Evaluation of Safety and Efficacy of Repeated Mesenchymal Stem Cell Transplantation in Patients with Amyotrophic Lateral Sclerosis (ALS) by Investigating Patient's Specific microRNAs as Novel Biomarkers: A Clinical Trial Study.

Background: Since there is currently no cure for amyotrophic lateral sclerosis (ALS), it is essential to search for diagnostic biomarkers and novel treatments to reduce the severity of this disease. One of these treatment approaches is stem cell transplantation.

Objective: This study aims to evaluate the safety and efficacy of repeated transplantation of autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) in patients with ALS by analyzing clinical and molecular data.

LINC01322 may serve as a potential diagnostic marker for advanced stage tumors in renal cell carcinoma patients eligible for total nephrectomy.

Background: Renal cell carcinoma (RCC) is a common urological cancer globally and shows a favorable prognosis in early stages of the tumor progression. Due to the poor prognosis for metastatic RCC patients, it is crucial to explore the molecular biology of RCC progression to establish efficient diagnostic and therapeutic markers for these patients. Long non-coding RNAs (lncRNAs) have critical roles in regulation of tumor cell proliferation, migration, and apoptosis during RCC progression.

Cliotide U1, a Novel Antimicrobial Peptide Isolated From Leaves.

Aims: Antibiotic resistance is currently a major challenge to scientists. Thus, attempts have been made to develop new compounds with antimicrobial activity. In this research, a new antimicrobial peptide with antibacterial activity was isolated from the plant .

Factors Associated with the Clinical Outcomes of Ankle Instability Surgery.

Objectives: More than 20% of patients experience chronic lateral ligamentous instability of the ankle (CLLIOTA) following the appropriate management of an ankle sprain. The modified Broström-Gould (MBG) procedure has become the standard treatment for the anatomic repair of symptomatic CLLIOTA.

Methods: This retrospective, single-group study included all patients with CLLIOTA who underwent surgery using the MBG technique in Shahid Kamyab Hospital, Mashhad, Iran, between July 2015 and August 2020.

Artificial Intelligence and the State of the Art of Orthopedic Surgery.

Artificial Intelligence (AI) is rapidly transforming healthcare, particularly in orthopedics, by enhancing diagnostic accuracy, surgical planning, and personalized treatment. This review explores current applications of AI in orthopedics, focusing on its contributions to diagnostics and surgical procedures. Key methodologies such as artificial neural networks (ANNs), convolutional neural networks (CNNs), support vector machines (SVMs), and ensemble learning have significantly improved diagnostic precision and patient care.

Time Trends in Major Adverse Cardiovascular Events After Percutaneous Coronary Intervention: Meta-Analysis on Sex Differences.

Background: Percutaneous coronary intervention (PCI) is considered the procedure of choice for patients with acute coronary syndrome (ACS), as it significantly improves cardiovascular outcomes. However, considerable uncertainty persists regarding the potential sex differences in PCI outcomes, due to conflicting results in previous studies.

Objectives: This meta-analysis aims to evaluate potential sex-related differences in cardiovascular adverse outcomes after PCI among ACS patients.

Low-Dose Caffeine Supplementation Is a Valuable Strategy for Increasing Time to Exhaustion, Explosive Power, and Reducing Muscle Soreness in Professional Male Kickboxers.

Background: Caffeine is a well-established ergogenic aid that enhances physical performance and recovery. However, its dose-dependent effects on key performance metrics in combat sports like kickboxing remain insufficiently explored.

Objective: This study aimed to evaluate the effects of varied doses of acute caffeine supplementation on performance indices and perceived muscle pain in kickboxing athletes.

Charcot-Marie-Tooth disease: A case report initially manifested by bilateral vocal cord paralysis.

Charcot-Marie-Tooth is an inherited disorder involving multiple genes, causing progressive nerve damage affecting sensation and movement. The complexity of the condition often leads to various possible diagnoses along with neuropathic diseases, sometimes resulting in significant delays in diagnosis and treatment. Thorough clinical examinations, suspicion based on symptoms, electromyography, nerve conduction tests, and specific genomic testing can expedite diagnosis.

Dietary exposure to aflatoxin B1, aflatoxin G1, ochratoxin A, and patulin through fruit juice consumption: A probabilistic assessment of health risk.

The present investigation assessed the risk of dietary exposure to four mycotoxins, namely aflatoxin B1 (AFB1), aflatoxin G1 (AFG1), ochratoxin A (OTA), and patulin (PAT) via fruit juice consumption for Iranian consumers. In 96 fruit juice samples obtained from Iran market, mycotoxins levels were determined using liquid chromatography-tandem mass spectrometry. Also, probabilistic health risk assessment was conducted in terms of tolerable daily intake percentage (%TDI) and under cancer risk scenarios.

Global prevalence of malnutrition in older adults: A comprehensive systematic review and meta-analysis.

Objectives: Early detection and management of malnutrition is essential for the general health and well-being of the elderly. Various studies have reported different types of malnutrition prevalence in the elderly. the present study was aimed to determine the prevalence of malnutrition in the world' elderly through conducting a systematic review study and meta-analysis.

Exploring the application of dietary antioxidant index for disease risk assessment: a comprehensive review.

Oxidative stress contributes to the development of cardiometabolic diseases and cancers. Numerous studies have highlighted the adverse effects of high reactive oxygen species (ROS) levels in the progression of chronic noncommunicable diseases and also during infections. On the other hand, antioxidants play a crucial role in preventing oxidative stress or postponing cell damage via the direct scavenging of free radicals or indirectly via the Keap1/Nrf2/ARE pathway, among others.

Fistula in Crohn's disease: classification, pathogenesis, and treatment options.

Crohn's disease is a form of inflammation that affects the gastrointestinal (GI) tract. It is characterized by persistent inflammation in the gut, which can lead to the formation of abnormal connections called fistulas. These fistulas can occur between the GI tract and the abdominal cavity, adjacent organs, or the skin.

Superconductivity in o-MAX phases.

In recent years, MAX phases and their two-dimensional counterparts, MXenes, have emerged as significant subjects of interest in the fields of science and engineering, owing to their varied geometries, compositions, and extensive range of applications. This research employs first-principles calculations to explore the geometrical structures, electronic characteristics, phonon dispersions, dynamic stability, electron-phonon coupling (EPC), and superconducting properties of 27 out-of-plane ordered double transition metal carbides, referred to as o-MAX phases, characterized by the general formula MM'AlC (where M = Nb, Mo, W and M' = Sc, Ti, Zr, Hf, V, Nb, Ta, Mo, W). We have identified 16 superconducting o-MAX phases, with four specific compounds WVAlC, WNbAlC, WTaAlC, and MoNbAlC exhibiting a critical temperature () that surpasses 10 K, representing the highest reported experimentally for MAX phases thus far.

Review of carbonaceous nanoparticles for antibacterial uses in various dental infections.

The mouth cavity is the second most complex microbial community in the human body. It is composed of bacteria, viruses, fungi, and protozoa. An imbalance in the oral microbiota may lead to various conditions, including caries, soft tissue infections, periodontitis, root canal infections, peri-implantitis (PI), pulpitis, candidiasis, and denture stomatitis.

Systematic review and meta-analysis on the carbapenem-resistant hypervirulent Klebsiella pneumoniae isolates.

Background: The global dissemination of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) poses a critical threat to public health. However, comprehensive data on the prevalence and resistance rates of CR-hvKp are limited. This systematic review and meta-analysis aim to estimate the pooled prevalence of carbapenem resistance among hvKp strains and assess the distribution of carbapenemase genes.

Putting the broken pieces of life together, Baloch family caregivers' confrontation with schizophrenia: a phenomenological study.

Background: Long-term care of patients with schizophrenia, which creates a burden of care, leads to disruption in interactions, social and personal relationships, changes in lifestyle, and shifts in the roles of family members. This study aimed to explore the lived experiences of family caregivers who are caring for a family member with schizophrenia within the Baloch ethnicity.

Methods: This is a qualitative study, using a descriptive phenomenological approach.

Sensor-based technologies for motion analysis in sports injuries: a scoping review.

Background: Insightful motion analysis provides valuable information for athlete health, a crucial aspect of sports medicine. This systematic review presents an analytical overview of the use of various sensors in motion analysis for sports injury assessment.

Methods: A comprehensive search of PubMed/MEDLINE, Scopus, and Web of Science was conducted in February 2024 using search terms related to "sport", "athlete", "sensor-based technology", "motion analysis", and "injury.

Postural stability measures as diagnostic tools for chronic ankle instability: a comprehensive assessment.

Background: Chronic ankle instability (CAI) is characterized by recurrent sprains and persistent symptoms, which impair postural control. This study evaluates the diagnostic utility of various linear and nonlinear postural stability measures in distinguishing individuals with CAI from healthy controls.

Methods: Postural stability was assessed in 24 participants (12 with CAI and 12 healthy controls) using a force platform under four conditions: hard surface with eyes open, hard surface with eyes closed, soft surface with eyes open, and soft surface with eyes closed.

Exploring serum miR-33b as a novel diagnostic marker for hypercholesterolemia and obesity: insights from a pilot case-control study.

Obesity and atherosclerosis are significant metabolic diseases characterized by disrupted lipid metabolism. MicroRNAs (miRNAs) are small, conserved, non-coding RNA sequences consisting of approximately 22 nucleotides, playing crucial roles in biological and pathological functions. Among these, miR-33a/b is particularly associated with metabolic diseases, notably obesity and atherosclerosis.

Key performance indicators in emergency department simulation: a scoping review.

Background: One way to measure emergency department (ED) performance is using key performance indicators (KPIs). Thus, identifying reliable KPIs can be critical in appraising ED performance. This study aims to introduce and classify the KPIs related to ED in simulations through the Balanced Scorecard (BSC) framework.

Exploring the impact of genetic factors and fatty acid quality on visceral and overall Fat levels in overweight and obese women: a genetic risk score study.

Background: Recent studies suggest a link between dietary fat quality and obesity. Genetic risk scores (GRS) can predict obesity risk based on genetic factors. This study investigates how GRS and fatty acid quality affect visceral adiposity index (VAI) and body adiposity index (BAI) in overweight and obese women.

Global seroprevalence of Toxoplasma gondii in pregnant women: a systematic review and meta-analysis.

Background: Toxoplasmosis in pregnancy is associated with serious and irreversible maternal and fetal detrimental consequences. Also, different seroprevalence of Toxoplasma gondii in pregnancy is reported in many countries. The present systematic review and meta-analysis study aimed to determine the global seroprevalence of Toxoplasma gondii in pregnant women.