Positive Heparin/PF4 Antibodies and High Mortality Rate: a Retrospective Case-Series Analysis.

Introduction: Heparin-induced thrombocytopenia (HIT) is a potentially lethal complication of unfractionated or low-molecular weight heparin therapy. We aimed to determine the incidence and mortality rate of patients with positive heparin/platelet factor 4 (PF4) antibodies, which is a rapid detection test of HIT.

Methods: Coronary artery bypass grafting and mitral and aortic valve surgeries were evaluated.

Postoperative thrombotic effects of tranexamic acid in open heart surgery.

Background: Following the administration of tranexamic acid, the occurrence of thromboembolic events is a controversial issue.

Aims: In this retrospective cohort study, we aimed to determine the possible thromboembolic complications due to tranexamic acid as a prophylactic method in patients undergoing open heart surgery.

Methods: The data of 172 adult patients undergoing open heart surgery were analyzed.

Coagulopathy during liver transplantation.

In this review article, we aimed to mainly review the principles for the management of hemostasis, changes that occur in the hemostatic system, and the techniques to reduce hemorrhage during liver transplantation. Hemostasis is a defense mechanism that may ensue from vascular damage and hemorrhage and consists of multiple phases which involve cellular and humoral elements of coagulation. In the presence of a cause, such as trauma-induced liver injury or hepatic failure that may trigger coagulopathy, the process becomes more problematic, and moreover, severe coagulation disorders may arise in daily practice unless the situation is intervened correctly and on time.