The immune cells profiles of individuals with sulfur mustard-induced serious long-term respiratory complications.

Sulfur mustard (SM) induced pulmonary disorder is a heterogeneous disease characterized by uncontrolled inflammatory immune responses. In this cross-sectional study carried out in Isfahan-Iran, our objective was to thoroughly evaluate the clinical health and peripheral blood leukocyte profiles of adult veterans exposed to SM 25-30 years. In total, 361 people were studied in two groups, 287 chemical veterans with pulmonary complications and 64 healthy individuals as a control group.

A randomized, controlled trial study of the effectiveness of mindfulness-based stress reduction program on depression and physical problems in depressed elderly individuals.

The aim of this study was to investigate the effectiveness of mindfulness-based stress reduction (MBSR) program on depression and physical problems in depressed elderly individuals. This randomized controlled trial was conducted on two groups of 30 depressed elderly individuals over 60 years old using purposive sampling. The GDS and the PE-PSI questionnaires were administered to both groups before and after the intervention.

Psychometric properties of Persian version of health literacy for Iranian school-age children scale.

Health literacy may play an important role in the attainment of the United Nations Sustainable Development Goals. The aim of this study was to assess the psychometric properties of the Persian version of Health Literacy for School-Aged Children (P-HLSAC) employing data that covered the entire school path. This cross-sectional study was conducted in 2023-24 among 605 school-aged students in Isfahan, Iran.

Placenta location, a prognostic determinant for the incidence of preeclampsia.

Background: Preeclampsia is one of the complications of pregnancy with uncertain etiology. Nevertheless, it is believed that the condition may arise due to abnormal trophoblastic invasion, resulting in vascular remodeling and increased resistance in the spiral arteries. It is assumed that the location of the placenta might have contributed to the formation of trophoblastic invasion and further placental supply.

Degradation of azo dye (direct red 89) using HO/periodate process- parameter optimization and mixture composition evaluation.

As a fast and efficient process, a periodate (PI)-based advanced oxidation process was used to degrade direct red 89 (DR89), wherein hydrogen peroxide (HO) was employed to activate PI (HO/PI process) to investigate the effect of operating parameters and mixture composition. The PI was efficiently activated by HO to degrade 67% of DR89 within 1 min. Acidic pH was more favorable to high-efficiency degradation than the basic pH; at pH 3 degradation rate was 94.

NRF-Mediated Autophagy and UPR: Exploring New Avenues to Overcome Cancer Chemo-Resistance.

The development of chemo-resistance remains a significant hurdle in effective cancer therapy. NRF1 and NRF2, key regulators of redox homeostasis, play crucial roles in the cellular response to oxidative stress, with implications for both tumor growth and resistance to chemotherapy. This study delves into the dualistic role of NRF2, exploring its protective functions in normal cells and its paradoxical support of tumor survival and drug resistance in cancerous cells.

Interactions of spontaneous abortion with gene and dietary carotenoids; a case-control study.

Spontaneous abortion (SA) is considered one of the most prevalent adverse outcomes of pregnancy. SA may occur due to genetic susceptibility and various maternal factors such as nutritional status. The aim of this study was to assess how dietary carotenoids and the gene are related to SA.

Development, implementation, and evaluation of a spiritual health promotion program for mothers of children with acute leukemia based on mobile health: A mixed-methods protocol study.

Background: Considering the importance of the spiritual health promotion of Mothers of Children with Acute Leukemia (MoCwAL), designing a native mobile health (mHealth) application that is compatible with the beliefs, values, and cultural context of Iranian society is essential. This study aims to develop a Spiritual Health Promotion Program (SHPP) for MoCwAL based on a mHealth application, including design, implementation, and evaluation.

Materials And Methods: This is a sequential exploratory mixed-methods study (qual → QUAN).

Improving the quality of psychiatric residency training in Isfahan University of Medical Sciences by learning teams and changing curriculum implementation: An action research study.

Background: The deficiencies in the training of psychiatric residents in Isfahan, including the segregation of residency programs by year, the confinement of training to hospital departments, and the residents' limited exposure to the perspectives of other faculty members, had not been given significant attention. However, the inevitable alterations in the Department of Psychiatry and the impact of the coronavirus disease 2019 pandemic have brought these issues to the forefront, highlighting the need for program modifications. The objective of this study is to enhance the quality of psychiatric residency training by changing the implementation of the curriculum.

Population aging management from the perspective of the health field of Iran and other countries: A scoping review.

Population aging is one of the challenging phenomena where due to health changes and the importance of different levels of prevention, the country's health system is most responsible for it. Therefore, it is responsible for providing responsible service and dealing with challenges and obstacles to successfully face the aging phenomenon. In this regard, the study was conducted aiming to identify inefficiencies and solutions to face the phenomenon of population aging from the perspective of the health field in Iran and other countries.

The effect of dignity therapy on anxiety and depression in patients with chronic obstructive pulmonary disease: A randomized clinical trial.

Background: Anxiety and depression can prolong the treatment process and impose financial burdens on the health system in chronic obstructive pulmonary disease. Dignity therapy is one of the methods of eliminating these symptoms. The present study was conducted to investigate the effect of dignity therapy on the severity of anxiety and depression in patients with chronic obstructive pulmonary disease.

A novel smartphone application for bladder cancer management (BCM App): Design, development, and usability evaluation.

Background: Providing clinical guidelines to clinicians using innovative technologies seems practical and useful. This study aimed to design, develop, and evaluate a smartphone application to assist urologists in managing bladder cancer (BCM App).

Materials And Methods: The study was conducted in three phases, following the user-centered design model, at the urology clinic of Khorshid Hospital (Isfahan, Iran) in 2021.

Development of occupational well-being measurement model in the employee of Abadan University of Medical Sciences.

Background: Given the importance of healthcare centers and the employees of medical centers and affiliated institutions in providing comprehensive health services to the community, especially patients, as well as training the students in health-related fields, it is crucial to address the occupational well-being of university employees who are prone to physical and mental disorders. Therefore, this study aims to develop a model for the occupational well-being of employees at the Abadan University of Medical Sciences.

Materials And Methods: Two hundred Abadan University of Medical Sciences employees were selected using stratified sampling.

A Systematic Review on Clinical Evidence for Topical Metformin: Old Medication With New Application.

Background And Aims: Metformin is a widely used oral agent for controlling diabetes mellitus, but it also has other therapeutic benefits for various conditions. In addition, conventional oral metformin, and topical metformin have been used in, in-vitro studies in the treatment of acne, psoriasis, wound healing, and and so forth. While topical metformin has shown promising results in animal studies, there is limited data on its effectiveness in humans.

Community-Acquired Pneumonia in Adults: A Mono-Center Retrospective Study.

Background: Adult community-acquired pneumonia is the most common cause of hospitalization and a leading cause of death. Identification of microorganisms causing community-acquired pneumonia.

Materials And Methods: A cross-sectional design was used.

Ataxia With Vitamin E Deficiency: Case Series, Vitamin E Therapy Response, Founder Effect, and In Silico Analysis.

Ataxia with Vitamin E Deficiency (AVED) is a rare autosomal recessive genetic disorder, that caused by pathogenic variants in the TTPA gene, which encodes the alpha-tocopherol transfer protein. This study investigates eight patients from three consanguineous Iranian families, using exome sequencing (ES) and Sanger sequencing to identify novel pathogenic variants in the TTPA gene. Two variants were identified: c.

New horizons for promising influences of sulforaphane in the management of metabolic syndrome: a mechanistic review.

The disorder known as metabolic syndrome (MetS) represents a substantial threat to society since it is linked to a higher risk of heart disease, diabetes, stroke, and other health issues. Although there is no known cure for metabolic syndrome, lifestyle changes in diet and physical activity can help. Sulforaphane (SFN), a compound in cruciferous vegetables, has been recognized as a promising treatment for addressing metabolic syndrome.

NF-κB pathway and angiogenesis: insights into colorectal cancer development and therapeutic targets.

Colorectal cancer (CRC) is currently ranked as the third most common type of cancer, contributing significantly to mortality and morbidity worldwide. Epigenetic and genetic changes occurred during CRC progression resulted in the cell proliferation, cancer progression, angiogenesis, and invasion. Angiogenesis is one of the crucial steps during cancer progression required for the delivery of essential nutrients to cancer cells and removes metabolic waste.

Cardiovascular disease burden in the North Africa and Middle East region: an analysis of the global burden of disease study 1990-2021.

Aims: Cardiovascular diseases (CVD) are a leading cause of mortality and morbidity in the North Africa and Middle East (NAME) region. Due to the paucity of research on this issue, we aimed to estimate the burden of CVD and its attributable risk factors in the NAME region.

Methods And Results: Data from the Global Burden of Disease (GBD) were retrieved to estimate the incidence, prevalence, deaths, years of life lost, years lived with disability, disability-adjusted life years (DALYs) for CVD across 21 countries and both sexes.

Impact of shock index (SI), modified SI, and age-derivative indices on acute heart failure prognosis; A systematic review and meta-analysis.

Background: Heart failure (HF) is still associated with quite considerable mortality rates and usage of simple tools for prognosis is pivotal. We aimed to evaluate the effect of shock index (SI) and its derivatives (age SI (ASI), modified SI (MSI), and age MSI (AMSI)) on acute HF (AHF) clinical outcomes.

Methods: PubMed/Medline, Scopus and Web of science databases were screened with no time and language limitations till February 2024.

The impact of home care on individuals with chronic heart failure: A comprehensive review.

Background: Heart failure is a widespread condition linked to elevated mortality rates, readmission incidents, and healthcare expenditures. Home care has emerged as a promising strategy for managing patients with heart failure. This study seeks to comprehensively review the impact of home care on individuals diagnosed with heart failure.

Temporal trend of short-term mortality in acute myocardial between 2000-2017: A multi-centric Iranian registry.

Background: The study explores the enduring challenges of cardiovascular disease mortality, emphasizing myocardial infarction rates as a proxy for cardiovascular disease in Iran. It analyzes the 28-day mortality trends after Acute Myocardial Infarction (AMI) from 2000 to 2017.

Methods: This retrospective cohort study is based on data from a multi-centric hospital-based registry in Isfahan.

Coronary artery calcification score as the determinant of coronary artery disease in chronic kidney disease patients: A preliminary study.

Background: Coronary computed tomography angiography (CCTA) is a noninvasive cardiovascular imaging procedure that visualizes coronary artery calcifications (CAC), a marker of subclinical atherosclerosis. Due to different calcification patterns in patients with chronic kidney disease (CKD) compared to the general population, this study aims to present diagnostic cut-off values for CAC to detect early coronary artery disease (CAD) in CKD patients.

Methods: This cross-sectional study included 807 patients: 407 with CKD and 400 controls with normal kidney function who underwent CCTA during 2019-2021.

Molecular surveillance and antimicrobial susceptibility profile of bacterial contamination in pastries of Iranian confectioneries: a public health concern.

Introduction: Microbial contamination in food products such as pastries, poses a significant public health concern due to the potential risks of foodborne infection and outbreak, Therefore, to prevent these infections, it is essential to investigate the frequency and extent of microbial contamination as well as the level of drug resistance in pastries. Due to this issue, our study aimed to assess the microbial diversity and the drug susceptibility patterns of microbial pollutants in pastry shops in Markazi province, Iran.

Methods: The study involved collecting 120 pastry samples from 30 pastry shops in Markazi province, Iran.