Evaluation of a Simulation Program for Providing Telenursing Training to Nursing Students: Cohort Study.

Background: Telenursing has become prevalent in providing care to diverse populations experiencing different health conditions both in Israel and globally. The nurse-patient relationship aims to improve the condition of individuals requiring health services.

Objectives: This study aims to evaluate nursing graduates' skills and knowledge regarding remote nursing care prior to and following a simulation-based telenursing training program in an undergraduate nursing degree.

Exploring the Structural Origins of Optically Efficient One-Dimensional Lead Halide Perovskite Nanostructures.

Metal halide perovskites have excellent optoelectronic properties. This study aims to determine how the optoelectronic properties of a model perovskite, cesium lead bromide (CsPbBr), change with length and thickness in one dimension (1D). By examining the photophysics of CsPbBr quantum dots (QDs), nanowires (NWs), and nanorods (NRs), we observe the influence of confinement, exciton diffusion, and trapping on their optical properties.

Worldwide Innovative Network (WIN) Consortium in Personalized Cancer Medicine: Bringing next-generation precision oncology to patients.

The human genome project ushered in a genomic medicine era that was largely unimaginable three decades ago. Discoveries of druggable cancer drivers enabled biomarker-driven gene- and immune-targeted therapy and transformed cancer treatment. Minimizing treatment not expected to benefit, and toxicity-including financial and time-are important goals of modern oncology.

Genetically supported targets and drug repurposing for brain aging: A systematic study in the UK Biobank.

Brain age gap (BAG), the deviation between estimated brain age and chronological age, is a promising marker of brain health. However, the genetic architecture and reliable targets for brain aging remains poorly understood. In this study, we estimate magnetic resonance imaging (MRI)-based brain age using deep learning models trained on the UK Biobank and validated with three external datasets.

Real-life intense fear is communicated through context, not facial expressions.

Central emotion theories assume that during threatening and dangerous events the human face signals a prototypical, distinct, and universally recognized expression of fear which can be accurately decoded by conspecific perceivers. Due to the importance of fear expressions, an unusually large body of research has been dedicated to exploring their evolutionary origins, neurobiological mechanisms, and clinical significance. However, these studies typically utilize highly recognizable posed actor portrayals presumed to closely resemble the diagnostic physical appearance of real-life fearful faces.

The role of excitations in supercooled liquids: Density, geometry, and relaxation dynamics.

Low-energy excitations play a key role in all condensed-matter systems, yet there is limited understanding of their nature in glasses, where they correspond to local rearrangements of groups of particles. Here, we introduce an algorithm to systematically uncover these excitations up to the activation energy scale relevant to structural relaxation. We use it in a model system to measure the density of states on a scale never achieved before, confirming that this quantity shifts to higher energy under cooling, precisely as the activation energy does.

Long-term impact of bevacizumab for the treatment of brain radiation necrosis.

Purpose: To evaluate short and long-term efficacy of bevacizumab (Bev), for the treatment of radiation necrosis (RN) in patients with brain metastasis after stereotactic radiosurgery (SRS).

Methods: The database of a tertiary medical center was reviewed for all adult patients treated by Bev (from January 2018 to January 2023) for RN after having received SRS for BM. Clinical and MRI data were systematically collected at baseline, immediately after the completion of Bev treatment, and at 6, 12, and, when available, 24 months post-treatment.

The Effect of Adding a Smartphone-Based Platform to the Metabolic Bariatric Surgery Nutritional Preparation Process: A Randomized Controlled Trial.

Background: Metabolic bariatric surgery (MBS) candidates undergo a comprehensive nutritional preparation process by a registered dietitian (RD). The effect of eHealth interventions on the MBS preparation process is unknown.

Objectives: To assess the impact of adding an application to the nutritional preparation process on pre-surgery nutritional knowledge, physical, and behavioral parameters among MBS candidates.

Querying the capability of the post-HoLEP endoscopic aspect of the membranous urethral mucosa in predicting urinary incontinence: a prospective AI-based analysis.

Introduction: Transient stress urinary incontinence (SUI) after holmium laser enucleation of prostate (HoLEP) is commonly linked to intraoperative injury of the external urethral sphincter (EUS). We assessed the reliability of the post-HoLEP endoscopic appearance of the membranous urethra mucosa (MUM) in predicting post-HoLEP continence.

Methods: Forty HoLEPs were prospectively recorded by an artificial intelligence video platform capable of segmenting clips by surgical steps.

Comparing oncologic outcomes of partial and radical nephrectomy for T2 renal cell carcinoma: a propensity score matching cohort study and an external multicenter validation.

Purpose: There is very limited evidence on the optimal surgical treatment for patients with larger T2 renal tumors. This study aims to evaluate the oncologic outcomes of partial nephrectomy (PN) and radical nephrectomy (RN) in T2 renal cell carcinoma (RCC).

Methods: A retrospective data analysis was conducted on T2 RCC patients who underwent PN or RN between 2004 and 2019 using the SEER database, and validated with data from multiple centers in China from 2014 to 2019.

A cost-effectiveness study of PSMA-PET/CT for the detection of clinically significant prostate cancer.

Background: Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is currently under evaluation for detecting clinically significant prostate cancer. The PSMA-PET/CT may complement the current standard diagnostic pathway for prostate cancer, which includes prostate-specific antigen (PSA) testing and multiparametric magnetic resonance imaging (mpMRI). This study evaluated the cost-effectiveness and quality of life impact of incorporating PSMA-PET/CT into this diagnostic algorithm.

Addressing What Matters: A Pilot Study and Mixed Methods Evaluation of Patient Priorities Care in Four Clinical Settings.

Background: Older adults with multiple chronic conditions face significant challenges with their health. Patient Priorities Care (PPC) is an Age-Friendly approach that explores 'what matters' by identifying values, care preferences, and health priorities, and aligning healthcare based on patients' health outcome goals.

Methods: Patient priorities care was implemented in four clinical settings (Hospital in Home, a transitional care case management program and in two embedded clinics within specialty care settings) within a large academically affiliated Veteran Affairs hospital system.

Genomic differentiation and SNP variation reveal local adaptations to eastern Mediterranean environmental conditions in wild radishes.

Background And Aims: Morphological differences between the two genetically close wild radishes, Raphanus raphanistrum and R. pugioniformis, include differences in fruit structure that influence their dispersal ability and within population spatial structure. Here, we tested within- and among-populations genetic variation, hypothesizing that (i) short-distance dispersal of heavy fruits in R.

Fluorescent Silver Nanoclusters Associated with Double-Stranded Poly(dGdC) DNA.

Here, we demonstrate through AFM imaging and CD spectroscopy that the binding of silver ions (Ag) to poly(dGdC), a double-stranded (ds) DNA composed of two identical repeating strands, at a stoichiometry of one Ag per GC base pair induces a one-base shift of one strand relative to the other. This results in a ds nucleic acid-Ag conjugate consisting of alternating CC and GG base pairs coordinated by silver ions. The proposed organization of the conjugate is supported by the results of our Quantum Mechanical (QM) and Molecular Mechanics (MMs) calculations.

Ethics of consenting the 'unconsentable'.

Purpose: The purpose of this review is to highlight important ethical aspects of informed consent in the unconsentable patient or participant.

Recent Findings: Recent research and guidelines stress the need for detailed and honest communication respecting patient autonomy and the standards of informed consent. Emphasis is placed on full disclosure and guidance.

Successful Percutaneous Extraction of a WATCHMAN FLX Device From the Left Ventricular Outflow Tract.

Background: Although rare, embolization of left atrial appendage occlusion (LAAO) devices carries a significant morbidity and mortality burden.

Case Summary: An asymptomatic 77-year-old woman with inability to tolerate anticoagulation due to gastrointestinal bleeding presented for 45-day transesophageal echocardiography following LAAO with a Watchman device, which demonstrated incidental device migration to the left ventricular outflow tract (LVOT). Percutaneous extraction was performed using a novel technique with rat tooth/alligator forceps to successfully retrieve the Watchman from the LVOT using a transaortic approach.

A comparative analysis of surgical trends in upper urinary tract stone management in Ontario, Canada, and Israel.

Objective: To compare trends and incidence of surgical intervention among adults with urolithiasis in Ontario, Canada, and Israel.

Patients And Methods: A retrospective analysis was conducted using administrative databases from Clalit Health Service in Israel and IC/ES in Canada. The study included adults who underwent their initial surgical treatment for urolithiasis.

Transdermal therapeutic polymer: synthesis of biocompatible polymer using 5-aminolevulinic acid as a photosensitizer precursor and a polymer initiator.

Melanoma is the most malignant skin tumor caused by the malignancy of melanocytes that produce the melanin pigment. Various methods have been developed to combat melanoma, with photodynamic therapy (PDT) gaining the spotlight for its ability to eliminate cancer cells by generating reactive oxygen species through light-sensitive photosensitizers. 5-aminolevulinic acid (5-ALA) is the most commonly used PDT agent, which could be converted to the PpIX photosensitizer molecule within cancer cells.

AAPM-RSS Medical Physics Practice Guideline 9.b: SRS-SBRT.

The purpose of this Medical Physics Practice Guideline (MPPG) is to describe the minimum level of medical physics support deemed prudent for the practice of linear-accelerator, photon-based (linac) stereotactic radiosurgery (SRS), and stereotactic body radiation therapy (SBRT) services. This report is an update of MPPG 9.a published in 2017.

Efficacy and Safety of Chemical Venous Thromboembolism Prophylaxis in Spine Trauma Patients: A Systematic Review and Meta-analysis Comparing Anticoagulant Types.

Study Design: Systematic review and meta-analysis.

Objective: To determine whether venous thromboembolism (VTE) prophylaxis is necessary after spine trauma and to assess the efficacy and safety profiles of anticoagulation agents.

Summary Of Background Data: Venous stasis, endothelial disruption, hypercoagulability, and orthopedic injury in spine trauma predispose 12%-64% of patients to deep vein thrombosis (DVT).

3D reconstruction of resected retroperitoneal sarcoma tumour bed and ex vivo specimen.

Purpose: Retroperitoneal sarcomas (RPS) present a surgical challenge due to their complex anatomical relationships to organs and vascular structures. In this limited case series, we reconstructed the tumour beds of four cases of RPS and their ex vivo specimens.

Methods: Four patients underwent surgical resection of their retroperitoneal sarcoma at our centre in 2023-2024.