Dairy cow performance and nutrient utilization when offered high or low digestibility grass silages at 2 levels of total diet crude protein.

The hypothesis of this study was that grass silage digestibility would influence the response of dairy cows offered diets differing in CP content. Thirty-two mid-lactation Holstein dairy cows were used in a 2-period (21-d adaption phase, 7-d measurement phase), partially balanced change-over experiment. Four treatments were organized in a 2 × 2 factorial arrangement, comprising 2 grass silages differing in digestible OM in the DM (D-value; 748 and 668 g/kg DM, high-D and low-D, respectively) and 2 total diet CP levels (target 145 and 175 g/kg DM, high CP and low CP, respectively).

Evaluating the impact of 3-nitrooxypropanol supplementation on enteric methane emissions in pregnant nonlactating dairy cows offered grass silage.

Although 3-nitrooxypropanol (3-NOP; Bovaer10) has been proven to reduce enteric methane (CH) by ∼30% in indoor systems of dairying when the additive is mixed throughout TMR and partial mixed ration (PMR) diets, there has been limited research to date on the CH abatement potential of 3-NOP when mixed within a diet based on perennial ryegrass silage only and fed to pregnant nonlactating dairy cows. To investigate the effect of 3-NOP supplementation on enteric CH emissions of pregnant nonlactating dairy cows, a 6-wk study was undertaken in which treatment cows were supplemented with 3-NOP mixed within grass silage, whereas control cows were offered grass silage without additive supplementation. Enteric CH, hydrogen (H), and carbon dioxide (CO) were measured using a GreenFeed machine.

Goal attainment, medication adherence and guideline adherence in the treatment of hypertension and dyslipidemia in Irish populations: A systematic review and meta-analysis.

Background: The appropriate treatment high blood pressure (BP) and low-density lipoprotein cholesterol.(LDL-C), according to clinical guidelines, reduces a patient's risk of a cardiovascular event.

Aim: This systematic review aims to evaluate the attainment of BP and LDL-C goals among the Irish population in both primary and secondary prevention of cardiovascular diseases, the level of adherence to prescribing guidelines by doctors and the level of medication adherence among patients.

Vascularised Composite Allotransplantation - A guide to optimal dissemination of scientific outputs.

Purpose: The impact of academic research is not just important within the clinical domain but within society as a whole. Altmetric Attention Score (AAS) offers a means of assessing how scholarly outputs are interacted with online. Vascularised Composite Allotransplantation (VCA) is a modern but rapidly evolving topic which encompasses a broad range of complex and clinically significant surgical interventions.

Fat Grafting Versus Implants: Who's Happier? A Systematic Review and Meta-analysis.

Breast implants were first introduced in the 1960s and have long been used for augmentation and reconstructive breast surgery. More recently, fat grafting for breast augmentation has gained popularity due to the 'natural' outcome and lack of implant-related complications. The aim of this study was to conduct a systematic review and meta-analysis comparing patient-related outcome measures between fat grafting and implant-based primary augmentation using the validated BREAST-Q questionnaire.

Building Localized NADP(H) Recycling Circuits to Advance Enzyme Cascadetronics.

The catalytic action of enzymes of a cascade trapped within a mesoporous electrode material is simultaneously energized, controlled and observed through the efficient, reversible electrochemical NAD(P)(H) recycling catalyzed by one of the enzymes. In their nanoconfined state, nicotinamide cofactors are tightly channeled current carriers, mediating multi-step reactions in either direction (oxidation or reduction) with a rapid response time. By incorporating a hydrogen‑borrowing enzyme pair, the internal action of which opposes the external voltage bias driving oxidation or reduction, a reduction process can be performed under overall oxidizing conditions, and vice versa.

Nonlinear Harmonics: A Gateway to Enhanced Image Contrast and Material Discrimination.

Recent advancements in atomic force microscopy (AFM) have enabled detailed exploration of materials at the molecular and atomic levels. These developments, however, pose a challenge: the data generated by microscopic and spectroscopic experiments are increasing rapidly in both size and complexity. Extracting meaningful physical insights from these datasets is challenging, particularly for multilayer heterogeneous nanoscale structures.

Room Temperature Ethene to Propene (ETP) Tandem Catalysis using Single Crystalline Solid-State Molecular Pre-Catalysts.

A tandem catalytic ensemble of solid-state molecular organometallic (SMOM) crystalline pre-catalysts are deployed under batch or flow conditions for the ethene to propene process (ETP). These catalysts operate at ambient temperature and low pressure, via sequential ethene dimerization, butenes isomerization and cross-metathesis. Under flow conditions the on-stream ethene conversion (55%), initial propene selectivity (92%), stability (71% selectivity after 7 hrs) and low temperature/pressures are competitive with the best-in-class heterogenous systems, marking a new, in crystallo, approach to ETP.

Social determinants of student mental health before and after the Beirut port explosion: two cross-sectional studies.

Background: Students in Lebanon are facing the devastating impact of multiple national crises, including an unprecedented economic collapse and the Beirut port explosion that killed hundreds, injured thousands, and displaced hundreds of thousands of people. The aim of this study was to identify key social determinants of common mental health symptoms before and after the Beirut port explosion for students at the American University of Beirut, a university based around 4 km from the port.

Methods: Two cross-sectional studies were conducted using a representative sample of undergraduate and graduate students at the American University of Beirut.

Targeting MYC for the treatment of breast cancer: use of the novel MYC-GSPT1 degrader, GT19630.

Background: Since MYC is one of the most frequently altered driver genes involved in cancer formation, it is a potential target for new anti-cancer therapies. Historically, however, MYC has proved difficult to target due to the absence of a suitable crevice for binding potential low molecular weight drugs.

Objective: The aim of this study was to evaluate a novel molecular glue, dubbed GT19630, which degrades both MYC and GSPT1, for the treatment of breast cancer.

Utilizing hydrophobic sand to construct an air permeable aquiclude to enhance rice yields.

The Chinese government attaches great importance to the ecological restoration of abandoned open-pit mines, increasing the area of cultivated land, and ensuring food security. Soil reconstruction is a crucial step in ecological restoration of abandoned open-pit mines. This study investigated the utilization of hydrophobic sand to create an Air-Permeable Aquiclude (APAC) under the plant root zones, thereby minimizing water infiltration and enhancing soil aeration.

Parsimonious versus extensive bleeding score: can we simplify risk stratification after percutaneous coronary intervention and reduce bleeding events by de-escalation of the antiplatelet strategy?

Background And Aims: Due to the multitude of risk factors outlined in the guidelines, personalised dual antiplatelet therapy (DAPT) guidance after percutaneous coronary intervention (PCI) is complex. A simplified method was created to facilitate the use of risk stratification. We aimed to compare the predictive and prognostic value of the 'Zuidoost Nederland Hart Registratie' (ZON-HR) classification for bleeding risk with the PREdicting bleeding Complications In patients undergoing Stent implantation and subsEquent DAPT (PRECISE-DAPT) score and to determine the effect of ticagrelor monotherapy versus DAPT in patients with or without high bleeding risk (HBR).

A meta-core outcome set for stillbirth prevention and bereavement care following stillbirth in LMIC.

Study Objective: Stillbirth is burdensome in low-income and middle-income countries (LMICs), especially in sub-Saharan Africa and South Asia. Currently, there are two core outcome sets (COS) for stillbirth (prevention and bereavement care), but these were developed with limited reflection of the needs of parents in an LMIC setting. To address this gap, the objective of this study was to establish consensus on the most important outcomes for stillbirth prevention and bereavement care following stillbirth in sub-Saharan Africa and South Asia.

Healthy Lifestyle in the First 1000 Days and Overweight and Obesity Throughout Childhood.

Objectives: Investigate associations of different family healthy lifestyle scores (HLS) during the first 1000 days with childhood overweight and obesity (OWOB).

Methods: Cohort-specific analyses were conducted on participants (n = 25 006) from 4 European birth cohorts (The study on the pre- and early postnatal determinants of child health and development [EDEN], Elfe, France; Generation R, the Netherlands; and Lifeways, Ireland). Three composite HLSs were calculated: a maternal pregnancy HLS based on prepregnancy body mass index (BMI) and diet quality, physical activity, smoking status, and alcohol consumption during pregnancy; a parental pregnancy HLS additionally considering paternal BMI and smoking status; and an infancy HLS based on breastfeeding duration, age of solid food introduction, and exposure to passive smoking.

Clinical outcomes and management following progressive disease with anti-PD-(L)1 therapy in patients with advanced Merkel Cell Carcinoma.

Aim: Merkel Cell Carcinoma (MCC) is a rare skin cancer with a rising incidence worldwide. Anti-programmed death-1/ligand-1 (anti-PD-(L)1) therapies are effective for the treatment of advanced MCC. This study examines patterns of response / progression of advanced MCC to anti-PD-(L)1 therapies and describes subsequent management.

The inhibition of anammox system under Cu stress and mechanisms of biochar-mediated recovery.

Copper (Cu)-containing wastewater has proven difficult to effectively treat using the anammox process. In this study, the nitrogen removal efficiency (NRE), sludge characteristics, microbial community and recovery mechanisms of biochar-mediated anammox under Cu stress were elucidated. At a Custress of 5 mg/L, a 73.

Collagen silver-doped hydroxyapatite scaffolds reinforced with 3D printed frameworks for infection prevention and enhanced repair of load-bearing bone defects.

Osteomyelitis, a severe bone infection, is an extremely challenging complication in the repair of traumatic bone defects. Furthermore, the use of long-term high-dose antibiotics in standard treatment increases the risks of antibiotic resistance. Herein, an antibiotic-free, collagen silver-doped hydroxyapatite (coll-AgHA) scaffold reinforced with a 3D printed polycaprolactone (PCL) framework was developed with enhanced mechanical properties to be used in the repair of load-bearing defects with antimicrobial properties as a preventative measure against osteomyelitis.

Implementing Internet-Delivered Cognitive Behavioral Therapy for Depression and Anxiety in Adults: Systematic Review.

Background: Scientific implementation findings relevant to the implementation of internet-delivered cognitive behavioral therapy (iCBT) for depression and anxiety in adults remain sparse and scattered across different sources of published information. Identifying evidence-based factors that influence the implementation of iCBT is key to successfully using iCBT in real-world clinical settings.

Objective: This systematic review evaluated the following: (1) aspects that research articles postulate as important for the implementation of iCBT and (2) aspects relevant to the day-to-day running of iCBT services.

Burnout and organisational stressors among healthcare staff working with adults with intellectual disabilities in Ireland.

Background: The associations between organisational stressors and burnout among healthcare staff working with adults with intellectual disabilities are underexplored. This study investigated rates of burnout and associated stressors among Irish healthcare workers during the COVID-19 pandemic.

Materials And Methods: A convenience sample of 329 Irish frontline staff supporting adults with intellectual disabilities completed a survey assessing personal, work-related, and client-related burnout, and organisational stressors.

onEEGwaveLAD: A fully automated online EEG wavelet-based learning adaptive denoiser for artefacts identification and mitigation.

Electroencephalographic signals are obtained by amplifying and recording the brain's spontaneous biological potential using electrodes positioned on the scalp. While proven to help find changes in brain activity with a high temporal resolution, such signals are contaminated by non-stationary and frequent artefacts. A plethora of noise reduction techniques have been developed, achieving remarkable performance.

European Society of Cardiology quality indicators for the management of acute coronary syndrome.

Background: Closing the evidence-practice gap for the treatment of acute coronary syndrome (ACS) is central to improving quality of care. Under the European Society of Cardiology (ESC) framework, we aimed to develop updated quality indicators (QIs) for the evaluation of quality of care and outcomes for patients with ACS.

Methods: A Working Group of experts including members of the ESC Clinical Practice Guidelines Task Force for ACS, Acute CardioVascular Care Association and European Association of Percutaneous Cardiovascular Interventions followed the ESC methodology for QI development.

Aspartate Metabolism-Driven Gut Microbiota Dynamics and RIP-Dependent Mitochondrial Function Counteract Oxidative Stress.

Aspartate (Asp) metabolism-mediated antioxidant functions have important implications for neonatal growth and intestinal health; however, the antioxidant mechanisms through which Asp regulates the gut microbiota and influences RIP activation remain elusive. This study reports that chronic oxidative stress disrupts gut microbiota and metabolite balance and that such imbalance is intricately tied to the perturbation of Asp metabolism. Under normal conditions, in vivo and in vitro studies reveal that exogenous Asp improves intestinal health by regulating epithelial cell proliferation, nutrient uptake, and apoptosis.