A novel water-soluble polymer nanocomposite containing ultra-small FeO nanoparticles with strong antibacterial and antibiofilm activity.

A novel water-soluble polymer nanocomposite containing ultra-small iron oxide nanoparticles, intercalated into a biocompatible matrix of 1-vinyl-1,2,4-triazole and -vinylpyrrolidone copolymer has been synthesized for the first time. The use of an original polymer matrix ensured effective stabilization of the crystalline phase of iron oxides at an early stage of its formation in an ultra-small (2-8 nm, average diameter is 4.8 nm) nanosized state due to its effective interaction with the functional groups of copolymer macromolecules.

Real-Life Efficacy of Tofacitinib in Various Situations in Ulcerative Colitis: A Retrospective Worldwide Multicenter Collaborative Study.

Background And Aims: Tofacitinib (TFB) appears to be effective in the treatment of ulcerative colitis (UC); however, available real-world studies are limited by cohort size. TFB could be an option in the treatment of acute severe ulcerative colitis (ASUC). We aimed to investigate efficacy and safety of TFB in moderate-to-severe colitis and ASUC.

Spontaneous Transformation of Biomedical Polymeric Silver Salt into a Nanocomposite: Physical-Chemical and Antimicrobial Properties Dramatically Depend on the Initial Preparation State.

An antimicrobial polyacrylic silver salt (freshly prepared, stored for one year and model-aged) was studied by physical-chemical techniques for nanoparticle detection. In all cases, this salt represents a composite of radical-enriched macromolecules and silver(0) nanoparticles. As time passed, the initial small spherical nanoparticles were converted into larger non-spherical silver nanoparticles.

Application of -CF-Fluorophore BODIPY with Phenyl and Pyrazolyl Substituents for Lifetime Visualization of Lysosomes.

A bright far-red emitting unsymmetrical -CF-BODIPY fluorescent dye with phenyl and pyrazolyl substituents was synthesized by condensation of trifluoropyrrolylethanol with pyrazolyl-pyrrole, with subsequent oxidation and complexation of the formed dipyrromethane. This BODIPY dye exhibits optical absorption at λ ≈ 610-620 nm and emission at λ ≈ 640-650 nm. The BODIPY was studied on Ehrlich carcinoma cells as a lysosome-specific fluorescent dye that allows intravital staining of cell structures with subsequent real-time monitoring of changes occurring in the cells.

Complexes of ortho-Phthalic Acid in Spontaneous Animal Tumors.

The presence of diethyl-, dibutyl-, and 2-ethylhexyl phthalates in spontaneous animal tumors was determined for the first time. Small-cell breast cancer of the dog and Ehrlich ascites carcinoma with the cells are particularly rich of these compounds. It is assumed that the level of phthalates in these cells is due to the activity of expression of nuclear receptors for estrogens and progesterone, as well as the peculiarities of the metabolism of xenobiotics.

Strong Antimicrobial Activity of Highly Stable Nanocomposite Containing AgNPs Based on Water-Soluble Triazole-Sulfonate Copolymer.

A new hydrophilic polymeric nanocomposite containing AgNPs was synthesized by chemical reduction of metal ions in an aqueous medium in the presence of the copolymer. A new water-soluble copolymer of 1-vinyl-1,2,4-triazole and vinylsulfonic acid sodium salt (poly(VT-co-Na-VSA)) was obtained by free-radical copolymerization and was used as a stabilizing precursor agent. The structural, dimensional, and morphological properties of the nanocomposite were studied by UV-Vis, FTIR, X-ray diffraction, atomic absorption, transmission and scanning electron microscopy, dynamic and electrophoretic light scattering, gel permeation chromatography, thermogravimetric analysis, and differential scanning calorimetry.

Evaluation of the Safety and Toxicity of the Original Copper Nanocomposite Based on Poly-N-vinylimidazole.

A new original copper nanocomposite based on poly-N-vinylimidazole was synthesized and characterized by a complex of modern physicochemical and biological methods. The low cytotoxicity of the copper nanocomposite in relation to the cultured hepatocyte cells was found. The possibility to involve the copper from the nanocomposite in the functioning of the copper-dependent enzyme systems was evaluated during the incubation of the hepatocyte culture with this nanocomposite introduced to the nutrient medium.

Parathyromatosis as a cause of recurrence primary hyperparathyroidism: A case report.

Introduction And Importance: Parathyromatosis is a rare cause of recurrent hyperparathyroidism. The main cause of this pathology is secondary implantation into the surrounding tissues of the damaged parathyroid gland (rough manipulation of the gland tissue) during the primary operation. Nowadays, parathyromatosis remain a difficult diagnostic and therapeutic task.

Growth factors in the regulation of reparative response in the presence of peritoneal damage.

Objectives: To study the expression of growth factors in the regulation of tissue repair after peritoneal damage tissue response to peritoneal damage.

Methods: Experimental study in 35 male Wistar rats determining the evolution over time of the tissue response to aseptic peritoneal damage. A standardized bowel and peritoneal lesions were created in the right lower quadrant by laparotomy.

[Liver regeneration: resolved and problem issues].

Liver is an exceptional organ due to unique anatomical and physiological features, as well as advanced regenerative ability. Discovery of molecular mechanisms governing liver regeneration allowed researchers to use them to enhance liver regeneration. However, significant progress in this area was achieved through the introduction of gene therapy.

Surgical treatment of a functional parathyroid cyst in a patient with primary hyperparathyroidism: A case report.

Introduction: The frequency of parathyroid cysts in patients with primary hyperparathyroidism is from 1 to 2 %. Nowadays, parathyroid cysts remain a difficult diagnostic and therapeutic task.

Presentation Of Case: A 57-year-old woman was referred to an endocrine surgeon to evaluate a presence of a mass in the left lateral region of the neck, the appearance of shortness of breath.

Surgical treatment of double parathyroid adenomas in primary hyperparathyroidism: A clinical case.

Introduction: The frequency of occurrence of double parathyroid adenomas in patients with primary hyperparathyroidism is from 2 to 11% of cases. Nowadays, double adenomas remain a difficult diagnostic and therapeutic task.

Presentation Of Case: A 64-year-old woman was referred to an endocrine surgeon to evaluate a persistently elevating level of calcium.

NonToxic Silver/Poly-1-Vinyl-1,2,4-Triazole Nanocomposite Materials with Antibacterial Activity.

Novel silver/poly-1-vinyl-1,2,4-triazole nanocomposite materials-possessing antimicrobial activity against Gram-positive and Gram-negative bacteria-have been synthesized and characterized in the solid state and aqueous solution by complex of modern physical-chemical and biologic methods. TEM-monitoring has revealed the main stages of microbial cell () destruction by novel nanocomposite. The concept of direct polarized destruction of microbes by nanosilver proposed by the authors allows the relationship between physicochemical and antimicrobial properties of novel nanocomposites.

Mid-Term to Long-Term Outcomes After Total Cervical Disk Arthroplasty Compared With Anterior Diskectomy and Fusion: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Study Design: This study was a meta-analysis of published randomized controlled trials (RCTs).

Objective: We investigated the mid-term to long-term outcomes of cervical disk arthroplasty (CDA) versus anterior cervical diskectomy and fusion (ACDF) for the surgical treatment of symptomatic cervical disk degenerative disease.

Summary Of Background Data: ACDF has been widely performed for the surgical treatment of symptomatic cervical disk degenerative disease.

[Acute appendicitis within the strangulated femoral hernia].

Femoral hernia strangulation is usually observed in middle-aged women. There are few case reports of appendix strangulation in the femoral hernia. Acute appendicitis in a strangulated femoral hernia is relatively rare (0.

Acridine Orange: A Review of Novel Applications for Surgical Cancer Imaging and Therapy.

Acridine orange (AO) was first extracted from coal tar in the late nineteenth century and was used as a fluorescent dye. In this paper, we review emergent research about novel applications of AO for fluorescence surgery and cancer therapy. We performed a systematic search in the MEDLINE, PubMed, Cochrane library, Google Scholar, Embase, Web of Science, and Scopus database using combinations of the term "acridine orange" with the following: "surgical oncology," "neuropathology," "microsurgery," "intraoperative fluorescence," "confocal microscopy," "pathology," "endomicroscopy," "guidance," "fluorescence guidance," "oncology," "surgery," "neurooncology," and "photodynamic therapy.

Fluorescence Diagnosis in Neurooncology: Retrospective Analysis of 653 Cases.

This study is to analyze fluorescence sensitivity in the diagnosis of brain and spinal cord tumors. The authors conducted a multicenter retrospective analysis of data on 653 cases in 641 patients: 553 of them had brain tumors and 88 spinal cord tumors. Brain tumor resection was performed in 523 patients, of whom 484 were adults and 39 children.

[Possibilities and advantages of minimally invasive dorsal decompressive-stabilizing interventions in the treatment of degenerative spondylolisthesis of the elderly patients.].

The purpose of the study was a comparative analysis of the clinical and radiographic efficacy of minimally invasive rigid stabilization techniques and the traditional open interbody fusion with transpedicular fixation in the treatment of degenerative spondylolisthesis in elderly patients. The study included 65 elderly patients (over 60 years old) divided into 2 groups: the 1st group (MIS-TLIF, n=31), who underwent minimally invasive transforaminal interbody fusion, unilateral open contralateral transcutaneous transpedicular stabilization; the 2nd group (O-TLIF, n=34), operated using rigid stabilization from the median approach. For the comparative analysis, gender characteristics (gender, age), constitutional features (height, weight, body mass index), ASA physical status, intraoperative parameters of interventions and specificity of postoperative management of patients, clinical data, radiographic outcomes, complications were used.

A systematic review and meta-analysis comparing open versus endoscopic in situ decompression for the treatment of cubital tunnel syndrome.

To examine whether endoscopic in situ decompression (EISD) or open in situ decompression (OISD) would have superior outcomes with lower morbidity in patients with idiopathic cubital tunnel syndrome, we reviewed all studies compared both surgical techniques with regard to postoperative outcomes and complication profile in a systematic review design with meta-analysis. Two independent reviewers conducted a PRISMA-compliant search of PubMed, EMBASE, and the Cochrane Library databases for relevant studies about clinical comparisons of OISD and EISD in cubital tunnel syndrome. We performed all meta-analyses with the Review Manager 5.

[Analysis of the effectiveness of Dexmedetomidine in the treatment of degenerative diseases of the lumbar spine with minimally invasive puncture techniques in elderly patients.].

The aim of the study was a comparative analysis of the effectiveness of the use of Dexmedetomidine and Propofol in the treatment of degenerative diseases of the lumbar spine with minimally invasive puncture techniques in elderly patients. The study included 83 elderly patients (over 60 years old) who underwent laser denervation of facet joints (n=44) and posterolateral transforaminal endoscopic discectomy (n=39): in the first group, Dexmedetomidine (n=32), in the second group - Propofol (n=51). For the comparative analysis, gender characteristics (gender, age), constitutional features (height, weight, body mass index), the degree of physical status by ASA, the intensity of the pain syndrome before surgery, the duration of the operation, the degree of patient satisfaction with the Macnab surgery, the complications.

[Comparison of open and minimally invasive techniques in the surgical treatment of intradural extramedullary spinal tumors in elderly and senile patients.].

With an increase in the average life expectancy of the population, some histological types of symptomatic IEMT are more common in elderly and senile patients. Of the 45 patients included in the study, 27 (60%) patients underwent a microneurosurgical resection of the tumor tissue using minimally invasive techniques (minimally invasive group) and 18 (40%) to patients using the classical open method (open group). The duration of operative intervention in both cohorts of respondents is comparable and is 245,4±117,1 min and 261,1±108,6 min for open and minimally invasive groups, respectively (p=0,71).

Electrochemical behavior of titanium and platinum in dicarboxilic amino acids solution.

Titanium and platinum samples as components of bimetallic implants for the osteoregeneration process have been modified in solutions modeling biological systems and studied by means of cyclic voltammetry, electrochemical impedance spectroscopy and scanning probe microscopy. While aspartic and glutamic acids did not adsorb significantly on platinum in the potential region investigated, the presence of the amino acids affects oxide layer growth on the titanium surface under anodic polarization. The two studied amino acids behave differently on the titanium electrode surface due to differences in adsorption modes of these substances.

[The use of apparent diffusion coefficient in diagnosis of lumbar intervertebral disk degeneration in patients with middle and old age by diffusion-weighted MRI.].

The most common cause of low back pain is the intervertebral disk (IVD) degeneration. Standard modes of MRI (T1 and T2-modes) do not allow quantifying the degree of IVD degeneration. Diffusion-weighted MRI (DW MRI) is able to analyze the state of IVD structures by the diffusion of water molecules.

Microvascular Anastomosis Training in Neurosurgery: A Review.

Cerebrovascular diseases are among the most widespread diseases in the world, which largely determine the structure of morbidity and mortality rates. Microvascular anastomosis techniques are important for revascularization surgeries on brachiocephalic and carotid arteries and complex cerebral aneurysms and even during resection of brain tumors that obstruct major cerebral arteries. Training in microvascular surgery became even more difficult with less case exposure and growth of the use of endovascular techniques.