Prediction of facial nerve outcomes after surgery for vestibular schwannoma using machine learning-based models: a systematic review and meta-analysis.

Postoperative facial nerve (FN) dysfunction is associated with a significant impact on the quality of life of patients and can result in psychological stress and disorders such as depression and social isolation. Preoperative prediction of FN outcomes can play a critical role in vestibular schwannomas (VSs) patient care. Several studies have developed machine learning (ML)-based models in predicting FN outcomes following resection of VS.

ATM Expression and Activation in Ataxia Telangiectasia Patients with and without Class Switch Recombination Defects.

Background: Ataxia telangiectasia mutated (ATM) kinase plays a critical role in DNA double-strand break (DSB) repair. Ataxia telangiectasia (A-T) patients exhibit abnormalities in immunoglobulin isotype expression and class switch recombination (CSR). This study investigates the role of residual ATM kinase expression and activity in the severity of A-T disease.

The Potential Role of Toxoplasma gondii Infection in Multiple Sclerosis Development: A Seroepidemiological Study in North Khorasan Province, Iran.

Pourpose: This study aimed to investigate the seroepidemiological status of Toxoplasma gondii (T. gondii) infection in Multiple Sclerosis (MS) patients compared to controls.

Methods: The present study included 98 MS patients and 100 controls.

Mediating roles of weight stigma and physical activity avoidance in the associations between severity of gaming disorder and levels of physical activity among young adults.

Background And Aims: There are limited data regarding associations between gaming disorder and physical activity (PA). The present study investigated the direct association between these two variables and assessed the potentially mediating roles of PA avoidance and two types of weight stigma (i.e.

Progress in injectable hydrogels for hard tissue regeneration in the last decade.

Bone disorders have increased with increasing the human lifespan, and despite the tissue's ability to self-regeneration, in many congenital problems and hard fractures, bone grafting such as autograft, allograft, and biomaterials implantation through surgery is traditionally used. Because of the adverse effects of these methods, the emergence of injectable hydrogels without the need for surgery and causing more pain for the patient is stunning to develop a new pattern for hard tissue engineering. These materials are formed with various natural and synthetic polymers with a crosslinked network through various chemical methods such as click chemistry, Michael enhancement, Schiff's base and enzymatic reaction and physical interactions with high water absorption which can mimic the environment of cells.

Novel mutations found in genes involved in global developmental delay and intellectual disability by whole-exome sequencing, homology modeling, and systems biology.

Background: Genes associated with global developmental delay (GDD) and intellectual disability (ID) are increasingly being identified through next-generation sequencing (NGS) technologies. This study aimed to identify novel mutations in GDD/ID phenotypes through whole-exome sequencing (WES) and additional analyses.

Material And Methods: WES was performed on 27 subjects, among whom 18 were screened for potential novel mutations.

Perceived stress in end-of-life care: a qualitative study of Iranian nurses' experiences.

Background: Nurses experience high levels of stress while providing end-of-life care, which puts them under emotional pressure, stress and conflict. Therefore, this study aimed to explain the experiences of nurses during the provision of end-of-life care in Iran.

Methods: A qualitative descriptive study conducted using a conventional content analysis approach in Gorgan in 2023.

Review on up and downstream processing of L-asparaginase.

L-asparaginase (asparagine amidohydrolase) contributes to 40% of the total enzyme demands worldwide and is one-third of the global requirement as an anti-cancerous drug in treating acute lymphocytic leukemia (ALL), a type of leukemia. This protein breaks down L-asparagine into aspartic acid and ammonia those involved in ALL, rely on for growth and survival. Both non-recombinant and recombinant L-asparaginase can be produced by bacteria when a suitable substrate and method (solid-state fermentation (SSF) or submerged fermentation (SmF) which are techniques to grow microorganisms under controlled conditions), is provided.

Anisotropic Elasticity, Spin-Orbit Coupling, and Topological Properties of ZrTe and NiTe: A Comparative Study for Spintronic and Nanoscale Applications.

The present work investigates the interfacial and atomic layer-dependent mechanical properties, SOC-entailing phonon band structure, and comprehensive electron-topological-elastic integration of ZrTe and NiTe. The anisotropy of Young's modulus, Poisson's ratio, and shear modulus are analyzed using density functional theory with the TB-mBJ approximation. NiTe has higher mechanical property values and greater anisotropy than ZrTe.

Evaluation of the Effects of Retro-Cavity Preconditioning with or Without Ethylenediaminetetraacetic Acid on Root Surface pH and Dislodgement Resistance of NeoMTA2 and Mineral Trioxide Aggregate Flow Retro-Fills: An Ex Vivo Investigation.

The aim of this study was to investigate the effects of retro-cavity preconditioning with or without 17% ethylenediaminetetraacetic acid (EDTA) solution on root surface pH as well as dislodgement resistance of NeoMTA2 and MTA Flow retro-fills. Forty-eight single-rooted human incisors were selected. After completion of endodontic treatment, root-end resections were performed, and retro-cavities were prepared.

Adult patients with an exacerbation of asthma and a higher risk for pulmonary embolism: a cluster analysis.

Objective: Current literature acknowledges the complexity of exacerbation triggers in patients with asthma. We studied the clinical heterogeneity of patients with asthma exacerbation suspected of having pulmonary embolism using cluster analysis and compared the clusters regarding of the risks for pulmonary embolism.

Methods: In a secondary analysis of a dataset from the University of Florida, USA, individuals who experienced asthma exacerbation between June 2011 and October 2018 were included.

Electrochemical Determination of Doxorubicin in the Presence of Dacarbazine Using MWCNTs/ZnO Nanocomposite Modified Disposable Screen-Printed Electrode.

In the current work, the MWCNTs/ZnO nanocomposite was successfully synthesized using simple method. Then, FE-SEM, XRD, and EDX techniques were applied for morphological and structural characterization. Afterward, a sensitive voltammetric sensor based on modification of a screen-printed carbon electrode (SPCE) using MWCNTs/ZnO nanocomposite was developed for the determination of doxorubicin in the presence of dacarbazine.

Evaluation of Carboxymethyl Cellulose/Gelatin Hydrogel-Based Dressing Containing Cefdinir for Wound Healing Promotion in Animal Model.

The skin serves as a critical barrier against external pathogens, and its wound healing is a complex biological process that requires careful management to ensure optimal tissue regeneration. Hydrogels, a class of hydrophilic polymers, have emerged as promising materials for wound dressings due to their biocompatibility, biodegradability, and ability to create a moist wound environment conducive to cell proliferation and migration. In this research, a hydrogel dressing containing cefdinir (Cef) was made from a combination of carboxymethyl cellulose (CMC) and gelatin (Gel) by a physical crosslinking method, and their physicochemical, mechanical, and biological properties were investigated.

Employing Polymer and Gel to Fabricate Scaffold-like Cancellous Orthopedic Screw: Polycaprolactone/Chitosan/Hydroxyapatite.

Using metallic/polymeric orthopedic screws causes cavities in bone trauma after the attachment of broken bones, which prolongs the healing. Yet, it remains unknown how to overcome such a challenge. The main aim of this research was to use both polymers and gels to fabricate and study a new PCL/chitosan/hydroxyapatite scaffold-like orthopedic screw for cancellous bone trauma.

Properties, Antioxidant and Antibacterial Activity of Southern Meagre Fish () Skin Gelatin Reinforced with Clove Bud Extract.

The properties of biopolymer films prepared using Southern meagre fish () skin gelatin blends, both with and without clove bud extract (CE) at concentrations of 0.3% and 0.7%, were investigated.

Theoretical and Experimental Study of an Electrokinetic Micromanipulator for Biological Applications.

The ability to control and manipulate biological fluids within microchannels is a fundamental challenge in biological diagnosis and pharmaceutical analyses, particularly when buffers with very high ionic strength are used. In this study, we investigate the numerical and experimental study of fluidic biochips driven by ac electrothermal flow for controlling and manipulating biological samples inside a microchannel, e.g.

Muscle Activation Reduction During Walking with an Active Hip Exoskeleton.

To reduce hip joint muscles' activation during walking with an active hip exoskeleton. Few studies examine the optimal active assistance timing of the hip exoskeleton based on muscle activation characteristics. Sixteen gender-balanced healthy adults (mean age 28.

Diagnosis of Cognitive and Mental Disorders: A New Approach Based on Spectral-Spatiotemporal Analysis and Local Graph Structures of Electroencephalogram Signals.

Background/objectives: The classification of psychological disorders has gained significant importance due to recent advancements in signal processing techniques. Traditionally, research in this domain has focused primarily on binary classifications of disorders. This study aims to classify five distinct states, including one control group and four categories of psychological disorders.

Plant-Derived Anti-Cancer Therapeutics and Biopharmaceuticals.

In spite of significant advancements in diagnosis and treatment, cancer remains one of the major threats to human health due to its ability to cause disease with high morbidity and mortality. A multifactorial and multitargeted approach is required towards intervention of the multitude of signaling pathways associated with carcinogenesis inclusive of angiogenesis and metastasis. In this context, plants provide an immense source of phytotherapeutics that show great promise as anticancer drugs.

Canine tooth syndrome after frontoethmoidal osteoma surgery: a case report.

: Canine tooth syndrome is a rare condition defined by the simultaneous presence of superior oblique palsy and Brown syndrome, resulting from pathological changes in the trochlear region. This syndrome can develop through various mechanisms, including dog bites, head trauma, infections, inflammation, and scarring. This report highlights its occurrence following sinus surgery for the first time.

Comparison Valsalva maneuver and auriculotherapy on pain intensity of peripheral intravenous cannulation in adults: A randomized clinical trial.

Introduction: Effective pain management during peripheral intravenous cannulation (PIVC) poses a significant challenge for medical practitioners in the emergency department. A range of non-pharmacological interventions have been advanced to address this concern. This study aimed to compare the effects of the Valsalva maneuver (VM) and auriculotherapy on pain intensity during PIVC in adults.

A rapid colorimetric paper-based sensor strip for point-of-care monitoring of the blood plasma coagulation.

Coagulation disorders can lead to dangerous bleeding or clot formation. Since centralized laboratories cannot provide rapid results for timely treatment intervention in patients with coagulation disorders, the existence of coagulation sensors for the general public is necessary. The purpose of the present research is to design and fabricate a novel, portable, low-cost, paper-based colorimetric sensor for measuring blood prothrombin time.

A Review of the Antiviral Activity of Berberine.

Berberine is an isoquinoline alkaloid with strong pharmacological activity such as analgesic, antioxidant, neuroprotective, antivirus, anti-inflammatory, anti-seizure, anti-obesity, and hypolipidemic effects. Accumulated evidence indicates berberine plays an inhibitory role against infection of numerous viruses, including human immunodeficiency virus, respiratory syncytial virus, hepatitis C virus, human papillomavirus, human cytomegalovirus, and influenza virus. Berberine's antiviral action has shown promise, making it a viable option for synergistically enhancing the inhibitory effect of current antiviral medicines.

Prevalence and concentration of aflatoxin M1 in milk and dairy products: an umbrella review of meta-analyses.

Background: Aflatoxin M1 (AFM1) is a derivative of aflatoxin B1 and a significant contaminant of milk and dairy products. In this study, we implemented an umbrella review of all existing systematic reviews and meta-analyzing studies to apprise and summarize the worldwide prevalence and level of AFM1 in milk and dairy products.

Methods: We conducted a systematic review of structured review and meta-analysis articles published in English until January 2024, with no time limit.