Clinical Features and Genetic Characteristics of XLID Patients With KDM5C Gene Mutations: Insights on Phenotype-Genotype Correlations From 175 Previous Cases and Identification of a Novel Variant.

Background: X-linked intellectual disability (XLID) is a genetically heterogeneous disorder that results in cognitive impairment and developmental delays. Mutations in the KDM5C gene have been identified as a causative factor in XLID. This study aimed to identify novel variants associated with XLID and to investigate the clinical and genetic characteristics of XLID patients with mutations in the KDM5C gene.

Optimization of Green Synthesis Formulation of Selenium Nanoparticles (SeNPs) Using Peach Tree Leaf Extract and Investigating its Properties and Stability.

Background: Selenium nanoparticles (SeNPs) are highly sought after in diverse industries for their distinct properties and advantages. SeNPs can be synthesized via several methods, including the use of microwave, bain-marie, autoclave, and heater.

Objective: The objective is to optimize the SeNP synthesis formulation, emphasizing stability, concentration, particle size minimization, and uniformity using central composite design.

Effects of Amino Acid Supplementation on the Growth Performance of Broiler Chicks Challenged With Coccidiosis: A Meta-Analysis.

This meta-analysis aimed to evaluate the effects of amino acid supplementation on the growth performance of broiler chicks challenged with coccidiosis. Data were collected on authorship, publication year, study sample characteristics and outcomes of interest related to growth performance. Effect sizes were calculated for both overall effects and the individual effects of each amino acid.

The effect of different light spectra on selenium bioaccumulation by cyanobacteria in flat plate photobioreactors.

Selenium (Se) plays a crucial role in human health, influencing conditions such as cancer, diabetes, and neurological disorders. With global population growth and unequal nutrient distribution threatening food security, new approaches are needed to meet the nutritional needs of the world. Se is essential for immune function, metabolism, and antioxidant defense, and in regions suffering from food insecurity and malnutrition, selenium-enriched food could offer an affordable solution.

How can AI-integrated applications affect the financial engineers' psychological safety and work-life balance: Chinese and Iranian financial engineers and administrators' perspectives.

Background: The integration of AI in finance has significantly reshaped the role of financial engineers, improving efficiency and decision-making. However, it also affects psychological safety and work-life balance. Financial engineers face increased pressure to keep up with evolving technologies, fear of job displacement due to automation, and blurred boundaries between work and personal life.

Developing and validating of educational-therapeutic package based on psychological flexibility for nurses in the intensive care unit of COVID-19: Application of grounded theory.

Background: Caring for COVID-19 patients has caused high stress and burnses. Therefore, the current research aims to develop and validate an educational-therapeutic package based on psychological flexibility for COVID-19 nurses.

Materials And Methods: The approach of this research was Exploratory Sequential Mixed Method, which was carried out in 2019 to 2021.

Association between IL-6 -174 G/C (rs1800795) and IL-1A -889 C/T (rs1800587) cytokine variants with polycystic ovary syndrome in Iranian women: A case-control study.

Background And Aim: Infertility in women has various causes, one of which is ovulation disorders. Polycystic ovary syndrome (PCOS) affecting ovulation is a complex idiopathic disease in which genetic polymorphisms may be involved. This study aimed to investigate the relationship between IL-6 -174 G/C and IL-1A -889 G/A cytokine polymorphisms with polycystic ovary syndrome in a population of Iranian women.

Comparative Analysis of the Effects of Magnesium Oxide Nanoparticles on Sperm Parameters in Fresh and Frozen Samples.

Background: Freezing is a crucial technique in reproductive science utilized for the preservation of sperm samples. However, the process of freezing and thawing sperm can result in detrimental effects on sperm quality. One of the major mechanisms underlying this decline in sperm quality is the generation of reactive oxygen species during the freeze process.

Does flaxseed supplementation affect apo-lipoproteins? A GRADE-assessed systematic review and meta-analysis.

Several studies indicated the ameliorating effects of flaxseed supplementation on apolipoproteins, although others have conflicting results. Therefore, the present research was conducted in order to accurately and definitively understand the effect of flaxseed on apolipoproteins in adults. All articles published up to Juan 2024 were systematically searched through PubMed, Scopus, Embase, and Web of Science to collect all randomized clinical trials (RCTs).

The global prevalence of E-cigarettes in youth: A comprehensive systematic review and meta-analysis.

Objectives: Smoking, especially cigarettes, is known as one of the most common social and health problems among people. E-cigarettes are another form of tobacco that has been an ordinary daily occurrence.Study Design: systematic review and meta-analysis.

A novel integration of regret-based methodology and bankruptcy theory for waste load allocation.

Developing a suitable index for Waste Load Allocation (WLA) is essential for both industrial polluters and environmental organizations. Identifying the index that best describes the quality conditions of the river is the main concern of this study. To achieve this purpose, a novel framework incorporating a regret-based index and a bankruptcy-based approach to address the impacts of low water quality and pollutant locations within the WLA are introduced.

Effects of Nigella sativa supplementation on lipid profiles in adults: An updated systematic review and meta-analysis of randomized controlled trials.

Background And Aim: Several experiments have suggested that Nigella sativa (N. sativa) supplementation may have a beneficial effect on the lipid profile. However, the results from these trials have been inconclusive.

Detection of tetanus toxoid with iron magnetic nanobioprobe.

Diagnosis of diseases with low facilities, speed, accuracy and sensitivity is an important matter in treatment. Bioprobes based on iron oxide nanoparticles are a good candidate for early detection of deadly and infectious diseases such as tetanus due to their high reactivity, biocompatibility, low production cost and sample separation under a magnetic field. In this study, silane groups were coated on surface of iron oxide nanoparticles using tetraethoxysilane (TEOS) hydrolysis.

Celiac Disease: A Review from Genetic to Treatment.

Celiac disease (CD) is a complex disorder influenced by genetic and environmental factors. When people with a genetic predisposition to CD consume gluten, an inflammatory response is triggered in the small intestine, and this reaction can be alleviated by the elimination of gluten from the diet. The clinical manifestations of CD vary greatly from person to person and begin at a young age or in adulthood.

Noncoding RNAs and programmed cell death in hepatocellular carcinoma: Significant role of epigenetic modifications in prognosis, chemoresistance, and tumor recurrence rate.

Hepatocellular carcinoma (HCC) is the most common type of liver cancer with a high death rate in the world. The molecular mechanisms related to the pathogenesis of HCC have not been precisely defined so far. Hence, this review aimed to address the potential cross-talk between noncoding RNAs (ncRNAs) and programmed cell death in HCC.

Meta-analysis of microarray data to determine gene indicators involved in cisplatin resistance in non-small cell lung cancer.

Background: Lung cancer is a major cause of cancer-related mortality worldwide, with a 5-year survival rate of approximately 22%. Cisplatin is one of the standard first-line chemotherapeutic agents for non-small cell lung cancer (NSCLC), but its efficacy is often limited by the development of resistance. Despite extensive research on the molecular mechanisms of chemoresistance, the underlying causes remain elusive and complex.

Movement examination of the lumbar spine using a developed wearable motion sensor.

A system for monitoring spinal movements based on wearable motion sensors is proposed here. For this purpose, a hardware system is first developed that measures data of linear acceleration, angular velocity, and the magnetic field of the spine. Then, the obtained data from these sensors are combined in a proposed complementary filter, and their angular variations are estimated.

Analysis of Elements and Physicochemical and Microbial Properties of Iranian Honeys.

Honey is one of the most valuable food products, which, in addition to its nutritional value, also has therapeutic properties. In our study, the physicochemical (Brix, viscosity, free acid content, pH, moisture, diastase activity, 5-hydroxymethylfurfural (HMF), proline content, sugars content, and reducing sugars content) and microbial (mold and yeast content) characteristics and 15 element contents (As, Cd, K, Al, Pb, Hg, Ba, Ni, Na, Ca, Mg, Fe, Mn, Zn, and Se) of the samples were evaluated. Among the essential elements, the maximum mean was related to K (630 ± 50.

Antibody-modified Gold Nanobiostructures: Advancing Targeted Photodynamic Therapy for Improved Cancer Treatment.

Photodynamic therapy (PDT) is an innovative, non-invasive method of treating cancer that uses light-activated photosensitizers to create reactive oxygen species (ROS). However, challenges associated with the limited penetration depth of light and the need for precise control over photosensitizer activation have hindered its clinical translation. Nanomedicine, particularly gold nanobiostructures, offers promising solutions to overcome these limitations.

CHMMOTv1 - cardiac and hepatic multi-echo (T2) MRI images and clinical dataset for Iron overload on thalassemia patients.

Introduction: Regarding deep learning networks in medical sciences for improving diagnosis and treatment purposes and the existence of minimal resources for them, we decided to provide a set of magnetic resonance images of the cardiac and hepatic organs.

Database Description: The dataset included 124 patients (67 women and 57 men) with thalassemia (THM), the age range of (5-52) years. Patients were divided into two groups: with follow-up (1-5 times) at time intervals of about (5-6) months and without follow-up.