Experimental study on the simultaneous effect of smart water and clay particles on the stability of asphaltene molecule and emulsion phase.

Enhancing oil recovery in sandstone reservoirs, particularly through smart water flooding, is an appealing area of research that has been thoroughly documented. However, few studies have examined the formation of water-in-heavy oil emulsion because of the incompatibility between the injected water-folded ions, clay particles, and heavy fraction in the oil phase. In this study, we investigated the synergistic roles of asphaltene and clay in the smart water flooding process using a novel experimental approach.

Modeling future sediment retention service in the Bagh-e-Shadi Forest protected area using InVEST and the ACCESS-ESM1-5 climate model.

Assessing the impact of climate change on water-related ecosystem services (ES) in Protected Areas (PAs) is essential for developing soil and water conservation strategies that promote sustainability and restore ES. However, the application of ES research in Protected Area (PA) management remains ambiguous and has notable shortcomings. This study primarily aimed to assess the SDR-InVEST (Sediment Delivery Ratio-Integrated Valuation of Ecosystem Services and Tradeoffs) model for estimating ES, including soil loss, sediment export, and sediment retention, under various climate change scenarios from 1997 to 2100 in the data-scarce region of the Bagh-e-Shadi Forest PA.

FeO@HA-Cu(OAc) nanocomposite as a nanomagnetic water-compatible catalyst for efficient synthesis of 1,2,3-triazoles in water.

A new humic acid-based nanomagnetic copper(II) composite was prepared and used as an eco-friendly recoverable catalyst for synthesizing 1,4-disubstituted 1,2,3-triazoles. The synthesis was done via the three-component click reaction of alkyl halide, sodium azide, and terminal alkyne with good to excellent yield. A simple magnetic copper acetate composite, FeO@HA-Cu(OAc), was prepared using humic acid and characterized by SEM, TEM, XRD, EDX, EDS-mapping, VSM, TGA, AAS, and FT-IR.

Effect of plasma free fatty acids on lung function in male COPD patients.

Inflammation and oxidative stress play a pivotal role in COPD pathogenesis. Free fatty acids (FFA) as signaling molecules through a series of G-proteins coupled receptors, play an important role in regulation of the immune system and oxidative stress. For this reason, we decided to investigate the profile of FFA in the plasma in the COPD patients.

Efficacy and Safety of Hibiscus sabdariffa in Cardiometabolic Health: An Overview of Reviews and Updated Dose-Response Meta-Analysis.

Background: Conventional treatments for cardiometabolic diseases face limitations related to cost, efficacy, and side effects. Hibiscus sabdariffa (HS) is a common food product and a potential alternative. However, previous studies have shown inconsistent results and lacked assessments of result certainty, intervention safety, and subgroup analysis credibility.

GRP78: A New Promising Candidate in Colorectal Cancer Pathogenesis and Therapy.

Colorectal cancer (CRC) is a significant global health challenge, marked by varying incidence and mortality rates across different regions. The pathogenesis of CRC involves multiple stages, including initiation, promotion, progression, and metastasis, influenced by genetic and epigenetic factors. The chaperone protein glucose-regulated protein 78 (GRP78), crucial in regulating the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress, plays a pivotal role in CRC pathogenesis.

Carvacrol attenuates varicocele-induced infertility in rats.

Carvacrol is a common ingredient in the pharmaceutical, cosmetic, and perfume industries. It possesses various pharmaceutical properties including pain relief, anti-cell death, antioxidant, anti-cancer, and anti-inflammatory effects. We investigated the protective impact of carvacrol on infertility caused by varicocele in rats.

Artificial intelligence-enabled obesity prediction: A systematic review of cohort data analysis.

Background: Obesity, now the fifth leading global cause of death, has seen a dramatic rise in prevalence over the last forty years. It significantly increases the risk of diseases such as type 2 diabetes and cardiovascular disease. Early identification of obesity risk allows for preventative actions against obesity-related factors.

Graphene oxide-enhanced photothermal therapy: laser parameter optimization and temperature modeling for hela cancer cell mortality.

Photothermal therapy, in which a laser is an effective tool, is a promising method for cancer treatment. Laser parameters, including power, irradiation time, type of laser radiation (continuous or chopped), and the concentration of the photothermal agent, can affect the efficiency of this method. Therefore, this study investigated and compared the effects of different laser parameters on the efficiency of photothermal treatment for cervical cancer, which is the fourth most prevalent cancer in women.

A fractal-fractional order modeling approach to understanding stem cell-chemotherapy combinations for cancer.

The main objective of this work is to study the mathematical model that combines stem cell therapy and chemotherapy for cancer cells. We study the model using the fractal fractional derivative with the Mittag-Leffler kernel. In the analytical part, we study the existence of the solution and its uniqueness, which was studied based on the fixed point theory.

Acid-decorated chitosan-magnetic aluminum ferrite as a bionanocomposite catalyst for green synthesis of biologically active [4,3‑d]pyrido[1,2‑a]pyrimidin-6‑ones.

In this study, a novel hybrid nanostructure consisting of acid-decorated chitosan and magnetic AlFeO nanoparticles was fabricated. The acid-decorated chitosan provided a stable and biocompatible matrix for the magnetic AlFeO nanoparticles. Various techniques including Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction patterns (XRD), thermogravimetric analysis (TGA), vibrating sample magnetometry (VSM), specific surface area (BET), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDS) were used to characterize and confirm the successful synthesis of the hybrid nanostructure.

A fault tolerant CSA in QCA technology for IoT devices.

According to recent research, with the ever-increasing use of Internet of Things (IoT) devices, there has arisen an ever-growing need for high-performance yet low-power circuits that can efficiently process information. Quantum-dot Cellular Automata (QCA) has emerged as a promising alternative to conventional complementary metal-oxide-semiconductor (CMOS) technology due to its great potential in digital design at nanoscale levels on account of very low power consumption and very high processing speed. However, QCA circuits are inherently prone to faults due to variations in manufacturing processes and due to the influence of environmental factors.

Hybrid clustering strategies for effective oversampling and undersampling in multiclass classification.

Multiclass imbalance is a challenging problem in real-world datasets, where certain classes may have a low number of samples because they correspond to rare occurrences. To address the challenge of multiclass imbalance, this paper introduces a novel hybrid cluster-based oversampling and undersampling (HCBOU) technique. By clustering and separating classes into majority and minority categories, this algorithm retains the most information during undersampling while generating efficient data in the minority class.

Nanosilicon application changes the morphological attributes and essential oil compositions of hemp (Cannabis sativa L.) under water deficit stress.

Various practical strategies have been employed to mitigate the detrimental effects of water deficit stress on plants such as application of nano-stimulants. Nanosilicon plays a crucial role in alleviating the deleterious impacts of both abiotic and biotic stresses in plants by modulating various phyto-morphological and physiological processes. This study aimed to examine the combined effects of drought stress and nanosilicon application on the morphological traits and essential oil content and compositions of hemp (Cannabis sativa L.

Computational Analyses of Alkaloids as Green Corrosion Inhibitors on Fe(110).

One of the successful techniques developed for the inhibition of metal corrosion is the utilization of phytochemicals from plant extracts as corrosion inhibitors. Theoretical studies are utilized to predict how organic components behave on metal surfaces and can pave the way for the development and synthesis of innovative, efficient corrosion inhibitors. However, atomic-level insights into the inhibition mechanisms of these green components are still needed.

Milk-derived bioactive peptides in insulin resistance and type 2 diabetes.

Diabetes is a global health issue affecting over 6% of the world and 11 % of the US population. It is closely linked to insulin resistance, a pivotal factor in Type 2 diabetes development. This review explores a promising avenue for addressing insulin resistance through the lens of Milk-Derived Bioactive Peptides (MBAPs).

Encapsulation of walnut husk and pomegranate peel extracts by alginate and chitosan-coated nanoemulsions.

Walnut husk extract (WHE) and pomegranate peel extract (PPE) were produced through ultrasound-assisted extraction. Total phenol, flavonoid and tannin contents (TPC, TFC and TTC), antioxidant and antimicrobial activities were determined. The best extracts were used for production of alginate (Alg) and chitosan (CS)-coated nanoemulsions containing WHE (NWHE) or PPE (NPPE).

Development of electrospun whey protein isolate nanofiber mat for omega-3 nanoencapsulation: Microstructural and physical property analysis.

This study aimed to develop bead-free nanofibers for effective omega-3 encapsulation using optimal mixing ratios of whey protein isolate (WPI)/polyvinyl alcohol (PVA) blends via electrospinning method. Various WPI-PVA ratios (100:0, 90:10, 80:20, 70:30, 60:40, 50:50 v/v) were examined for surface tension, viscosity, and conductivity. SEM images revealed uneven nanofibers with bead at 90:10 and 80:20 ratios, while the 70:30 ratio produced uniform and bead-free nanofibers with an average diameter of 262.

Zinc oxide nanoparticle-embedded tannic acid/chitosan-based sponge: A highly absorbent hemostatic agent with enhanced antimicrobial activity.

This study reports the development of a highly absorbent Chitosan (CS)/Tannic Acid (TA) sponge, synthesized via chemical cross-linking with Epichlorohydrin (ECH) and integrated with zinc oxide nanoparticles (ZnO NPs) as a novel hemostatic anti-infection agent. The chemical properties of the sponges were characterized using Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), and zeta potential measurements. Morphological and elemental analyses conducted through scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDAX) revealed a uniform distribution of ZnO NPs, with particle sizes below 20 nm.

Folic acid-targeted β-lactoglobulin nanocarriers for enhanced delivery of 5-fluorouracil and sodium butyrate in colorectal cancer treatment.

Colorectal cancer (CRC) remains a significant public health concern, emphasizing the need for innovative therapeutic strategies to improve patient outcomes. This study aimed to develop a highly efficient nanocarrier for targeted drug delivery, enhancing drug efficacy while minimizing concentrations and limiting adverse effects. We synthesized protein-based β-lactoglobulin (βlg) nanoparticles (NPs), loaded with 5-fluorouracil (5-FU) and sodium butyrate (NaB), and further functionalized with folic acid (FA) for specific targeting of folate receptor-positive CRC cells.

Management of intercostal artery pseudoaneurysm following posterior pedicle screw insertion: illustrative case.

Background: Pedicle screw insertion in posterior spinal surgery can cause vascular injuries, including rare intercostal artery pseudoaneurysms, which are typically discovered incidentally during reimaging. Onyx embolization is an effective treatment for small artery pseudoaneurysms.

Observations: A 36-year-old man who had initially presented with back pain that remained unresponsive to nonsteroidal anti-inflammatory drugs was diagnosed with a T7-8 sarcomatous lesion confirmed by magnetic resonance imaging and biopsy.

Acute anticonvulsant effects of dapsone on PTZ- and MES-induced seizures in mice: NLRP3 inflammasome inhibition and Nrf2/HO-1 pathway preservation.

Background: Epilepsy, a neurological disorder characterized by recurrent seizures, presents considerable difficulties in treatment, particularly when dealing with drug-resistant cases. Dapsone, recognized for its anti-inflammatory properties, holds promise as a potential therapeutic option. However, its effectiveness in epilepsy requires further investigation.

Exploring ferroptosis and miRNAs: implications for cancer modulation and therapy.

Ferroptosis is a novel, iron-dependent form of non-apoptotic cell death characterized by the accumulation of lipid reactive oxygen species (ROS) and mitochondrial shrinkage. It is closely associated with the onset and progression of various diseases, especially cancer, at all stages, making it a key focus of research for developing therapeutic strategies. Numerous studies have explored the role of microRNAs (miRNAs) in regulating ferroptosis by modulating the expression of critical genes involved in iron metabolism and lipid peroxidation.

The potential of alphapinene as a therapeutic agent for maternal hypoxia-induced cognitive impairments: a study on HO-1 and Nrf2 gene expression in rats.

This research seeks to address the gap in past studies by examining the role of the Nrf2 (nuclear factor erythroid 2-related factor 2) and HO-1 (heme oxygenase-1) signaling pathways in hypoxia and the potential effects of alpha-pinene on these factors. Wistar rats were divided into 7 experimental groups (n = 7): 1) control, 2 and 3) groups receiving alpha-pinene 5 and 10 mg/kg (i.p.

Varenicline Attenuates Memory Impairment in Amyloid-Beta-Induced Rat Model of Alzheimer's Disease.

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder characterized by cognitive decline. Despite extensive research, therapeutic options remain limited. Varenicline, an αβ nicotinic acetylcholine receptor agonist, shows promise in enhancing cognitive function.