A comparison of the effectiveness of standard anterior bracket placement versus smile arc protection method: A randomized clinical trial.

Objectives: This randomized two-arm parallel trial aimed to compare the effectiveness of standard anterior bracket positioning with the smile arc protection (SAP) method in terms of occlusal and smile morphometric indices, and perceived post-treatment smile aesthetics.

Methods: Patients needing nonextraction orthodontic treatment were randomly assigned to either the SAP or standard bracket placement group. Inclusion criteria were ages 11 to 25 years, nonextraction treatment, and good oral hygiene, all treated using the Roth 0.

Comprehensive systems biology analysis of microRNA-101-3p regulatory network identifies crucial genes and pathways in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. This study aimed to explore the role of hsa-miR-101-3p in HCC pathogenesis by identifying key genes and pathways. A comprehensive bioinformatics analysis revealed twelve hub genes (ETNK1, BICRA, IL1R1, KDM3A, ARID2, GSK3β, EZH2, NOTCH1, SMARCA4, FOS, CREB1, and CASP3) and highlighted their involvement in crucial oncogenic pathways, including PI3K/Akt, mTOR, MAPK, and TGF-β.

Development and comparative analysis of clobetasol-loaded microneedle patches versus clobetasol propionate ointment in experimental induced-psoriasis model.

The utilization of dissolvable microneedles (MNs) is a promising and cutting-edge approach to drug delivery for the treatment of psoriasis, an autoimmune skin disorder characterized by the appearance of red, scaly patches on the skin. This study presents the development of a dissolving MN patch made of polyvinylpyrrolidone for the purpose of delivering Clobetasol 17-Propionate through the skin. The MN patches were evaluated for their physical characteristics, including morphology, solubility, strength, and ability to penetrate the skin.

Cloning, Expression, Characterization and in silico studies of L-asparaginase from Vibrio sp. (GBPx3).

L-asparaginase is a critical therapeutic enzyme for treating acute lymphoblastic leukemia (ALL), a common childhood malignancy. In this study, the L-asparaginase coding sequence from halophilic Vibrio sp. (GBPx3) was cloned, expressed in Escherichia coli, and characterized.

Exploring the potential of incorporating ZIF-67 into electrospun poly (vinyl alcohol)/chitosan nanofibrous mats for wound healing.

The current research emphasis is on the development of wound dressings that can inhibit bacterial infections and facilitate the treatment of complex wound healing processes. In this study, nanofibrous mats of polyvinyl alcohol/chitosan/ZIF-67(PVA/Cs/ZIF-67) were prepared using an electrospinning technique, to investigate their antibacterial and regenerative properties in a rat model of full-thickness skin wounds. ZIF-67 nanoparticles, with an average size of approximately 373.

Electrospun-modified xanthan gum nanofibers enhanced with nisin for food packaging applications.

This study investigates developing and characterizing electrospun nanofibers composed of polyvinyl alcohol (PVA) and oxidized xanthan gum (OXG), with nisin as a bioactive agent, for innovative food packaging applications. Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) confirmed successful crosslinking between PVA and OXG, along with uniform nisin dispersion within the fibers. The inclusion of OXG increased moisture content (MC) and water solubility (WS) while reducing porosity and water vapor permeability (WVP), demonstrating its role as a crosslinker.

Hyperhelianthemones A-D: Polycyclic polyprenylated benzoylphloroglucinols from Hypericum helianthemoides.

Phytochemical investigation of the n-hexane-soluble fraction of the aqueous ethanol extract of the aerial parts of Hypericum helianthemoides (Spach) Boiss. (Hypericaceae), furnished four undescribed polycylic polyprenylated benzoylphloroglucinols (PPBPs) 1-4, together with phytyl formate (5) and thirteen previously reported prenylated phloroglucinol derivatives, including yezo'otogirin C (6), hyperibrins A (7) and F (8), hyperibones G (9), J (10), La (11a)/Lb (11b), 7-epi-clusianone a (12a)/7-epi-clusianone b (12b), and hypermongones A (13), C (14), E (15), G (16), H (17), and sampsonione L (18). The structures of 1-4 were established by extensive 1D and 2D NMR spectral analysis as well as HREI-MS.

Comparison of Vertical Marginal Discrepancy in High and Low Translucent Monolithic Zirconia Crowns in Repeated Firing Cycles.

Objective:  Increase in vertical marginal discrepancy (VMD) during repeated firing cycles and its clinical outcomes is a major concern for high and low translucent monolithic zirconia crowns. The purpose of this in vitro study was to evaluate and compare VMD in high and low translucent monolithic zirconia crowns in repeated firing cycles.

Material And Methods:  To perform this study, 10 monolithic zirconia crowns made by computer-aided design and computer-aided manufacturing method were used in two groups of five with high and low translucency, which were designed on Zimmer tissue-level implant abutment.

Divergent effects of noradrenergic activation and orexin receptor 1 blockade on hippocampal structure, anxiety-like behavior, and social interaction following chronic stress.

Chronic stress (Ch.S) has detrimental effects on the brain's structure and function, particularly in the hippocampus. The noradrenergic and orexinergic systems play crucial roles in the stress response and regulation of stress-related behaviors.

Monte Carlo-based estimation of patient absorbed dose in Tc-DMSA, -MAG3, and -DTPA SPECT imaging using the University of Florida (UF) phantoms.

It is generally accepted that children's organs are more sensitive to radiation than adults, due to their growth rate. Therefore, evaluating the absorbed dose in children to avoid irrecoverable damage is highly crucial. In this work, absorbed dose by different organs of children within the SPECT imaging for the Tc-MAG3, Tc-DTPA, and Tc-DMSA that are commonly employed for pediatric patients, were estimated through the use of Monte Carlo simulation and the University of Florida's (UF) voxel-wise phantoms at the ages of 4, 8, 11, and 14-years old.

Glutaraldehyde cross-linking for improving the techno-functional properties of biopolymeric food packaging films; a comprehensive review.

Biodegradable and/or edible films made from polysaccharides and proteins have gained attention for their potential to replace some traditional packaging materials in the food industry due to their abundance, biodegradability, and nutritional value. Glutaraldehyde (GLA), rapidly reacts with free deprotonated ε-amino groups in proteins, leading to crosslinking (CL) reactions. This review delves into the chemistry of GLA and explores the various biopolymeric food packaging materials crosslinked by GLA.

Carbonate chemistry and CO dynamics in the Persian Gulf.

This study examines the carbonate chemistry of the Persian Gulf within the Iranian Exclusive Economic Zone, using datasets collected during the PGE2102 expedition in September 2021. The water column was stratified, with a warm, oxic upper layer (0-25 m: 33.2 °C, salinity 38.

Melissa officinalis extract nanoemulsion, Caffeic acid and Quercetin as a novel inducer for investigating neural differentiation of human Wharton's jelly mesenchymal stem cells.

Background: Cell therapy utilizing mesenchymal stem cells, which have the ability to differentiate into different lineages, has garnered significant attention in recent years. Melissa officinalis is rich in biologically active compounds and exhibits antioxidant activity, antimicrobial properties, and sedative effects. Nanoemulsions can facilitate the effective transfer of substances and also protect drugs and biological materials from environmental factors.

Designing for practicality: a personalized and adaptive framework for real-time EMG-based hand motor decoding.

Despite remarkable advances in EMG-based hand motor decoding, developing a practical and reliable decoder for robotic prosthetic hands remains unsolved. This study highlights inter-individual, inter-session, and intra-session variabilities of EMG signals as practical challenges and introduces a novel personalized and adaptive motor decoding framework, designed to mitigate their impact and improve hand motor decoding. A dataset was collected from twelve participants (8 male, 4 female), incorporating EMG signals from three forearm muscles during 20 repetitions of 9 distinct hand motions.

Challenges in Diagnosing Rickettsial Infection: A Case Report of Rickettsia conorii in a Pediatric Patient in Iran.

Mediterranean spotted fever has recently been reported in Iran, yet it continues to be overlooked by healthcare professionals in the country. This case report details a 19-month-old child who presented with fever, edema and skin rashes and was initially misdiagnosed. Subsequent testing revealed a Mediterranean spotted fever infection through IgG seroconversion.

Music Therapy Intervention Using a Holy Quran Recitation Improves Feeding Status, Weight Gain and Length of Stay Among Preterm Infants in the Neonatal Intensive Care Unit: A Randomized Clinical Trial.

Background: One of the most important challenges that preterm infants face is nutritional problems. Poor postnatal weight gain can lead to various complications.

Purpose: To determine the effects of listening to the Holy Quran on the feeding status, postnatal weight gain, and length of hospital stay of preterm infants.

Spinal Osteotomies for Cervicothoracic Sagittal Imbalance Correction: A Systematic Review and Meta-Analysis.

Study DesignSystematic Review.ObjectivesCervicothoracic junction (CTJ) deformities, particularly kyphosis, significantly impact patients' quality of life, causing pain, dysphagia, and inability to maintain horizontal gaze. Various surgical osteotomy techniques are available to correct CTJ kyphosis, but their relative effectiveness and associated complications remain unclear.

An assessment of the uncertainties of methane generation in landfills.

The accurate estimation of methane generation in landfills is crucial for effective greenhouse gas management and energy recovery, requiring site-specific assessments due to the inherent variability in waste composition and properties before and after disposal. This study investigates the uncertainties associated with methane generation predictions by employing a combination of stoichiometric methods, Biochemical Methane Potential (BMP) assays, and Bayesian inference. Fresh and aged (1-year-old and 5-year-old) samples collected in the tropical Saravan dump site in Gilan, Iran, were used to evaluate the waste's methane generation potential and degradation rate in the field.

Neuroprotective Effects of Metformin in Stroke Patients: A Systematic Review and Meta-analysis of Cohort Studies.

Objectives: People with diabetes are 1.5 times more likely to experience stroke than those without diabetes, underlining the urgent need to address this issue. Metformin is often the initial medication chosen to manage diabetes mellitus (DM).

Native potential probiotics and postbiotics improve the gut-kidney axis by the modulation of autophagy signaling pathway.

The gut-kidney axis is the bidirectional relationship between the gut microbiota and the kidney function. Chronic inflammatory responses can impair kidney function and probiotics and postbiotics agents can have positive effects on gut health and kidney function by modulating inflammation through affecting autophagy signaling pathway. The aim of the current study was to evaluate the properties of our probiotic and postbiotics to improve kidney health by focusing the autophagy signaling pathway.

Examining team identity level and its impact on the happiness and involvement of football spectators.

Football spectators are in close and emotional interaction with teams and athletes. The sport team and the spectator are necessary to each other, and any play that has fewer spectators is less revenue. The purpose of this study was to investigate the interactive effect of team identity and play scenarios on football spectator's happiness and involvement.

Vancomycin- induced leukocytoclastic vasculitis in a patient with end-stage renal disease: a case report and literature review.

Introduction: Leukocytoclastic vasculitis (LCV) is a small-vessel inflammatory condition that can rarely occur as an adverse drug reaction (ADR). Vancomycin-induced LCV is an uncommon but potentially serious complication, particularly in patients with pre-existing renal impairment.

Reason For The Report: This case report describes a patient with end-stage renal disease (ESRD) who developed LCV following vancomycin therapy for a catheter-related infection.

Role of RB51 vaccine in cow milk contamination of traditional milk sales centers.

Brucellosis poses a major health and economic challenge in endemic areas, especially in Iran. This study aimed to determine the strains and epidemiological features of Brucella isolated from raw milk at traditional milk sales centers in western Iran. A total of 208 raw milk samples were collected from 104 dairy sales centers in Hamadan province during two sampling periods in 2023.

Combination therapy using parthenolide and doxorubicin induces apoptosis in Raji cells: insights into miR-27b and signaling pathway alterations.

Burkitt lymphoma, a highly aggressive form of non-Hodgkin lymphoma, have significant treatment challenges, such as chemotherapy-related toxicity and the risk of relapse, especially in older adults. Treatment of Raji cells, a Burkitt lymphoma cell line, with parthenolide in combination to doxorubicin may enhance therapeutic efficacy. This study aimed to evaluate cell viability and apoptosis following treatment with these agents, and to investigate the underlying molecular mechanisms involving miR-27b and the MET/PI3K/AKT signaling pathway.