Functionalized graphene oxide by 4-amino-3-hydroxy-1-naphthalenesulfonic acid as a heterogeneous nanocatalyst for the one-pot synthesis of tetraketone and tetrahydrobenzo[]pyran derivatives under green conditions.

4-Amino-3-hydroxy-1-naphthalenesulfonic acid-functionalized graphene oxide (GO-ANSA) was prepared and characterized using different spectroscopic, microscopic and analytical methods including energy-dispersive X-ray spectroscopy (EDS), EDS elemental mapping, Fourier-transform infrared (FT-IR) spectroscopy, field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), and thermogravimetry/differential thermogravimetry analysis (TGA/DTA). The obtained nanomaterial was used as a novel, highly efficient, and reusable solid acid carbocatalyst for the one-pot three-component synthesis of tetraketone, as well as tetrahydrobenzo[]pyran derivatives tandem Knoevenagel-Michael reactions under green conditions. All of the derivatives were prepared in EtOH, as a green solvent, under reflux conditions in high to excellent yields and very short reaction times.

Elucidating anticancer drugs release from UiO-66 as a carrier through the computational approaches.

The computational analysis of drug release from metal-organic frameworks (MOFs), specifically UiO-66, is the primary focus of this research. MOFs are recognized as nanocarriers due to their crystalline structure, porosity, and potential for added functionalities. The research examines the release patterns of three drugs: temozolomide, alendronate, and 5-fluorouracil, assessing various factors such as the drugs' distance from the UiO-66 centers, the interaction of drug functional groups with Zr metal ions, and the drug density throughout the nanocarrier.

Supramolecular Cu(ii) nanoparticles supported on a functionalized chitosan containing urea and thiourea bridges as a recoverable nanocatalyst for efficient synthesis of 1-tetrazoles.

A cost-effective and convenient method for supporting of Cu(ii) nanoparticles on a modified chitosan backbone containing urea and thiourea bridges using thiosemicarbazide (TS), pyromellitic dianhydride (PMDA) and toluene-2,4-diisocyanate (TDI) linkers was designed. The prepared supramolecular (CS-TDI-PMDA-TS-Cu(ii)) nanocomposite was characterized by using Fourier-transform infrared (FT-IR) spectroscopy, field emission scanning electron microscopy (FESEM), thermogravimetry/differential thermogravimetry analysis (TGA/DTA), energy-dispersive X-ray spectroscopy (EDS), EDS elemental mapping and X-ray diffraction (XRD). The obtained supramolecular CS-TDI-PMDA-TS-Cu(ii) nanomaterial was demonstrated to act as a multifunctional nanocatalyst for promoting of multicomponent cascade Knoevenagel condensation/click 1,3-dipolar azide-nitrile cycloaddition reactions very efficiently between aromatic aldehydes, sodium azide and malononitrile under solvent-free conditions and affording the corresponding ()-2-(1-tetrazole-5-yl)-3-arylacrylenenitrile derivatives.

Supramolecular Pd@methioine-EDTA-chitosan nanocomposite: an effective and recyclable bio-based and eco-friendly catalyst for the green Heck cross-coupling reaction under mild conditions.

Supramolecular palladium(ii) supported on modified chitosan by dl-methionine using an ethylenediaminetetraacetic acid linker (Pd@MET-EDTA-CS) was designed and prepared through a simple procedure. The structure of this novel supramolecular nanocomposite was characterized by different spectroscopic, microscopic and analytical techniques including FTIR, EDX, XRD, FESEM, TGA, DRS, TEM, AA, and BET. The obtained bio-based nanomaterial was successfully investigated, as a highly efficient and green heterogeneous catalyst, in the Heck cross-coupling reaction (HCR) for the synthesis of various valuable biologically active cinnamic acid ester derivatives from the corresponding aryl halides using several acrylates.

Magnetic polyborate nanoparticles as a green and efficient catalyst for one-pot four-component synthesis of highly substituted imidazole derivatives.

In this study, magnetic polyborate nanoparticles (MPBNPs) were prepared a simple procedure from boric acid by using ball-milling and then characterized by various spectroscopic, microscopic and analytical methods including FT-IR, EDX, XRD, FESEM, VSM and TGA analysis. The obtained MPBNPs were further explored, as a green and highly efficient catalyst, in the multi-component synthesis of a wide range of tetra-substituted imidazoles from cascade cyclocondensation as well as air oxidation of benzil or benzoin, aromatic aldehydes, primary amine and ammonium acetate in EtOH, as a green solvent, under reflux conditions. Additionally, environmentally friendly conditions for the preparation of the catalyst by the use of non-toxic reactants, facile procedure and high to excellent yields of the desired products as well as the use of a green solvent are some advantages of this new protocol.

l-Asparagine-EDTA-amide silica-coated MNPs: a highly efficient and nano-ordered multifunctional core-shell organocatalyst for green synthesis of 3,4-dihydropyrimidin-2(1)-one compounds.

In this study, new l-asparagine grafted on 3-aminopropyl-modified FeO@SiO core-shell magnetic nanoparticles using the EDTA linker (FeO@SiO-APTS-EDTA-asparagine) was prepared and its structures properly confirmed using different spectroscopic, microscopic and magnetic methods or techniques including FT-IR, EDX, XRD, FESEM, TEM, TGA and VSM. The FeO@SiO-APTS-EDTA-asparagine core-shell nanomaterial was found, as a highly efficient multifunctional and recoverable organocatalyst, to promote the efficient synthesis of a wide range of biologically-active 3,4-dihydropyrimidin-2(1)-one derivatives under solvent-free conditions. It was proved that FeO@SiO-APTS-EDTA-asparagine MNPs, as a catalyst having excellent thermal and magnetic stability, specific morphology and acidic sites with appropriate geometry, can activate the Biginelli reaction components.

Supported copper on a diamide-diacid-bridged PMO: an efficient hybrid catalyst for the cascade oxidation of benzyl alcohols/Knoevenagel condensation.

In this study, a novel periodic mesoporous organosilica (PMO) containing diamide-diacid bridges was conveniently prepared using ethylenediaminetetraacetic dianhydride to support Cu(ii) species and affording supramolecular Cu@EDTAD-PMO nanoparticles efficiently. Fourier transform infrared (FT-IR) and energy dispersive X-ray (EDX) spectroscopy, thermogravimetric analysis (TGA), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), Brunauer-Emmett-Teller (BET) analysis, and high-resolution transmission electron microscopy (HRTEM) results confirmed the successful synthesis of Cu@EDTAD-PMO. The stabilized Cu(ii) nanoparticles inside the mesochannels of the new PMO provided appropriate sites for selective oxidation of different benzyl alcohol derivatives to their corresponding benzaldehydes and subsequent Knoevenagel condensation with malononitrile.