5 results match your criteria: "Iran. salekdeh@RoyanInstitute.org.[Affiliation]"
Retraction Note to: Transient Activation of Reprogramming Transcription Factors Using Protein Transduction Facilitates Conversion of Human Fibroblasts Toward Cardiomyocyte-Like Cells.
Mol Biotechnol
January 2022
Department of Molecular Systems Biology at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Proteome analysis of endometrial tissue from patients with PCOS reveals proteins predicted to impact the disease.
Mol Biol Rep
November 2020
Department of Molecular Systems Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Banihashem Sq., Banihashem St., Ressalat highway, P.O. Box: 16635-148, 1665659911, Tehran, Iran.
Article Synopsis
- Polycystic ovary syndrome (PCOS) affects about 10% of women of reproductive age, leading to infertility, and the study investigates proteins that may cause issues with endometrial receptivity in these patients.
- Researchers used a shotgun proteomics approach to compare the endometrial protein profiles of PCOS patients during the luteal phase with those of healthy individuals, finding 150 proteins with higher abundance and 46 with lower abundance in PCOS patients.
- The study reveals significant metabolic and protein imbalances in the endometrial tissue of PCOS patients, which may hinder implantation and reproductive success, though further research is needed to confirm these findings on a larger scale.*
Correction to: Efficient Differentiation of Human Embryonic Stem Cells Toward Dopaminergic Neurons Using Recombinant LMX1A Factor.
Mol Biotechnol
January 2019
Department of Developmental Biology, University of Science and Culture, ACECR, Tehran, Iran.
The original version of this article was published without article note. The article note is given below.
View Article and Find Full Text PDFTransient Activation of Reprogramming Transcription Factors Using Protein Transduction Facilitates Conversion of Human Fibroblasts Toward Cardiomyocyte-Like Cells.
Mol Biotechnol
June 2017
Department of Molecular Systems Biology at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Derivation of cardiomyocytes directly from patients' own fibroblasts could offer a new therapeutic approach for those with ischemic heart disease. An essential step toward clinical application is to establish safe conversion of human fibroblasts into a cardiac fate. Here we aimed to efficiently and safely generate cardiomyocytes from human fibroblasts by direct delivery of reprogramming recombinant cell permeant form of reprogramming proteins followed by cardio-inductive signals.
View Article and Find Full Text PDFThe effect of Rho-associated kinase inhibition on the proteome pattern of dissociated human embryonic stem cells.
Mol Biosyst
March 2014
Department of Molecular Systems Biology at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Rho-associated kinase (ROCK) is an immediate downstream target of the Rho GTPase signaling pathway which participates in transducing the Rho GTPase signal to the actin cytoskeleton, leading to the assembly of focal adhesions and stress fibers. Competitive inhibition of ROCK enhances post-thaw viability, improves cloning efficiency and decreases anoikis in human embryonic stem cells (hESCs). The molecular mechanisms by which ROCK inhibition mediates such responses are largely unknown.
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