Polyp and tumor microenvironment reprogramming in colorectal cancer: insights from mucosal bacteriome and metabolite crosstalk.

Background: Highly frequent colorectal cancer (CRC) is predicted to have 3.2 million novel cases by 2040. Tumor microenvironment (TME) bacteriome and metabolites are proposed to be involved in CRC development.

Investigating impact of consulting midwives on maternal rights charter on perception of respectful maternity care and postpartum blues among postpartum women: a quasi-experimental study.

Introduction: Despite the existing reports on mistreatment and disrespectful maternal care, few studies have investigated interventions to mitigate this issue. The present study aims to assess the impact of consulting midwives on maternal rights charter on perception of respectful maternity care and postpartum blues among postpartum women in two hospitals in southern Iran.

Methodology: This quasi-experimental study was conducted on 437 postpartum women (217 mothers before the intervention and 220 mothers after the intervention) and 44 midwives working in the maternity ward of two hospitals affiliated to Bushehr University of Medical Sciences in 2023-2024.

Identification of emerging harms due to COVID-19 outbreak: a qualitative study in Iran.

Introduction: Although COVID-19 has altered various harms and exacerbated the prevalence of some of them, this period has also set the stage for the emergence of new harms. The present study aims to identify the emerging harms resulting from the COVID-19 outbreak in Iran.

Methods: The study was conducted using a qualitative content analysis approach through semi-structured interviews with 21 experts and professors knowledgeable about social harms and COVID-19 consequences who were selected through purposive and theoretical sampling.

Sexual dysfunction and quality of life across age groups in multiple sclerosis patients: a prospective cross-sectional analysis.

Introduction: As the most frequent chronic neurological disorder in young adults, Multiple sclerosis (MS) significantly affects neurological function, particularly the autonomic nervous system. While the physical symptoms are visible, MS also causes hidden effects like sexual dysfunction. Research indicates that sexual disorders are more prevalent in MS patients compared to other neurological conditions and are approximately five times more common than in the general population.

Circulating Levels of Glial Cell Line-Derived Neurotrophic Factor (GDNF) in Schizophrenia: a systematic review and meta-analysis.

Background: Glial cell line-derived neurotrophic factor (GDNF) has emerged as a potential biomarker for schizophrenia (SCZ). However, GDNF levels remain unclear in affected individuals compared to healthy controls. Therefore, we aimed to calculate a pooled estimate of GDNF levels in patients with SCZ in comparison with healthy controls.

Prevalence of common diarrheagenic enterobacteriaceae in Iran (2000-2023): a systematic review and meta-analysis.

Objective: Bacterial gastroenteritis is a significant public health concern, capable of causing severe infections. Among the various pathogens involved, those belonging to the Enterobacteriaceae family are the most frequently isolated and associated with gastrointestinal disorders. This study aimed to investigate the prevalence of common diarrheagenic Enterobacteriaceae in Iran over the past two decades, from 2000 to 2023.

Postoperative complications and long-term outcomes after total and subtotal thyroidectomy: a retrospective study.

The choice between total thyroidectomy (TT) and subtotal thyroidectomy (STT) can affect postoperative complications and long-term outcomes in these patients. This study aimed to investigate postoperative complications and long-term outcomes in patients who underwent TT and STT. This retrospective study investigated 1.

Prevalence of musculoskeletal disorders among garment workers: a systematic review and meta-analysis.

Background: Garment workers are at high risk of musculoskeletal disorders (MSDs) due to repetitive physical tasks, long working hours and varying workstations. As there is no existing epidemiological overview of MSDs among garment workers, this systematic review aimed to evaluate the global evidence on prevalence of MSDs in this population.

Methods: A systematic review of the literature was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

Relationship between multiple morbidities and performance on the Timed Up and Go test in elderly patients: a cross-sectional study.

Objective: To investigate how various morbidities affect older patients' performance on the Timed Up and Go (TUG) test.

Design: Cross-sectional study.

Setting: The seven government hospitals of Lahore, Pakistan, included are major tertiary care centres, representing an older patient population of Punjab, Pakistan.

The role of memory T cells in type 1 diabetes: Phenotypes, mechanisms, and therapeutic implications.

Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the loss of insulin-producing cells in the pancreatic islets. Patients with T1D have autoreactive CD4 and CD8 T cells that show specific features, indicating previous exposure to self-antigens. Despite that memory T cells are vital components of the adaptive immune system, providing enduring protection against pathogens; individuals with T1D have a higher proportion of memory T cells compared to healthy individuals with naїve phenotypes.

The neuroprotective effect of human umbilical cord MSCs-derived secretome against α-synuclein aggregates on the blood-brain barrier.

The blood-brain barrier (BBB) is a specialized network that maintains central nervous system homeostasis. Disruption of the BBB can lead to neuronal damage and contribute to neurodegenerative diseases like Parkinson's disease (PD), characterized by alpha-synuclein (αSN) aggregation, which forms intracellular inclusions. Mesenchymal stem cells (MSCs) have shown promise in alleviating the severity of neurological diseases through their paracrine secretions.

Genetic Diversity and Prevalence of Blastocystis Subtypes in Alborz Province, Iran: A Molecular Epidemiological Study.

The primary objective of this study was to evaluate the genetic diversity of Blastocystis. Additionally, it aimed to explore, for the first time in Iran, the potential association between Blastocystis infection and ABO blood groups. Another focus was to examine the relationship between Blastocystis subtypes and blood groups, an often overlooked risk factor, within the population of Alborz Province, Iran.

Green synthesis of a fluorescence optical probe for Fe based on Barberry derived carbon quantum dots: Deep insight on interaction from experimental and theoretical approach.

A green facile method was developed to synthesize the carbon quantum dots from barberry, a native plant, as a new carbon source. The synthesis strategy is a simple one-step hydrothermal process without requiring hazardous chemical reagents. The spherical structure of b-CDs with an average particle size of 3.

Long-term assessment of anti-SARS-CoV-2 antibody levels post-pandemic: Tracking the dynamics after two, three, and four COVID-19 vaccine doses.

Background: Given the limited available data about to the number of vaccine doses administered over an extended time in Iran, the immune status of vaccinated individuals and any potential disparities in this regard among those who received different numbers of vaccine doses remain unknown. Therefore, this study aimed to assess humoral immunity of individuals who received different doses of the COVID-19 vaccines in Iran.

Methods: This study was conducted from February, 2022 to December 2023 including 605 vaccinated subjects.

Association of detectable C-peptide levels with glycemic control and chronic complications in individuals with type 1 diabetes mellitus: A systematic review and meta-analysis.

Aims: Multiple studies have addressed the association between detectable levels of C-peptide and glycemic control, as well as the development of chronic complications of type 1 diabetes mellitus (T1DM), including both macrovascular and microvascular diseases. We aimed to summarize the available evidence on the clinical significance of detectable levels of C-peptide in T1DM.

Method: A systematic search was performed on online databases using the following key terms: T1DM, C-peptide, diabetes mellitus complications, and glycemic parameters.

Comparative evaluation of calretinin immunohistochemical expression in calcifying odontogenic cyst and ameloblastoma.

Background: Calretinin is a 29 kilodalton (KDa) calcium-binding protein that is expressed in normal and tumoral tissues. The expression of calretinin has been shown in the dental epithelium during odontogenesis and in different odontogenic cysts and tumors such as ameloblastoma. Since the epithelium of calcifying odontogenic cyst (COC) is similar to ameloblastoma and in both lesions, an arrangement of loose cells similar to stellate reticulum is seen, we aimed to investigate the comparative expression of calretinin in COC and ameloblastoma.

Understanding the experience of the mothers' ability to take care of their preterm infants related to in-hospital and post-discharge: a qualitative content analysis.

Background: Preterm infants may experience many health and developmental issues, which continue even after discharge from the neonatal intensive care unit. Once home, the mother, as a non-professional and the primary caregiver will be responsible for the essential care of her preterm infant.

Purpose: Understanding the take care ability in mothers with preterm infants.

A fair non-collateral consensus protocol based on Merkle tree for hierarchical IoT blockchain.

In recent years, there has been a growing interest among researchers in Internet of Things Blockchain (IoTB). A critical aspect of IoTB is its consensus protocol, which faces challenges such as limited bandwidth, energy constraints, and storage space restrictions. To tackle these challenges, Hierarchical IoTB (HIoTB) networks have been proposed.

Examining the Influence of Alexithymia, Gender, and Age on Drug Use among Iranian Students: the Mediating Role of Emotion Regulation Difficulties.

The objective of the present study was to predict drug use among Iranian students on the basis of alexithymia, gender, age, and the mediating role of emotion regulation difficulty. This research employed a descriptive-correlational approach (structural equation modeling). The statistical population included 400 high school students studying during the 2023-2024 academic year in the cities of Khorramabad and Ardabil.

Flaky sputtered silicon MWCNTs core-shell structure as a freestanding binder-free electrode for lithium-ion battery.

Core-shell silicon/multiwall carbon nanotubes are one of the most promising anode candidates for further improvement of lithium-ion batteries. Sufficient accommodation for massive volume expansion of silicon during the lithiation process and preventing pulverization and delamination with easy fabrication processes are still critical issues for practical applications. In this study, core-shell silicon/MWCNTs anode materials were synthesized using a facile and controllable PECVD technique to realize aligned MWCNTs followed by a silicon sputtering step.

Fish active packaging with ZnO/Fe-MMT nanoparticles.

Today, active packaging has become essential to increase food safety and decrease food spoilage. In this study, the aim was to delay spoilage and increase the shelf life of rainbow fish fillets with a new hybrid nanocomposite active packaging. Packaging was fabricated with Ethylene vinyl acetate and active compounds such as rosemary extract, zinc oxide nanoparticles, and modified iron (Fe-MMT).

Understanding Burnout among Surgical residents: a mixed method study.

Burnout is a complex condition that can strangely affect individuals in healthcare professions, such as surgeons and surgical residents. This study aimed to assess burnout and better explain the concept of burnout in surgical residents and the clarification strategies they take with this phenomenon to solve this problem. This mixed methods study was conducted at Shiraz University of Medical Sciences in 2022-2023 with two quantitative and qualitative phases.