden cardiac death: A potential role for ATP synthase.

Sudden cardiac death (SCD) is a major health concern, which can be the sign of a latent mitochondrial disease. However, mitochondrial DNA (mtDNA) contribution is largely unexplored in SCD at population level. Recently, mtDNA variants have been associated with congenital cardiopathy and higher risk of ischemic heart disease, suggesting them as potential risk factors also in SCD.

Human head and neck cancer cell lines response to cold atmospheric plasma activated media is affected by the chemistry of culture media.

Survival rate of head and neck squamous cell carcinomas (HNSCC) patients are still to date very poor, and the application of innovative clinical approaches are urgently needed. Cold atmospheric plasmas (CAPs) are partially ionized gases that have shown anti-tumor effectiveness over a wide range of cancer types with potential application into clinics. However, the comprehension of the mechanisms underlying indirect CAP effects plays a key role for the prediction of treatment outcomes.

Independent aggregation in the nordic day-ahead market: What is the welfare impact of socializing supplier compensation payments?

This paper addresses the participation of independent aggregators (IAs) for demand response (DR) in European electricity markets. An IA is an aggregator trading the flexibility of consumers of which it is not the electricity supplier. Particularly, we focus on the controversial issue of a compensation payment from the IA to the supplier for energy sourcing.

TAS2R38 genotype and CRS severity in children with cystic fibrosis.

Background: Cystic fibrosis is a heterogeneous disease whose severity and symptoms largely depend on the functional impact of mutations in the cystic fibrosis transmembrane conductance regulator gene. Other genes may also modulate the clinical manifestations and complications associated with cystic fibrosis. Genetic variants of the bitter taste receptor TAS2R38 have been shown to contribute to the susceptibility and severity of chronic rhinosinusitis.

Top 75 most-cited articles in hand microsurgery: A bibliometric and visualised analysis.

Introduction: Hand microsurgery is an important advancement of the speciality that has improved outcomes in hand trauma and hand surgical conditions. This bibliometric analysis aims to identify the 75 most cited hand microsurgery articles and explore their relevance to contemporary practice.

Methods: The Web of Science core collection database was used to screen and identify the top 75 most-cited articles relevant to hand microsurgery.

SARS-COV-2 re-infection and incidence of post-acute sequelae of COVID-19 (PASC) among essential workers in New York: a retrospective cohort study.

Background: After surviving Coronavirus Disease 2019 (COVID-19), some people develop symptoms known as post-acute sequelae of COVID-19 (PASC). PASC is an emerging phenomenon yet to be fully understood, and identifying risk factors has been challenging. This study investigated the association between the number of COVID-19 episodes and the incidence of PASC among essential workers.

Diagnosis and management of de novo non-specific spinal infections: European Association of Neurosurgical Societies (EANS) Spine Section Delphi consensus recommendations.

Introduction: The management of de novo non-specific spinal infections (spondylodiscitis - SD) remains inconsistent due to varying clinical practices and a lack of high-level evidence, particularly regarding the indications for surgery.

Research Question: This study aims to develop consensus recommendations for the diagnosis and management of SD, addressing diagnostic modalities, surgical indications, and treatment strategies.

Material And Methods: A Delphi process was conducted with 26 experts from the European Association of Neurosurgical Societies (EANS).

Multi-decadal tree-ring stable isotope records of apple and pear trees indicate coherent ecophysiological responses to environmental changes in alpine valleys.

The ecophysiological and ecohydrological impacts of climate change and progressively increasing atmospheric carbon dioxide (CO) concentration on agroecosystems are not well understood compared to the forest ecosystems. In this study, we utilized the presence of old apple and pear trees in the alpine valleys of Northern Italy (maintained for cultural heritage purposes) to investigate climate-scale physiological responses. We developed long-term tree-ring stable isotopic records (δC and δO) from apple (1976-2021) and pear trees (1943-2021).

Health outcomes in chronic kidney disease patients with cognitive impairment or dementia: a global collaborative analysis.

Background And Hypothesis: Mild cognitive impairment and dementia (CI) are common in patients with CKD. We aim to clarify whether and how CKD and CI coexistence increases adverse health outcomes.

Methods: This retrospective observational cohort study was conducted on CKD patients (stages 3-5) from the TriNetX platform.

Economic Evaluations of Health Service Interventions Targeting Patients with Multimorbidities: A Scoping Literature Review.

Introduction: Multimorbid patients have been growing, leading to an exponential increase in healthcare costs and patterns of resource utilization. Despite the heightened interest toward integrated care programs as a response to the complex need of multimorbid patients, economic evaluations of these programs remain scarce. This work investigated the economic evaluations of service interventions targeting multimorbid patients, to identify the characteristics of these programs and the methods applied to their evaluation.

Importance of the multidisciplinary approach in the surgical treatment of giant mediastinal neoplasms: a case series.

Background: Many reports described the importance of multidisciplinary meetings in providing oncologic patients with the best treatment strategies. This item improved overall survival, accuracy of staging and adherence to guidelines. For mediastinal neoplasms, collaboration between different surgical skills allows to deal with challenging/impossible surgical procedures.

AQP4 antibody-seropositive neuromyelitis optica spectrum disorder in a patient with mixed connective tissue disease: a case report.

Background: Neuromyelitis optica spectrum disorders (NMOSDs) are degenerative diseases frequently associated with severe recurrences and high risk of progressive disability. In this report, we describe an unusual case of a patient with the coexistence between NMOSD and mixed connective tissue disease (MCTD).

Case Description: A 58-year-old Caucasian man was admitted to the Emergency Department (ED) with low back pain and walking inability.

The role of energy deposition on the luminescence sensitization in porphyrin-functionalized SiO/ZnO nanoparticles under X-ray excitation.

Hybrid nanoscintillators, which feature a heavy inorganic nanoparticle conjugated with an organic emitter, represent a promising avenue for advancements in diverse fields, including high-energy physics, homeland security, and biomedicine. Many research studies have shown the suitability of hybrid nanoscintillators for radiation oncology, showing potential to improve therapeutic results compared to traditional protocols. In this work, we studied SiO/ZnO nanoparticles functionalized with porphyrin as a photosensitizer, capable of producing cancer cytotoxic reactive oxygen species for possible use in radio-oncological therapeutics.

Can Family Policies Enhance Fertility? An Ex Ante Evaluation Through Factorial Survey Experiments.

This article explores the family policies-fertility nexus by assessing the potential impact of parental leaves, childcare services, and child benefits on fertility through a factorial survey experiment (FSE). We focus on Italy, where persistently low fertility rates are often linked to limited welfare support for families. We surveyed 4,022 respondents aged 20-44 and exposed them to various scenarios characterized by different family policy packages.

Office-Based Endoscopic Urological Procedures Under Local Anesthesia: Prospective Evaluation of Feasibility, Pain, and Patient Preference.

Several diagnostic and therapeutic endoscopic urological procedures, such as stent placement, ureteroscopy, and bladder stone lithotripsy, can be performed in a hospital, an ambulatory surgery center, in the office with IV sedation, or in the office using only topical anesthesia. The potential benefits of performing procedures in the office setting using topical anesthesia include efficiency and cost reduction. The potential harms are failure to achieve the desired outcome and patient pain.