58 results match your criteria: "Istanbul Yedikule Chest Diseases and Thoracic Surgery Education and Research Hospital[Affiliation]"

Sex differences in clinical and polysomnographic features of obstructive sleep apnea: The Turkish sleep apnea database (TURKAPNE) cohort.

Sleep Med

December 2024

Department of Pulmonary Medicine, Koc University School of Medicine, Istanbul, Türkiye; Koc University Research Center for Translational Medicine (KUTTAM), Istanbul, Türkiye; Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Sahlgrenska Academy, Gothenburg, Sweden; Department of Clinical Sciences, Respiratory Medicine and Allergology, Lund University School of Medicine, Lund, Sweden; Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address:

Background: Previous reports from relatively small clinical cohorts have suggested that the clinical presentation of obstructive sleep apnea (OSA) differs between men and women.

Objective: We aimed to explore sex differences in clinical and polysomnographic features of OSA in a large nationwide registry.

Methods: Participants from the ongoing Turkish Sleep Apnea Database (TURKAPNE) Study from 34 centers were included in the current analysis.

View Article and Find Full Text PDF
Article Synopsis
  • Lung cancer is a significant issue for patients with Idiopathic Pulmonary Fibrosis (IPF), but there is limited research on those with non-IPF Pulmonary Fibrosis (PF); this study compares the two groups in terms of characteristics and survival.
  • The study analyzed data from 251 patients diagnosed with lung cancer between 2010 and 2022, finding that most were elderly men with a high smoking rate, and differing patterns of lung imaging between the two groups.
  • Both IPF-LC and non-IPF PF-LC patients had high 5-year mortality rates around 64%, with the shortest survival noted in non-IPF PF patients with unclassified PF.
View Article and Find Full Text PDF

A descriptive analysis of 21 patients with pulmonary amyloidosis: An observational study.

Medicine (Baltimore)

November 2024

Department of Chest Diseases, Yedikule Chest Diseases and Thoracic Surgery Education and Research Hospital, University of Health Sciences Turkey, Istanbul, Turkey.

Pulmonary amyloidosis is an extremely rare disease, often detected incidentally because of its asymptomatic nature and potential to result in fatal outcomes. In this study, we aimed to present the clinical and radiological features of patients diagnosed with pulmonary amyloidosis by biopsy. This descriptive study included 21 patients with pathologically diagnosed pulmonary amyloidosis.

View Article and Find Full Text PDF
Article Synopsis
  • * Genomic profiling of ACC shows low tumor mutational burden, a lack of actionable targets, and negative PD-L1, leading to recommendations for a specific combination of anti-PD-1 and anti-CTLA-4 immunotherapy.
  • * A successful complete response was noted in a patient with treatment-resistant locally recurrent lacrimal gland ACC through personalized immunotherapy combined with other therapeutic strategies, highlighting the importance of considering patient-specific factors in immune-cold cancers.
View Article and Find Full Text PDF

Background: Chronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable disease. Despite optimal medical therapy and pulmonary rehabilitation, bronchoscopic and surgical lung volume reduction may still be necessary. Identifying the target lobe is crucial for the success of these treatments.

View Article and Find Full Text PDF

A rare AAT variant presenting in a COPD patient: Q0 amersfoort mutation.

Respir Med Case Rep

July 2024

Department of Pulmonology, Yedikule Chest Diseases and Thoracic Surgery Education and Research Hospital, University of Health Sciences, İstanbul, Turkiye.

Article Synopsis
  • Alpha-1 antitrypsin (AAT) deficiency is a condition where the liver produces low levels of a protein that protects the lungs, leading to emphysema and liver disease, and it may also cause respiratory and skin issues.
  • A 56-year-old non-smoking male with a history of COPD experienced worsening breathing difficulties and had reduced AAT levels detected through testing after imaging showed emphysematous changes in his lungs.
  • Genetic analysis revealed a specific mutation linked to AAT deficiency, highlighting the importance of considering this condition in patients with unexplained COPD symptoms, especially non-smokers.
View Article and Find Full Text PDF

Background And Aim: Persistent interstitial lung disease (ILD) after COVID-19 infection can lead to severe loss of respiratory function and a decrease in the quality of life. There is no consensus regarding the treatment of post-COVID-19-ILD. This study aims to investigate the effectiveness of immunosuppressive treatment for this group of patients.

View Article and Find Full Text PDF
Article Synopsis
  • Alpha-1 antitrypsin deficiency (AATD) is a genetic condition that affects AAT levels and is linked to respiratory diseases like COPD, bronchiectasis, and asthma; this study aimed to identify cases of AATD in Turkish patients with these conditions.
  • The study included 1,088 patients, mostly with COPD, and found that 5% had AATD mutations, with a mix of common and rare mutations identified.
  • The research concluded that AATD mutations are a significant genetic factor contributing to lung disease in the studied population, highlighting the need for awareness and genetic testing among patients with respiratory symptoms.
View Article and Find Full Text PDF

Initial alpha-1 antitrypsin screening in Turkish patients with chronic obstructive pulmonary disease.

Turk J Med Sci

August 2023

Department of Pulmonology, Yedikule Chest Diseases and Thoracic Surgery Education and Research Hospital, University of Health Sciences, İstanbul, Turkiye.

Background: Alpha-1 antitrypsin (AAT) deficiency is associated with several types of pathology, and the reported effects of mutations in the ATT-encoding gene vary worldwide. No Turkish study has yet appeared. We thus explored the AAT status of Turkish patients with chronic obstructive pulmonary disease (COPD).

View Article and Find Full Text PDF

Objective: A 1-day point prevalence study was planned to obtain country data by determining the clinical characteristics, follow-up and treatment methods of coronavirus disease 2019 (COVID-19) cases that required intensive care unit (ICU) treatment in the second year of the pandemic.

Material And Methods: All patients who were hospitalized in the ICUs due to COVID-19 between March 11, 2022, 08.00 am, and March 12, 2022, 08.

View Article and Find Full Text PDF

Background: We aimed to investigate the contribution of serum IgG testing to the history of exposure in the diagnosis of fibrotic hypersensitivity pneumonitis.

Methods: A single-center, retrospective, cross-sectional study including 63 patients pathologically diagnosed with fibrotic hypersensitivity pneumonitis in line with the guidelines of the American Thoracic Society. Descriptive statistics were presented and Kappa statistic was performed to evaluate the compatibility between panel and the history of exposure.

View Article and Find Full Text PDF

The role of endobronchial ultrasonography elastography in the diagnosis of hilar and mediastinal lymph nodes.

Turk J Med Sci

June 2023

Department of Pulmonology, Yedikule Chest Diseases and Thoracic Surgery Education and Research Hospital, University of Health Sciences, İstanbul, Turkey.

Background: Endobronchial ultrasonography (EBUS) is a minimally invasive diagnostic tool in the diagnosis of mediastinal lymph nodes (LNs) and has sonographic features. We aimed to investigate the diagnostic accuracy of EBUS elastography, which evaluates tissue compressibility integrated into EBUS, on malignant vs. benign mediastinal-hilar LNs.

View Article and Find Full Text PDF

Background: Acute exacerbation events, which can develop during the natural course of chronic obstructive pulmonary disease (COPD) can lead to worsening quality of life, increased hospital costs, and higher rates of morbidity and mortality. In recent years, individuals at heightened risk of COPD exacerbations have been said to display a so-called "frequent exacerbator (FE)" phenotype, defined as having two or more exacerbation events (or ≥ 1 exacerbation with a hospitalization) within 1 year.

Materials And Methods: We conducted a retrospective study involving 299 patients with COPD.

View Article and Find Full Text PDF

Management of recurrent hemoptysis: a single-center experience.

Turk J Med Sci

December 2022

Department of Interventional Radiodiagnostic, İstanbul Education and Research Hospital, University of Health Sciences, İstanbul, Turkey.

Background: A successful planning methodology for patients with hemoptysis promises overall improvement in patient care. Conducted in a reference center for chest diseases, the present study aims to analyze characteristics and predictors of interventional methods in patients with recurrent hemoptysis.

Methods: The present study is a single-center, retrospective observational study.

View Article and Find Full Text PDF

This study explores the relationship between spirituality and hope levels in lung cancer patients. Cancer patients often use their spirituality as a way of coping. Among a sample of 124 Turkish lung cancer patients, spirituality levels were assessed using the Spiritual Orientation Scale (SOS) and hope levels were measured using the Herth Hope Scale (HHS).

View Article and Find Full Text PDF

Objective: To evaluate the persistence of symptoms and health-related quality of life of coronavirus disease-2019 patients.

Methods: The cross-sectional study was conducted from April to September 2020 at Health Sciences University, Yedikule Chest Diseases Hospital, Istanbul, Turkey, and comprised patients of either gender who had to be hospitalised and treated for coronavirus disease-2019. Those who had spent <3 months (46-90 days) post-discharge formed Group 1, those having spent 3-6 were in Group 2, while those with >6 months post-discharge were in Group 3.

View Article and Find Full Text PDF

Frequency of alpha-1 antitrypsin deficiency and unexpected results in COPD patients in Turkey; rare variants are common.

Turk J Med Sci

October 2022

Department of Pulmonology, Yedikule Chest Diseases and Thoracic Surgery Education and Research Hospital, University of Health Sciences, İstanbul, Turkey.

Background: Alpha-1 antitrypsin (α1-AT) is a protease inhibitor that is largely released from liver cells. It inhibits neutrophil elastase and its deficiency increases the risk of developing chronic obstructive pulmonary disease (COPD). The frequency of α1-AT deficiency has been reported with different prevalence rates in different parts of the world.

View Article and Find Full Text PDF

Clinical effects of intranasal corticosteroids on nasal symptoms in subjects with chronic rhinitis during COVID-19.

Allergy Asthma Proc

March 2022

From the Division of Immunology and Allergic Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

The clinical effects of intranasal corticosteroids (INC) on nasal symptoms and the clinical course of coronavirus disease 2019 (COVID-19) in subjects with chronic rhinitis (CR) seem unclear. To evaluate the clinical effects of INCs on nasal symptoms in subjects with CR and with COVID-19. In subjects with CR and diagnosed with COVID-19 at four tertiary centers, quality of life and nasal symptoms were assessed by using the 22-item Sino-Nasal Outcome Test (SNOT-22) and the visual analog scale (VAS), respectively.

View Article and Find Full Text PDF

Background: The aim of this study was to evaluate the effect of prognostic factors and lymph node ratio (LNR) on survival in patients with resected non-small-cell lung cancer (NSCLC).

Methods: Data from 421 patients with NSCLC who underwent complete resection between 2009 and 2015 were evaluated retrospectively. LNR was defined as the ratio of positive lymph nodes to the total number of lymph nodes removed.

View Article and Find Full Text PDF

Adherence to subcutaneous immunotherapy with aeroallergens in real-life practice during the COVID-19 pandemic.

Allergy

January 2022

Division of Immunology and Allergic Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Background: The success of subcutaneous immunotherapy (SCIT) mostly depends on regular injections. Our aim was to investigate adherence to SCIT with aeroallergens during the COVID-19 pandemic and demonstrate clinical consequences of treatment disruptions in real life.

Methods: Visual analogue scale for quality of life (VAS-QoL), VAS for symptom scores (VAS-symptom), medication scores (MSs), and total symptom scores (TSS-6) were recorded during the pandemic in 327 adult allergic rhinitis and/or asthmatic patients receiving maintenance SCIT, and these scores were compared with the pre-pandemic data.

View Article and Find Full Text PDF

Background And Objectives: Transbronchial cryobiopsy (cryo-TBB) is increasingly being used in the diagnosis of diffuse parenchymal lung diseases (DPLD). Varying diagnostic success and complication rates have been reported. Herein we report our experience with cryo-TBB, focusing on diagnostic yield, factors affecting diagnosis, and safety.

View Article and Find Full Text PDF

Anxiety and health-related quality of life after cardiac surgery.

Arch Med Sci Atheroscler Dis

April 2020

Department of Cardiovascular Surgery, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.

Introduction: The aim of this study was to investigate the effect of elective cardiac surgery on health-related quality of life (HRQoL).

Material And Methods: One hundred and eight (35 women and 73 men, mean age 62.3 ±12.

View Article and Find Full Text PDF

Aneurysms and occlusive pathologies of the aorta are frequently associated with atherosclerosis; however, thoracoabdominal aortic aneurysm accompanied by Leriche syndrome is an extremely rare condition with challenging treatment strategy and without established surgical treatment protocols. In this report, we present our treatment strategy in a 64-year-old male patient with ischemic heart disease and type 5 thoracoabdominal aortic aneurysm accompanied by Leriche syndrome.

View Article and Find Full Text PDF

Background: We aimed to evaluate the results of the combined use of rotational atherectomy (RA) followed by drug-coated balloon (DCB) treatment against DCB angioplasty alone in patients who had significantly calcified and symptomatic femoropopliteal peripheral arterial disease.

Methods: Patients presented to the clinic with symptoms of chronic limb ischemia of femoropopliteal segment such as moderate or severe claudication and rest pain, who received endovascular therapy between January 2016 and January 2018 in our hospital comprised the study cohort and investigated, retrospectively. Patients with minor or major tissue loss were excluded from the study.

View Article and Find Full Text PDF