4 results match your criteria: "Iran.Electronic address: sahar_kiani@royaninstitute.org.[Affiliation]"
Co-delivery of minocycline and paclitaxel from injectable hydrogel for treatment of spinal cord injury.
J Control Release
May 2020
Department of Stem Cell and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran; Department of Developmental Biology, University of Science and Culture, Tehran, Iran.
Spinal cord injury (SCI) induces pathological and inflammatory responses that create an inhibitory environment at the site of trauma, resulting in axonal degeneration and functional disability. Combination therapies targeting multiple aspects of the injury, will likely be more effective than single therapies to facilitate tissue regeneration after SCI. In this study, we designed a dual-delivery system consisting of a neuroprotective drug, minocycline hydrochloride (MH), and a neuroregenerative drug, paclitaxel (PTX), to enhance tissue regeneration in a rat hemisection model of SCI.
View Article and Find Full Text PDFHuman embryonic stem cell-derived neural stem cells encapsulated in hyaluronic acid promotes regeneration in a contusion spinal cord injured rat.
Int J Biol Macromol
April 2020
Department of Brain and Cognitive Sciences, Cell Science Research Center, ROYAN Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. Electronic address:
spinal cord injury (SCI) is a traumatic damage that can causes a loss of neurons around the lesion site and resulting in locomotor and sensory deficits. Currently, there is widely attempts in improvement of treatment strategy and cell delivering to the central nervous system (CNS). The usage of hyaluronic acid (HA), the main components of the ECM in CNS tissue and neural stem cells (NSCs) niche, is a good selection that can increase of viability and differentiation of NSCs.
View Article and Find Full Text PDFIn Vitro Differentiation of Neural-Like Cells from Human Embryonic Stem Cells by A Combination of Dorsomorphin, XAV939, and A8301.
Cell J
January 2018
Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.Electronic address:
Article Synopsis
- The research aims to improve the efficiency of generating functional motor neurons from human embryonic stem cells (hESCs) using a cocktail of small molecules instead of traditional morphogen factors.
- Five different stages of the differentiation process were analyzed, showing that the hESC-derived neural ectoderm expressed essential neural markers and demonstrated characteristics of motor neurons through various testing methods.
- Although the differentiated motor neurons expressed key markers, the electrical activity measured indicated that the voltage-gated ion channels were insufficient for generating action potentials, suggesting further refinement is needed in the differentiation protocol.
Development of membrane ion channels during neural differentiation from human embryonic stem cells.
Biochem Biophys Res Commun
September 2017
Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. Electronic address:
Objective: For human embryonic stem cells (hESCs) to differentiate into neurons, enormous changes has to occur leading to trigger action potential and neurotransmitter release. We attempt to determine the changes in expression of voltage gated channels (VGCs) and their electrophysiological properties during neural differentiation.
Materials And Methods: The relative expressions of α-subunit of voltage gated potassium, sodium and calcium channels were characterized by qRT-PCR technique.