A case series of patients with β-thalassemia trait and iron overload: from multifactorial hepcidin suppression to treatment with mini-phlebotomies.

Not available.

Exploring the Phenomenon of Victim Blaming Toward Women With an Intimate Partner Violence Experience and the Role of Empathy.

Women who have experienced intimate partner violence (IPV) often encounter victim blaming from the general population, where individuals attribute responsibility to the victim's behavior for the violent episode. This phenomenon is influenced by levels of empathy, with lower empathy correlating with a higher likelihood of blaming women exposed to partner violence. Two studies were conducted.

Total hip arthroplasty preoperative planning for childhood hip disorders' sequelae: Focus on developmental dysplasia of the hip.

Developmental dysplasia of the hip (DDH) poses significant challenges in both childhood and adulthood, affecting up to 10 per 1000 live births in the United Kingdom and United States. While newborn screening aims to detect DDH early, missed diagnoses can lead to severe complications such as hip dysplasia and early onset osteoarthritis in adults. Treatment options range from less invasive procedures like hip-preserving surgery to more extensive interventions such as total hip arthroplasty (THA), depending on the severity of the condition.

From Dielectric to Electro-Responsive Thermoplastics: An Approach Based on Electro-Thermal Reorientation and Charged Gas Activation.

The transition from insulator to electro-responsive has been successfully achieved by earlier studies for some inorganic materials by applying external stimuli that modify their 3D and/or electronic structures. In the case of insulating polymers, this transition is frequently accomplished by mixing them with other electroactive materials, even though a few physical treatments that induce suitable chemical modifications have also been reported. In this work, a smart approach based on the application of an electro-thermal reorientation process followed by a charged gas activation treatment has been developed for transforming insulating 3D printed polymers into electro-responsive materials.

Anti-PD1 therapies induce an early expansion of Ki67CD8 T cells in metastatic non-oncogene addicted NSCLC patients.

Pembrolizumab (an anti-PD1 antibody) alone or combined with chemotherapy represented the standard of care for advanced non-oncogene addicted non-small cell lung cancer (NSCLC) patients. These therapies induced early modifications of the immune response impacting the clinical outcome. Identifying early changes in the immune system was critical to directing the therapeutic choice and improving the clinical outcome.

Advancements and future perspectives in nutrient film technique hydroponic system: a comprehensive review and bibliometric analysis.

In the context of climate change, reducing the environmental impact of agriculture has become increasingly critical. To ensure sustainable food production, it is essential to adopt cultivation techniques that maximize resource efficiency, particularly in water and nutrient usage. The Nutrient Film Technique (NFT) is one such hydroponic system, designed to optimize water and nutrient use, making it a valuable tool for sustainable agriculture.

Effect of a metal artifact reduction algorithm on cone-beam computed tomography scans of titanium and zirconia implants within and outside the field of view.

Purpose: This study aimed to evaluate the impact of a metal artifact reduction (MAR) algorithm on cone-beam computed tomography (CBCT) scans of titanium and zirconia implants, both within and outside the field of view (FOV).

Materials And Methods: In this study, a dry human mandible was positioned in a CBCT scanner with only its left quadrant included in the FOV. Each type of implant (titanium and zirconia) was placed once in the right second premolar extraction socket and once in the left second premolar extraction socket of the mandible.

Semiquantitative 2-[F]FDG PET/CT-based parameters role in lymphoma.

2-deoxy-2-[F]-fluoro-D-glucose (2-[F]FDG) positron emission tomography/computed tomography (PET/CT) plays a crucial role in the management of lymphoma in different settings, such as staging disease, assessing response to therapy, predicting prognosis, and planning RT. Beside visual analysis, several semiquantitative parameters were introduced to study lymphoma with promising results. These parameters can represent different disease characteristics, like body composition (such as sarcopenic index), dissemination of disease (Dmax), tumor burden (including metabolic tumor volume) and texture features.

Probing Temperature Changes Using Nonradiative Processes in Hyperbolic Meta-Antennas.

Multilayered metal-dielectric nanostructures display both a strong plasmonic behavior and hyperbolic optical dispersion. The latter is responsible for the appearance of two separated radiative and nonradiative channels in the extinction spectrum of these structures. This unique property can open plenty of opportunities toward the development of multifunctional systems that simultaneously can behave as optimal scatterers and absorbers at different wavelengths, an important feature to achieve multiscale control of light-matter interactions in different spectral regions for different types of applications, such as optical computing or detection of thermal radiation.

Cognitive appraisals linking dispositional mindfulness to athletes' emotions: a multi-states theory approach.

Purpose: The aim of the study was to examine the relationship between dispositional mindfulness, cognitive appraisals, emotions, and psychobiosocial experiences in athletes within the framework of multi-states (MuSt) theory.

Method: A convenience sample of 334 Italian athletes (188 men and 146 women), aged 18-48 years ( = 24.77,  = 7.

Tail Fin Regeneration in Zebrafish: The Role of Non-canonical Crosstalk Between STAT3 and Vitamin D Pathway.

Stat3 is a transcription factor with a key role in cell proliferation and migration. Using the zebrafish line we showed that the genetic ablation results in a marked decrease of tail fin regrowth, demonstrating that this transcription factor is fundamental in the regeneration process. Stat3 activity is finely modulated by post-translational modifications that occur in several residues of the protein (i.

Distinct chromosomal mutation associated with cefiderocol resistance in : a combined bioinformatics and mass spectrometry approach to unveil and validate the -acquired chemoresistance.

is a significant public health concern due to the emergence of antibiotic-resistant strains. Cefiderocol (FDC), a novel siderophore cephalosporin, has shown promise as a last-line treatment for multidrug-resistant Gram-negative bacteria. However, the emergence of -acquired FDC-resistant strains highlights the need for advanced tools to identify resistance-associated genomic mutations and address the challenges of FDC susceptibility testing.

Hand hygiene, knowledge and training motivational drives: findings from a survey in a university hospital.

This study assessed healthcare workers' (HCWs) knowledge and adherence to hand hygiene principles in a large Italian university hospital, focusing on identifying knowledge gaps and evaluating training effectiveness. A specifically designed 17-item questionnaire, based on the World Health Organization (WHO) Hand Hygiene Knowledge Questionnaire, was used to measure theoretical knowledge, the role of training, and the impact of experience. The survey had an 8% participation rate (542 responses from a total of 6,749 HCWs), with higher responses among nurses and doctors.

Long-term trends in educational inequalities in alcohol-attributable mortality, and their impact on trends in educational inequalities in life expectancy.

Background: Previous studies on socio-economic inequalities in mortality have documented a substantial contribution of alcohol-attributable mortality (AAM) to these inequalities. However, little is known about the extent to which AAM has contributed to time trends in socio-economic inequalities in mortality.

Objective: To study long-term trends in educational inequalities in AAM and assessed their impact on trends in educational inequalities in life expectancy in three European countries.

Cardiovascular risk profile with SCORE2 and SCORE2-OP: comparing Portugal, Spain, Italy, and France using the new European predictive models.

Introduction: This study aims to characterize the cardiovascular risk profile in countries with low-to-moderate cardiovascular mortality risk (Italy, Portugal, France, and Spain) using the SCORE2 and SCORE2-OP models. It also examines regional variations and the involvement of healthcare professionals in performing risk assessments.

Methods: A retrospective observational study was conducted using data from 24,434 cardiovascular risk assessments performed between December 2022 and July 2023 through a digital application used by physicians.

The expanding role of 16s ribosomal RNA PCR in the management of patients with infective endocarditis undergoing cardiac surgery.

Background: Aetiological diagnosis and targeted antibiotic therapy are essential to improve the prognosis of patients with infective endocarditis. Molecular tests on blood have been reported to be effective in identifying the causative organism and are recommended when blood cultures are negative. The role of molecular tests on the surgically excised valve is still unclear and needs further investigation.

Therapeutic Potential of Feline Adipose-Derived Stem Cell Exosomes in the Treatment of Feline Idiopathic Cystitis: A Characterization and Functional Analysis of miRNA Content.

Feline Idiopathic Cystitis (FIC), is a chronic lower urinary tract condition in cats analogous to PBS/IC in women, which presents significant treatment challenges due to its idiopathic nature. Recent advancements in regenerative medicine highlight the potential of Adipose Tissue-Derived Stem Cells (ADSCs), particularly through their secretome, which includes mediators, bioactive molecules, and extracellular vesicles (EVs). Notably, exosomes, a subset of EVs, facilitate cell-to-cell communication and, when derived from ADSCs, exhibit anti-inflammatory properties and contribute to tissue regeneration.

Prospective per-target analysis of the added value of the PrecisionPoint Transperineal Access System in cognitive prostate biopsy of MRI targets.

Objectives: The objective of this study is to evaluate the diagnostic performance of perineal access cannulas tethered to a biplanar ultrasound probe in cognitive transperineal prostate biopsies of targets identified by multiparametric magnetic resonance imaging (mpMRI) by comparing the results of the PrecisionPoint (PP) Transperineal Access System with the double-freehand (DFH) technique.

Patients And Methods: All patients who underwent cognitive transperineal prostate biopsy of mpMRI targets using the PP or DFH technique between November 2020 and September 2023 were enrolled. All data related to mpMRI target biopsies were stratified by technique, visibility in transrectal ultrasound and analysed by comparing PP versus DFH.

Transformers deep learning models for missing data imputation: an application of the ReMasker model on a psychometric scale.

Introduction: Missing data in psychometric research presents a substantial challenge, impacting the reliability and validity of study outcomes. Various factors contribute to this issue, including participant non-response, dropout, or technical errors during data collection. Traditional methods like mean imputation or regression, commonly used to handle missing data, rely upon assumptions that may not hold on psychological data and can lead to distorted results.

Words before pictures: the role of language in biasing visual attention.

Background: The present study investigated whether semantic processing of word and object primes can bias visual attention using top-down influences, even within an exogenous cueing framework. We hypothesized that real words and familiar objects would more effectively bias attentional engagement and target detection than pseudowords or pseudo-objects, as they can trigger prior knowledge to influence attention orienting and target detection.

Methods: To examine this, we conducted two web-based eye-tracking experiments that ensured participants maintained central fixation on the screen during remote data collection.

The effect of transcranial Direct Current Stimulation on the Iowa Gambling Task: a scoping review.

Introduction: Among the tasks employed to investigate decisional processes, the Iowa Gambling Task (IGT) appears to be the most effective since it allows for deepening the progressive learning process based on feedback on previous choices. Recently, the study of decision making through the IGT has been combined with the application of transcranial direct current stimulation (tDCS) to understand the cognitive mechanisms and the neural structures involved. However, to date no review regarding the effects of tDCS on decisional processes assessed through the IGT is available.