2 results match your criteria: "Israel Soroka University Medical Center[Affiliation]"

Regulation of autophagy by α1-antitrypsin: "a foe of a foe is a friend".

Mol Med

October 2014

Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel Soroka University Medical Center, Beer-Sheva, Israel.

Autophagy is involved in both the cell protective and the cell death process but its mechanism is largely unknown. The present work unravels a novel intracellular mechanism by which the serpin α1-antitrypsin (AAT) acts as a novel negative regulator of autophagic cell death. For the first time, the role of intracellularly synthesized AAT, other than in liver cells, is demonstrated.

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