1 results match your criteria: "Iqra National University (INU) Peshawar[Affiliation]"
Heliyon
January 2025
Department of Allied Health Sciences, Molecular Biology Lab, Iqra National University (INU) Peshawar, 25000, Peshawar, Pakistan.
Fluorinated phospholipid analogs Edelfosine and Ilmofosine drug reveal expressive potential as antineoplastic factors though targeted interaction with heat shock protein (HSP70KDa1A), an essential mediator in cancer pathophysiology. Using evolved computational approaches, this research evaluated their ADMET (absorption, distribution, metabolism, excretion and toxicity) profiles receptor binding affinities and molecular dynamics. Molecular docking discernible vigorous interactions with Edelfosine drug displaying greater binding stability and consistent hydrogen bonding as confirmed by 100 ns molecular dynamics simulations.
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