Interaction of genetics risk score and fatty acids quality indices on healthy and unhealthy obesity phenotype.

Background: The growth in obesity and rates of abdominal obesity in developing countries is due to the dietary transition, meaning a shift from traditional, fiber-rich diets to Westernized diets high in processed foods, sugars, and unhealthy fats. Environmental changes, such as improving the quality of dietary fat consumed, may be useful in preventing or mitigating the obesity or unhealthy obesity phenotype in individuals with a genetic predisposition, although this has not yet been confirmed. Therefore, in this study, we investigated how dietary fat quality indices with metabolically healthy obesity (MHO) or metabolically unhealthy obesity (MUO) based on the Karelis criterion interact with genetic susceptibility in Iranian female adults.

Uncovering cerebral blood flow patterns corresponding to Amyloid-beta accumulations in patients across the Alzheimer's disease continuum using the arterial spin labeling.

Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder ranging from mild cognitive impairment (MCI) to AD dementia. Abnormal cerebral perfusion alterations, influenced by amyloid-beta (Aβ) accumulations, have been implicated in cognitive decline along this spectrum.

Objective: This study investigates the relationship between cerebrospinal fluid (CSF) Aβ1-42 levels and regional cerebral blood flow (CBF) changes across the AD continuum using the Arterial Spin Labeling (ASL) technique.

Investigating the validity of mCIM and sCIM phenotypic methods in screening Pseudomonas aeruginosa isolates producing IMP, VIM, and NDM metallo-beta-lactamases isolated from burn wounds.

Metallo-beta-lactamase-producing Pseudomonas aeruginosa (P. aeruginosa) is a major pathogen in burn wounds, often exhibiting high levels of antibiotic resistance, which complicates treatment strategies. This study deals with the validity of the modified Carbapenem Inactivation Method (mCIM) and the simplified Carbapenem Inactivation Method (sCIM) phenotypic tests for screening metallo-beta-lactamase (MBL) production by P.

Targeting ferroptosis in gastrointestinal tumors: Interplay of iron-dependent cell death and autophagy.

Ferroptosis is a regulated cell death mechanism distinct from apoptosis, autophagy, and necroptosis, marked by iron accumulation and lipid peroxidation. Since its identification in 2012, it has developed into a potential therapeutic target, especially concerning GI disorders like PC, HCC, GC, and CRC. This interest arises from the distinctive role of ferroptosis in the progression of diseases, presenting a new avenue for treatment where existing therapies fall short.

Differences in the distribution of steroids in sterol-containing liposomes: A study by liposome electrokinetic chromatography.

This study was conducted to investigate possible differences in the interactions of some selected steroids based on their distribution coefficients with cholesterol- or ergosterol-rich liposomes. Structurally cholesterol and ergosterol have very close resemblance to each other and generally it is thought that they behave in a similar manner. In this work we will show that this is not the case.

Improvement of ovarian function in a premature ovarian failure mouse model using Vitex agnus-castus extract.

Objective: Premature ovarian failure (POF) leads to infertility. Numerous researchers have endeavored to enhance ovarian function through antioxidant interventions. Extract from Vitex agnus-castus (VAC) has demonstrated a protective effect.

Clinical Features and Genetic Characteristics of XLID Patients With KDM5C Gene Mutations: Insights on Phenotype-Genotype Correlations From 175 Previous Cases and Identification of a Novel Variant.

Background: X-linked intellectual disability (XLID) is a genetically heterogeneous disorder that results in cognitive impairment and developmental delays. Mutations in the KDM5C gene have been identified as a causative factor in XLID. This study aimed to identify novel variants associated with XLID and to investigate the clinical and genetic characteristics of XLID patients with mutations in the KDM5C gene.

Differential Impact of VNTR Polymorphism in the CBS Gene on Gastric and Breast Cancers Risk.

The cystathionine beta-synthase (CBS) gene plays a critical role in numerous physiological processes, including cellular proliferation, bioenergetics, and redox balance, and has been implicated in many cancers, including breast and gastric cancers. Previous studies have suggested that VNTR polymorphism in intron 13 of the CBS gene may influence enzyme activity, as an increase in the number of repeats in this VNTR leads to a reduction in the activity of the CBS enzyme. In this case-control study, for the first time, we genotyped 107 patients with gastric cancer (and 111 healthy controls) and 138 patients with breast cancer (and 124 healthy controls) for the CBS VNTR polymorphism using PCR.

The role of CXCL12/CXCR4/CXCR7 axis in cognitive impairment associated with neurodegenerative diseases.

Neurodegenerative diseases, including Alzheimer's Disease (AD), Parkinson's Disease (PD), Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS), are characterized by progressive neuronal loss and cognitive impairment (CI). The: Cysteine-X-cysteine chemokine ligand 12(CXCL12)/CXC chemokine receptor type 4 (CXCR4)/CXC chemokine receptor type 7 (CXCR7) axis has emerged as a critical molecular pathway in the development of CI in these disorders. This review explores the role of this axis in the pathogenesis of CI across these neurodegenerative diseases, synthesizing current evidence and its implications for targeted therapies.

Synthesis and Evaluation of PCL/Chitosan/CQD-Fe Magnetic Nanocomposite for Wound Healing: Emphasis on Gene Expression.

The development of an effective and rapid method for healing the skin is of crucial importance. In this study, we prepared a porous scaffold made of polycaprolactone (PCL) and carbon quantum dots (CQDs), Fe, and Chitosan (Cs) as the scaffold core to cover the skin. Then evaluated antibacterial, biocompatibility, and wound healing properties as well as the expression of genes effective in wound healing.

Free vibration and buckling analysis of axially functionally graded tapered Timoshenko beams using B-spline-based isogeometric analysis.

This study considers Timoshenko beam theory and the isogeometric analysis method to investigate the free vibration and buckling of axially functionally graded (AFG) tapered beams. The governing equations are obtained from the kinematic assumptions of Timoshenko beam theory and Hamilton's principle. The isogeometric analysis approach is implemented to solve the motion equations.

A comprehensive overview of FFRG and IHCC allograft cartilages in revision rhinoplasty: a systematic review.

Background: This study aims to compare the complications and satisfaction associated with favorable allografts, Fresh Frozen Rib Graft (FFRG) and Irradiated Homologous Costal Cartilage (IHCC), in revision rhinoplasty.

Methods: The PRISMA guidelines were adhered to in the conduct of this systematic review. No limitations were applied to the types of studies included.

Source apportionment, ecological and health risks of potentially toxic elements in street dusts across different land uses in city of Kermanshah, Iran.

In this study, the contamination, ecological and human health risks as well as source apportionment of As, Cd, Co, Cr, Cu, Mn, Ni, Pb, Zn, and V in street dusts of different land-uses in Kermanshah, Iran were investigated. A total of 192 dust samples were taken from 16 sites and were analyzed for their elemental contents using ICP-OES. The computed mean values for the geo-accumulation index (I-geo) and the pollution index (PI) ranged from - 6.

Differential effects of β-hydroxybutyrate and α-ketoglutarate on HCT-116 colorectal cancer cell viability under normoxic and hypoxic low-glucose conditions: exploring the role of SRC, HIF1α, ACAT1, and SIRT2 genes.

Recent therapeutic strategies have highlighted the potential of β-hydroxybutyrate (BHB) and α-ketoglutarate (α-KG) as effective anticancer agents, particularly for colon cancer. These metabolites can modulate cellular metabolism and induce epigenetic changes, inhibiting tumor growth. Nonetheless, certain cancer cells may utilize ketone bodies, like BHB as nutrient sources under hypoxic conditions, potentially reducing treatment efficacy.

Optimal sizing model of battery energy storage in a droop-controlled islanded multi-carrier microgrid based on an advanced frequency droop model.

This paper introduces an optimal sizing approach for battery energy storage systems (BESS) that integrates frequency regulation via an advanced frequency droop model (AFDM). In addition, based on the AFDM, a new formulation for charging/discharging of the battery with the purpose of system frequency control is presented. The studied MG system that consists of PV units, a diesel generator (DG), a combined heat and power (CHP) unit, a gas boiler, and a BESS is designed to meet the consumers' thermal and electrical load requirements as well as system frequency regulation.

Calcium carbonate sediment corrosion and formation investigation in drinking water distribution network in Sough City, Iran.

One of the major problems facing the water industry is corrosion and sedimentation, which causes problems such as reduced water quality and the useful life of water supply network equipment. This study aimed to investigate the corrosion and sediments formed in the drinking water distribution network of Sough City. In this cross-sectional study, samples were prepared from 7 wells, water storage reservoirs, and a dedicated water supply network in this area from 2006 to 2017.

Dual COX-2/TNF-α Inhibitors as Promising Anti-inflammatory and Cancer Chemopreventive Agents: A Review.

Cyclooxygenases (COX) play a pivotal role in inflammation and are responsible for the production of prostaglandins (PGs). Two types of COXs have been identified as key biological targets for drug design: Constitutive COX-1 and inducible COX-2. Nonsteroidal anti-inflammatory drugs (NSAIDs) target COX-1, while selective COX-2 inhibitors are designed for COX-2.

C-Phycocyanin and Phycocyanobilin as a Novel Adjuvant in Hepatitis B Vaccine.

Background: Vaccine adjuvants are components that enhance immune responses to an antigen. Given the importance of adjuvants, research on novel adjuvants with higher efficacy and fewer adverse effects remains crucial. ( sp.

Dendrosomal Curcumin Showed Cytotoxic Effects on Breast Cancer Cell Line by Inducing Mitochondrial Apoptosis Pathway and Cell Division Arrest.

Background: Mutations in the have been linked to the initiation and progression of breast cancer, as well as resistance to chemotherapy. Therefore, the development of novel treatment approaches is essential to combat this disease.

Objectives: This study aimed to evaluate the effects of dendrosomal curcumin (DNC) on the breast cancer cell line MDA-MB231.

Investigation of the Cytotoxic and Antiproliferative Effects of Liposomal Daunorubicin on Human Colorectal Cancer (HCT116) Cell Line.

Background: The incidence of colorectal cancer is increasing globally. Daunorubicin (DNR), an anthracycline antibiotic, is effective against various cancers. The PI3K/AKT/mTOR signaling pathway is crucial in regulating cell growth and cancer growth.

Quantitative in-vitro evaluation of enamel surface roughness following two debonding procedures using laser scanning confocal microscope.

Background: The objective of the in vitro study was to evaluate the impact of two adhesive removal techniques on the surface roughness of the human enamel surface using laser scanning confocal microscopy (LSCM).

Methods: Forty healthy first upper molar teeth were included in this experiment (20 teeth per each group). T0 measurement of surface roughness parameter of the teeth were conducted using LSCM.

Recognition and classification of facial expression using artificial intelligence as a key of early detection in neurological disorders.

The recognition and classification of facial expressions using artificial intelligence (AI) presents a promising avenue for early detection and monitoring of neurodegenerative disorders. This narrative review critically examines the current state of AI-driven facial expression analysis in the context of neurodegenerative diseases, such as Alzheimer's and Parkinson's. We discuss the potential of AI techniques, including deep learning and computer vision, to accurately interpret and categorize subtle changes in facial expressions associated with these pathological conditions.

Polyethylene nanoplastics affected morphological, physiological, and molecular indices in tomato (Solanum lycopersicum L.).

This study explored morphological, physiological, molecular, and epigenetic responses of tomatoes (Solanum lycopersicum) to soil contamination with polyethylene nanoplastics (PENP; 0.01, 0.1, and 1 gkg soil).

Phylogenetic and molecular analysis of hemagglutinin gene and Fsp-coding region of canine distemper virus: Insight into novel vaccine development.

Canine distemper virus (CDV) causes a highly contagious and lethal disease in a vast range of carnivorous and non-carnivorous species. The study aimed to genetically investigate the hemagglutinin (H) gene and Fsp-coding region of CDV isolates from vaccinated dogs. Phylogenetic analysis of the H gene and Fsp-coding region showed that our viruses belonged to the Arctic-like lineage which was distinct from two commonly used vaccine strains (America-1 lineage strains) in Iran.

The ANFIS-RSM based multi-objective optimization and modelling of ultrasound-assisted extraction of polyphenols from jamun fruit (Syzygium cumini).

Given their potential as natural substitutes for artificial additives and their health advantages, the extraction of bioactive substances like polyphenols from plant sources is becoming more and more significant. Nevertheless, it is still difficult to achieve effective extraction with minimal time and energy. In order to optimize polyphenol extraction from ripe jamun fruit pulp, including traditional and ultrasound-assisted methods, this study assessed the prediction power of response surface methodology (RSM) and adaptive neuro-fuzzy inference systems (ANFIS).