2 results match your criteria: "Isahaya Ryoiku Center[Affiliation]"
Treatment of gastric hemorrhage by pulverized omeprazole and antacid--concomitant administration via a nasogastric tube.
Int J Clin Pharmacol Ther
November 2004
Department of Hospital Pharmacy, Isahaya Ryoiku Center, Nagasaki, Japan.
Gastroesophageal reflux (GER) is a common episode in pediatric patients with severe motor and intellectual disabilities (SMID) and occasionally leads to a severe clinical state accompanied with nausea, hematemesis, melena, wheezing, pneumonia, anemia and/or failure to thrive. We report here a case of a 14-year-old male with Lennox syndrome who had been treated with a histamine H2 blocker intravenously or via a nasogastric tube for repeated gastric hemorrhage due to severe GER. Since his gastric hemorrhage became resistant to the H2 blocker, we decided to replace it with a proton pump inhibitor (PPI).
View Article and Find Full Text PDF[An increase in serum phenytoin concentration by changes of dosage form: case reports and its mechanism].
Yakugaku Zasshi
May 2002
Department of Hospital Pharmacy, Isahaya Ryoiku Center, Japan.
Article Synopsis
- Phenytoin (PHT) has nonlinear pharmacokinetics, meaning small dose changes can significantly impact serum levels.
- Although the main formulations (tablets, 97% fine granules, and 10% powder) are considered bioequivalent, changes in formulation can lead to notable increases in serum PHT levels.
- A study showed that switching from 97% fine granules to 10% powder resulted in a 16% higher serum concentration-to-dose ratio, indicating potential risks of PHT toxicity with such formulation changes.