Adverse perinatal outcomes associated with true knot of the umbilical cord - A multicenter retrospective study.

Objective: To estimate the prevalence of true knot of the umbilical cord (TKUC) and identify associated adverse maternal and neonatal outcomes.

Study Design: A multicenter retrospective cohort study was conducted, including all women with singleton pregnancies who delivered between 24 and 42 weeks of gestation from 2005 to 2021 at two large obstetrical centers. Gross pathological examinations of the placenta and umbilical cord were routinely performed immediately after delivery.

App- and Wearable-Based Remote Monitoring for Patients With Myasthenia Gravis and Its Specialists: Feasibility and Usability Study.

Background: Myasthenia gravis (MG) is rare, chronic autoimmune disorder of the neuromuscular junction that requires specialized care and often lifelong treatment, facing challenges due to its rarity and the limited availability of specialists. Telemedical solutions in specialized centers hold considerable promise in bridging this gap by increasing access to this care to a broader patient population in a timely manner. However, there is no research regarding interventional remote care solutions in the field of MG to date.

A comparison of the ventilatory responses to wearing either a hood or a mask escape respirator with identical nose-cups.

Differences in escape respirator design can influence the wearer's ventilatory response and impact inspired oxygen (O) and carbon dioxide (CO) concentrations. There has been minimal investigation into the differences between hood and mask designs as escape respirators that compare between the ventilatory responses of wearing either a hood or mask escape respirator with an identical nose-cup. Thirty-nine healthy young males participated in the study.

Sequential Respiratory Syncytial Virus and Bacterial Infections in the Nasopharynx of Zambian Infants and Mothers.

Background: Respiratory syncytial virus (RSV) is a major cause of severe respiratory infections in infants, especially under 5 years of age. Several studies have reported that interactions between RSV and bacteria like Streptococcus pneumoniae (SP), Moraxella catarrhalis (MC), Haemophilus influenzae (HI) and Staphylococcus aureus (SA) may influence their pathogenicity and the clinical outcome of infection. However, existing knowledge about RSV-bacterial interactions in infants comes primarily from cross-sectional studies, which cannot evaluate the influence of infection sequence on these interactions.

Unidirectional recruitment between MeCP2 and KSHV-encoded LANA revealed by CRISPR/Cas9 recruitment assay.

Kaposi's sarcoma-associated herpesvirus (KSHV, HHV-8) is associated with several human malignancies. During latency, the viral genomes reside in the nucleus of infected cells as large non-integrated plasmids, known as episomes. To ensure episome maintenance, the latency protein LANA tethers the viral episomes to the cell chromosomes during cell division.

Strategies for relapse prevention among people with schizophrenia in KwaZulu-Natal Province, South Africa: Healthcare providers' perspectives.

Introduction: Relapse is a significant challenge among people with schizophrenia and is broadly recognized by the aggravation of positive or negative symptoms, the need for re-hospitalization, more intensive case management, and/or changes in medication. The quality of inpatient care and proper transition to outpatient care are crucial in reducing the risk of relapse. Healthcare providers play vital roles in ensuring the continuity of care after patients are discharged from the hospital.

'We're all in this together': the protective role of belongingness in the contribution of moral injury to mental health among participants in Israel's civil protest movement.

Participating in long-term protests against government actions can affect protesters' mental health and expose protesters to potentially morally injurious events (PMIEs), such as the betrayal by leaders they once trusted. This study aimed to shed light on the potential psychological buffers against the deleterious effects of exposure to PMIEs of betrayal among protesters and to examine the moderating role of belongingness in the relationships between protesters' exposure to PMIEs and stress, PTSD and depression levels. The study sample comprised 4036 Israeli protesters (= 54.

Mode of delivery among preterm twins and offspring health, a retrospective cohort study.

Unlabelled: Although cesarean delivery (CD) has been linked to long-term health risks in singleton infants, the impact of delivery mode on long-term health outcomes in preterm twins remains underexplored. A retrospective cohort study was conducted at a tertiary medical center in Israel from 1991 to 2021, comparing preterm twins vaginally delivered (VD) versus cesarean section, excluding cases with congenital malformations or perinatal deaths. Kaplan-Meier survival curves were used to compare the cumulative incidence, and Cox proportional hazards models were applied to adjust for potential confounders.

Treatment stigma mediates relationships between morally injurious events and depression, PTSD and anxiety symptoms.

Morally injurious events (MIEs), encompassing personal transgressions, witnessing others commit transgressions, or experiencing betrayal by leaders, can conflict with one's moral/ethical principles, evoking outrage and profound mistrust. Although MIEs are associated with depression, PTSD, and anxiety, the mechanisms linking MIEs to psychiatric symptomatology remain unclear, especially among civilians in times of collective trauma. This study explored one potential mechanism: stigma toward mental-health treatment, which can deter help-seeking and exacerbate guilt, shame, and mistrust.

Implementing Accuracy, Completeness, and Traceability for Data Reliability.

Importance: While it is well known that data quality underlies evidence validity, the measurement and impacts of data reliability are less well understood. The need has been highlighted in the 21st Century Cures Act of 2016 and US Food and Drug Administration (FDA) Real-World Evidence Program framework in 2018, draft guidance in 2021 and final guidance in 2024. Timely visibility into implementation may be provided by the Transforming Real-World Evidence With Unstructured and Structured Data to Advance Tailored Therapy (TRUST) study, a Verantos Inc-led FDA-funded demonstration project to explore data quality and inform regulatory decision-making.

Connectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors.

Importance: The weak link between subjective symptom-based diagnostics for posttraumatic psychopathology and objective neurobiological indices hinders the development of effective personalized treatments.

Objective: To identify early neural networks associated with posttraumatic stress disorder (PTSD) development among recent trauma survivors.

Design, Setting, And Participants: This prognostic study used data from the Neurobehavioral Moderators of Posttraumatic Disease Trajectories (NMPTDT) large-scale longitudinal neuroimaging dataset of recent trauma survivors.

Development of an NGS-Based Estimation of Integrated HBV DNA in Liver Biopsies and Detection in Liquid Biopsies.

This study characterized a hepatitis B virus (HBV) hybridization-capture next-generation sequencing (HBV-NGS) assay and applied it to develop a model for estimating the integrated HBV DNA (iDNA) quantity and for HBV genetics liquid biopsy. Using HBV monomers and reconstituted cell line DNA (SNU398, Hep3B, and PLC/PRF/5), the HBV-NGS assay demonstrated high coverage uniformity, reproducibility across HBV genotypes A-D, and 0.1% sensitivity for detecting iDNA.

Complete genome and transcriptome of 3488, a clinical isolate with a novel deletion at the RD1 locus.

In members of the complex, the RD1 locus encodes a type VII secretion system involved in virulence. Herein, we describe the genome and transcriptomic analysis of 3488, a clinical isolate from a cat, with a 14.2 kb deletion that encompasses the RD1 locus.

The complete genome sequence of the crayfish pathogen Candidatus n.g. n.sp. provides insight into pathogenesis and the phylogeny of the Coxiellaceae family.

The Coxiellaceae bacterial family, within the order Legionellales, is defined by a collection of poorly characterized obligate intracellular bacteria. The zoonotic pathogen and causative agent of human Q fever, , represents the best-characterized member of this family. Coxiellaceae establish replicative niches within diverse host cells and rely on their host for survival, making them challenging to isolate and cultivate within a laboratory setting.

FDG PET/CT in vascular graft infection: a pictorial review.

Vascular graft infections (VGI) are rare but severe complications following vascular surgery, with significant morbidity and mortality. Diagnosing VGI requires a multidisciplinary approach combining clinical, laboratory, and imaging findings. While CTA remains the first-line imaging modality, its limitations in detecting chronic or low-grade infections highlight the value of advanced nuclear medicine techniques, particularly [F]FDG PET/CT.

Increased cancer risk in a cohort of patients with acromegaly in Israel.

The association between acromegaly and cancer had been assessed mainly in population studies with inconsistent results. The objective of this study was to investigate the risk of cancer in a large cohort of patients with acromegaly compared with matched controls. The comprehensive computerized database of the largest healthcare provider organization in Israel was searched for patients diagnosed with acromegaly in 2000-2021.

Allogeneic Hematopoietic Cell Transplantation in Patients With Acute Myeloid Leukemia With Myelodysplasia-Related Genetic Features: Relevance of the Genetic Underlying Category. A Retrospective Analysis on Behalf of the Acute Leukemia Working Party of the EBMT.

Patients (pts) with myelodysplasia-related AML (MR-AML) are now genetically recategorized, with three different groups in the International Consensus Classification: AML with mutated TP53 (TP53-AML), with myelodysplasia-related gene mutations (MR-GM AML), and with myelodysplasia-related cytogenetic abnormalities (MR-CG AML). Moreover, TP53-AML is determined by the presence of an additional complex karyotype (TP53-mut CK and non-CK AML, respectively). Nonetheless, the relevance of this classification to transplantation outcomes is largely unknown.

Genetic Etiology Influences the Low-Frequency Components of Globus Pallidus Internus Electrophysiology in Dystonia.

Background: Elevated low-frequency activity (4-12 Hz) within the globus pallidus internus (GPi) has been consistently associated with dystonia. However, the impacts of the genetic etiology of dystonia on low-frequency GPi activity remain unclear; yet it holds importance for adaptive deep brain stimulation (DBS) treatment.

Methods: We compared the properties of GPi electrophysiology acquired from 70 microelectrode recordings (MER) trajectories of DYT-GNAL, DYT-KMT2B, DYT-SGCE, DYT-THAP1, DYT-TOR1A, DYT-VPS16, and idiopathic dystonia (iDYT) patients who underwent GPi-DBS surgery across standard frequency bands.

Academic voices on the health and humanitarian crises in Gaza.

Academic publications on human rights violations in Gaza surged after Israel's large-scale destruction following Hamas's 7 October 2023 attack. We analysed the uncoordinated cooperative efforts documented in these works by reviewing publications addressing the health and humanitarian crises in Gaza between October 2023 and April 2024. We present a unified academic voice advocating for recognizing and restoring human rights for the people of Gaza.

Associations Between Stroke Type, Ischemic Stroke Subtypes, and Poststroke Cognitive Trajectories.

Background: It is unclear how poststroke cognitive trajectories differ by stroke type and ischemic stroke subtype. We studied associations between stroke types (ischemic and hemorrhagic), ischemic stroke subtypes (cardioembolic, large artery atherosclerotic, lacunar/small vessel, and cryptogenic/other determined causes), and poststroke cognitive decline.

Methods: We pooled participants from 4 US cohort studies (1971-2019).

Quality of Early Intervention Program Services in Mother-Child Health Care Centers for At-Risk Population: Multiple Perspectives.

Aims: Mother-Child Health Centers in Israel offer comprehensive health-care services, including unique screening programs that serve as important preventive services for families of lower socioeconomic status. This study aimed to explore the service quality regarding family-centered care and professionalism from the perspectives of parents, providers, and observers.

Methods: Eighty-nine Arabic-speaking parents of children ( = 17.

RCE-IFE: recursive cluster elimination with intra-cluster feature elimination.

The computational and interpretational difficulties caused by the ever-increasing dimensionality of biological data generated by new technologies pose a significant challenge. Feature selection (FS) methods aim to reduce the dimension, and feature grouping has emerged as a foundation for FS techniques that seek to detect strong correlations among features and identify irrelevant features. In this work, we propose the Recursive Cluster Elimination with Intra-Cluster Feature Elimination (RCE-IFE) method that utilizes feature grouping and iterates grouping and elimination steps in a supervised context.

Optical genome and epigenome mapping of clear cell renal cell carcinoma.

Cancer cells display complex genomic aberrations that include large-scale genetic rearrangements and epigenetic modulation that are not easily captured by short-read sequencing. This study presents a novel approach for simultaneous profiling of long-range genetic and epigenetic changes in matched cancer samples, focusing on clear cell renal cell carcinoma (ccRCC). ccRCC is a common kidney cancer subtype frequently characterized by a 3p deletion and the inactivation of the von Hippel-Lindau () gene.