15,000 results match your criteria: "Iran Polymer & Petrochemical Institute[Affiliation]"

A new path in bone tissue engineering: polymer-based 3D-printed magnetic scaffolds (a comprehensive review of and studies).

J Biomater Sci Polym Ed

December 2024

Department of Biomaterials and Tissue Engineering, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Bone tissue engineering is a promising approach to address the increasing need for bone repair. Scaffolds play a crucial role in providing the structural framework for cell growth and differentiation. 3D printing offers precise control over scaffold design and fabrication.

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Folic Acid-Decorated Chitosan-PLGA Nanobiopolymers for Targeted Drug Delivery to Acute Lymphoblastic Leukemia Cells: Studies.

Technol Cancer Res Treat

December 2024

Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran.

Objectives: This study developed a drug delivery system (DDS) using folic acid (FA)-functionalized chitosan (CS) and poly (lactic-co-glycolic acid) (PLGA) nanocarriers for targeted sodium butyrate (NB) delivery to leukemia cells (NALM6). The goal was to enhance NB's therapeutic efficacy while reducing its cytotoxicity to non-malignant cells.

Methods: FA-CS-PLGA nanocarriers were synthesized and characterized using Fourier-transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS), zeta potential analysis, transmission electron microscopy (TEM), and thermogravimetric analysis (TGA).

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An electrochemical aptasensor has been developed specifically for the sensitive and selective determination of ochratoxin A (OTA), one of the most important mycotoxins. The aptasensor utilizes a glassy carbon electrode that has been modified with toluidine blue (TB) encapsulated in a Zn-based metal-organic framework (TB@Zn-MOF). The results demonstrate that in the presence of OTA, the peak current of the differential pulse voltammogram (DPV) related to TB oxidation is notably decreased.

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Background: This randomized clinical trial aimed to evaluate the effect of intracanal cryotherapy with 2-4 °C normal saline irrigation on post-operative pain after single-visit non-surgical root canal retreatment.

Methods: Forty-six single-rooted, single-canal teeth requiring non-surgical root canal retreatment were randomly assigned to two groups (n = 23): a cryotherapy group and a control group. All the treatments were completed during a single visit.

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Vanadium single-atoms coordinated artificial peroxidases as biocatalyst-linked immunosorbent assay for highly-sensitive carcinoembryonic antigen immunoassay.

Biomaterials

May 2025

College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China; Department of Endodontics, Department of Orthodontics, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China. Electronic address:

In medical and biomedical fields, enzyme-mimetic nanomaterials have garnered significant interest as efficacious signal enhancers for biocatalyst-linked immunosorbent assays (BLISA). Despite the burgeoning enthusiasm, engineering artificial biocatalysts that exhibit both exceptional catalytic proficiency and pronounced colorimetric signal output remains a formidable challenge. Inspired by the heme structures and biocatalytic activities of horseradish peroxidase, we introduce the synthesis of vanadium single-atoms (SAV) coordinated artificial peroxidases as BLISA for highly sensitive and selective carcinoembryonic antigen (CEA) immunoassay.

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Here, a zirconium-based metal organic framework-dispersive solid phase extraction method was established as an efficient, robust, and accurate approach for quantifying apixabanin human plasma samples prior to capillary electrophoresis with diode array detection. Various types of metal organic frameworks based on UiO-66-NH were synthesized by altering modulators and solvents and applied as sorbents in the extraction procedure. Among the tested sorbents, UiO-66-NH prepared in dimethylformamide in the presence of acetic acid was found to be the best sorbent in this method for the extraction of apixaban with high extraction efficiency comparable to other types of UiO-66-NH metal organic frameworks.

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Article Synopsis
  • Psoriasis is an autoimmune skin disease, and Boswellia serrata (BS) gum resin shows potential in managing inflammatory conditions, although its effectiveness is limited due to poor absorption in the body.
  • The study tests a new formulation of Boswellia called Boswellia nano emulsion gel (BNG) on mice with dermatitis induced to resemble psoriasis, finding that BNG significantly reduces inflammation and the associated symptoms.
  • Results indicated that treatment with BNG lowers gene expression linked to inflammation compared to control groups, suggesting its therapeutic potential, but more clinical studies are needed to confirm these findings in humans.
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Synergistic effects of doxorubicin loaded silk fibroin nanoparticles and Cu-TiO nanoparticles for local chemo-sonodynamic therapy against breast cancer.

Int J Biol Macromol

December 2024

Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; Leicester School of Pharmacy, De Montfort University, Leicester, UK. Electronic address:

A promising new approach to mitigate the adverse effects of chemotherapeutic drugs on healthy tissues involves combining sonodynamic therapy with topical chemotherapy to enhance the therapeutic efficacy of anticancer drugs. In this study, we introduce a multi-functional in situ chitosan hydrogel (CS) containing silk fibroin nanoparticles (SFNPs) loaded with doxorubicin (DOXSFNPs) and CuO/TiO nanoparticles (CTNPs) for combination therapy. The developed DOXSFNPs exhibited a size of 257 ± 6 nm, a zeta potential of -14.

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Plant-derived bioactive polysaccharides (PDBPs), versatile polymers originating from various botanical sources, exhibit a spectrum of biological functionalities crucial for human health. This review delves into the multifaceted roles of these bioactive compounds, elucidating their immune-boosting properties, antioxidant prowess, anti-inflammatory capabilities, and contributions to gut health. Amidst their pivotal roles, the efficiency of PDBPs delivery and bioavailability in the human system stands as a central determinant of their efficacy and utilization.

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Periodontitis (PD) is a chronic gum illness that may be hard to cure for a number of reasons, including the fact that no one knows what causes it, the side effects of anti-microbial treatment, and how various kinds of bacteria interact with one another. As a result, novel therapeutic approaches for PD treatment must be developed. Additionally, supplementary antibacterial regimens, including local and systemic medication administration of chemical agents, are necessary for deep pockets to assist with mechanical debridement of tooth surfaces.

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Chitosan-casein as novel drug delivery system for transferring Phyllanthus emblica to inhibit Pseudomonas aeruginosa.

BMC Biotechnol

December 2024

Department of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.

This study investigated the ability of Phyllanthus emblica encapsulated within chitosan-coated casein (CS-casein-Amla) nanoparticles to inhibit the growth of multi-drug-resistant Pseudomonas aeruginosa (P. aeruginosa) bacteria and prevent the formation of biofilms. The MDR strains underwent screening, and the morphological characteristics of the resulting nanoparticles were assessed using SEM, DLS, and FTIR.

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Background: Enterococcus faecalis (E. faecalis) is the most common microorganism responsible for post-endodontic infections, which can penetrate deep into dentinal tubules. This study aimed to compare the survival of E.

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Article Synopsis
  • This study explores the relationship between thyroid disorders and polycystic ovary syndrome (PCOS), highlighting similarities in energy metabolism and hormonal factors.
  • It involved a case-control design with three groups: healthy women, women with PCOS and hypothyroidism, and women with PCOS without hypothyroidism, measuring various serum levels to assess thyroid function and related metabolic factors.
  • Results showed that low levels of CTRP-5 and high levels of ASP and complement C3 in PCOS patients may indicate thyroid dysfunction, impacting lipid and glucose metabolism, suggesting a need for more research on hypothyroidism prevalence in PCOS.
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Controlled release of trifluralin herbicide using luminescent Vibrio-derived polyhydroxyalkanoate (PHA) microcapsules.

Int J Biol Macromol

December 2024

Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran; Industrial Biotechnology Research Group, Institute of biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran; Nano Research Center, Ferdowsi University of Mashhad, Mashhad, Iran. Electronic address:

The controlled release of herbicides using new and safe materials can mitigate environmental pollution. Polyhydroxyalkanoate (PHA) is a type of biopolymer that can be produced by various bacteria. It has properties that make it suitable for encapsulation and controlled release applications.

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Continuum-Particle Coupling for Polymer Simulations.

J Chem Theory Comput

January 2025

Eduard-Zintl-Institut für Anorganische und Physikalische Chemie, Technical University of Darmstadt, Peter-Grünberg-Str. 8, Darmstadt D-64287, Germany.

We report a concurrent hybrid multiscale simulation method, in which a particle domain is coupled with a surrounding continuum domain. The particle domain consists of a coarse-grained model of poly(lactic acid) and the continuum domain is treated using the finite element method. The coarse-grained model is derived from an atomistic model, using the iterative Boltzmann inversion scheme.

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The aim of this research is to explore the effectiveness of epoxy-resin@polypyrole composites as a corrosion inhibitor when applied as a coating on carbon steel 1018 in a 3.5 wt % sodium chloride electrolyte solution. The anticorrosion properties of these composite coatings can be optimized by manipulating their morphology.

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Today, plastic plays a pervasive role in everyday life. Their improper disposal can create ongoing environmental challenges. Polyurethane (PU) is a polymer with elastomeric properties that exhibits significant adhesion and durability.

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This research investigated the sound insulation performance of 3D woven hybrid fabric-reinforced composites using natural fibers, such as jute, along with E-glass and biomass derived from agro-waste, e.g., coffee husk and waste palm fiber.

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Polymers have become essential in advancing bone tissue engineering, providing adaptable bone healing and regeneration solutions. Their biocompatibility and biodegradability make them ideal candidates for creating scaffolds that mimic the body's natural extracellular matrix (ECM). However, significant challenges remain, including degradation by-products, insufficient mechanical strength, and suboptimal cellular interactions.

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Regenerative medicine by applying tissue engineering and cell transplantation has provided a new door in wound healing. This study tracked healing effect of human Wharton's jelly stem cells (WJSCs) labeled with superparamagnetic iron oxide nanoparticles (SPIONs) seeded onto poly vinyl alcohol/chitosan/carbon nanotubes (PVA/CS/CNT) in burn wounds by magnetic resonance imaging (MRI) and Prussian Blue staining. .

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A promising approach for wound treatment is using multilayer wound dressings that offer multifunctional properties. In this study, a bilayered electrospun/hydrogel gelatin-based scaffold integrated with honey and curcumin was developed to treat wounds under an in vivo study. The first layer consisted of an enzymatic cross-linked gelatin hydrogel containing honey and curcumin, which gelatin/PCL nanofibers reinforced.

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Background: Poly (β-amino Ester) nanocarriers show promise for gene therapy, but their effectiveness can be limited by the environment within the body. This study aims to understand how common cell culture media components affect optimized PBAE nanocarrier performance in gene delivery.

Methods: Optimized PBAE was synthesized based on Michael addition reaction and characterized by different assays, this study employed techniques like DLS and TEM to characterize PBAE nanocarriers, followed by cellular uptake analysis (flow cytometry and confocal imaging) and evaluation of gene expression under different polymer/DNA ratio ratios and media conditions.

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In recent years, biopolymer-based food packaging films have emerged as promising alternatives to petroleum-based plastic food packaging films. Various additives have been explored to enhance their properties, and one such group of additives is natural plant aldehydes. These aldehydes are commonly employed to improve the antibacterial and antioxidant properties of biopolymer-based food packaging films.

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Glucantime and quercetin electrospun nanofiber membranes: Fabrication and their evaluation as dressing for cutaneous leishmaniasis.

Mol Biochem Parasitol

December 2024

Department of Clinical Pharmacy, School of Pharmacy, Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran. Electronic address:

Cutaneous leishmaniasis is considered as one of the most concerns of the World Health Organization (WHO). The main objective of this study was to use polycaprolactone (PCL) nanofiber scaffolds in order to provide a topical drug delivery system capable of delivering glucantime (glu) and quercetin (qur) to cutaneous leishmaniasis wounds. First, PCL/glu/qur, PCL/glu, and PCL/qur nanofibers were prepared by an electrospinning method followed by characterization through scanning electron microscopy (SEM) and fourier transform infrared spectroscopy (FTIR).

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