Understanding the Psychological Factors Linking Pelvic Pain and Health-related Quality of Life in Endometriosis: The Influence of Illness Representations and Coping Strategies.

Background: Endometriosis is a prevalent chronic gynecological condition characterized by severe pelvic pain, negatively affecting women's health-related quality of life (HRQOL). The Common-Sense Model of Illness Self-regulation has revealed the importance of illness perceptions and coping strategies in explaining the impact of illness on HRQOL across several conditions. These aspects have never been assessed in endometriosis.

Assessment and management of frailty in individuals living with dementia: expert recommendations for clinical practice.

Frailty complicates the care of individuals with dementia, increasing their vulnerability to adverse outcomes. This Personal View presents expert recommendations for managing frailty in individuals with dementia, aimed at health-care providers, particularly those in primary care. We conducted a rapid literature review followed by a consensus process involving 18 international experts on dementia and frailty.

Plaque heterogeneity influences in-stent restenosis following drug-eluting stent implantation: Insights from patient-specific multiscale modelling.

In-stent restenosis represents a major cause of failure of percutaneous coronary intervention with drug-eluting stent implantation. Computational multiscale models have recently emerged as powerful tools for investigating the mechanobiological mechanisms underlying vascular adaptation processes during in-stent restenosis. However, to date, the interplay between intervention-induced inflammation, drug delivery and drug retention has been under-investigated.

High-density versus point-by-point electroanatomical activation mapping of a cranial vena cava tachycardia in a dog.

A seven-year-old, male intact Newfoundland was referred for catheter ablation of supraventricular tachycardia. Activation mapping was performed using an electroanatomical mapping system to visualize the activation wavefront in a color-coded fashion on an anatomical shell. Atrial flutter with an early-meets-late signal (i.

Background parenchymal enhancement in CEM and MRI: Is there always a high agreement?

Introduction: Background parenchymal enhancement (BPE) refers to the physiological enhancement of breast fibroglandular tissue. This study aimed to determine the agreement of BPE evaluation between contrast enhanced mammography (CEM) and magnetic resonance imaging (MRI) and investigate potential confounders.

Materials And Methods: This retrospective, IRB-approved study included women recalled from screening or with inconclusive findings on mammography and/or ultrasound, who underwent both CEM and MRI between 2018 and 2022.

Raising awareness of alcohol as a modifiable risk factor for breast cancer: A randomized controlled trial comparing the efficacy of accessing an interactive website with a non-interactive website.

Background: Alcohol consumption is a potentially modifiable risk factor for breast cancer (BC). Reducing alcohol consumption within the daily amount at low-risk for alcohol-related consequences (daily alcohol threshold) may contribute to preventing BC new cases. However, most women are unaware of risk factors for BC, the daily alcohol threshold, and how to measure alcohol use.

Older workers spend less time in extreme trunk and upper-arm postures during order-picking tasks: Results from field testing.

Order picking tasks require repetitive trunk and upper arms movements that may increase the risk of developing musculoskeletal disorders, particularly among older workers due to the decline of their physical capabilities with aging. We proposed an approach based on a limited number of wearable inertial sensors to assessed exposures to non-neutral trunk and upper arms postures among both older and young workers during their regular work-shifts. The obtained data were processed accordingly to international standards (ISO 11226 and EN 1005-4) to detect the existence of possible differences associated with age-specific working strategies.

Serum metabolomics and lipoproteomics discriminate celiac disease and non-celiac gluten sensitivity patients.

Background&aims: Celiac disease (CD) and potential CD (pCD) are immune-mediated disorders triggered by the ingestion of gluten. In non-celiac gluten sensitivity (NCGS) neither allergic nor autoimmune mechanisms are involved. Relationships between NCGS and CD need to be further investigated.

Drug-Drug Interactions Between DAAs and Anticoagulants or Antiplatelets: A Position Paper of the Italian Anticoagulation Clinics.

The natural history of chronic hepatitis C virus (HCV) infection has changed after the introduction of direct-acting antiviral agents (DAAs). Screening programs have been ongoing to reach the World Health Organisation's goal of HCV elimination by 2030, and most infected people are eligible for treatment. Given the increased cardiovascular risk in people with HCV infection and the metabolic pathways of DAAs, it is not uncommon to face the issue of drug-drug interactions (DDIs) with antiplatelet or anticoagulant drugs.

Gastrointestinal Perforations Associated With JAK Inhibitors: A Disproportionality Analysis of the FDA Adverse Event Reporting System.

Background: Gastrointestinal perforations have been reported in a small number of rheumatoid arthritis (RA) patients treated with Janus kinase (JAK) inhibitors in clinical trials. However, large-scale postmarketing data repositories are needed to further investigate this potentially rare but serious adverse event.

Methods: A retrospective, pharmacovigilance study of the FDA adverse event reporting system (July 2014 to September 2023) assessing the reporting of gastrointestinal perforations following JAK inhibitors compared to biological disease-modifying antirheumatic drugs (bDMARDs) in RA patients.

Epigenetic Modulations of Non-Coding RNAs: A Novel Therapeutic Perspective in Sjӧgren's Syndrome.

Sjögren's syndrome (SS) is an autoimmune disease that can be classified as an epithelitis based on the immune-mediated attack directed specifically at epithelial cells. SS predominantly affects women, is characterized by the production of highly specific circulating autoantibodies, and the major targets are the salivary and lachrymal glands. Although a genetic predisposition has been amply demonstrated for SS, the etiology remains unclear.

The Neurophysiological Impact of Touch-Based Therapy: Insights and Clinical Benefits.

The evidence on how touch-based therapy acts on the brain activity opens novel cues for the treatment of chronic pain conditions for which no definitive treatment exists. Touch-based therapies, particularly those involving C-tactile (CT)-optimal touch, have gained increasing attention for their potential in modulating pain perception and improving psychological well-being. While previous studies have focused on the biomechanical effects of manual therapy, recent research has shifted towards understanding the neurophysiological mechanisms underlying these interventions.

Addressing the Effect of Exercise on Glial Cells: Focus on Ependymal Cells.

A growing body of research highlights the positive impact of regular physical activity on improving physical and mental health. On the other hand, physical inactivity is one of the leading risk factors for noncommunicable diseases and death worldwide. Exercise profoundly impacts various body districts, including the central nervous system.

Prognostic and Predictive Biomarkers of Oligometastatic NSCLC: New Insights and Clinical Applications.

This review discusses the current data on predictive and prognostic biomarkers in oligometastatic NSCLC and discusses whether biomarkers identified in other stages and widespread metastatic disease can be extrapolated to the oligometastatic disease (OMD) setting. Research is underway to explore the prognostic and predictive value of biological attributes of tumor tissue, circulating cells, the tumor microenvironment, and imaging findings as biomarkers of oligometastatic NSCLC. Biomarkers that help define true OMD and predict outcomes are needed for patient selection for oligometastatic treatment, and to avoid futile treatments in patients that will not benefit from locoregional treatment.

Mineral composition in mussel and clam from Faro Lake of Messina: risk assessment for human health.

Bivalve are exposed to a wide range of contaminants, some of which may be toxic to human health. The aim of this study was to detect essential and non-essential elements such as Na, Ca, Mg, Cr, Mn, Fe, Ni, Cu, Zn, As, Cd, Pb, Hg, Be and Co in water, sediments, and and from Faro Lake. It is a lake of marine origin located on the northern coast of Messina (Sicily), where shellfish farming has been practiced for many years.

Molecular Tracking of in an Archived Spleen Sample in Iran: A Case Report.

Rodents are the primary reservoir hosts for zoonotic cutaneous leishmaniasis (ZCL) caused by . Knowing reservoir hosts is crucial for leishmaniasis surveillance and control programs in endemic areas. In this study, we examined an archived spleen of obtained during a pest control program in 2000 in Tehran, the capital of Iran.

Laser-Treated Screen-Printed Carbon Electrodes for Electrochemiluminescence imaging.

Electrochemiluminescence (ECL) is nowadays a powerful technique widely used in biosensing and imaging, offering high sensitivity and specificity for detecting and mapping biomolecules. Screen-printed electrodes (SPEs) offer a versatile and cost-effective platform for ECL applications due to their ease of fabrication, disposability, and suitability for large-scale production. This research introduces a novel method for improving the ECL characteristics of screen-printed carbon electrodes (SPCEs) through the application of CO laser treatment following fabrication.

: a Python package for simplifying cBioPortal data access in cancer research.

Objectives: In recent years, the rise of big data and artificial intelligence has led to an increasing expansion of databases and web services in biomedical research. cBioPortal is one of the most widely used platforms for accessing cancer genomic and clinical data. The primary objective of this study was to develop a tool that simplifies programmatic interaction with cBioPortal's web service.

Investigating a new alarming outbreak of in Tuscany (Central Italy): molecular characterization and gene typing elucidate the complex phytoplasma ecology in the vineyard agroecosystem.

(FD) is a major grapevine disease in Europe, despite the quarantine status of its causal agent [FD phytoplasma (FDp)] and the mandatory monitoring and vector control practices. As alarming FD epidemic outbreaks continue to appear in Tuscany (Central Italy), a 4-year survey was carried out in the main wine-growing areas of the region, where FD presence was investigated in both primary and secondary FDp hosts and vectors, i.e.

Comparison analysis between standard polysomnographic data and in-ear-electroencephalography signals: a preliminary study.

Study Objectives: Polysomnography (PSG) currently serves as the benchmark for evaluating sleep disorders. Its discomfort makes long-term monitoring unfeasible, leading to bias in sleep quality assessment. Hence, less invasive, cost-effective, and portable alternatives need to be explored.

Hybrid dark-field and attenuation contrast retrieval for laboratory-based X-ray tomography.

X-ray dark-field imaging highlights sample structures through contrast generated by sub-resolution features within the inspected volume. Quantifying dark-field signals generally involves multiple exposures for phase retrieval, separating contributions from scattering, refraction, and attenuation. Here, we introduce an approach for non-interferometric X-ray dark-field imaging that presents a single-parameter representation of the sample.