Development of three-layer microneedle system for controlled and sustained release of Levonorgestrel: A pioneering approach to long-term contraceptive delivery.

The increasing prevalence of unintended pregnancies, a persistent issue affecting public health and hindering progress towards the Sustainable Development Goals (SDGs), highlights the critical need for innovative contraceptive approaches. While current methods, including hormonal contraceptives such as levonorgestrel (LNG), offer potential solutions, challenges like limited access and inconsistent use persist. This study introduces a new approach with the development of a three-layer microneedle (TIMN) containing LNG designed to provide extended contraceptive efficacy.

Unveiling the anti-obesity potential of Kemuning (Murraya paniculata): A network pharmacology approach.

Obesity has become a global issue that affects the emergence of various chronic diseases such as diabetes mellitus, dysplasia, heart disorders, and cancer. In this study, an integration method was developed between the metabolite profile of the active compound of Murraya paniculata and the exploration of the targeting mechanism of adipose tissue using network pharmacology, molecular docking, molecular dynamics simulation, and in vitro tests. Network pharmacology results obtained with the skyline query technique using a block-nested loop (BNL) showed that histone acetyltransferase p300 (EP300), peroxisome proliferator-activated receptor gamma (PPARG), and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) are potential targets for treating obesity.

The Photophysics and Photochemistry of Phenylalanine, Tyrosine, and Tryptophan: A CASSCF/CASPT2 Study.

Among all amino acids, the three aromatic systems including phenylalanine, tyrosine, and tryptophan are known to manifest UV light absorption at the higher wavelengths. Their fluorescent properties are important for protein detection and determination of the spatial structure. Based on quantum chemical calculations, the absorption spectra in the 0-12 eV UV range of these aromatic amino acids were interpreted, and the photochemistry of the lowest-lying excited states was studied.

Modulating Cation and Water Transports for Enhanced CO Electrolysis via Ionomer Coating.

Electrification of the chemical industry has been considered an enabler for energy transition on a massive scale. In this context, carbon monoxide electroreduction (COR) to produce multi-carbon (C ) products is considered one of the forefront emerging technologies. The key challenge in COR comes from the excessive cation crossover to the cathode via electromigration and water diffusion, which limits CO availability and impedes product selectivity.

Molecular Docking Study of the C-10 Massoia Lactone Compound as an Antimicrobial and Antibiofilm Agent against .

Antimicrobial resistance is now considered a global health problem because it reduces the effectiveness of antimicrobial drugs. According to the World Health Organization (WHO), the highest mortality rate is associated with infections caused by multidrug-resistant microorganisms, with approximately 700,000 deaths worldwide each year. The aim of this study was to determine the potential of C-10 massoia lactone to inhibit the growth of fungi and biofilm, and molecular docking studies were performed to determine the nature of the inhibition.

Characteristics of organic matter released from drinking water treatment sludge under different storage conditions: Evaluation based on activated carbon adsorbability.

Recycling water from drinking water treatment sludge (DWTS) as raw water raises several problems in the drinking water supply. In this study, the impact of storage temperatures and oxygen conditions for DWTS on the characteristics of dissolved organic matter (DOM) released from sludge was evaluated in terms of adsorbability by activated carbon. Results showed that the adsorbability of the released DOM varied greatly with storage temperatures and oxygen conditions.

Density Functional Study on the Photopolymerization of Styrene Using Dinuclear Ru-Pd and Ir-Pd Complexes with Naphthyl-Substituted Ligands.

A density functional study was performed to investigate the mechanism of the photocatalytic reactivity of styrene polymerization using dinuclear Ru-Pd and Ir-Pd catalytic complexes. In previous experiments with these catalysts, the reactivity increased, and more polymer products were yielded compared to dimers under visible light irradiation. The best catalytic reactivity was obtained using an Ir-Pd complex containing naphthyl substituents at the phenyl ligands coordinated to Ir (-).

Phosphate Ion Removal from Synthetic and Real Wastewater Using MnFe2O4 Nanoparticles: A Reusable Adsorbent.

The purpose of this study was to eliminate phosphate (P) from wastewater using MnFe2O4 nanoparticles. BET, TGA/DTG, FTIR, SEM, TEM, VSM, XRD and EDX/Map analyses were used to determine the MnFe2O4 surface properties. The specific surface area of the adsorbent was 196.

One-pot alkanolamines-assisted synthesis of magnetic mesoporous silica for synthetic dye adsorption.

Magnetic mesoporous silica (MMS) was synthesized in a one-pot system using various alkanolamines (triethanolamine, diethanolamine, tris (hydroxymethyl)aminomethane) as a basic catalyst. The characterization of the composites was conducted using scanning electron microscope, transmission electron microscope, X-ray diffractometer, surface area analyzer, and X-ray photoelectros spectroscopy. The MMS synthesized with tris(hydroxymethyl)aminomethane (MMS) showed the highest specific surface area, pore volume, and average pore diameter.

Direct synthesis of lemongrass essential oilsilver nanoparticles (EO-AgNPs) as biopesticides and application for lichen inhibition on stones.

Lemongrass essential oil is used directly to kill lichens and has many disadvantages such as being less effective, volatile, and inefficient. Lichens are a type of microbe that grows in rocks and cause biodeteriorations of rock material because they are highly erosive. Therefore, this research aims to investigate the direct synthesis of lemongrass essential oil-silver nanoparticles (EO-AgNPs) as biopesticides and application for lichens inhibition on stones.

Techno-economic analysis of rooftop solar power plant implementation and policy on mosques: an Indonesian case study.

Indonesia is pushing the implementation of renewable energy to meet its climate action target. Solar energy is abundant, and its utilization is prioritized, including rooftop solar power plant (RSPP). This research presents a techno-economic analysis of an RSPP installed in a mosque in Ngombol subdistrict, Purworejo district, Central Java, Indonesia.

Improving the Separation of CO/CH Using Impregnation of Deep Eutectic Solvents on Porous Carbon.

The separation of CO/CH using porous carbon can be increased by the presence of a functional group of nitrogen on the carbon surface. This study explores the potential of porous carbon derived from the palm kernel shell (C-PKS) impregnated with a deep eutectic solvent (DES), which is one of the chemicals containing a nitrogen element. The DES was composed of a quaternary ammonium salt of choline chloride (ChCl) and a hydrogen bond donor of alcohol.

OMICS approaches in cardiovascular diseases: a mini review.

Ranked in the topmost position among the deadliest diseases in the world, cardiovascular diseases (CVDs) are a global burden with alterations in heart and blood vessels. Early diagnostics and prognostics could be the best possible solution in CVD management. OMICS (genomics, proteomics, transcriptomics, and metabolomics) approaches could be able to tackle the challenges against CVDs.

Dispersion of Carbon Nanotubes with "Green" Detergents.

Solubilization of carbon nanotubes (CNTs) is a fundamental technique for the use of CNTs and their conjugates as nanodevices and nanobiodevices. In this work, we demonstrate the preparation of CNT suspensions with "green" detergents made from coconuts and bamboo as fundamental research in CNT nanotechnology. Single-walled CNTs (SWNTs) with a few carboxylic acid groups (3-5%) and pristine multi-walled CNTs (MWNTs) were mixed in each detergent solution and sonicated with a bath-type sonicator.

Fermentation of Jamaican Cherries Juice Using Elevates Antioxidant Potential and Inhibitory Activity against Type II Diabetes-Related Enzymes.

Jamaican cherry ( Linn.) is tropical tree that is known to produce edible fruit with high nutritional and antioxidant properties. However, its use as functional food is still limited.

Self-nanoemulsifying Delivery of Andrographolide: Ameliorating Islet Beta Cells and Inhibiting Adipocyte Differentiation.

Insulin resistance is a characteristic of non-insulin-dependent diabetes mellitus associated with obesity and caused by the failure of pancreatic beta cells to secrete sufficient amount of insulin. Andrographolide (AND) improves beta-cell reconstruction and inhibits fat-cell formation. This research aimed to improve the delivery of water-insoluble AND in self-nanoemulsifying (ASNE) formulation, tested in streptozotocin (STZ)-induced diabetic rats and 3T3-L1 preadipocyte cells.

Development of New Indonesian Propolis Extract-Loaded Self-emulsifying: Characterization, Stability and Antibacterial Activity.

This study aimed to prepare, characterize, examine the stability and evaluation of the antibacterial activity of Indonesian propolis extract-loaded self-emulsifying (PESE). Oil, emulsifier, and co-emulsifier were selected as the carrier for the PESE formulation through a propolis-extract solubility test on each carrier, followed by evaluation of the nanoemulsion region in a pseudo ternary phase diagram. Pre-concentrate of PESE was prepared with the addition of 150 mg/mL propolis extract followed by characterization for the transmittance, globule size, zeta potential, thermodynamic stability, robustness to dilution, and accelerated stability.

The Effects of Local Food-Based Enteral Nutrition to Improve Nutritional Status of Post-Stroke Patients.

 We used local-based enteral formula for post-stroke patients to see its effects on the nutritional status.  This is an experimental research with a pre- and post-test study design in post-stroke patients. Participants underwent clinical and laboratory examinations to assess their nutritional status before and after the enteral nutrition supplementation.

Density Functional Study of Metal-to-Ligand Charge Transfer and Hole-Hopping in Ruthenium(II) Complexes with Alkyl-Substituted Bipyridine Ligands.

In this study, we present a density functional study of four ruthenium complexes by means of UV-visible spectroscopy and Marcus theory. These molecules, [Ru(bipyP)(bipy)] (P1), [Ru(bipyP)(dmb)] (P2), [Ru(bipyP)(dtbb)] (P3), and [Ru(bipyP)(dnb)] (P4), where bipyP = 2,2'-bipyridine-4,4'-diphosphonic acid, bipy = 2,2'-bipyridine, dmb = 4,4'-dimethyl-2,2'-bipyridine, dtbb = 4,4'-di--butyl-2,2'-bipyridine, and dnb = 4,4'-dinonyl-2,2'-bipyridine, are photosensitizers for applications in dye-sensitized photo-electrochemical cells (DSPECs). Because of the undetermined P4 conformation in the experiment, we modeled three P4 conformers with straight (P4-straight) and bent nonyl chains (P4-bend1 and bend2).

Novel Amides Derivative with Antimicrobial Activity of var. Leaves from Indonesia.

var. is a tropical plant closely related to the common piper. has also been dubbed a promising source of natural antioxidants in herbal health products, antibacterial, antifungal, antimalarial, cytotoxic activity against the cancer cell lines K562 and HL-60, and antileishmanial.

The Breast Size Satisfaction Survey (BSSS): Breast size dissatisfaction and its antecedents and outcomes in women from 40 nations.

The Breast Size Satisfaction Survey (BSSS) was established to assess women's breast size dissatisfaction and breasted experiences from a cross-national perspective. A total of 18,541 women were recruited from 61 research sites across 40 nations and completed measures of current-ideal breast size discrepancy, as well as measures of theorised antecedents (personality, Western and local media exposure, and proxies of socioeconomic status) and outcomes (weight and appearance dissatisfaction, breast awareness, and psychological well-being). In the total dataset, 47.

Ethylene Adsorption Using Cobalt Oxide-Loaded Polymer-Derived Nanoporous Carbon and Its Application to Extend Shelf Life of Fruit.

Suppressing the amount of ethylene during storage has been of interest as a method to enhance shelf life of fruit. In this work, ethylene removal by adsorption using cobalt oxide-impregnated nanoporous carbon has been studied. Nanoporous carbon with a high surface area up to 2400 m g was prepared by carbonization process biomass and synthetic polymer at 850 °C.

Boron Doped Graphene Quantum Structure and MoS Nanohybrid as Anode Materials for Highly Reversible Lithium Storage.

Herein, the boron-doped graphene quantum structure (BGQS), which contains both the advantages of 0-D graphene quantum dot and 2-D reduced graphene oxide, has been fabricated by top-down hydrothermal method and then mixed with molybdenum sulfide (MoS) to serve as an active electrode material for the enhanced electrochemical performance of lithium ion battery. Results show that 30 wt% of BGQS/MoS nanohybrid delivers the superior electrochemical performance in comparison with other BGQS/MoS and bare components. A highly reversible capacity of 3,055 mAh g at a current density of 50 mA g is achieved for the initial discharge and a high reversible capacity of 1,041 mAh g is obtained at 100 mA g after 50 cycles.

Re-entry Adjustment and Job Embeddedness: The Mediating Role of Professional Identity in Indonesian Returnees.

The present study examined the relationship between difficulty in re-entry adjustment and job embeddedness, considering the mediating role of sense of professional identity. The online data on demographic characteristics, difficulty on re-entry adjustment, sense of professional identity, and job embeddedness were collected from 178 Indonesian returnees from multiple organizations. The results showed that difficulty in re-entry adjustment was a significant predictor of a sense of professional identity; a sense of professional identity was a significant predictor of job embeddedness.