Numerical examination of expanding the effectiveness of thermal photovoltaic framework by changing the level of heat transfer conveyance.

In photovoltaic systems, only a tiny portion of solar radiation reaches the module's surface and is converted to electrical energy. The remaining solar radiation is wasted, which raises cell temperature and reduces electrical efficiency. This research focused on examining the effects of different factors on nanofluids.

Rutin-coated zinc oxide nanoparticles: a promising antivirulence formulation against pathogenic bacteria.

The use of engineered nanoparticles against pathogenic bacteria has gained attention. In this study, zinc oxide nanoparticles conjugated with rutin were synthesized and their antivirulence properties against Pseudomonas aeruginosa and Staphylococcus aureus. The physicochemical characteristics of ZnO-Rutin NPs were investigated using SEM, FT-IR, XRD, DLS, EDS, and zeta potential analyses.

The critical role and functional mechanism of microRNA-146a in doxorubicin-induced apoptosis in breast cancer cells.

Background: Breast cancer among women is the most frequently diagnosed cancer and the leading cause of death worldwide. There many advances in diagnosing and treating this disease, early diagnosis and treatment are still a significant challenge in the early stages. In recent years, microRNAs have attracted much attention in cancer diagnosis and treatment.

Advances in microbial exoenzymes bioengineering for improvement of bioplastics degradation.

Plastic pollution has become a major global concern, posing numerous challenges for the environment and wildlife. Most conventional ways of plastics degradation are inefficient and cause great damage to ecosystems. The development of biodegradable plastics offers a promising solution for waste management.

Internal absorbed dose calculation in body organs due to injection of Rhenium-188 labeled to Mu-9 antibody.

The use of radiopharmaceuticals has gained a special place in the diagnosis and treatment of cancers and evaluation of the function of different organs of the body. In this study, the absorbed dose distribution of organs after injection of Re-Mu-9 has been investigated using MIRD method and MCNP-4C simulation code. The Re-Mu-9 labeled was injected the mouse body and the amount of Re-labeled accumulation was evaluated after 1, 4 and 2 4 h.

Diclofenac-loaded PLGA nanoparticles downregulate LasI/R quorum sensing genes in pathogenic P. aeruginosa isolates.

Poly(lactic-co-glycolic acid) (PLGA) is a biocompatible polymer that can gradually and consistently release drugs in a controlled manner. In this study, diclofenac sodium-loaded PLGA nanoparticles (DS-PLGA NPs) were produced by solvent evaporation technique and characterized using SEM, DLS, and zeta potential analyses. The antibacterial and antivirulence potential of DS-PLGA NPs against P.

Harnessing CRISPR technology for viral therapeutics and vaccines: from preclinical studies to clinical applications.

The CRISPR/Cas system, identified as a type of bacterial adaptive immune system, have attracted significant attention due to its remarkable ability to precisely detect and eliminate foreign genetic material and nucleic acids. Expanding upon these inherent capabilities, recent investigations have unveiled the potential of reprogrammed CRISPR/Cas 9, 12, and 13 systems for treating viral infections associated with human diseases, specifically targeting DNA and RNA viruses, respectively. Of particular interest is the RNA virus responsible for the recent global outbreak of coronavirus disease 2019 (COVID-19), which presents a substantial public health risk, coupled with limited efficacy of current prophylactic and therapeutic techniques.

CRISPR/Cas9-mediated base editors and their prospects for mitochondrial genome engineering.

Base editors are a type of double-stranded break (DSB)-free gene editing technology that has opened up new possibilities for precise manipulation of mitochondrial DNA (mtDNA). This includes cytosine and adenosine base editors and more recently guanosine base editors. Because of having low off-target and indel rates, there is a growing interest in developing and evolving this research field.

Synthesis of colloidal silica nanofluid and assessment of its impact on interfacial tension (IFT) and wettability for enhanced oil recovery (EOR).

Ever-increasing global energy demand, from one hand and reduced oil initially in place in oil reservoirs due to production and reduced natural reservoir production capacity, on the other hand, has encouraged researchers to investigate different methods to improve and increase enhanced oil recovery (EOR) from oil reservoirs. One method is to employ nanotechnology in injected water, where nanoparticles could affect interfacial tension (IFT) between water and oil and wettability through properties, including high specific surface area and nanoparticle size. However, a major challenge in using nanoparticles in injected water is the instability of these particles in water, which ultimately reduces the efficiency of EOR.

Toxicity of Carboplatin-Niosomal Nanoparticles in a Brain Cancer Cell Line.

Objective: Cancer poses a significant challenge in modern medicine, standing as the primary cause of death in many countries, second only to cardiovascular diseases. Among the various treatments available, carboplatin, a chemotherapy drug, is employed for specific cancer types, including brain carcinoma. The main objective of this investigation is to enhance the therapeutic efficacy of carboplatin by utilizing niosomal nanocarriers.

Characteristics and Cytotoxic Effects of Nano-Liposomal Paclitaxel on Gastric Cancer Cells.

Objective: Addressing both the initial treatment response and subsequent paclitaxel resistance is a pivotal concern. Nano drug delivery, an emerging approach, presents a cutting-edge alternative to conventional chemotherapy.

Methods: This investigation synthesized PEGylated nanoparticles (NPs) via the Reverse Phase Evaporation technique for liposomal NPs.

Artificial intelligence in estimating fractional flow reserve: a systematic literature review of techniques.

Background: Fractional Flow Reserve (FFR) is the gold standard for the functional evaluation of coronary arteries, which is effective in selecting patients for revascularization, avoiding unnecessary procedures, and reducing treatment costs. However, its use is limited due to invasiveness, high cost, and complexity. Therefore, the non-invasive estimation of FFR using artificial intelligence (AI) methods is crucial.

The potential therapeutic effects of Galbanic acid on cancer.

Galbanic acid (GBA), as a natural compound has potential anticancer properties. It has been documented that GBA shows promising therapeutic potential against various types of cancer, including breast, lung, colon, liver, and prostate cancer. Several mechanisms involve im anti-tumor effects of GBA include apoptosis induction, cell cycle arrest, inhibition of angiogenesis, suppression of metastasis, and modulation of immune responses.

Modeling land use/cover change based on LCM model for a semi-arid area in the Latian Dam Watershed (Iran).

The monitoring and modeling of changes, based on a time-series LULC approach, is fundamental for planning and managing regional environments. The current study analyzed the LULC changes as well as estimated future scenarios for 2027 and 2037. To achieve accuracy in predicting LULC changes, the Land Change Modeler (LCM) was used for the Latian Dam Watershed, which is located approximately in the northeast of Tehran.

Human Dose Assessment of Ga-NODAGA-RGD-BBN Heterodimer Peptide based on Animal Data.

Aims: Calculation of the absorbed dose in human organs is one of the first steps for developing new radiopharmaceuticals. The aim of this study is to estimate the human absorbed dose of a newly developed Ga-NODAGA-RGD-BBN radiolabeled compound.

Materials And Methods: Ga-NODAGA-RGD-BBN was prepared by varying different parameters at optimized conditions.

Impact of elicitors on essential oil compositions and phytochemical constituents in Lavandula stoechas L.

Lavandula stoechas L. (LS) is an aromatic evergreen herb used broadly in the food, pharmaceutical, and perfume industries. However, the inducer effect of elicitors on secondary metabolites (SMs) biosynthesis in LS is nebulous.

Development of an online cancer data collection and processing tool for population-based cancer registries in a low-resource setting: The CanDCap experience from Golestan, Iran.

Background: Golestan Population-based Cancer Registry (GPCR) with more than 15-years experiences developed an in-house online software called Cancer Data Collection and Processing (CanDCap) to improve its data collection operations from the conventional offline method to new online method. We aimed to report the methods and framework that GPCR applied to design and implementation of the CanDCap.

Methods: CanDCap was designed based on International Agency for Research on Cancer (IARC) protocols and standards and according to the GPCR workflow.

A Review on Biotechnological Approaches Applied for Marine Hydrocarbon Spills Remediation.

The increasing demand for petroleum products generates needs for innovative and reliable methods for cleaning up crude oil spills. Annually, several oil spills occur around the world, which brings numerous ecological and environmental disasters on the surface of deep seawaters like oceans. Biological and physico-chemical remediation technologies can be efficient in terms of spill cleanup and microorganisms-mainly bacteria-are the main ones responsible for petroleum hydrocarbons (PHCs) degradation such as crude oil.

Effects of Guideline-based Computerized Provider Order Entry Systems on the Chemotherapy Order Process: a Systematic Review.

Background: Computerized Provider Order Entry (CPOE) systems developed based on clinical guidelines are believed to greatly reduce chemotherapy medication prescription errors.

Objective: The present study reviewed the effects of guideline-based CPOEs on the chemotherapy order process.

Methods: PubMed, Scopus, Embase, Web of Science, and IEEE Xplore databases published up to 1 June 2020 were systematically searched for studies investigating the effect of guideline-based CPOEs on the chemotherapy order process.

Measuring the customer satisfaction of public transportation in Tehran during the COVID-19 pandemic using MCDM techniques.

The expeditiously spreading of coronavirus disease 2019 (COVID-19) has affected every facet of human lives, including transportation. Due to some characteristics of COVID-19, like high infectivity, people prefer to use their private cars more than before. On the one hand, this circumstance caused public transportation to face an unprecedented decrease in demand and, consequently, revenue.

Ibuprofen involves with the reduced expression of pelD and pelF in pathogenic Pseudomonas aeruginosa strains.

Biofilm formation is an important factor in disease development by Pseudomonas aeruginosa. Similar to many bacterial species, biofilm formation in P. aeruginosa is regulated by the bacterial quorum sensing system.

Association between the Expression Levels of MicroRNA-101, -103, and -29a with Autotaxin and Lysophosphatidic Acid Receptor 2 Expression in Gastric Cancer Patients.

Background: Gastric cancer (GC) is regarded as the most prevalent malignancy with the high mortality rate, worldwide. However, gastroscopy, a biopsy of suspected sample, and detecting CEA, CA19-9, and CA72-4 are presently used, but these diagnostic approaches have several limitations. Recently, microRNAs as the most important member of noncoding RNAs (ncRNAs) have received attention; recent evidence demonstrates that they can be used as the promising candidate biomarkers for GC diagnosis.

Does ibuprofen affect the expression of alginate genes in pathogenic Pseudomonas aeruginosa strains?

Conversion to mucoid form is a crucial step in the pathogenesis of P. aeruginosa in burns and cystic fibrosis (CF) patients. Alginate is considered the major component of biofilm and is highly associated with the formation of mucoid biofilm in this species.

The in-vitro study of novel phospholipid micelles loaded with amphotericin B on plasmodium falciparum protozoan.

Malaria is one of the most challenging parasitic infectious diseases in tropical and subtropical regions all over the world. The increasing drug resistance of plasmodium falciparum even makes the treatment procedure of malaria challenging and more problematic. Therefore, it is essential to develop new antimalarial drugs for effective treatments.