Fludarabine or cyclophosphamide in combination with total body irradiation as myeloablative conditioning prior to allogeneic hematopoietic cell transplantation for acute lymphoblastic leukemia: an analysis by the Acute Leukemia Working Party of the EBMT.

In this registry-based study we retrospectively compared outcomes of allogeneic hematopoietic cell transplantation (allo-HCT) for adult patients with acute lymphoblastic leukemia (ALL) following conditioning with total body irradiation (TBI) combined with either cyclophosphamide (Cy) or fludarabine (Flu). TBI 12 Gy + Cy was used in 2105 cases while TBI 12 Gy + Flu was administered to 150 patients in first or second complete remission. In a multivariate model adjusted for other prognostic factors, TBI/Cy conditioning was associated with a reduced risk of relapse (HR = 0.

The Thalamic and Intracortical Inhibitory Function of Somatosensory System Is Unchanged in Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis.

Purpose: In mesial temporal lobe epilepsy with hippocampal sclerosis, there is parietal atrophy and cognitive involvement in related domains. In this context, we hypothesized that inhibitory input into somatosensory cortex and thalamus may be increased in these patients, which could improve after epilepsy surgery. Thus, we analyzed the inhibitory function of somatosensory system by studying surround inhibition (SI) and recovery function of somatosensory evoked potentials in patients with mesial temporal lobe epilepsy with hippocampal sclerosis.

Changes in brainstem excitatory and inhibitory pathways in dry eye syndrome.

Background: We hypothesized that there may be changes in sensory integration pathways in patients with dry eye. To confront this issue, we analyzed blink reflex (BR), prepulse modulation (PPM) of BR, and excitability recovery of BR to paired stimuli in 17 experimental subjects with dry eye syndrome.

Method: We included 17 experimental subjects, 8 with primary and 9 with secondary, dry eye syndrome.

Recovery function of somatosensory evoked potentials in juvenile myoclonic epilepsy.

We analysed the recovery function of somatosensory evoked potentials (SEPs) in juvenile myoclonic epilepsy (JME) patients. We hypothesized that there may be disinhibition in the recovery of SEPs at 20-100 ms intervals in JME patients. We recorded SEPs and SEP recovery in 19 consecutive patients with JME admitted for a routine follow-up examination, and in a control group composed of 13 healthy subjects who were similar to the patient group regarding age and sex.

[Tahya Efendi fountain-the resurrection].

Eighteenth century, Ottoman fountain "Yahya Efendi Ceşmesi 1735" was ruined and its stones removed in 1982. Due to administrative and burocratic impediments in Turkish official courses; it took sixteen years to rebuilt and/or reconstruct the fountain in Cerrahpaşa Medical School court-yard in 1998. Reconstruction was held by Cerrahpaşa Department of Obstetrics and Gynecology and supported by University of Istanbul.

[Istanbul University Cerrahpaşa School of Medicine Department of Obstetrics and Gynecology: the list of diplomas and the related thesis of graduates in the twentieth century (1892-2000)].

Obstetrics Gynecology Department of Cerrahpaşa Faculty of Medicine is the first and the unique clinic which has ever been founded in Ottoman Empire by Besim Omer Pasha (Akalin) in 1892 under the name of "Veladethane" (meaning labor-in hospital) upon a decree of the Emperor. In 1909, it has been transferred from its first building located in Demirkapi Sirkeci to Kadirga and following a change from Kadiga to Haydaraşa in 1928. In 1933, after the university reform, it has moved again from Haydarpaşa.