Synthesis and Evaluation of PCL/Chitosan/CQD-Fe Magnetic Nanocomposite for Wound Healing: Emphasis on Gene Expression.

The development of an effective and rapid method for healing the skin is of crucial importance. In this study, we prepared a porous scaffold made of polycaprolactone (PCL) and carbon quantum dots (CQDs), Fe, and Chitosan (Cs) as the scaffold core to cover the skin. Then evaluated antibacterial, biocompatibility, and wound healing properties as well as the expression of genes effective in wound healing.

Supervised machine learning and genotype by trait biplot as promising approaches for selection of phytochemically enriched genotypes.

Sumac is considered as a medicinal and industrial plant. Climate change threats natural ecosystems and hence, evaluation of sumac's genetic diversity, identification of superior genotypes, and conservation of such materials is important. In this study, 5 wild populations of sumac were investigated.

The feasibility study of transfer arc plasma pyrolysis system for petrochemical wastes: Hydrogen production from Antar, OTD, and Tar.

One of the best and most advanced methods for disposal of urban, hospital, industrial, and other hazardous waste is to convert waste into combustible gases in reactors based on plasma arc technology. Also used for renewable energy generation, this technology involves thermal treatment without a combustion process; therefore, the waste is completely decomposed into simple molecules in a near vacuum environment almost devoid of Oxygen at elevated temperatures. The present research uses a thermal transferred arc plasma reactor to conduct a feasibility study on the pyrolysis of three types of wastes: Antar, Orthotoluenediamine (OTD), and Tar.

Formulation of functional probiotic dairy dessert with date honey as a sucrose replacement: Chemical, physical, and sensory analysis.

Second-grade dates can be valorized through their use in the production of nutritive foods with health benefits. In this study, date honey (DH) and (PB) in various concentrations were used to formulate a dairy dessert. The effects of adding DH (0-20.

Assessment on surface integrity in electrochemical grinding of AISI 304.

Electrochemical grinding (ECG) offers advantages such as burr-free and stress-free material removal. Despite its proven potential, limited research has addressed the comprehensive effects of key process parameters on the surface integrity of AISI 304 stainless steel, particularly for applications requiring high-quality finishes, such as medical components. This study bridges this gap by systematically investigating the influence of ECG key parameters including voltage, rotational speed, and electrolyte concentration on main surface integrity parameters including current density, surface roughness, microhardness, and surface texture.

Free vibration and buckling analysis of axially functionally graded tapered Timoshenko beams using B-spline-based isogeometric analysis.

This study considers Timoshenko beam theory and the isogeometric analysis method to investigate the free vibration and buckling of axially functionally graded (AFG) tapered beams. The governing equations are obtained from the kinematic assumptions of Timoshenko beam theory and Hamilton's principle. The isogeometric analysis approach is implemented to solve the motion equations.

Molecular mechanisms of mTOR-mediated cisplatin response in tumor cells.

Cisplatin (CDDP) is one of the main chemotherapeutic drugs that is widely used in many cancers. However, CDDP resistance is a frequent therapeutic challenge that reduces prognosis in cancer patients. Since, CDDP has noticeable side effects in normal tissues and organs, it is necessary to assess the molecular mechanisms associated with CDDP resistance to improve the therapeutic methods in cancer patients.

Predictive performance of noninvasive factors for liver fibrosis in severe obesity: a screening based on machine learning models.

Objectives: Liver fibrosis resulting from nonalcoholic fatty liver disease (NAFLD) and metabolic disorders is highly prevalent in patients with severe obesity and poses a significant health challenge. However, there is a lack of data on the effectiveness of noninvasive factors in predicting liver fibrosis. Therefore, this study aimed to assess the relationship between these factors and liver fibrosis through a machine learning approach.

Systematic Review of Patient Preference Studies in Non-metastatic Breast Cancer Adjuvant Medication Therapy: Attribute Selection.

Context: Breast cancer poses significant challenges due to its high incidence and prevalence, necessitating heightened attention. Understanding how patients prioritize different treatment options based on various attributes can assist healthcare decision-makers in maximizing patient utility. The discrete choice experiment, a conjoint method, facilitates preference elicitation by presenting different attributes and choices.

Curcumin-Etoposide Synergy: Unveiling the Molecular Mechanisms of Enhanced Apoptosis and Chemoresistance Attenuation in Breast Cancer.

Background: Combining natural compounds with chemotherapeutic agents has emerged as a promising approach for cancer treatment. Curcumin (Cur), a natural polyphenol, is known for its anti-cancer properties, including the ability to induce apoptosis and arrest cell cycle progression.

Objectives: This study aimed to evaluate the effects of Cur and etoposide (ETO), both individually and in combination, on the induction of apoptosis in breast cancer (BC) cell lines.

Assessment of psychometric properties of the Persian version of the spiritual care competency self-assessment tool.

Background: Spiritual care is essential for the health and well-being of patients and their families, so nursing and midwifery students should have professional competency in this field.

Objectives: The present study aimed to translate the Spiritual Care Competency Self-Assessment Tool for nursing and midwifery students into Persian and evaluate its psychometric properties.

Methods: This study has a methodological study design.

The Impact of Astroglia Kir4.1 Channel Dysfunction on Neuronal Activity and Autism-Related Behavioral Abnormalities.

Autism spectrum disorder (ASD) is marked by neurobehavioral developmental deficits, potentially linked to disrupted neuron-glia interactions. The astroglia Kir4.1 channel plays a vital role in regulating potassium levels during neuronal activation, and mutations in this channel have been associated with ASD.

A Randomized Controlled Trial of the Getting Our Hearts Right Program and the Prevention and Relationship Enhancement Program in a Sample of Iranian Couples.

For several decades, to enhance relationship quality, marriage and relationship education (MRE) programs have focused on teaching communication skills and conflict management. However, new explanations reveal that the effectiveness of communication skills in MRE programs may largely depend on virtues. Through a randomized controlled trial (RCT), the present study examined the effectiveness of the Getting Our Hearts Right Program (GOHR; a virtue-based approach) and the Prevention and Relationship Enhancement Program (PREP; a skill-based approach).

Effect of Occlusal Scheme and Bone-Level Implant Number and Position on Stress Distribution in Kennedy Class II Implant-Assisted Removable Partial Dentures: A 3D Finite Element Analysis.

Objectives: To assess the effect of occlusion and implant number/position on stress distribution in Kennedy Class II implant-assisted removable partial denture (IARPD).

Materials And Methods: IARPDs were designed in six models: with one implant (bone level with a platform of 4 mm and length of 10 mm) at the site of (I) canine, (II) between first and second premolars, (III) first molar, (IV) second molar, or two implants at the sites of (V) canine-first molar, and (VI) canine-second molar. A conventional RPD served as control.

Investigating the Post-Disaster Reproductive Health Challenges of Iranian Women: A Systematic Review.

Objectives: Disasters pose serious threats to people's health, including reproductive health (RH); therefore, we conducted this study to investigate Iranian women's post-disaster RH challenges.

Methods: This study was conducted as a systematic review, and all published articles until the end of May 2022 were selected by searching in international and domestic scientific databases, including Web of Science, PubMed, Scopus, and Google Scholar, SID, and Magiran. The quality assessment of the studies was done using the Strobe checklist.

Tracking the correlation of mineral intakes among family pairs over nine years: a longitudinal study.

Background: This study aimed to assess possible changes in mineral intake correlation between family pairs over time. Mineral intake was measured using a food frequency questionnaire.

Methods: FCOR command of the Statistical Analysis for Genetic Epidemiology software was used to determine the correlation coefficients of minerals in relative pairs.

Genetic and epigenetic alterations in night shift nurses with breast cancer: a narrative review.

This narrative review explores the link between breast cancer and night shift work in nurses, focusing on genetic and epigenetic factors. Breast cancer disproportionately affects women globally, and night shift work is increasingly recognized as a potential risk factor. Nurses who work consecutive overnight shifts face elevated risks due to disruptions in their circadian rhythms.

Emotional intelligence as a predictor of clinical competence in nursing students.

Background: Clinical competence and emotional intelligence are both essential factors for the success of nursing students in their profession. Due to the inconsistent findings regarding the relationship between clinical competence and emotional intelligence in nursing students, this study aims to investigate this relationship among nursing students at Alborz University of Medical Sciences, Iran.

Methods: In this descriptive, correlational, cross-sectional study, 220 nursing students from the 2nd to the 8th semester were included in the study by census method.

The associations between diet-induced inflammation and the improvement or worsening of hepatic steatosis and fibrosis: a longitudinal analysis of RaNCD cohort study.

Background: Persistent inflammation plays a crucial role in the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). We aimed to scrutinize the associations of diet-induced inflammation with the improvement or worsening of hepatic steatosis and fibrosis in MASLD.

Methods: This longitudinal study involved 2,537 participants from the Ravanser Non-Communicable Disease (RaNCD) cohort (2015-2023).

Analysis of equity in the distribution of human resources and hospital beds and its association with the COVID-19 mortality rate: a case of Iran.

Background And Objective: Equitable distribution of health resources is important to achieving equity, guaranteeing access to healthcare services, and improving societies' health status. This study aimed to examine equity in the distribution of health resources and its association with the mortality caused by COVID-19 in South Khorasan province, east Iran.

Method: This was a secondary analysis of data from a cross-sectional study conducted in South Khorasan province in 2022.

The role of human leukocyte antigen in HTLV-1 infection and progression to ATLL and HAM/TSP: a systematic review and meta-analysis.

Background: Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that leads to lifelong infection and multiple diseases, including HAM/TSP and ATLL. Despite extensive research, the exact pathophysiology of HTLV infection and its related diseases is enigmatic. In this study, we aimed to review and analyze the effect of different HLA alleles as protective or predisposing factors in HTLV-1 infection and its progression to related diseases.

Assessing the development of health technology assessment in Iran: a policy analysis using Kingdon's Multiple streams framework: a qualitative study.

Background: Health Technology Assessment (HTA) is crucial for optimizing healthcare investments and improving system efficiency. In Iran, the rising costs of healthcare technologies and systemic inefficiencies have highlighted the need for a structured HTA framework. However, despite academic discussions, HTA has not yet been fully integrated into formal health policy.

A comprehensive overview of FFRG and IHCC allograft cartilages in revision rhinoplasty: a systematic review.

Background: This study aims to compare the complications and satisfaction associated with favorable allografts, Fresh Frozen Rib Graft (FFRG) and Irradiated Homologous Costal Cartilage (IHCC), in revision rhinoplasty.

Methods: The PRISMA guidelines were adhered to in the conduct of this systematic review. No limitations were applied to the types of studies included.

Cigarette smoking and perceived risk of cardiovascular disease in Iran.

Introduction: Studies have consistently demonstrated a strong link between cigarette smoking and an increased risk of cardiovascular diseases (CVD). On the other hand, studies have shown that most smokers do not have a real understanding of the cardiovascular health hazards of smoking. Therefore, the study aimed to determine the perceived risk of Myocardial Infarction (MI), Hypertension (HTN), and Stroke among current smokers in Iran.

Endometriosis and risk of cardiovascular disease: a systematic review and meta-analysis.

Background: This systematic review and meta-analysis aimed to evaluate the association between endometriosis and the risk of cardiovascular disease (CVD).

Methods: A comprehensive literature search was conducted in PubMed (Medline), Scopus, Web of Science, and Embase, covering studies published from January 2000 to April 2023. Cohort and case-control studies investigating the relationship between endometriosis and CVD risk were included.