Prognostic value of systemic immune-inflammation index in older patients with acute coronary syndrome.

Objectives: Contemporary studies assessing the importance of the systemic immune-inflammation index (SII) in older patients presenting with acute coronary syndrome (ACS) are scarce. This study investigated the impact and prognostic value of the SII regarding long-term mortality in older patients with ACS.

Methods: The study included 401 older patients aged 75 years and above admitted with ACS between May 2015 and December 2022.

Traces of Earthquake: Traumatic Life Experiences and Their Effects on Volunteer Nurses in the Earthquake Zone-An Interpretative Phenomenological Study.

Introduction: It is crucial to understand the effects that traumatic events related to natural disasters have on individuals in as much detail as possible. However, the literature investigating the traumatic life experiences of nurses, who play a key role in disaster management, is still limited.

Objective: The aim of this study was to explore in depth the traumatic life experiences of volunteer nurses who participated in relief efforts after two major earthquakes in the southeastern region of Türkiye.

Association of the glycemic background patterns and the diabetes management efficacy in poorly controlled type 2 diabetes.

Background: Inadequate glycemic control in patients with type 2 diabetes (T2DM) is a major public health problem and a significant risk factor for the progression of diabetic complications.

Aim: To evaluate the effects of intensive and supportive glycemic management strategies over a 12-month period in individuals with T2DM with glycated hemoglobin (HbA1c) ≥ 10% and varying backgrounds of glycemic control.

Methods: This prospective observational study investigated glycemic control in patients with poorly controlled T2DM over 12 months.

Pseudobulbar Affect Correlates with Mood Symptoms and Low Quality of Life in Patients with Parkinson's Disease: A Comprehensive Cross-Sectional Study.

Objectives: Despite being recognized for a long time as a characteristic of Parkinson's disease (PD), pseudobulbar affect (PBA) is still a symptom that is underdiagnosed and undertreated. This study aimed to assess the association between PBA and various mood disturbances, as well as the impact on quality of life in PD patients.

Methods: Sixty-eight patients with PD were enrolled in this study.

Can fast wall shear stress computation predict adverse cardiac events in patients with intermediate non-flow limiting stenoses?

Background And Aims: Coronary angiography-derived wall shear stress (WSS) may enable identification of vulnerable plaques and patients. A new recently introduced software allows seamless three-dimensional quantitative coronary angiography (3D-QCA) reconstruction and WSS computation within a single user-friendly platform carrying promise for clinical applications. This study examines for the first time the efficacy of this software in detecting vulnerable lesions in patients with intermediate non-flow limiting stenoses.

The Association Between Medication Adherence and Rational Drug Use Knowledge and Health Literacy in Older Adults Residing in Nursing Homes.

Background: Medication adherence is a crucial factor in managing and treating chronic diseases in older adults. Health literacy (HL) skills and rational drug use (RDU) knowledge are important for individuals to make informed decisions about medication adherence behaviours.

Aim: This study was conducted to determine the association between medication adherence and rational drug use knowledge and health literacy in older adults residing in nursing homes.

Leflunomide exerts neuroprotective effects in an MPTP‑treated mouse model of Parkinsonism.

Neuroinflammation and the immune response are recognized as significant mechanisms contributing to the progression and pathophysiology of Parkinson's disease (PD). Consequently, extensive research is being conducted on drugs targeting inflammation and immune response. Leflunomide, known for its anti‑inflammatory and immunomodulatory properties, is currently used as a disease‑modifying agent for the treatment of rheumatoid arthritis.

Phenotypes linked to duplication upstream of SOX9: New insights into presentation and diagnosis.

Context: Duplications occurring upstream of the SOX9 gene have been identified in a limited subset of patients with 46,XX testicular/ovotesticular differences/disorders of sex development (DSD). However, comprehensive understanding regarding their clinical presentation and diagnosis is limited.

Objective: To gain further insight into the diagnosis of a large cohort of 46,XX individuals with duplications upstream of SOX9.

Maternal health experiences on respectful and adequate care of immigrant women: A prospective multicenter study.

Objective: Migration of pregnant women can be challenging. Access to adequate and respectful care may not be possible. We aimed to assess the maternity care that immigrant women receive and their satisfaction with the care they experience.

Nursing approaches in home chemotherapy: A systematic review.

Aim: To systematically explore the existing literature by examining nursing approaches to home chemotherapy treatment.

Background: With the rising number of patients with cancer, home chemotherapy has gained prominence. Nurses play a crucial role in this process and bear significant responsibilities.

The association between transformational leadership and teachers' creativity: professional resilience and job satisfaction as mediators.

This study investigated the associations between transformational leadership, teachers' job satisfaction, professional resilience, and creativity. The sample included 417 teachers of public and private schools in Istanbul. The data collection tools were "Transformational Leadership Scale", "Teachers' Professional Resilience Scale", "Job Satisfaction Scale", and "Organizational Creativity Scale".

A study protocol to develop virtual reality software in the care management of patients in intensive care.

Background: The use of virtual reality is increasing in nursing to ensure patient safety and to improve the quality of care in the education of nurses.

Aim: To develop a virtual reality software for intensive care patient care management and to investigate the effect of this software on novice intensive care nurses.

Study Design: This study protocol contains a randomized controlled experimental design research.

Characterization of liver, adipose, and fecal microbiome in obese patients with MASLD: links with disease severity and metabolic dysfunction parameters.

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses a range of histological findings from the generally benign simple steatosis to steatohepatitis (MASH) which can progress to fibrosis and cirrhosis. Several factors, including the microbiome, may contribute to disease progression.

Results: Here, we demonstrate links between the presence and abundance of specific bacteria in the adipose and liver tissues, inflammatory genes, immune cell responses, and disease severity.

Effect of Virtual Reality on Pain, Anxiety, and Vital Signs in Endoscopy.

Aim: This study was conducted to evaluate the effect of relaxation exercise with VR (Virtual Reality) glasses on pain severity, anxiety level, and vital signs in patients undergoing endoscopy.

Methods: This is a quasi-experimental study including a control group with a pretest/post-test applied. This study was conducted with a total of 100 patients, including 50 patients in the intervention and 50 patients in the control group.

"The M-APNE score: an objective screening tool for OSA highlighting the area under the inspiratory flow-volume curve".

Background: Polysomnography (PSG) is resource-intensive but remains the gold standard for diagnosing Obstructive Sleep Apnea (OSA). We aimed to develop a screening tool to better allocate resources by identifying individuals at higher risk for OSA, overcoming limitations of current tools that may under-diagnose based on self-reported symptoms.

Methods: A total of 884 patients (490 diagnosed with OSA) were included, which was divided into the training, validation, and test sets.

Does the healthy plate model workshop improve nutrition knowledge, behaviors, and habits in school-age children? The impact of workshop on dietary habits : Original article.

Background: This study was conducted to identify the impacts of the healthy plate model workshop on 4th-graders nutrition knowledge, behaviors, and habits.

Methods: The study was conducted from March to June 2023 in the Uskudar district of Istanbul, involving 102 children (50% girls) with a mean age of 10.2 ± 0.

Microbial Contamination of Nebulizers in Patients With Cystic Fibrosis.

Objective: Nebulizer contamination has potential harmful effects on the respiratory system. The aim was to investigate the contamination profile of the nebulizers in cystic fibrosis patients and evaluate the relationship between hygiene practices and microbial contamination. Materials and Methods: Microbiological swab samples were taken from 3 different locations of the nebulizers of 102 patients.

The Impact of Domestic Violence and Sexual Assault on Family Dynamics and Child Development: A Comprehensive Review.

This review synthesizes current research on domestic violence and sexual assault, focusing on their short-term and long-term effects on family dynamics, particularly on the development and well-being of children and adolescents. The article employs a curated body of literature, including surveys, reviews, program evaluations, and international health reports, to elucidate the direct and collateral damage caused by such trauma within families. The review critically examines the intersecting consequences of abuse, including immediate psychological distress and long-term socio-economic and educational disruptions for affected youths.

Evaluating ChatGPT and Google Gemini Performance and Implications in Turkish Dental Education.

Artificial intelligence (AI) has emerged as a transformative tool in education, particularly in specialized fields such as dentistry. This study evaluated the performance of four advanced AI models - ChatGPT-4o (San Francisco, CA: OpenAI), ChatGPT-o1, Gemini 1.5 Pro (Mountain View, CA: Google LLC), and Gemini 2.

Comparison of the effectiveness of botulinum toxin, dry needling, pharmacological treatment, and manual therapy for bruxism-induced myalgia: a prospective randomized study.

Bruxism is a significant phenomenon that should not be underestimated, given its prevalence and consequences. The major symptoms associated with bruxism include myalgia, decreased quality of life, and limited mandibular movements. This study aimed to evaluate and compare the effectiveness of four treatment methods for managing bruxism-related symptoms: botulinum toxin (BoNT-A), dry needling (DN), pharmacological therapy (PT), and manual therapy (MT).

The Effect of Nurses' Professional Values on Missed Nursing Care: The Mediating Role of Moral Sensitivity.

The aim of this study is to determine the mediating role of moral sensitivity in the effect of nurses' professional values on missed nursing care. A descriptive and correlational study was conducted with 640 nurses working in the inpatient units of a public and a private hospital with the MISSCARE Survey-Turkish, the Moral Sensitivity Questionnaire, and the Revised Nursing Professional Values Scale. Data analyses were performed using the Statistical Package for Social Sciences 26.

Comparative Evaluation of Chatbot Responses on Coronary Artery Disease.

Objective: Coronary artery disease (CAD) is the leading cause of morbidity and mortality globally. The growing interest in natural language processing chatbots (NLPCs) has driven their inevitable widespread adoption in healthcare. The purpose of this study was to evaluate the accuracy and reproducibility of responses provided by NLPCs, such as ChatGPT, Gemini, and Bing, to frequently asked questions about CAD.

Analysis of healthcare utilization before the diagnosis of radiologically isolated syndrome.

Background: Previous studies have shown that people with multiple sclerosis (MS) had frequent healthcare visits up to 10 years before being diagnosed but with no information from magnetic resonance imaging (MRI) scans of the connection with the radiologically isolated syndrome (RIS).

Objective: To analyze healthcare use 3 years before the RIS diagnosis.

Methods: We examined healthcare usage before the first scan in RIS cases from 2010 to 2019.

Data Mining Approach to Melatonin Treatment in Alzheimer's Disease: New Gene Targets and .

Melatonin is a hormone released by the pineal gland that regulates the sleep-wake cycle. It has been widely studied for its therapeutic effects on Alzheimer's disease (AD), particularly through the amyloidosis, oxidative stress, and neuroinflammation pathways. Nevertheless, the mechanisms through which it exerts its neuroprotective effects in AD are still largely unknown.