Long-term outcome and risk stratification in compensated advanced chronic liver disease after HCV-cure.

Background And Aims: Around 750,000 patients per year will be cured of HCV infection until 2030. Those with compensated advanced chronic liver disease remain at risk for hepatic decompensation and de novo HCC. Algorithms have been developed to stratify risk early after cure; however, data on long-term outcomes and the prognostic utility of these risk stratification algorithms at later time points are lacking.

Adjusting the Yo-Yo IRT-1 equation to estimate VO2max of sub-elite football referees: a gender-comparative study.

Background: To gain optimal positioning to make sure the game laws are applied in uniform way, the performance of field referee must be periodically evaluated to have constantly adequate training during a match and during the competitive season. Considering that field Yo-Yo Intermittent Recovery Test-Level 1 is frequently employed in elite team sport players to estimate maximal oxygen uptake (VO2max) in field settings, the aim of this cross-sectional, gender-comparative study was to develop a new adjusted Yo-Yo-1 equation for estimating VO2max in football referees.

Methods: During off-season, 20 male (21.

Effectiveness of the handgrip test for assessing readiness in national level basketball players: a cohort study.

Background: Assessing player readiness is crucial in elite basketball. This study aims to provide a practical method for monitoring player readiness through the handgrip test and identify associations with wellness scales.

Methods: Fifteen players (age: 25.

Moderate anxiety may improve functional balance in older women with low muscle strength: a preliminary observation.

Background: Anxiety commonly affects older individuals with negative consequences on various physical and motor performances such as balance. When coupled with age-related muscular strength loss, the effects on the ability to perform daily tasks could be particularly detrimental, particularly in older women who are more susceptible to anxiety, muscular strength losses and falls. The study aimed to verify the effects of anxiety on balance performance in relation to muscular strength level in healthy older women.

Transition of Perovskite Solar Technologies to Being Flexible.

Perovskite technologies has taken giant steps on its advances in only a decade time, from fundamental science to device engineering. The possibility to exploit this technology on a thin flexible substrate gives an unbeatable power to weight ratio compares to similar photovoltaic systems, opening new possibilities and new integration concepts, going from building integrated and applied photovoltaics (BIPV, BAPV) to internet of things (IoT). In this perspective, the recent progress of perovskite solar technologies on flexible substrates are summarized, focusing on the challenges that researchers face upon using flexible substrates.

Self-inflicted oral-dental mutilations (SIODMs) in paediatric patients: a systematic review of case reports and case series.

Aim: Self-inflicted oral-dental mutilations (SIODMs) are the result of an intentional or unintentional action that leads to anatomical and functional damage to the soft and hard tissues of the oral cavity. In paediatric patients they can be associated with both organic and functional diseases. A systematic review was conducted aiming to consolidate and integrate the existing knowledge on SIODM in paediatric patients.

Vaginal delivery of the second twin: simulation to improve trainee knowledge and comfort.

Background: Vaginal delivery in twins is feasible but challenging. Successful vaginal delivery of a non-vertex second twin depends on knowledge of specific obstetrical maneuvers. Skill acquisition at the patient's bedside is difficult, making simulation training an integral part of obstetrics and gynecology residency programs.

Crystallization in load-controlled shearing flows of monosized spheres.

Identical, inelastic spheres crystallize when sheared between two parallel, bumpy planes under a constant load larger than a minimum value. We investigate the effect of the inter-particle friction coefficient of the sheared particles on the flow dynamics and the crystallization process with discrete element simulations. If the imposed load is about the minimum value to observe crystallization in frictionless spheres, adding small friction to the granular assembly results in a shear band adjacent to one of the planes and one crystallized region, where a plug flow is observed.

Upgrade of Weak σ-hole Bond Donors via Cr(CO)3 Complexation.

Molecular recognition mediated by s-hole interactions is enhanced as the electrostatic potential at the σ-hole becomes increasingly positive. Traditional methods to strengthen σ-hole donor ability of atoms such as halogens often involve covalent modifications, such as, introducing electron-withdrawing substituents (neutral or positively charged) or electrochemical oxidation. Metal coordination, a relatively underexplored approach, offers a promising alternative.

Evidence of dissemination of a -type integrative and conjugative element to , mediating acquisition of and other resistance determinants.

A strain positive for the metallo-beta-lactamase gene and resistant to trimethoprim-sulfamethoxazole was unexpectedly isolated from a surveillance rectal swab. The characterization of the strain revealed carriage of a 91 kb integrative and conjugative element (ICE) harboring several resistance determinants [, , , , ∆, , and ], closely related with a group of -type ICEs widespread among and other pseudomonads. Results highlighted the possible spreading of similar elements to , mediating the acquisition of relevant resistances.

Effect of Intrathecal Baclofen on Bladder Function in Patients With Severe Supraspinal Spasticity.

Introduction: Neurogenic bladder dysfunction is a prevalent condition characterized by impaired bladder control resulting from neurological conditions, for example, spinal cord injury or traumatic brain injury (TBI). Detrusor overactivity is a typical symptom of central nervous system damage. A lesion affecting the pontine neural network typically results in loss of tonic inhibition exerted by the pontine micturition center and causes involuntary detrusor contractions.

Identification and treatment of false methane values produced by the tunable diode laser absorption spectroscopy technology equipped on unmanned aerial vehicles.

Fugitive or diffuse methane emissions constitute an important source of damage to the environment, much greater even than CO2 both over a time span of 20 years and over a longer time span of 100. It is therefore of preeminent importance to undertake all the efforts necessary to implement new tools, protocols, and methods that contribute to the identification and measurement of these emissions to implement site-specific actions of mitigation, repair, and conscious management of the emitting plants. Among the remote sensing and leak detection technologies currently used, the tunable diode laser absorption spectroscopy (TDLAS) method plays a relevant role.

Acts from the cracks: Representations and positions of the decolonial in the geopolitical (de)construction of power-entangled knowledge.

This paper examines the geopolitical implications of knowledge production in psychology through two studies that respond to the growing body of work on the 'Decolonisation of Knowledge' and the 'Decolonisation of Psychology' over the past two decades. By adopting a constructivist approach, particularly through the lens of Social Representation Theory (SRT), these studies explore the ways in which geopolitical contexts shape decolonial activism within psychological and scientific discourse. The first study sheds light on the lexical divergences in the construction of knowledge within the domains of psychology.

Prognostic Value of Signal Abnormalities on Brain MRI in Post-Anoxic Super-Refractory Status Epilepticus: A Single-Center Retrospective Study.

Background: Epileptiform activity, including status epilepticus (SE), occurs in up to one-third of comatose survivors of cardiac arrest and may predict poor outcome. The relationship between SE and hypoxic-ischemic brain injury (HIBI) is not established.

Methods: This is a single-center retrospective study on consecutive patients with post-anoxic super-refractory SE.

Single-Cell RNA Sequencing Analysis Reveals Exercise-Induced Transcriptional Dynamics in Half-Marathon Runners.

Previous studies in sports science suggested that regular exercise has a positive impact on human health. However, the effects of endurance sports and their underlying mechanisms are still not completely understood. One of the main debates regards the modulation of immune dynamics in high-intensity exercise.

Investigating gender dynamics in forensic toxicology: The role of masculinity and femininity in alcohol and drug abuse.

The concept of "gender" refers to the socially constructed characteristics that define feminine or masculine behavior, which are constantly changing and can influence access to healthcare and patterns of help-seeking. These factors significantly impact forensic toxicology, a key area within the medicolegal landscape, forcing the adoption of a gender-sensitive approach to better understand the differing impacts of substances on men and women. Research indicates significant disparities in drug use between genders; men are more likely to abuse alcohol and illicit drugs, while women tend to use prescription medications.

The iMab antibody selectively binds to intramolecular and intermolecular i-motif structures.

i-Motifs (iMs) are quadruplex nucleic acid conformations that form in cytosine-rich regions. Because of their acidic pH dependence, iMs were thought to form only in vitro. The recent development of an iM-selective antibody, iMab, has allowed iM detection in cells, which revealed their presence at gene promoters and their cell cycle dependence.

Number of Previous Strokes and the Association With Clinical Outcomes of Patients With Atrial Fibrillation: Longitudinal Data From the GLORIA-AF Registry.

Background: Patients with atrial fibrillation (AF) who suffered a previous stroke are at increased risk of recurrent thromboembolic events and other major outcomes. The impact of the number of stroke episodes on the natural history of patients with AF is still unclear.

Methods And Results: Using data from the international, multicenter, and prospective GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation) Registry Phase III, we categorized patients with a recent diagnosis of non-valvular AF according to the number of previous strokes (either 0, 1, or ≥2 episodes).

Welfare Status in Dairy Cows during Confined and Grazing Periods in the North American Pacific Northwest using Blood Parameters and Visual Assessments.

Grazing is usually associated with higher well-being in dairy cows. However, current research on the welfare of grazing cows lacks validation via blood profiling. We monitored four dairy farms that seasonally graze in the temperate North American Pacific Northwest, USA, to address this gap.

Predictive Role of Soluble B-Cell Maturation Antigen in Short-Term Monitoring of Differently Treated Multiple Myeloma Patients: A Prospective Study.

Background: The management of multiple myeloma is challenging because the disease is incurable and unexpected relapses can threaten a patient's survival. Several assessment systems are currently available, but they often require invasive or costly procedures (e.g.

Clonal analysis of SepSecS-specific B and T cells in autoimmune hepatitis.

Autoimmune hepatitis (AIH) is a rare chronic inflammatory liver disease characterized by the presence of autoantibodies, including those targeting O-phosphoseryl-tRNA:selenocysteine-tRNA synthase (SepSecS), also known as soluble liver antigen (SLA). Anti-SepSecS antibodies have been associated with a more severe phenotype, suggesting a key role for the SepSecS autoantigen in AIH. To analyze the immune response to SepSecS in patients with AIH at the clonal level, we combined sensitive high-throughput screening assays with the isolation of monoclonal antibodies (mAbs) and T cell clones.

(CECT7484 and CECT7485) and (CECT7483) enhance actin cytoskeleton and CYP1A1 expression restoring epithelial permeability alterations induced by irritable bowel syndrome mediators.

Irritable bowel syndrome (IBS) is a multifactorial condition with heterogeneous pathophysiology, including intestinal permeability alterations. The aim of the present study was to assess the ability of a probiotic blend (PB) consisting of two strains (CECT7484 and CECT7485) and one strain of (CECT7483) to recover the permeability increase induced by mediators from IBS mucosal biopsies and to highlight the underlying molecular mechanisms. Twenty-one IBS patients diagnosed according to ROME IV criteria (11 IBS-D and 10 IBS-M) and 7 healthy controls were enrolled.

Implementation of the enhanced adult DIVA score in an emergency department: A prospective observational study.

Background: Short peripheral catheter (SPC) placement is a routine invasive procedure in clinical settings that is crucial for administering fluids, medications, or blood components. Approximately 11% of adult patients arriving at the Emergency Department (ED) experience difficulties with intravenous access (DIVA), necessitating advanced techniques for successful placement. The Enhanced Adult DIVA (EA-DIVA) score serves as a validated tool to promptly identify patients with DIVA.