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Heterozygosis deficit of polymorphic markers linked to the β-globin gene cluster region in the Iranian population.
Iran J Basic Med Sci
June 2015
Division of Genetics, Department of Biology, Faculty of Science, University of Isfahan, Isfahan, Iran ; Molecular Genetics Department, Isfahan Medical Genetics Center, Isfahan, Iran.
Objectives: Iran is considered as one of the high-prevalence areas for β-thalassemia with a rate of about 10% carrier frequency. Molecular diagnosis of the disease is performed both by direct sequencing and indirectly by the use of polymorphic markers present in the beta globin gene cluster. However, to date there is no reliable information on the application of the markers in the Iranian population.
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