3 results match your criteria: "Ireland. abhay.pandit@universityofgalway.ie.[Affiliation]"
Reproducing extracellular matrix adverse remodelling of non-ST myocardial infarction in a large animal model.
Nat Commun
February 2023
CÚRAM, SFI Research Centre for Medical Devices, University of Galway, Galway, Ireland.
The rising incidence of non-ST-segment elevation myocardial infarction (NSTEMI) and associated long-term high mortality constitutes an urgent clinical issue. Unfortunately, the study of possible interventions to treat this pathology lacks a reproducible pre-clinical model. Indeed, currently adopted small and large animal models of MI mimic only full-thickness, ST-segment-elevation (STEMI) infarcts, and hence cater only for an investigation into therapeutics and interventions directed at this subset of MI.
View Article and Find Full Text PDFAdhesive hydrogels in osteoarthritis: from design to application.
Mil Med Res
January 2023
CÚRAM, SFI Research Centre for Medical Devices, University of Galway, Galway, H91 TK33, Ireland.
Osteoarthritis (OA) is the most common type of degenerative joint disease which affects 7% of the global population and more than 500 million people worldwide. One research frontier is the development of hydrogels for OA treatment, which operate either as functional scaffolds of tissue engineering or as delivery vehicles of functional additives. Both approaches address the big challenge: establishing stable integration of such delivery systems or implants.
View Article and Find Full Text PDFMetabolic reprogramming and membrane glycan remodeling as potential drivers of zebrafish heart regeneration.
Commun Biol
December 2022
CÚRAM, SFI Research Centre for Medical Devices, University of Galway, Galway, Ireland.
Article Synopsis
- The zebrafish heart can regenerate after injury, making it a useful model for studying limited regeneration in mammals, particularly in neonatal stages.
- Researchers have found that during heart regeneration in zebrafish, there's a metabolic shift from using mitochondria for energy to relying on glycolysis, alongside changes in glycosylation (the addition of sugar structures to proteins).
- By detailing the specific types of glycans present during regeneration, the study suggests that these metabolic and glycan changes drive heart repair and offer insights for developing new therapies for heart regeneration in mammals.