5,987 results match your criteria: "Istanbul 29 Mayıs University[Affiliation]"

Background: We aimed to examine the efficacy of intravenous vitamin C (IV-VC) in the treatment of hospitalized patients with moderate or severe COVID-19.

Method: We conducted a single-center and retrospective study including patients with COVID-19 diagnosis who were hospitalized. Patients were categorized into three groups as those who received low-dose (LDVC group, 2 g/day, n = 183) or high-dose IV-VC (HDVC group, 25 g/day, n = 41) and who did not receive IV-VC (control group, n = 46).

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Aim: To determine the effect of kangaroo mother care (KMC) on perfusion index, heart rate, and oxygen saturation in premature infants who were discharged early and admitted to the neonatal intensive care unit (NICU) in the following days.

Methods: This study has a randomized controlled experimental design and uses a pretest-posttest control group model. This study included infants between December 2019 and December 2020 who were discharged early and subsequently admitted to the NICU.

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Spontaneous hemoperitoneum in pregnancy (SHIP) is defined as sudden, nontraumatic intraperitoneal bleeding that occurs during pregnancy or up to 42 days postpartum. The incidence ranges between 4 and 4.9 per 100 000 births.

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Introduction: The study was performed to examine the effects of death anxiety on diet-fluid restriction non-adherence in hemodialysis patients.

Methods: This descriptive, cross-sectional, and correlational study was performed with 118 hemodialysis patients who received treatment in the dialysis unit of a university hospital and a state hospital in Elazığ, eastern Turkey. The study data were obtained with the "Descriptive Data Form", "Death Anxiety Scale", and "Dietary and Fluid Restriction Non-Adherence Scale".

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The impact of COVID-19 infection on multiple sclerosis disease course across 12 countries: a propensity-score-matched cohort study.

Ther Adv Neurol Disord

November 2024

Department of Neuroscience, Central Clinical School, Monash University, 99 Commercial Road, Melbourne, VIC 3004, Australia.

Background: The relationship between coronavirus disease 2019 (COVID-19) infection and multiple sclerosis (MS) relapse and disease progression remains unclear. Previous studies are limited by small sample sizes and most lack a propensity-matched control cohort.

Objective: To evaluate the effect of COVID-19 infection on MS disease course with a large propensity-matched cohort.

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Highlighting roles of autophagy in human diseases: a perspective from single-cell RNA sequencing analyses.

Drug Discov Today

December 2024

Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Autophagy, the lysosome-driven breakdown of intracellular components, is pivotal in regulating eukaryotic cellular processes and maintaining homeostasis, making it physiologically important even under normal conditions. Cellular mechanisms involving autophagy include the response to nutrient deprivation, intracellular quality control, early development, and cell differentiation. Despite its established health significance, the role of autophagy in cancer and other diseases remains complex and not fully understood.

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Article Synopsis
  • - The study analyzed the antidiabetic, antimicrobial, antioxidant, and genotoxic properties of extracts from two plant species in the Asteraceae family by examining their methanol extracts for phenolic and fatty oil content.
  • - Key compositions of the fatty oils included methyl hexadecanoate and heptacosane, with both species showing significant α-amylase inhibition using hexane extracts.
  • - The extracts demonstrated varying antioxidant activities, with effective antimicrobial properties and confirmed safety against genotoxicity, suggesting their potential in medical applications for diabetes management and microbial infection treatment.
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Purpose: Syrian refugees (SRs) have had difficulties in the diagnosis, treatment, and follow-up of chronic diseases, such as cancer, because of the conflict in the region. The cancer diagnosis and treatment process of SR are also a matter of curiosity. We aimed to compare the demographic characteristics and survival outcome data of SRs and Turkish citizens (TCs), and colorectal cancer (CRC) is one of the most common cancer types seen with similar frequency globally.

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Objectives: This study aimed to investigate the potential roles of proprotein convertase subtilisin/ kexin type 9 (PCSK9) and apelin in the etiology of fibromyalgia syndrome (FS).

Patients And Methods: The retrospective study was conducted between May 2022 and February 2023. Fifty-eight female FS patients (mean age: 45.

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Article Synopsis
  • This study investigates risk factors for all-cause mortality and major cardiovascular events in patients undergoing ambulatory blood pressure monitoring, which helps track blood pressure outside of clinical settings.! -
  • The research analyzed data from 1,291 patients, finding that survival rates improved with certain blood pressure patterns and age, while poorer outcomes were associated with smoking and specific blood pressure dips.! -
  • The study emphasizes the importance of diastolic blood pressure dipping and nighttime variability in predicting health outcomes, highlighting the need for personalized treatment approaches in hypertension management.!
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Background And Objective: This investigation evaluates the safety and efficacy of stereotactic radiosurgery (SRS) vs observation for Koos grade I vestibular schwannomas (VS).

Methods: In a multicenter study, we retrospectively analyzed data of patients with Koos grade I VS who underwent SRS (SRS group) or were observed (observation group). Propensity score matching was used to equilibrate demographics, tumor size, and audiometric data across groups.

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Article Synopsis
  • Pneumothorax is a rare but serious complication of COVID-19 that leads to worse patient outcomes, requiring more respiratory support, longer hospital stays, and increased mortality.
  • This observational study reviewed 100 patients in the COVID-19 ICU who underwent tube thoracostomy due to pneumothorax, analyzing their demographics and clinical data.
  • Findings indicated that the majority of patients were older males (median age 68), with high rates of intubation and significant respiratory support needed, highlighting critical factors that could predict mortality in these cases.
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A retrospective epidemiological analysis of maxillofacial fractures at a tertiary referral hospital in istanbul: a seven-year study of 1,757 patients.

Maxillofac Plast Reconstr Surg

November 2024

Faculty of Medicine, Department of Otorhinolaryngology, Marmara University, Pendik Training and Research Hospital, Fevzi Çakmak, Muhsin Yazıcıoğlu Street, Istanbul, 34899, Turkey.

Background: The aim of the study was to evaluate the etiology, incidence, demographics, and characteristics of maxillofacial fractures treated at a university hospital over a seven-year period.

Methods: We performed a retrospective analysis of 1,757 patients with maxillofacial fractures who were referred to our department between May 2012 and March 2019. The patients' demographic and clinical characteristics were noted, as well as the fracture type, location, and etiology.

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Background: Acute appendicitis is one of the most common surgical emergencies. With antibiotic-first treatment strategies gaining importance, the risk of an appendiceal tumor as an incidental finding or as the cause of appendicitis presents an obstacle to a conservative approach. Neuroendocrine tumors, the most frequent type of appendiceal tumors, are difficult to diagnose preopera-tively due to their small size.

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Purpose: To retrospectively analyze long-term outcomes of pediatric pars planitis (PP).

Methods: PP was defined as vitreal inflammation with snowbank or snowball formation in the absence of a related disease. Eighty-five eyes of 44 patients were included in this study.

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Aim: The purpose is to develop a care package for the prevention of medical device-related pressure injuries using the Delphi Method.

Design: The study is a methodological.

Method: The care package was developed using the Delphi Method, a consensus-based technique.

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Article Synopsis
  • The study focused on children with symptomatic omphalomesenteric duct (OMD) anomalies, analyzing 35 cases from a hospital over four years.
  • Most patients were male (82.8%) with symptoms primarily related to gastrointestinal tract obstruction, acute abdomen, or umbilical issues.
  • Surgical interventions varied, with successful outcomes and only two complications, showcasing the effectiveness of surgical treatment for these anomalies.
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Mast cells are commonly found in pancreatic ductal adenocarcinoma (PDAC), yet their role in the disease remains uncertain. Although mast cells have been associated with depression in several diseases, their connection to PDAC in this context remains unclear. This study explored the correlation between mast cells and psychosocial stress in patients with PDAC.

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Emergency lumbar disc herniation surgery with spinal anesthesia during pregnancy: Clinical features and long-term outcome.

J Clin Neurosci

December 2024

Medicana Hospital, Neurosurgery Clinic, Bursa, Turkey; Biruni University, Faculty of Medicine, Neurosurgery Department, İstanbul, Turkey. Electronic address:

Background: This study aimed to review the safety and prognosis of emergency lumbar microdiscectomy surgery during pregnancy.

Methods: The study included a cohort of ten consecutive pregnant patients who underwent urgent lumbar microdiscectomy surgery between 2016 and 2022-perioperative and perinatal clinical data derived from medical records-a retrospective analysis. The patients were evaluated based on age, gestational age, gravidity, parity, neurological examination findings, and visual analog scale (VAS) pain scores with the early and late postoperative results of mother and newborns with follow-up.

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Purpose: We investigated the efficacy and safety of a high-flow nasal cannula (HFNC) at different flow rates compared to noninvasive ventilation (NIV) in patients with acute chronic obstructive pulmonary disease (COPD) exacerbations.

Methods: This prospective, randomized, single-blind study assigned patients to one of three study groups. The NIV group (n = 47) received bilevel positive airway pressure.

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Herein, we aimed to investigate the physicochemical, bioactive, microbial, and sensory properties of 5 different ultraviolet (UV) treatment conditions, varying in flow rate (1.5-2.5-3.

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Reclassification of CTO Crossing Strategies in the ERCTO Registry According to the CTO-ARC Consensus Recommendations.

JACC Cardiovasc Interv

October 2024

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Italy. Electronic address:

Article Synopsis
  • The CTO-ARC identified the need for standardized definitions in chronic total occlusion (CTO) procedures to avoid bias in attributing complications to different crossing strategies.
  • A study analyzed data from 8,673 patients in the European Registry of Chronic Total Occlusions, finding that the antegrade approach was used in 79.2% of cases, while retrograde was used in 20.8%.
  • Results showed that alternative antegrade crossing had lower technical success rates and higher complication rates compared to true antegrade and retrograde methods, though it was primarily used as a rescue strategy in most instances.
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Background: To investigate the relationship between anxiety and white coat hypertension (WCH) using the hospital anxiety and depression scale-anxiety (HADS-A) score.

Methods: Participants lacking a pre-existing diagnosis of hypertension but displaying increased office blood pressure were included in this study. Subsequently, they were classified as either newly diagnosed sustained hypertension (SustHT) or white coat hypertension (WCH) patients, as determined by 24-hour ambulatory blood pressure monitoring measurements.

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Polymeric micelles were prepared for the delivery of donepezil, a leading Alzheimer's disease drug, to enhance its transport across the blood-brain barrier (BBB). Poly(ethylene glycol)--poly(-butyl methacrylate) amphiphilic block copolymers were synthesized reversible addition-fragmentation chain transfer (RAFT) polymerization. The polymers were characterized by gel permeation chromatography and nuclear magnetic resonance spectroscopy.

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Effects of Different Auditory Stimuli and Cognitive Tasks on Balance in Healthy Young Adults.

Audiol Neurootol

December 2024

Division of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Bezmialem Vakif University, Istanbul, Turkey.

Introduction: This study investigated the effect of different auditory stimuli and cognitive tasks on balance in healthy young adults.

Methods: Thirty-three participants, aged 23.33 ± 2.

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