Enhancing road performance and sustainability: A study on recycled porous warm mix asphalt.

The growing demand for sustainable infrastructure has increased interest in eco-friendly design solutions such as porous asphalt (PA) pavements, which manage stormwater runoff and mitigate urban heat islands, and warm mix asphalt (WMA), which reduces energy consumption and emissions during production. This study evaluates the mechanical and environmental performance of four warm mix porous asphalt (WPA) mixtures incorporating recycled materials and by-products: reclaimed asphalt pavement (RAP), aramid pulp fibres, and electric arc furnace (EAF) steel slag. A Life Cycle Assessment (LCA) with a cradle-to-cradle approach was conducted to comprehensively assess environmental impacts.

Isolation and characterisation of a heparosan capsular polysaccharide and a core oligosaccharide from Moraxella lincolnii strain CCUG 52988.

Moraxella lincolnii is a Gram-negative bacterium that resides in the upper respiratory tract (URT) of humans and may have a role as a member of a protective microbial community. Structural characterisation studies of its outer membrane glycan structures are very limited. We report here the isolation and structural characterisation (NMR, GLC-MS) of a capsular polysaccharide (CPS) and an oligosaccharide (OS) (lipooligosaccharide (LOS)-derived) isolated from strain CCUG 52988.

Characterisation of the HollandPTC R&D proton beamline for physics and radiobiology studies.

HollandPTC is an independent outpatient center for proton therapy, scientific research, and education. Patients with different types of cancer are treated with Intensity Modulated Proton Therapy (IMPT). Additionally, the HollandPTC R&D consortium conducts scientific research into the added value and improvements of proton therapy.

Enhancing door-to-door waste collection forecasting through ML.

We explore the application of machine learning (ML) techniques to forecast door-to-door waste collection, addressing the challenges in municipal solid waste (MSW) management. ML models offer a promising solution to optimize waste collection operations, especially amid growing urban populations and evolving waste generation rates. Leveraging comprehensive data from a northeastern Italian municipality, including various waste types, our study investigates ML algorithms' efficacy in predicting household waste collection requirements.

Effects of Magnesium-Doped Hydroxyapatite Nanoparticles on Bioink Formulation for Bone Tissue Engineering.

Bioprinting of nanohydroxyapatite (nHA)-based bioinks has attracted considerable interest in bone tissue engineering. However, the role and relevance of the physicochemical properties of nHA incorporated in a bioink, particularly in terms of its printability and the biological behavior of bioprinted cells, remain largely unexplored. In this study, two bioinspired nHAs with different chemical compositions, crystallinity, and morphologies were synthesized and characterized: a more crystalline, needle-like Mg-doped nHA (N-HA) and a more amorphous, rounded Mg- and CO-doped nHA (R-HA).

Identification of an exosite at the neutrophil elastase/alpha-1-antitrypsin interface.

Neutrophil elastase (NE) is released by activated neutrophils during an inflammatory response and exerts proteolytic activity on elastin and other extracellular matrix components. This protease is rapidly inhibited by the plasma serine protease inhibitor alpha-1-antitrypsin (AAT), and the importance of this protective activity on lung tissue is highlighted by the development of early onset emphysema in individuals with AAT deficiency. As a serpin, AAT presents a surface-exposed reactive centre loop (RCL) whose sequence mirrors the target protease specificity.

Assessment of Clinical Predictability of Overbite Reduction and Curve of Spee Levelling in Clear Aligner Treatment.

Objective: This retrospective study aims to assess the predictability of Overbite (OVB) reduction and Curve of Spee (COS) levelling in patients with deep bite malocclusion treated with Clear Aligner Therapy (CAT). The research evaluates the accuracy of the prescribed movements in growing and non-growing patients.

Materials And Methods: Thirty-six patients treated with Invisalign from January 2018 using SmartTrack were included.

Pomalidomide, Bortezomib, and Dexamethasone Versus Bortezomib and Dexamethasone in Relapsed or Refractory Multiple Myeloma: Final Survival and Subgroup Analyses From the OPTIMISMM Trial.

Introduction: In the OPTIMISMM trial, pomalidomide/bortezomib/dexamethasone (PVd) significantly prolonged median progression-free survival (PFS) versus bortezomib/dexamethasone (Vd) in lenalidomide-exposed relapsed and refractory multiple myeloma (RRMM). We report final overall survival (OS) and updated efficacy analyses.

Methods: Adults with RRMM who had 1-3 prior regimens, including lenalidomide (≥ 2 cycles), were assigned (1:1) to PVd or Vd.

CO and Temperature Induced Switching of a Flexible Metal-Organic Framework with Surface-Mounted Nanoparticles.

Within the material family of metal-organic frameworks (MOFs) the subclass of flexible MOFs (flexMOFs) has attracted great attention, showing structural flexibility as a response to external stimuli such as guest adsorption, temperature, and pressure. Hybrid composites like nanoparticle (NP) loaded flexible MOFs, which stand to potentially combine advantageous properties of both are yet largely unexplored. Here the synthesis of flexMOFs with surface mounted nanoparticles, e.

cHild -in-mothEr Approach for DeliverING Renal Denervation System: The HEADING-IN Technique.

Renal denervation is an emerging strategy for the management of uncontrolled hypertension. However, real-world experience is still modest, in particular for the management of complex anatomy, with available data being limited to the selected population of randomized clinical trials. We first describe the feasibility of delivering the renal denervation system to the target site with a child-in-mother technique, using a common coronary guiding extension, in a patient with severe tortuosity and double renal arteries.

Gut Neuropathies and Intestinal Motility Disorders.

Background: The enteric nervous system plays a key role in the coordination of gastrointestinal motility together with sympathetic, parasympathetic, and extrinsic sensory pathways. In some cases, abnormalities in neural activity in these pathways contribute to disorders of gut motility. Where this is associated with damage or death of enteric neurons, usually detected by microscopy, this is considered a gut neuropathy.

Registries on transcatheter edge-to-edge repair in heart failure: Current evidence and future perspectives.

Aims: Secondary mitral regurgitation (SMR) and tricuspid regurgitation (TR) are the most common valvular heart diseases in patients with heart failure (HF). Transcatheter edge-to-edge repair (TEER) devices designed for treating MR and TR have been successfully tested in randomized controlled trials, but methodological issues have often challenged their interpretation. This manuscript aimed to provide an overview of TEER registries on SMR and TR in HF, highlighting their key features, describing clinical characteristics and outcomes of patients receiving these devices, and exploring the available data limitations.

A Study of Bioactivities and Composition of a Cocktail of Supernatants Derived from Lactic Acid Bacteria for Potential Food Applications.

Growing interests in replacing conventional preservatives and antibiotics in food and pharmaceutical industries have driven the exploration of bacterial metabolites, especially those from strains with generally recognized as safe (GRAS) status, such as lactic acid bacteria (LAB). In this study, a supernatant cocktail derived from multiple LAB strains was prepared and its bioactivities-antimicrobial, antibiofilm, antioxidant, cytotoxicity, and stability-were thoroughly investigated. The cocktail's main components were identified using thermal and protease treatments, gas chromatography coupled to mass spectrometry (GC-MS), and flame ionization detection (GC-FID).

Emperor Leo I "the Thracian": a possible case of Graves' orbitopathy.

Representation of exophthalmos in ancient artworks is reported by several authors. In the present paper we analyze a sculpture belonging to the V century AD, likely embodying the eastern Roman emperor Leo I. As the portrait statue is sculpted with uncommon prominent eyes, we discuss the possibility that the historical personage was affected by exophthalmos due to Graves' orbitopathy.

Preliminary assessment of waste accumulation along riverbanks in Italy.

This paper presents a preliminary assessment of waste accumulation along riverbanks in Italy, aiming to provide baseline data for future monitoring and management efforts. The study surveyed 18 stations along 16 rivers across different regions of Italy, from north to south, to quantify and characterise the types and abundance of litter present along their banks. Field surveys were conducted by Legambiente citizen scientists applying a standardised protocol to record and categorise litter items systematically.

Discriminazione Basata sul Genere-Barriers Persist for Women Gastroenterologists in Italy.

Despite growing numbers of women entering medicine, women remain underrepresented in gastroenterology (GI) in the United States and globally, and barriers to equity persist. Prior studies describing gender makeup and ongoing challenges for women in GI have largely reflected the physician experience in the United States (US). In this study by Venezia et al.

Novel sigma 1-antagonists with -(+)-normetazocine scaffold: synthesis, molecular modeling, and antinociceptive effect.

Inflammatory pain represents one of the unmet clinical needs for patients, as conventional therapies cause several side effects. Recently, new targets involved in inflammatory pain modulation have been identified, including the sigma-1 receptor (σ1R). Selective σ1R antagonists have demonstrated analgesic efficacy in acute and chronic inflammatory pain models.

Paired nerve stimulation with selective compensation effect.

Background: In this study we investigate the selective compensation of paired peripheral nerves in healthy humans, focusing on distinct axonal conduction velocities in different fibre types. Using paired associative stimulation (PAS) with adjustable parameters, we aimed to modulate and compensate for neuronal activity along the median nerve.

Methods: Six healthy volunteers (3 male, 3 female, aged: 22-49) participated in the current study.