Understanding problematic TikTok use: A systematic review of emerging diagnostic and therapeutic implications in clinical psychology.

TikTok's rapid rise has spurred concerns about its potential to cause problematic use behaviors, which some consider akin to addiction. This systematic review seeks to understand the diagnostic and therapeutic implications of TikTok use within the scope of clinical psychology. From September 15, 2023 to March 30, 2024 a systematic review was conducted to investigate whether this new pathological condition can be recognized as a behavioral addiction.

When two become one: perceptual completion in pea plants.

Pea plants depend on external structures to reach the strongest light source. To do this, they need to perceive a potential support and to flexibly adapt the movement of their motile organs (e.g.

Zinc Ion Dyshomeostasis in Autism Spectrum Disorder.

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with significant social, communicative, and behavioral challenges, and its prevalence is increasing globally at an alarming rate. Children with ASD often have nutritional imbalances, and multiple micronutrient deficiencies. Among these, zinc (Zn) deficiency is prominent and has gained extensive scientific interest over the past few years.

Enforcement of stem-cell dormancy by nucleophosmin mutation is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis.

Mutations in the NPM1 gene (NPMc+) and in the FLT3 gene (FLT3-ITD) represent the most frequent co-occurring mutations in Acute Myeloid Leukemia (AML), yet the cellular and molecular mechanisms of their cooperation remain largely unexplored. Using mouse models that faithfully recapitulate human AML, we investigated the impact of these oncogenes on pre-leukemic and leukemic hematopoietic stem cells (HSCs), both separately and in combination. While both NPMc+ and Flt3-ITD promote the proliferation of pre-leukemia HSCs, only NPMc+ drives extended selfrenewal by preventing the depletion of the quiescent HSC pool.

Inorganic Nanomaterials Meet the Immune System: An Intricate Balance.

The immune system provides defense against foreign agents that are considered harmful for the organism. Inorganic nanomaterials can be recognized by the immune system as antigens, inducing an immune reaction dependent on the patient's immunological anamnesis and from several factors including size, shape, and the chemical nature of the nanoparticles. Furthermore, nanomaterials-driven immunomodulation might be exploited for therapeutic purposes, opening new horizons in oncology and beyond.

Population Genetic Structure and Human Adaptation of Kaposi Sarcoma-Associated Herpesvirus.

Background: Kaposi sarcoma-associated herpesvirus (KSHV), the etiologic agent of Kaposi sarcoma, is human-specific and is thought to have emerged from primate-infecting gammaherpesviruses. KSHV seroprevalence shows geographic variation, being highest in sub-Saharan Africa, intermediate in the Mediterranean area, and low in most other locations. However, KSHV prevalence is also particularly high in specific regions such as the Miyako Islands (Japan).

Reversing Glycation with a Dietary Supplement Containing Rosemary Extract.

Objective: The authors sought to explore the skin deglycation ability of rosemary extract dietary supplements to support skin health and improve the signs of skin aging.

Methods: A PubMed literature search for English-language articles on rosemary extract effects on glycation and skin aging in clinical and/or preclinical settings was conducted.

Results: Endogenous and exogenous glycative stress and reactive oxygen species lead to the accumulation of advanced glycation endproducts (AGEs), accelerating skin aging.

Thermal and nutrient stress drove Permian-Triassic shallow marine extinctions.

The Permian-Triassic climate crisis can provide key insights into the potential impact of horizon threats to modern-day biodiversity. This crisis coincides with the same extensive environmental changes that threaten modern marine ecosystems (i.e.

Unraveling the impact of laser refractive surgery on corneal ectasia: an study.

Introduction: Laser refractive surgeries are a safe option for low-to-moderate refractive corrections, providing excellent visual outcomes. Over the years, various procedures have been introduced into clinical practice, but the most performed today remain Photorefractive Keratectomy (PRK), Laser Keratomileusis (LASIK), and Small Incision Lenticule Extraction (SMILE). Although laser refractive treatments are considered safe, clinicians have focused on the risk of post-surgical ectasia, a rare but serious complication.

A global survey about undiagnosed rare diseases: perspectives, challenges, and solutions.

Background: Undiagnosed rare diseases (URDs) are a complex and multifaceted challenge, especially in low-and medium-income countries. They affect individuals with unique clinical features and lack a clear diagnostic label. Although the Undiagnosed Diseases Network International (UDNI) definition of URDs is not universally accepted, it is widely recognized.

Generational differences in healthcare: the role of technology in the path forward.

Healthcare systems worldwide are under increasing pressure due to aging populations, rising prevalence of chronic diseases, and heightened patient expectations. Generational differences significantly impact perceptions of health, healthcare decision-making, use of digital technologies, and attitudes toward preventative health. This perspective article explores these differences through the lens of Generational Cohort Theory, focusing on six generations: the Silent Generation, Baby Boomers, Generation X, Millennials, Generation Z, and Generation Alpha.

Patterns of Use of e-Cigarettes and Their Respiratory Effects: A Critical Umbrella Review.

E-cigarettes (ECs) are a well-established consumer product. To study their respiratory health effects, there is the issue of heterogenous patterns of use: concurrently with cigarette smoking (dual use), exclusive use after smoking cessation (exclusive use), or use initiated without any prior or current use of cigarettes (naïve use). Our primary goal was to synthesize the evidence on the respiratory effects of ECs use in adults, categorized by their pattern of use.

Lower Lip Reconstruction With the New Ascending Mental Artery Perforator Flap.

Full-thickness defects of the lower lip pose a considerable challenge for reconstructive surgeons. The primary objective should be the restoration of oral sphincter competence, achieving both functionally and aesthetically favorable outcomes. For defects involving more than one-third of the lower lip, multiple locoregional flaps have been described as the optimal solution due to their color and texture match.

Corrigendum: Gestational diabetes mellitus and polycystic ovary syndrome, a position statement from EGOI-PCOS.

[This corrects the article DOI: 10.3389/fendo.2025.

The Use of Digital Technologies in Physiotherapy Higher Education: a Mixed-Methods Study.

Background: Previous studies demonstrated that digital tools can be effectively integrated into physiotherapy higher education. However, their adoption remains limited. This study aimed to 1) evaluate the perceived knowledge, confidence, and frequency of digital technology use among Italian lecturers and 2) explore lecturers' experiences with digital technology in higher education.

Designing qualitative research with value in the clinical and epidemiological context: what, why and how.

Clinical and epidemiological research is indispensable for improvements in evidence-based healthcare and health outcomes, but it also leaves important gaps in our understanding of health and illness. Qualitative research has been increasingly recognized as a key to addressing some of these gaps, using both exploratory (to gain a more complete and in-depth understanding of problems) and explanatory (to explain quantitative results) approaches. By finding out 'what's going on' and bringing people's stories to light, qualitative research is widely advocated as crucial in enhancing patient-centered research and healthcare.

Perspectives on access to imaging digital health records in oncology: A mixed methods systematic review.

Background: Digital Health Records (DHR) have become essential for managing patient data, including radiology and nuclear medicine reports. The wider adoption of DHR globally presents an opportunity to improve patient engagement and empowerment through effective access and sharing of imaging investigations. This review aims to synthesize literature on views, experiences, expectations, and preferences of oncology patients and healthcare professionals (HCP) when accessing imaging via DHR.

Evaluating Risk in Kidney Living Donors.

Kidney donation is a safe procedure for carefully screened donors. The growing shortage of organs and improved survival rates among recipients of living donor transplants have broadened the criteria for acceptable living donors, including older individuals and those with pre-existing health conditions. Consequently, ensuring both the short- and long-term safety of living donors is of paramount importance.

Consumer Disposition Toward Fairness in Agri-Food Chains (FAIRFOOD): Scale Development and Validation.

Unlabelled: Fairness in agri-food supply chains receives increasing consumer, industry, and political attention but is currently under-conceptualized and lacks appropriate frameworks for measurement. Therefore, building on a theoretically grounded conceptualization of consumer dispositions toward fairness in agri-food supply chains, we developed and validated a 14-item fairness measurement scale (FAIRFOOD). The scale comprises of four dimensions (economic, environmental, social, and informational) which are manifestations of the same construct (higher-order structure).

Risk and protective factors in academic burnout: exploring the mediating role of interpersonal emotion regulation in the link with social support.

Interpersonal Emotion Regulation (IER) may serve as a critical link between the established roles of social support and emotion regulation in mitigating academic burnout. This study explored the hypothesis that IER influences academic burnout through its impact on social support. 156 undergraduate students were involved in the study, with measures assessing academic burnout (Maslach Burnout Inventory-Student Survey), IER (Difficulties in Interpersonal Emotion Regulation), and social support (Multidimensional Scale of Perceived Social Support).

Micro-encapsulated and colonic-release sodium butyrate modulates gut microbiota and improves abdominal pain in patients with symptomatic uncomplicated diverticular disease.

The role of gut microbiota (GM) in the pathogenesis of Symptomatic Uncomplicated Diverticular Disease (SUDD) remains controversial. Here, we assessed the efficacy of a butyrate formulation in modulating GM and abdominal pain in patients with SUDD. A retrospective study was conducted in patients with SUDD who were treated with a delayed- and colonic-release formulation of butyrate (two capsules bid, for a total dose of 400 mg butyrate) for 3 months.

The prognosis of mild cognitive impairment: A systematic review and meta-analysis.

Introduction: Knowledge gaps remain about the prognosis of mild cognitive impairment (MCI). Conversion rates to dementia vary widely, and reversion to normal cognition has gained attention. This review updates evidence on MCI conversion risk and probability of stability and reversion.