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Neuroinflammation and Nociception in Intervertebral Disc Degeneration: A Review of Precision Medicine Perspective.

Spine J

January 2025

Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras 56000, Kuala Lumpur, Malaysia; CÚRAM, SFI Research Centre for Medical Devices, School of Medicine, University of Galway, Galway H91 W2TY, Ireland. Electronic address:

Intervertebral disc (IVD) degeneration is a major cause of low back pain (LBP), which results in disability worldwide. However, the pathogenesis of IVD degeneration mediating LBP remains unclear. Current conservative treatments and surgical interventions are both to relieve the symptoms and minimise pain; nevertheless, they are unable to reverse the degeneration.

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