4 results match your criteria: "Israel. gatzmon@univ.haifa.ac.il.[Affiliation]"
The d3GHR carrier epigenome in Druze clan longevity.
Sci Rep
September 2024
Department of Human Biology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel.
The Druze are a distinct group known for their close community, traditions, and consanguineous marriages, dating back to the eleventh century. This practice has led to unique genetic variations, impacting both pathology and gene-associated phenotypes. Some Druze clans, particularly those with exceptional long-lived family heads (ELLI), attracted attention.
View Article and Find Full Text PDFCorrection to: Genome integrity as a potential index of longevity in Ashkenazi Centenarian's families.
Geroscience
October 2024
Faculty of Natural Sciences, University of Haifa, Haifa, Israel.
Genome integrity as a potential index of longevity in Ashkenazi Centenarian's families.
Geroscience
October 2024
Faculty of Natural Sciences, University of Haifa, Haifa, Israel.
Article Synopsis
- - The study investigates genomic changes, specifically copy number variants (CNVs), in a cohort of Ashkenazi Jewish centenarians, their children, and unrelated controls, to understand factors influencing longevity.
- - Among 670 participants, it was found that centenarians had more total CNVs compared to controls, but they retained better genomic integrity, indicated by a lower total length of lost genomic material.
- - The research also revealed that offspring had the highest number of unique CNVs, which may contribute to longevity preservation, with significant genomic regions linked to crucial biological functions identified.
Telomeres and Longevity: A Cause or an Effect?
Int J Mol Sci
July 2019
Department of Human Biology, University of Haifa, Haifa 3498838, Israel.
Telomere dynamics have been found to be better predictors of survival and mortality than chronological age. Telomeres, the caps that protect the end of linear chromosomes, are known to shorten with age, inducing cell senescence and aging. Furthermore, differences in age-related telomere attrition were established between short-lived and long-lived organisms.
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