Efficacy of Cevimeline on Xerostomia in Sjögren's Syndrome Patients: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Background: Xerostomia, or dry mouth, is a common and debilitating symptom in patients with Sjögren's syndrome, affecting their quality of life. Although Cevimeline, a muscarinic agonist, has been investigated as a potential treatment, its efficacy and optimal dosage remain uncertain. This study aims to assess the effectiveness of Cevimeline in relieving xerostomia in patients with Sjögren's syndrome by a meta-analysis of randomized clinical trials (RCT).

Assessing the potential of fedaleh () essential oils as a natural herbicide for spring-summer crops.

Large quantities of chemical herbicides are used in agroecosystems every year, which not only imposes a significant financial burden on farmers but also leads to environmental pollution. To address this challenge, the present study aimed to replace Treflan with Fedaleh essential oils (EO). Treflan is a commonly used chemical herbicide for spring-summer crops, and has been chosen as a prevalent and abundant weed in many agricultural ecosystems.

Impact of oral administration of calcitriol to prevent symptomatic hypocalcemia after total thyroidectomy: Systematic review and meta-analysis.

Background: One of the most common complications of total thyroidectomy is post-operative transient or persistent hypoparathyroidism that can cause symptomatic hypocalcaemia. To prevent this complication, shorten the period of hospitalization and reduce morbidity, routine supplementation of oral vitamin D and calcium has been suggested. This systematic review and meta-analysis aims to critically assess the association between pre-operative calcitriol supplementation and post-operative hypocalcaemia.

A single-stage dual-source inverter using low-power components and microcomputers.

This paper is an attempt to provide a dual-source inverter, an intelligent inverter topology that links two isolated DC sources to a single three-phase output through single-stage conversion. The converter is designed to be utilized in hybrid photovoltaic fuel cell systems, among other renewable energy applications. The proposed dual-source inverter employs a single DC-AC converter, as opposed to conventional dual-source hybrid inverters which make use of several input DC-DC modules to obtain the voltage formed across the inverter's input DC-link.

Point-Of-Care Ultrasonography for Identification of Skin and Soft Tissue Abscess in Adult and Pediatric Patients; a Systematic Review and Meta-Analysis.

Introduction: Differentiating the soft tissue abscess from other types of skin and soft tissue infections (SSTIs) poses a particular challenge because they have similar physical evaluation findings, but each disease has a different course, outcome, and treatment. This meta-analysis aimed to investigate the diagnostic accuracy of point-of-care ultrasonography for diagnosis of soft tissue abscess in the emergency departments.

Methods: A comprehensive literature search of MEDLINE, Scopus, Web of Science, Embase, and Google Scholar, from inception to January 2023, was conducted to identify relevant studies investigating the diagnostic performance of point-of-care ultrasonography for identification of abscess.

Nanocomposite Based on HA/PVTMS/ClFeHO as a Gas and Temperature Sensor.

In this paper, a novel nanocrystalline composite material of hydroxyapatite (HA)/polyvinyltrimethoxysilane (PVTMS)/iron(II)chloride tetrahydrate (ClFeH-O) with hexagonal structure is proposed for the fabrication of a gas/temperature sensor. Taking into account the sensitivity of HA to high temperatures, to prevent the collapse and breakdown of bonds and the leakage of volatiles without damaging the composite structure, a freeze-drying machine is designed and fabricated. X-ray diffraction, FTIR, SEM, EDAX, TEM, absorption and photoluminescence analyses of composite are studied.

Exploring the use of chamomile ( L.) bioactive compounds to control flixweed ( L.) in bread wheat ( L.): Implication for reducing chemical herbicide pollution.

Intensive chemical herbicide use has resulted in human health and environmental issues. This study evaluated the phytotoxic potential of chamomile extract as a bioherbicide to minimize chemical herbicide use in wheat production. Treatments including four concentrations (0, 50, 100, and 150 mL/L) of three different chamomile plant parts (root, shoot, and root + shoot) extracts were applied to flixweed as a major weed in wheat production.

Immunologic aspects of migraine: A review of literature.

Migraine headaches are highly prevalent, affecting 15% of the population. However, despite many studies to determine this disease's mechanism and efficient management, its pathophysiology has not been fully elucidated. There are suggested hypotheses about the possible mediating role of mast cells, immunoglobulin E, histamine, and cytokines in this disease.

Immunoglobulin transmission to infants born to mothers with COVID-19.

Background: COVID-19 infection is a severe condition in pregnant women. Previous studies have suggested that anti-COVID-19 antibodies may be able to be transmitted from mother to fetus, which in itself is a protective factor in infants against the disease. However, few studies have been done in this area.

Effects of 5 wt.% Polycaprolactone, Polyhydroxybutyrate and Polyvinyltrimethoxysilane on the Properties of Ag/Zn/Mg Alloy.

Mg-based alloys have several suitable properties for biomaterials, but they have major problems of being less antibacterial and have a low mechanical strength. To solve these problems, a new combination of Ag/Zn/Mg was prepared in this study, where the presence of Zn and Ag can help to increase the bioactivity. The use of 5 wt.

The role of microRNA-30c in targeting interleukin 6, as an inflammatory cytokine, in the mesenchymal stem cell: a therapeutic approach in colorectal cancer.

Introduction: Colorectal cancer (CRC) is the third most prevalent cancer and the second significant cause of cancer-associated death worldwide. The microRNA-30 is a substantial member of the miRNA family and plays a vital role in expanding several cancers. This microRNA potentially targets interleukin 6 as an inflammatory cytokine in CRC.

Atherosclerosis and multiple sclerosis: An overview on the prevalence of risk factors.

Background: Atherosclerosis is the leading cause of ischemic heart disease and coronary artery disease. The process of atherosclerosis develops over a period of years and is mainly immune-mediated. Data regarding the prevalence of vascular disease and atherosclerosis among people with multiple sclerosis (pwMS) is inconsistent, therefore, we aimed to provide an overview of the prevalence of atherosclerotic risk factors in pwMS.

Risk factors of severe COVID-19 in people with multiple sclerosis : A systematic review and meta-analysis.

Objectives: To gather, synthesize, and meta-analyze data regarding the risk factors associated with a severe course of COVID-19 among patients with multiple sclerosis (pwMS).

Methods: MEDLINE, Embase, Scopus, and WoS were searched in May 2021. Briefly, the eligibility criteria included: 1) studies assessing COVID-19 severity among adult pwMS; 2) definitive diagnoses or high clinical suspicion of COVID-19; 3) a categorization of COVID-19 severity into at least two categories; 4) quantitative effect size and precision measurements; and 5) English language; and 6) clear effect size/precision measures.

Mechanism and adverse effects of COVID-19 drugs: a basic review.

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus disease 2019 (COVID-19) is chronic, inflammatory. Although the exact mechanisms of COVID-19 have not been yet discovered some drugs are found helpful for its treatment.

New Approach for Preparing In Vitro Bioactive Scaffold Consisted of Ag-Doped Hydroxyapatite + Polyvinyltrimethoxysilane.

Recently, researchers have focused on the biocompatibility and mechanical properties of highly porous structures of biomaterials products. Porous composites are a new category of bioengineering that possess excellent functional and structural properties. In this study, the physical and mechanical properties of prepared doped silver (Ag)-hydroxyapatite (HA) by the mechanochemical and spark plasma sintering (SPS) methods were investigated.

MicroRNA-30c delivered by bone marrow-mesenchymal stem cells induced apoptosis and diminished cell invasion in U-251 glioblastoma cell line.

Background: Glioblastoma multiform (GBM) is the most belligerent and prevalent brain malignancy among adults. Due to the blood-brain barrier (BBB), drug administration is confronted by massive challenges, making resectional surgery the only treatment pipeline. MicroRNAs have recently absorbed the attention of studies for correlating with the progression of various malignancies.

Serum level measurement of progranulin in relapsing-remitting multiple sclerosis and neuromyelitis optica patients.

Background: Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system (CNS) with unknown etiology and variable clinical evolution. Although the role of serum progranulin levels in the pathogenesis of MS remains unclear, it is well known that progranulin is involved in several physiological and pathophysiological process of CNS including modulation of neurite outgrowth, neuronal differentiation, and neuronal survival. Therefore, in this study, we aimed to measure serum levels of progranulin in patients with neuromyelitis optica (NMO) and relapsing-remitting multiple sclerosis (RRMS) in comparison with healthy control subjects.

MicroRNA and exosome: Key players in rheumatoid arthritis.

Rheumatoid arthritis (RA) is known as one of important autoimmune disorders which can lead to joint pain and damage throughout body. Given that internal (ie, genetic and epigenetic alterations) and external factors (ie, lifestyle changes, age, hormones, smoking, stress, and obesity) involved in RA pathogenesis. Increasing evidence indicated that cellular and molecular alterations play critical roles in the initiation and progression of RA.

Adsorptive removal of Pb (II) by means of hydroxyapatite/chitosan nanocomposite hybrid nanoadsorbent: ANFIS modeling and experimental study.

In the current study, the prediction efficiency of lead adsorption by highly functional nanocomposite adsorbent of hydroxyapatite (HAp)/chitosan using ANFIS system was investigated. In this regard, the nanocomposite was applied in order to investigate the lead adsorption capacity. The operational conditions were pH (2-6), contact time between lead ions and adsorbent (15-360 min), shaker velocity (80-400 rpm), temperature (25-55 °C), amount of adsorbent (0.

Exosomes and microRNAs: New potential therapeutic candidates in Alzheimer disease therapy.

Exosomes are biological nanocarriers which could be involved in a variety of basic physiological events. They exert their effects via targeting their cargos (i.e.

Design, Synthesis, Biological Evaluation and Molecular Modeling Study of Novel Indolizine-1-Carbonitrile Derivatives as Potential Anti-Microbial Agents.

A novel one-pot two step tandem reaction for the synthesis of indolizine-1-carbonitrile derivatives (5a-i) was identified. The route comprises 1,3-dipolar cycloaddition reaction of aromatic aldehyde derivatives (1a-i), malononitrile (2) and 1-(2-(4-bromophenyl)-2-oxoethyl)-2-chloropyridin-1-ium (4) under ultrasound irradiation at room temperature in the presence of triethylamine at acetonitrile. The product compounds were tested against bacteria and fungi.

A Novel Approach to Discriminate Subgroups in Multiple Sclerosis.

Multiple sclerosis (MS) is an autoimmune disease of central nervous system. Since different types of immune cells are involved in MS pathogenesis, in this study we aimed to evaluate serum levels of several immunological components including soluble CD4 (sCD4), sCD8, sCD163, and immunoglobulins as markers of activity of T-cells, macrophages, and B-cells in different types of MS. Serum levels of sCD4, sCD8, and sCD163 of patients with relapsing-remitting MS (RRMS, n=61), primary progressive MS (PRMS, n=31), secondary progressive MS (SPMS, n=31), clinical isolated syndrome (CIS, n=31) and neuromyelitis optica (NMO, n=31), and healthy controls (n=49) were measured using enzyme-linked immunosorbent assay (ELISA).

Relationship between articular and nonarticular manifestations in inflammatory bowel diseases.

Background: Musculoskeletal manifestations (MSM) of inflammatory bowel diseases (IBDs) are usually the most frequent extraintestinal manifestations. However, they are not paid enough attention during regular office visits. This cross-sectional study aimed to draw a clinical picture of MSM and their relationships with other findings in patients with IBD.